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1. 发明申请

WO0046594A9 METHODS, DEVICES AND SYSTEMS FOR CHARACTERIZING PROTEINS 审中-公开
标题翻译：用于表征蛋白质的方法，装置和系统
公开(公告)号：WO0046594A9
公开(公告)日：2001-11-15
申请号：PCT/US0002680
申请日：2000-02-02
申请人： CALIPER TECHN CORP , DUBROW ROBERT S , BLOXSOM CHRISTOPHER , CHOW CALVIN Y H , PARCE JOHN WALLACE
发明人： DUBROW ROBERT S , BLOXSOM CHRISTOPHER , CHOW CALVIN Y H , PARCE JOHN WALLACE
IPC分类号： G01N27/447 , G01N37/00 , G01N27/26
CPC分类号： G01N27/44747 , G01N27/44791
摘要： A method of characterizing a polypeptide, comprising providing a first capillary channel (104) having a separation buffer disposed within, wherein the separation buffer comprises a non-crosslinked polymer solution, a buffering agent, a detergent, and a lipophilic dye. The separation buffer is provided such that, at the time of detection, the detergent concentration in the buffer is not above the critical micelle concentration. The polypeptide is introduced into one end of the capillary channel. An electric field is applied across the polymer solution at different rates. The polypeptide is then detected as it passes a point (176) along the length of the capillary channel.
摘要翻译：一种表征多肽的方法，包括提供其中设置有分离缓冲液的第一毛细通道（104），其中所述分离缓冲液包含非交联聚合物溶液，缓冲剂，洗涤剂和亲脂性染料。提供分离缓冲液，使得在检测时，缓冲液中的洗涤剂浓度不高于临界胶束浓度。将多肽引入毛细管通道的一端。以不同的速率在整个聚合物溶液上施加电场。然后当毛细通道沿着毛细通道的长度通过点（176）时，检测多肽。

2. 发明申请

WO03084629A2 METHODS, SYSTEMS AND APPARATUS FOR SEPARATION AND ISOLATION OF ONE OR MORE SAMPLE COMPONENTS OF A SAMPLE BIOLOGICAL MATERIAL 审中-公开
标题翻译：用于分离和分离样品生物材料的一个或多个样品组分的方法，系统和装置
公开(公告)号：WO03084629A2
公开(公告)日：2003-10-16
申请号：PCT/US0309628
申请日：2003-03-27
申请人： CALIPER TECHN CORP , DUBROW ROBERT S , BOUSSE LUC J , PHAN HUAN L
发明人： DUBROW ROBERT S , BOUSSE LUC J , PHAN HUAN L
IPC分类号： B01L3/00 , G01N27/447 , B01D
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502753 , B01L3/502784 , B01L2200/0605 , B01L2200/0631 , B01L2200/10 , B01L2300/0816 , B01L2400/0421 , B01L2400/0487 , G01N27/44791 , Y10T436/25
摘要： Devices, systems and methods for use in separating sample materials into different sample components and then isolating one or more of the sample components for further processing or analysis are disclosed. Devices employ configurations that optionally allow a sample material to be electrophoretically separated into sample components in a separation matrix within a separation conduit. The sample components may then be detected in a detection zone in the separation conduit and then selected components shunted to a component collection conduit within the device downstream of the detection zone for further processing or analysis based on information received at the detection zone. Methods of using these devices, and systems that incorporate these devices are also envisioned.
摘要翻译：公开了用于将样品材料分离成不同样品组分，然后分离一个或多个样品组分用于进一步处理或分析的装置，系统和方法。设备采用可选地允许样品材料在分离管道内的分离基质中电泳分离成样品组分的构型。然后可以在分离管道中的检测区域中检测样品组分，然后根据在检测区域接收的信息，将检测区域下游的选定部件分流到设备下游的组件收集管道，以进一步处理或分析。也可以设想使用这些装置的方法，以及并入这些装置的系统。

3. 发明申请

WO0021666A9 EXTERNAL MATERIAL ACCESSION SYSTEMS AND METHODS 审中-公开
标题翻译：外部材料加入系统和方法
公开(公告)号：WO0021666A9
公开(公告)日：2000-08-31
申请号：PCT/US9923814
申请日：1999-10-12
申请人： CALIPER TECHN CORP , CHOW ANDREA W , DUBROW ROBERT S , PARCE J WALLACE , SUNDBERG STEVEN A , WOLK JEFFREY A , CHIEN RING LING , GALLAGHER STEVEN JAMES , KNAPP MICHAEL R , KOPF SILL ANNE R , MEHTA TAMMY BURD
发明人： CHOW ANDREA W , DUBROW ROBERT S , PARCE J WALLACE , SUNDBERG STEVEN A , WOLK JEFFREY A , CHIEN RING-LING , GALLAGHER STEVEN JAMES , KNAPP MICHAEL R , KOPF-SILL ANNE R , MEHTA TAMMY BURD
IPC分类号： B01L3/00 , G01N35/00 , G01N35/10 , B01L3/02
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要： Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.
摘要翻译：提供了用于将大量不同材料快速，有效且可重复地引入微流体分析装置的方法，设备和系统。特别地，改进的集成移液器芯片配置，例如，描述了能够取样非常少量需要分析的材料，将材料输送到微流体分析通道网络中，并对材料进行所需分析的吸管或电吸附器。

4. 发明申请

WO9956954A8 METHODS OF FABRICATING POLYMERIC STRUCTURES INCORPORATING MICROSCALE FLUIDIC ELEMENTS 审中-公开
标题翻译：制备微波流体元素的聚合物结构方法
公开(公告)号：WO9956954A8
公开(公告)日：2001-02-15
申请号：PCT/US9909674
申请日：1999-05-03
申请人： CALIPER TECHN CORP
发明人： GANDHI KHUSHROO , DUBROW ROBERT S , BOUSSE LUC J
IPC分类号： B01L3/00 , B29C65/00 , B29C65/02 , B32B38/04 , B32B38/06 , G01N27/447 , B32B31/26 , G01N27/00
CPC分类号： G01N27/44791 , B01L3/502707 , B01L2200/12 , B07C5/342 , B29C65/02 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/71 , B29C66/712 , B29C66/723 , B29C66/73115 , B29C66/73343 , B29C66/73365 , B29C66/8322 , B29L2031/756 , B32B37/0023 , B32B38/06 , B32B2037/0092 , B32B2310/028 , B32B2310/0843 , Y10T156/10 , Y10T428/2495 , Y10T428/266 , B29K2081/06 , B29K2069/00 , B29K2067/00 , B29K2055/02 , B29K2033/12 , B29K2027/18 , B29K2027/14 , B29K2027/06 , B29K2023/18 , B29K2023/12 , B29K2023/06
摘要： The present invention generally provides improved methods of fabricating polymeric microfluidic devices (10) that incorporate microfluidic structures, whereby the fabrication process does not substantially distort or deform such structures. The methods of the invention generally provide enhanced bonding processes for mating and bonding substrate layers (12, 18) to define the microscale channel networks (16) therebetween.
摘要翻译：本发明通常提供了制造结合微流体结构的聚合微流体装置（10）的改进方法，由此制造过程基本上不扭曲或变形这种结构。本发明的方法通常提供用于匹配和接合衬底层（12,18）的增强的接合方法，以在其间限定微量通道网络（16）。

5. 发明申请

WO9943432A9 MICROFLUIDIC DEVICES AND SYSTEMS INCORPORATING COVER LAYERS 审中-公开
标题翻译：微流体装置和系统包含盖层
公开(公告)号：WO9943432A9
公开(公告)日：2000-03-02
申请号：PCT/US9903902
申请日：1999-02-23
申请人： CALIPER TECHN CORP
发明人： DUBROW ROBERT S , KENNEDY COLIN B , NAGLE ROBERT
IPC分类号： B01L3/00 , G01N27/447 , G01N35/00 , G01N27/26
CPC分类号： B01L3/502715 , B01L3/5085 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N27/44791 , G01N2035/00148 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides microfluidic devices that comprise a body structure (100) comprising at least a first microscale channel network (114) disposed therein. The body structure (100) has a plurality of ports (106) disposed in the body structure (100), where each port (106) is in fluid communication with one or more channels (114) in the first channel network. The devices also include a cover layer (200) comprising a plurality of apertures (206) disposed through the cover layer (200). The cover layer (200) is mated with the body structure (100) whereby each of the apertures (206) is aligned with a separate one of the plurality of ports (106).
摘要翻译：本发明提供了包括身体结构（100）的微流体装置，所述体结构（100）至少包括设置在其中的第一微尺度通道网络（114）。主体结构（100）具有设置在主体结构（100）中的多个端口（106），其中每个端口（106）与第一通道网络中的一个或多个通道（114）流体连通。这些装置还包括覆盖层（200），其包括穿过覆盖层（200）设置的多个孔（206）。覆盖层（200）与主体结构（100）配合，由此每个孔（206）与多个端口（106）中的单独一个对准。

6. 发明申请

WO2007078304A3 MEDICAL DEVICE APPLICATIONS OF NANOSTRUCTURED SURFACES 审中-公开
标题翻译：纳米结构表面的医疗器械应用
公开(公告)号：WO2007078304A3
公开(公告)日：2008-12-11
申请号：PCT/US2006010928
申请日：2006-03-23
申请人： NANOSYS INC , DUBROW ROBERT S , BOCK LAWRENCE A , DANIELS R HUGH , HARDEV VEERAL D , NIU CHUNMING , SAHI VIJENDRA
发明人： DUBROW ROBERT S , BOCK LAWRENCE A , DANIELS R HUGH , HARDEV VEERAL D , NIU CHUNMING , SAHI VIJENDRA
IPC分类号： A61B17/56
CPC分类号： A61L31/10 , A61F13/02 , A61L27/34 , A61L2400/12 , A61L2420/04 , A61N1/05 , B82Y30/00 , Y10S977/762 , Y10S977/764 , Y10S977/773 , Y10S977/811 , Y10S977/813 , Y10S977/90 , Y10S977/904 , Y10S977/906 , Y10T428/12111 , Y10T428/249924 , Y10T428/29
摘要： Novel nanofiber enhanced surface area substrates, structures comprising such substrates and methods and uses for such substrates in various medical devices are disclosed. Methods for enhancing cellular functions on a surface of a medical device Implant include providing a medical device implant with a plurality of nanofibers and exposing the device implant to cells such as osteoblasts.
摘要翻译：公开了新型纳米纤维增强表面积基板，包括这种基板的结构以及各种医疗装置中的这种基板的方法和用途。用于增强医疗装置表面上的细胞功能的方法植入物包括提供具有多个纳米纤维的医疗装置植入物，并将装置植入物暴露于细胞如成骨细胞。

7. 发明申请

WO2009023061A2 DIELECTRICS USING SUBSTANTIALLY LONGITUDINALLY ORIENTED INSULATED CONDUCTIVE WIRES 审中-公开
标题翻译：介质使用大体垂直绝缘导电线
公开(公告)号：WO2009023061A2
公开(公告)日：2009-02-19
申请号：PCT/US2008007211
申请日：2008-06-10
申请人： NANOSYS INC , DUBROW ROBERT S , MILLER JEFFREY , STUMBO DAVID P
发明人： DUBROW ROBERT S , MILLER JEFFREY , STUMBO DAVID P
IPC分类号： H01G4/10
CPC分类号： H01B7/0009 , B82Y99/00 , H01B3/004 , H01G4/018 , H01G4/20 , Y10T428/249924
摘要： A dielectric material is disclosed comprising a plurality of substantially longitudinally oriented wires which are coupled together, wherein each of the wires includes a conductive core comprising a first material and one or more insulating shell layers comprising a compositionally different second material disposed about the core. In one embodiment, a dielectric layer is disclosed comprising a substrate comprising an insulating material having a plurality of nanoscale pores defined therein having a pore diameter less than about 100 nm, and a conductive material disposed within the nanoscale pores. Methods are also disclosed to create a dielectric material layer comprising, for example, providing a plurality of wires, wherein each of the wires includes a core comprising a first material and one or more insulating layers comprising a compositionally different second material disposed about the core; substantially longitudinally orienting said plurality of wires along their long axes; coupling the wires together; and depositing an insulating coating on at least one of a top and/or a bottom end of the wires.
摘要翻译：公开了一种介电材料，其包括多个基本上纵向定向的导线，所述导线耦合在一起，其中每个导线包括包含第一材料的导电芯和包含围绕芯设置的组成不同的第二材料的一个或多个绝缘壳层。在一个实施例中，公开了一种介电层，该介电层包括含有绝缘材料的衬底和设置在纳米级孔内的导电材料，绝缘材料具有限定在其中的多个纳米级孔隙，孔隙直径小于约100nm。还公开了制造电介质材料层的方法，该电介质材料层例如包括提供多个导线，其中每个导线包括包含第一材料的芯和包含围绕芯布置的组成不同的第二材料的一个或多个绝缘层; 使所述多根丝线沿其长轴基本纵向定向; 将导线连接在一起; 以及在导线的顶端和/或底端中的至少一个上沉积绝缘涂层。

8. 发明申请

WO2007136412A3 METHODS FOR ORIENTED GROWTH OF NANOWIRES ON PATTERNED SUBSTRATES 审中-公开
标题翻译：用于在图案化基底上的纳米线的生长的方法
公开(公告)号：WO2007136412A3
公开(公告)日：2008-11-20
申请号：PCT/US2006048456
申请日：2006-12-20
申请人： NANOSYS INC , PAN YAOLING , DUAN XIANGFENG , DUBROW ROBERT S , GOLDMAN JAY L , MOSTARSHED SHAHRIAR , NIU CHUNMING , ROMANO LINDA T , STUMBO DAVID P , FISCHER-COLBRIE ALICE , SAHI VIJENDRA , ROBBINS VIRGINIA
发明人： PAN YAOLING , DUAN XIANGFENG , DUBROW ROBERT S , GOLDMAN JAY L , MOSTARSHED SHAHRIAR , NIU CHUNMING , ROMANO LINDA T , STUMBO DAVID P , FISCHER-COLBRIE ALICE , SAHI VIJENDRA , ROBBINS VIRGINIA
IPC分类号： H01L21/31 , B05D5/12
CPC分类号： C30B29/605 , B82Y30/00 , C30B11/12 , C30B29/06 , Y10T428/24917
摘要： The present invention is directed to systems and methods for nanowire growth and harvesting. In an embodiment, methods for nanowire growth and doping are provided, including methods for epitaxial oriented nanowire growth using a combination of silicon precursors, as well as us of patterned substrates to grow oriented nanowires. In a further aspect of the invention, methods to improve nanowire quality through the use of sacrifical growth layers are provided. In another aspect of the invention, methods for transferring nanowires from one substrate to another substrate are provided.
摘要翻译：本发明涉及用于纳米线生长和收获的系统和方法。在一个实施例中，提供了用于纳米线生长和掺杂的方法，包括使用硅前体的组合的外延取向纳米线生长的方法，以及我们用于生长取向的纳米线的图案化衬底。在本发明的另一方面，提供了通过使用牺牲生长层来提高纳米线质量的方法。在本发明的另一方面，提供了将纳米线从一个衬底转移到另一个衬底的方法。

9. 发明申请

WO2006118595A2 NANOSTRUCTURED THIN FILMS AND THEIR USES 审中-公开
标题翻译：纳米薄膜及其用途
公开(公告)号：WO2006118595A2
公开(公告)日：2006-11-09
申请号：PCT/US2005032962
申请日：2005-09-14
申请人： NANOSYS INC , NIU CHUNMING , DANIELS ROBERT HUGH , DUBROW ROBERT S , GOLDMAN JAY L
发明人： NIU CHUNMING , DANIELS ROBERT HUGH , DUBROW ROBERT S , GOLDMAN JAY L
IPC分类号： B01D59/44
CPC分类号： A61L27/303 , A61L31/122 , H01J49/0418 , Y10S977/701 , Y10T428/12736 , Y10T428/12743
摘要： The present invention generally discloses the use of a nanostructured non- silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.
摘要翻译：本发明通常公开了在支撑衬底上使用纳米结构的非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和传递到吸附在活性层上的一种或多种分析物。本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储，光学和传感器。

10. 发明申请

WO2006078281A2 SYSTEMS AND METHODS FOR HARVESTING AND INTEGRATING NANOWIRES 审中-公开
标题翻译：用于收集和整合纳米粒子的系统和方法
公开(公告)号：WO2006078281A2
公开(公告)日：2006-07-27
申请号：PCT/US2005014922
申请日：2005-04-29
申请人： NANOSYS INC , ROMANO LINDA T , CHEN JIAN , DUAN XIANGFENG , DUBROW ROBERT S , EMPEDOCLES STEPHEN A , GOLDMAN JAY L , HAMILTON JAMES M , HEALD DAVID L , LEMMI FRANCESCO , NIU CHUNMING , PAN YAOLING , PONTIS GEORGE , SAHI VIJENDRA , SCHER ERIK C , STUMBO DAVID P , WHITEFORD JEFFERY A
发明人： ROMANO LINDA T , CHEN JIAN , DUAN XIANGFENG , DUBROW ROBERT S , EMPEDOCLES STEPHEN A , GOLDMAN JAY L , HAMILTON JAMES M , HEALD DAVID L , LEMMI FRANCESCO , NIU CHUNMING , PAN YAOLING , PONTIS GEORGE , SAHI VIJENDRA , SCHER ERIK C , STUMBO DAVID P , WHITEFORD JEFFERY A
IPC分类号： H01L21/20
CPC分类号： C30B29/605 , B82Y10/00 , C30B11/12 , H01L21/02439 , H01L21/02513 , H01L21/02521 , H01L21/02532 , H01L21/02603 , H01L21/02606 , H01L21/02639 , H01L21/02645 , H01L21/02653 , H01L29/0673 , H01L29/0676 , H01L29/068 , H01L29/125 , H01L29/66469 , H01L29/775 , H01L29/78684 , H01L29/7869 , H01L29/78696 , H01L51/0048 , Y10S977/762 , Y10S977/938 , Y10T428/139 , Y10T428/2902 , Y10T428/2949
摘要： The present invention is directed to methods to harvest, integrate and exploit nanomaterials, and particularly elongated nanowire materials. The invention provides methods for harvesting nanowires that include selectively etching a sacrificial layer placed on a nanowire growth substrate to remove nanowires. The invention also provides methods for integrating nanowires into electronic devices that include placing an outer surface of a cylinder in contact with a fluid suspension of nanowires and rolling the nanowire coated cylinder to deposit nanowires onto a surface. Methods are also provided to deposit nanowires using an ink-jet printer or an aperture to align nanowires. Additional aspects of the invention provide methods for preventing gate shorts in nanowire based transistors. Additional methods for harvesting and integrating nanowires are provided.
摘要翻译：本发明涉及收获，整合和利用纳米材料，特别是细长的纳米线材料的方法。本发明提供了收获纳米线的方法，其包括选择性地蚀刻放置在纳米线生长衬底上以去除纳米线的牺牲层。本发明还提供了将纳米线整合到电子器件中的方法，其包括将圆筒的外表面与纳米线的流体悬浮液接触并滚动纳米线涂覆的圆柱体以将纳米线沉积到表面上。还提供了使用喷墨打印机或用于对准纳米线的孔以沉积纳米线的方法。本发明的另外的方面提供了用于防止基于纳米线的晶体管中的栅极短路的方法。提供了收集和集成纳米线的其他方法。

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