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1. 发明申请

WO2008131035A2 METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION USING RARE CELLS 审中-公开
标题翻译：用于诊断，预处理或治疗使用稀有细胞的条件的方法
公开(公告)号：WO2008131035A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/060527
申请日：2008-04-16
申请人： CELLPOINT DIAGNOTICS, INC. , KOPF-SILL, Anne, R. , WU, Lena , STOUGHTON, Roland
发明人： KOPF-SILL, Anne, R. , WU, Lena , STOUGHTON, Roland
IPC分类号： G01N33/569 , A61B5/00
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , G01N1/31 , G01N33/5091 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2333/705

2. 发明申请

WO0070353A3 HIGH THROUGHPUT ASSAY SYSTEMS AND METHODS 审中-公开
标题翻译：高通量测量系统和方法
公开(公告)号：WO0070353A3
公开(公告)日：2001-04-26
申请号：PCT/US0013200
申请日：2000-05-12
申请人： CALIPER TECHN CORP , HODGE C NICHOLAS , KNAPP MICHAEL R , KOPF SILL ANNE R , NIKIFOROV THEO T , PARCE J WALLACE , CHOW CALVIN Y H
发明人： HODGE C NICHOLAS , KNAPP MICHAEL R , KOPF-SILL ANNE R , NIKIFOROV THEO T , PARCE J WALLACE , CHOW CALVIN Y H
IPC分类号： G01N33/50 , C07B61/00 , C12M1/34 , C12Q1/00 , C12Q1/02 , C12Q1/25 , C12Q1/26 , C12Q1/34 , C12Q1/48 , C12Q1/527 , C40B60/14 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00 , G01N33/68 , G01N1/10
CPC分类号： C12Q1/00 , B01J2219/00317 , B01J2219/00707 , B01J2219/00781 , C40B60/14 , G01N33/5302 , G01N2333/726 , G01N2333/765 , G01N2333/795 , G01N2333/80 , G01N2333/90245 , G01N2333/91171 , G01N2333/9121 , G01N2333/924 , G01N2333/95
摘要： Pre-screened libraries, such as pre-screened chemical composition libraries useful for drug screening, are generated using target independent assays. The methods typically involve screening of master libraries in microfluidic devices for effects that are correlated to one or more target independent parameter. Also included are multi-module workstations, such as microfluidic workstations,and integrated systems, for performing target independent assays.
摘要翻译：预筛选的文库，例如用于药物筛选的预筛选化学组成文库，是使用目标独立测定法生成的。所述方法通常涉及筛选微流体装置中的主文库以获得与一个或多个目标独立参数相关的效果。还包括多模块工作站，例如微流控工作站和集成系统，用于执行目标独立测定。

3. 发明申请

WO2013075902A1 DIGITAL MICROFLUIDICS SYSTEM WITH DISPOSABLE CARTRIDGES 审中-公开
标题翻译：具有可拆卸盒的数字微流控系统
公开(公告)号：WO2013075902A1
公开(公告)日：2013-05-30
申请号：PCT/EP2012/070985
申请日：2012-10-23
申请人： TECAN TRADING AG , BJÖRNSON, Torleif , FEIGLIN, Marc, N. , KOPF-SILL, Anne, R. , FRANKLIN, Michael, Benjamin , LEE, Travis , WANG, Kailiang
发明人： BJÖRNSON, Torleif , FEIGLIN, Marc, N. , KOPF-SILL, Anne, R. , FRANKLIN, Michael, Benjamin , LEE, Travis , WANG, Kailiang
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/505 , B01L2200/027 , B01L2200/0673 , B01L2300/043 , B01L2300/044 , B01L2300/089 , B01L2300/123 , B01L2400/0427
摘要： A digital microfluidics system (1) for manipulating samples in liquid droplets within disposable cartridges (2) is disclosed. The disposable cartridges (2) comprise a bottom layer (3), a top layer (4), and a gap (6) between the bottom and top layers (3,4). The digital microfluidics system (1) comprises a base unit (7) with at least one cartridge accommodation site (8); at least one electrode array (9) that comprises a number of individual electrodes (10); at least one cover plate (12) located at the cartridge accommodation site(s) (8); and a central control unit (14) for controlling the selection of the individual electrodes (10) of the electrode array(s) (9) and for providing these electrodes (10) with individual voltage pulses for manipulating liquid droplets within said cartridges (2) by electrowetting. The at least one cover plate (12) of the digital microfluidics system (1) further comprises an electrically conductive material (15) that extends substantially parallel to the electrode array (9) of the cartridge accommodation site (8) the at least one cover plate (12) is assigned to. The electrically conductive material (15) of the cover plate (12) is not connected to a source of a distinct electrical potential during manipulating samples in liquid droplets (23). Also disclosed are a selection of disposable cartridges (2) and a method for manipulating samples in liquid droplets (23) that adhere to a hydrophobic surface (17).
摘要翻译：公开了一种用于在一次性盒（2）内操作液滴中的样品的数字微流体系统（1）。一次性盒（2）包括底层（3），顶层（4）和底层（3,4）之间的间隙（6）。数字微流体系统（1）包括具有至少一个筒容纳部位（8）的基部单元（7）。包括多个单独电极（10）的至少一个电极阵列（9）。至少一个位于所述药筒容纳部位（8）的盖板（12）; 以及用于控制电极阵列（9）的各个电极（10）的选择并且为这些电极（10）提供用于操纵所述盒（2）内的液滴的各个电压脉冲的中央控制单元（14））通过电润湿。数字微流体系统（1）的至少一个盖板（12）还包括基本上平行于墨盒容纳部位（8）的电极阵列（9）延伸的导电材料（15），所述至少一个盖板（12）被分配给。在操作液滴（23）中的样品时，盖板（12）的导电材料（15）不连接到不同电位的源。还公开了一次性盒（2）的选择和用于操纵粘附到疏水表面（17）的液滴（23）中的样品的方法。

4. 发明申请

WO2001073417A1 ULTRA HIGH THROUGHPUT MICROFLUIDIC ANALYTICAL SYSTEMS AND METHODS 审中-公开
标题翻译：超高速微流控分析系统及方法
公开(公告)号：WO2001073417A1
公开(公告)日：2001-10-04
申请号：PCT/US2001/009074
申请日：2001-03-22
申请人： CALIPER TECHNOLOGIES CORP. , KOPF-SILL, Anne, R. , CHOW, Andrea, W. , JANN, Peter, C. , JENSEN, Morten, J. , SPAID, Michael , KENNEDY, Colin, B. , KENNEDY, Michael
发明人： KOPF-SILL, Anne, R. , CHOW, Andrea, W. , JANN, Peter, C. , JENSEN, Morten, J. , SPAID, Michael , KENNEDY, Colin, B. , KENNEDY, Michael
IPC分类号： G01N27/26
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/54 , B01L9/527 , B01L2200/023 , B01L2200/027 , B01L2200/028 , B01L2200/147 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44782 , G01N35/0099 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421
摘要： Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.
摘要翻译：分析系统和方法，其使用模块化接口结构（600）来提供样本基板（630）和分析单元（610）之间的界面，其中分析单元（610）具有用于实现各种分析和控制功能的特定接口布置。使用模块化接口结构（600）的每个模块的多个变体有利地提供了使用具有特定分析和控制系统接口布置的特定基板或类别的基板执行大量测试的成本有效和有效的方式。还提供了用于同时分析多个并行微通道（622）中的反应或条件的改进的光学照明和检测系统。

5. 发明申请

WO0149414A2 ULTRA HIGH THROUGHPUT SAMPLING AND ANALYSIS SYSTEMS AND METHODS 审中-公开
标题翻译：超高压采样和分析系统及方法
公开(公告)号：WO0149414A2
公开(公告)日：2001-07-12
申请号：PCT/US0035658
申请日：2000-12-28
申请人： CALIPER TECHN CORP , WOLK JEFFREY A , BIONDI SHERRI ANN , PARCE JOHN WALLACE , JENSEN MORTEN J , KOPF SILL ANNE R
发明人： WOLK JEFFREY A , BIONDI SHERRI ANN , PARCE JOHN WALLACE , JENSEN MORTEN J , KOPF-SILL ANNE R
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , C40B40/06 , C40B60/14 , G01N1/02 , G01N21/64 , G01N35/10
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/02 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/143 , B01L2300/0819 , B01L2300/0861 , B01L2400/022 , B01L2400/0406 , C12Q2565/629 , C40B40/06 , C40B60/14 , G01N35/10 , G01N2001/028 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , Y10T436/25 , Y10T436/2575
摘要： Systems and method of sampling compounds into a microfluidic channel, comprising: providing a plurality of different compounds reversibly immobilized on a first surface of substrate; providing a capillary element having a capillary channel disposed therethrough, the capillary element having at least one open end, and a volume of solubilizing fluid present at the open end of the capillary element; moving the solubilizing fluid at the open end of the capillary element into contact with a fist compound on the surface of the substrate; sensing when the solubilizing fluid contacts the surface of the substrate, the solubilizing fluid dissolving at least a portion of the first compound; and drawing at least a portion of the dissolved first compound into the capillary element.
摘要翻译：将化合物取样成微流体通道的系统和方法，包括：提供可逆地固定在基材的第一表面上的多种不同的化合物; 提供毛细管元件，其具有穿过其中的毛细通道，所述毛细管元件具有至少一个开口端，以及存在于毛细管元件的开口端的增溶液体积; 将毛细管元件的开口端处的增溶液移动到与基底表面上的第一化合物接触; 当增溶流体接触基底的表面时，感测溶解至少一部分第一化合物的溶解流体; 并将至少一部分溶解的第一化合物吸入毛细管元件中。

6. 发明申请

WO2016011134A1 MICROFLUIDICS CARTRIDGE WITH PIPETTING GUIDE 审中-公开
标题翻译：具有导管指导的微流控盒
公开(公告)号：WO2016011134A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040534
申请日：2015-07-15
申请人： TECAN TRADING AG , LAY, Tiffany , HOFFMEYER, Daniel , KOPF-SILL, Anne, R. , PERROUD, Thomas
发明人： LAY, Tiffany , HOFFMEYER, Daniel , KOPF-SILL, Anne, R. , PERROUD, Thomas
IPC分类号： B01L3/02 , B81B1/00 , G01N27/447 , G01N27/453
CPC分类号： B01L3/502792 , B01L3/0275 , B01L3/50273 , B01L2200/027 , B01L2300/0816 , B01L2300/161 , B01L2400/0427
摘要： A disposable cartridge (1) is configured for use in a digital microfluidics system (3) for manipulating samples in liquid portions or droplets (4). The digital microfluidics system (3) comprises a cartridge accommodation site (2) and a central control unit (7) for controlling the selection of individual electrodes (8) of an electrode array (5) located at said cartridge accommodation site (2) and for providing a number of said electrodes (8) with individual voltage pulses for manipulating liquid portions or droplets (4) by electrowetting. The disposable cartridge (1) comprises a hydrophobic working surface (10) and a rigid cover (11 ) with a second hydrophobic surface (12), the hydrophobic surfaces (10,12) facing each other and being separated or being separable in essentially parallel planes by a gap (13) with a gap height (14).
摘要翻译：一次性盒（1）被配置用于数字微流体系统（3），用于操纵液体部分或液滴中的样品（4）。数字微流体系统（3）包括用于控制位于所述盒容纳位置（2）的电极阵列（5）的各个电极（8）的选择的盒容纳部位（2）和中央控制单元（7），以及用于通过电润湿来提供多个具有用于通过电润湿操纵液体部分或液滴（4）的各个电压脉冲的所述电极（8）。一次性药筒（1）包括具有第二疏水表面（12）的疏水性工作表面（10）和刚性覆盖物（11），所述疏水性表面（10,12）彼此面对并且基本平行地分离或可分离通过具有间隙高度（14）的间隙（13）。

7. 发明申请

WO0173417A9 ULTRA HIGH THROUGHPUT MICROFLUIDIC ANALYTICAL SYSTEMS AND METHODS 审中-公开
标题翻译：超高速微流控分析系统及方法
公开(公告)号：WO0173417A9
公开(公告)日：2004-05-27
申请号：PCT/US0109074
申请日：2001-03-22
申请人： CALIPER TECHN CORP , KOPF-SILL ANNE R , CHOW ANDREA W , JANN PETER C , JENSEN MORTEN J , SPAID MICHAEL , KENNEDY COLIN B , KENNEDY MICHAEL
发明人： KOPF-SILL ANNE R , CHOW ANDREA W , JANN PETER C , JENSEN MORTEN J , SPAID MICHAEL , KENNEDY COLIN B , KENNEDY MICHAEL
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , G01N21/05 , G01N21/64 , G01N27/447 , G01N35/00 , G01N37/00 , G01N27/26
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/54 , B01L9/527 , B01L2200/023 , B01L2200/027 , B01L2200/028 , B01L2200/147 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44782 , G01N35/0099 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421
摘要： Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.
摘要翻译：分析系统和方法，其使用模块化接口结构（600）来提供样本基板（630）和分析单元（610）之间的界面，其中分析单元（610）具有用于实现各种分析和控制功能的特定接口布置。使用模块化接口结构（600）的每个模块的许多变体有利地提供了使用具有特定分析和控制系统接口布置的特定基板或类别的基板执行大量测试的成本有效和有效的方式。还提供了用于同时分析多个并行微通道（622）中的反应或条件的改进的光学照明和检测系统。

8. 发明申请

WO1998000231A1 HIGH-THROUGHPUT SCREENING ASSAY SYSTEMS IN MICROSCALE FLUIDIC DEVICES 审中-公开
标题翻译：微型流体装置中的高通量筛选分析系统
公开(公告)号：WO1998000231A1
公开(公告)日：1998-01-08
申请号：PCT/US1997010894
申请日：1997-06-24
申请人： CALIPER TECHNOLOGIES CORPORATION , PARCE, John, Wallace , KOPF-SILL, Anne, R. , BOUSSE, Luc, J.
发明人： CALIPER TECHNOLOGIES CORPORATION
IPC分类号： B01J19/00
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： The present invention provides microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems. The device includes a series of channels (110, 112), and optional reagent channel (114), fabricated into the surface of the substrate. At least one of these channels will typically have very small cross-sectional dimensions, e.g. in the range of from about 0.1 mu m to about 500 mu m. The device also includes reservoirs (104, 106 and 108), disposed and fluidly connected at the ends of the channels (110 and 114). As shown, sample channel (112) is used to introduce the plurality of different test compounds into the device. As such, this channel will generally be fluidly connected to a source of large numbers of separate test compounds that will be individually introduced into the sample channel (112) and subsequently into channel (110).
摘要翻译：本发明提供了用于进行高通量筛选测定的微流体装置和方法。特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。该装置包括一系列通道（110,112）和可选的试剂通道（114），其制造在基板的表面中。这些通道中的至少一个通常具有非常小的横截面尺寸，例如，在约0.1μm至约500μm的范围内。装置还包括在通道（110和114）的端部处设置并流体连接的储存器（104,106和108）。如图所示，使用样品通道（112）将多种不同的测试化合物引入装置。因此，该通道通常将流体地连接到将分别引入样品通道（112）并随后进入通道（110）的大量单独测试化合物的源。

9. 发明申请

WO2008131048A2 DEVICES AND METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION BY ENRICHING RARE CELLS 审中-公开
标题翻译：用于通过增加稀有细胞来诊断，预处理或治疗条件的装置和方法
公开(公告)号：WO2008131048A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/060546
申请日：2008-04-16
申请人： CELLPOINT DIAGNOTICS, INC. , KOPF-SILL, Anne, R.
发明人： KOPF-SILL, Anne, R.
IPC分类号： G01N33/569 , A61B5/00
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , G01N1/31 , G01N33/5091 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2333/705
摘要： The invention encompasses methods and devices for diagnosing, theranosing, or prognosing a condition in a patient by enriching a sample in rare cells. The devices can be a microfluidic device comprising an array of obstacles and one or more binding moieties. The devices and methods can allow for enrichment of cells based on size and affinity, recovery of cells in locations on the microfluidic device, release of cells from the microfluidic device, flow of sample through the microfluidic device, and retention of rare cells from a sample obtained from a patient having a condition.
摘要翻译：本发明包括通过在罕见细胞中富集样品来诊断，鉴别或预测病人状况的方法和装置。装置可以是包含障碍物阵列和一个或多个结合部分的微流体装置。装置和方法可以允许基于大小和亲和力富集细胞，在微流体装置上的位置回收细胞，从微流体装置释放细胞，通过微流体装置的样品流，以及从样品中保留稀有细胞从具有病症的患者获得。

10. 发明申请

WO2005113148A1 SINGLE MOLECULE AMPLIFICATION AND DETECTION OF DNA LENGTH 审中-公开
标题翻译：单分子放大和DNA长度的检测
公开(公告)号：WO2005113148A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/017065
申请日：2005-05-16
申请人： CALIPER LIFE SCIENCES, INC. , KNAPP, Michael, R. , BAKER, Jill, M. , CHOW, Andrea, W. , KOPF-SILL, Anne, R. , SPAID, Michael, A.
发明人： KNAPP, Michael, R. , BAKER, Jill, M. , CHOW, Andrea, W. , KOPF-SILL, Anne, R. , SPAID, Michael, A.
IPC分类号： B01L3/00
CPC分类号： C12Q1/6851 , B01L3/5027 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2300/1833 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12Q1/6818 , C12Q1/6837 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6441 , C12Q2565/102 , C12Q2537/143 , C12Q2545/113 , C12Q2531/113 , C12Q2565/629 , C12Q2527/143
摘要： Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of nucleic acids are provided. Methods and systems are provided for determining and quantifying lengths of nucleic acids of interest.
摘要翻译：提供了用于进行单分子扩增用于核酸检测，定量和统计分析的方法和系统。提供了用于确定和定量感兴趣的核酸的长度的方法和系统。

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