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1. 发明申请

WO2019116016A1 FLUIDIC APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2019116016A1
公开(公告)日：2019-06-20
申请号：PCT/GB2018/053583
申请日：2018-12-11
申请人： CAMBRIDGE ENTERPRISE LIMITED , FLUIDIC ANALYTICS LIMITED
发明人： KNOWLES, Tuomas Pertti Jonathan , SAAR, Kadi Liis , KARTANAS, Tadas , MUELLER, Thomas
IPC分类号： B01L3/00 , G01N27/447 , G01N15/02
CPC分类号： B01L3/502776 , B01L3/502715 , B01L2200/027 , B01L2200/0636 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0421 , G01N15/0266 , G01N27/44704 , G01N27/44769 , G01N2015/0288
摘要： A fluidic device is provided. The fluidic device comprises a separation channel having at its upstream end a junction, a first channel for supplying a first fluid flow, a second channel for supplying a second fluid flow. The first and second channels meet at the junction are adapted to provide the first fluid flow in the separation channel sheathed by the second fluid flow,such that the first fluid flow does not contact the separation channel walls. The separation channel, the first and second channels are provided as a unitary piece, or where the separation channel and the first and second channels are provided as a non-unitary piece comprising a plurality of parts, the parts are of the same material.

2. 发明申请

WO2019089268A1 SYSTEMS AND METHODS RELATING TO PORTABLE MICROFLUIDIC DEVICES FOR PROCESSING BIOMOLECULES 审中-公开
公开(公告)号：WO2019089268A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/056961
申请日：2018-10-23
申请人： CONSERVATION X LABS, INC. , UNIVERSITY OF WASHINGTON
发明人： BAISCH, David , HOLMES, Hallie, Ray , BOHRINGER, Karl, F.
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/686
CPC分类号： C12Q1/6844 , B01L3/502792 , B01L7/525 , B01L2200/0621 , B01L2200/0673 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0851 , B01L2300/0867 , B01L2300/1827 , B01L2400/0433 , B01L2400/0688 , B01L2400/088 , C12Q2531/101 , C12Q2563/159 , C12Q2565/607 , C12Q2565/629
摘要： Aniosotropic Ratchet Conveyor ("ARC")-based biomolecule processing devices and related methods are described. The ARC-based biomolecule processing devices include (i) a substrate having an ARC track defined on or within the substrate and including a biomolecule receiving area, which is designed to receive biomolecule, and a reconstituting area, which is designed to contain dry reagents and is designed to receive a transport solution such that at the reconstituting area, dry reagents are reconstituted with transport solution; and (ii) a microheater area disposed at or near the biomolecule receiving area, fitted with a microheater, which is designed to heat biomolecule that is received through the biomolecule receiving area and designed to process heated biomolecule and dry reagents reconstituted with transport solution. The ARC track includes an arrangement of a plurality of hydrophilic rungs disposed on a hydrophobic region such that between consecutive hydrophobic rungs, a portion of the hydrophobic region is exposed.

3. 发明申请

WO2018075577A1 METHODS OF INTEGRATED MICROFLUIDIC PROCESSING FOR PREVENTING SAMPLE LOSS 审中-公开
标题翻译：用于防止样本损失的集成微流体处理方法
公开(公告)号：WO2018075577A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/057083
申请日：2017-10-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： XIE, Xiaoliang Sunney , CHANG, Chi-Han , XING, Dong
IPC分类号： B01L3/00 , B01L99/00 , C12Q1/68 , G01N35/00
CPC分类号： C12Q1/6806 , B01L3/502715 , B01L3/502761 , B01L3/502784 , B01L2200/0642 , B01L2300/0867 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , G01N15/1484 , G01N33/487 , G01N2015/1006
摘要： The present disclosure provides methods of pre-loading processing and loading of an aqueous sample solution to a device such as a microfluidic device or chip in order to prevent sample loss due to dead volume retention of the aqueous sample solution or sample sticking to wall of test tubes or reaction containers, methods of integrated processing of an aqueous sample solution on an on-chip well and direct feeding of the processed in-well solution into microfluidic circuits for further processing without any transfer apparatus in order to prevent sample loss, methods of utilizing phase separation of different matters for reactions with any number of steps of reagent addition at any desired volume or mass ratios determined by the chosen reaction and transfer apparatus while preventing loss of rare or valuable samples, methods of fabricating a portable all-in-one device and using it for applications including isothermal reactions, and methods of using a portable and integrated device at a remote site for medical doctors, scientists, police officers, and the like to perform on-site studies.
摘要翻译：本公开提供了预加载处理和将含水样品溶液加载到诸如微流体装置或芯片的装置的方法，以防止由于含水样品的死体积保留而引起的样品损失溶液或样品粘附到试管或反应容器的壁上，将水性样品溶液集成处理在芯片上的方法以及将处理的井内溶液直接馈送到微流体回路中用于进一步处理而没有任何传递装置为了防止样品损失，利用所选择的反应和转移设备确定的任何期望的体积或质量比，在防止稀有或有价值样品损失的同时，以任意数量的试剂添加步骤利用不同物质相分离的方法，制造方法一种便携式一体化设备，并将其用于包括等温反应在内的应用，以及使用便携式和集成的方法 d设备在远程医疗机构，医生，科学家，警务人员等进行现场研究。

4. 发明申请

WO2017209821A2 NON-OPTICAL LABEL-FREE BIOMOLECULAR DETECTION AT ELECTRIALLY DISPLACED LIQUID INTERFACES USING INTERFACIAL ELECTROKINETIC TRANSDUCTION (IET) 审中-公开
标题翻译：使用界面电动力学转换（IET）的电光标签液体界面的非光学标签生物分子检测
公开(公告)号：WO2017209821A2
公开(公告)日：2017-12-07
申请号：PCT/US2017/022005
申请日：2017-03-13
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： GAGNON, Zachary , MAVROGIANNIS, Nicholas
CPC分类号： G01N27/026 , B01L3/50273 , B01L2300/0636 , B01L2300/0867 , B01L2400/0415 , B01L2400/0424 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N27/447
摘要： An embodiment in accordance with the present invention is directed to a non-optical, label-free microfluidic biosensor utilizing an electrical liquid interface between two co-flowing liquids - one with a higher conductivity and one with a higher dielectric constant. The analyte-of-interest is in one solution while the receptor is in the adjacent stream. The electric interface acts as a substrate, when an alternating current electric field is applied perpendicularly across the interface, liquid displacement occurs which is frequency dependent. When a reaction occurs at the interface, it alters the electrical properties of the electrical interface, altering the frequency dependent liquid motion, which is then monitored by impedance spectroscopy downstream.
摘要翻译：根据本发明的实施方式涉及利用两种共流液体之间的电液界面的非光学无标记微流体生物传感器，一种具有较高电导率，一种具有更高的介电常数。目标分析物处于一种溶液中，而受体位于相邻的物流中。当交流电场垂直地施加在界面上时，电接口用作衬底，发生取决于频率的液体位移。当界面处发生反应时，它会改变电气界面的电气特性，改变频率相关的液体运动，然后通过阻抗谱下游进行监测。

5. 发明申请

WO2017119904A1 POLYMERASE CHAIN REACTION DEVICE INCLUDING EJECTION NOZZLES 审中-公开
标题翻译：聚合酶链反应装置，包括喷射喷嘴
公开(公告)号：WO2017119904A1
公开(公告)日：2017-07-13
申请号：PCT/US2016/012708
申请日：2016-01-08
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
发明人： TORNIAINEN, Erik D. , GOVYADINOV, Alexander , KORNILOVICH, Pavel , MARKEL, David P.
IPC分类号： C12M1/42 , C12Q1/68 , B01L3/00 , B01L7/00 , B05B17/00
CPC分类号： B01L7/52 , B01L3/0268 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1827 , B01L2400/0442 , C12M1/42
摘要： Examples include polymerase chain reaction (PCR) devices. Example PCR devices comprise a fluid input, ejection nozzles, and a set of microfluidic channels that fluidly connect the fluid input and the ejection nozzles. Each microfluidic channel comprises a reaction chamber, and examples further comprise at least one heating element, where the at least one heating element is positioned in the reaction chamber of each microfluidic channel. The at least one heating element is to heat fluid in the reaction chamber of each fluid channel. The device may eject fluid via the ejection nozzles.
摘要翻译：例子包括聚合酶链式反应（PCR）装置。示例性PCR装置包括流体输入装置，喷嘴以及流体连接流体输入装置和喷嘴的一组微流体通道。每个微流体通道包括反应室，并且实例还包括至少一个加热元件，其中至少一个加热元件位于每个微流体通道的反应室中。该至少一个加热元件用于加热每个流体通道的反应室中的流体。该设备可能会通过喷嘴喷射液体。

6. 发明申请

WO2017093763A2 SAMPLE PREPARATION SYSTEM AND CARTRIDGE 审中-公开
标题翻译：样品制备系统和培养皿
公开(公告)号：WO2017093763A2
公开(公告)日：2017-06-08
申请号：PCT/GB2016/053817
申请日：2016-12-05
申请人： THE TECHNOLOGY PARTNERSHIP PLC
发明人： HARDING, Piers Sebastian , HOWARD, Gary Stephen , JEPPS, Gary Keith
IPC分类号： C12N15/10 , G01N35/00 , G01N35/10 , B01L7/00
CPC分类号： C12N15/1003 , B01L3/021 , B01L3/545 , B01L7/52 , B01L2200/04 , B01L2200/0647 , B01L2200/0684 , B01L2200/141 , B01L2300/021 , B01L2300/022 , B01L2300/043 , B01L2300/044 , B01L2300/0672 , B01L2300/0681 , B01L2300/0841 , B01L2300/0867 , B01L2300/0887 , B01L2400/0421 , G01N35/00732 , G01N35/0098 , G01N35/1079 , G01N35/1083 , G01N2035/00465 , G01N2035/0403 , G01N2035/0436
摘要： A sample preparation cartridge for use with a sample preparation device, the cartridge includes a housing defining plural separate segments, at least one of said segments comprising a fixed section of a pipette component; and a moveable head comprising a pipette tip, the head being configured, in use, to be moved between a position in which the pipette tip is in sealed engagement with the fixed section of pipette component and a position in which pipette tip is positioned adjacent to another of said plural segments. With the present invention a disposable sample preparation cartridge and corresponding analytical reader can be provided in a very cost effective and simple manner whilst still ensuring high quality sample preparation for analysis.
摘要翻译：一种与样品制备装置一起使用的样品制备盒，所述盒包括限定多个分离段的外壳，所述分段中的至少一个包括移液管部件的固定部分; 以及包括移液管尖端的可移动头部，所述头部在使用中被配置成在所述移液管尖端与所述移液管部件的所述固定部分密封接合的位置和所述移液管尖端邻近所述多个段中的另一个段。利用本发明，一次性样品制备盒和相应的分析读取器可以以非常经济和简单的方式提供，同时仍然确保用于分析的高质量样品制备。

7. 发明申请

WO2017070571A3 DEVICES, SYSTEMS AND METHODS FOR SAMPLE DETECTION 审中-公开
标题翻译：用于样品检测的装置，系统和方法
公开(公告)号：WO2017070571A3
公开(公告)日：2017-06-08
申请号：PCT/US2016058263
申请日：2016-10-21
申请人： LANDERS JAMES P , JACKSON KIMBERLY RENEE , MILLS DANIEL , GARNER GAVIN T , DUVALL JACQUELYN A , LI JINGYI
发明人： LANDERS JAMES P , JACKSON KIMBERLY RENEE , MILLS DANIEL , GARNER GAVIN T , DUVALL JACQUELYN A , LI JINGYI
IPC分类号： B01L3/00 , C12N15/10 , C12Q1/68 , G01N21/75 , G01N33/52 , G01N33/53 , G01N33/543 , G01N33/68 , G01N35/00
CPC分类号： B01L3/502738 , B01L2200/0647 , B01L2300/0803 , B01L2300/0867 , B01L2400/0409 , B01L2400/043 , B01L2400/0633 , B01L2400/0638 , C12Q1/6809 , C12Q1/6827 , C12Q1/6844 , C12Q1/6858 , C12Q2563/143 , C12Q2563/149 , C12Q2565/113 , G01N33/52 , G01N33/53 , G01N33/54326 , G01N33/68 , G01N35/00069 , G01N35/0098 , H04N2201/0081
摘要： This disclosure provides for apparatuses, systems and methods for in vitro sample detection. For example in one embodiment, this disclosure provides an automated Pe-toner microfluidic device (and related method) on a centrifugal platform for DNA sample lysis and DNA extraction. A second embodiment provides a system and method for qualitative detection, quantification, and real-time monitoring of nucleic acid amplification products using magnetic bead aggregation inhibition. A third embodiment provides a platform for simultaneous detection of mRNA markers from blood, cell-free semen, sperm, saliva, and vaginal fluid. The third embodiment comprises a system and method that provide for simple, rapid, and fluorescence-free detection of body fluids using mRNA marker amplification and optical detection for mRNA marker analysis with a smart phone with image analysis.
摘要翻译：本公开提供了用于体外样品检测的装置，系统和方法。例如，在一个实施方案中，本公开内容在用于DNA样品裂解和DNA提取的离心平台上提供了自动Pe-调色剂微流体装置（和相关方法）。第二实施方案提供了使用磁珠聚集抑制来定性检测，定量和实时监测核酸扩增产物的系统和方法。第三个实施方案提供了用于同时检测来自血液，无细胞精液，精子，唾液和阴道液的mRNA标记物的平台。第三实施例包括一种系统和方法，其利用具有图像分析的智能电话使用mRNA标记物扩增和用于mRNA标记物分析的光学检测来提供简单，快速且无荧光的体液检测。

8. 发明申请

WO2016077341A3 INSTRUMENT AND CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM EMPLOYING ELECTROWETTING FLUID MANIPULATION 审中-公开
标题翻译：用于在使用电解液流体操作的封闭样品制备和反应系统中进行测定的仪器和盒
公开(公告)号：WO2016077341A3
公开(公告)日：2017-06-08
申请号：PCT/US2015059947
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS INC , ADVANCED LIQUID LOGIC INC
发明人： KAYYEM JON FAIZ , FORD SEAN , PAMULA VAMSEE K , SRINIVASAN VIJAY , COREY SCOTT , MURPHY BRIAN , WRIGHT DAVID WALTER , AIELLO DOMINIC
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L3/502792 , B01L3/52 , B01L7/525 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/04 , B01L2300/06 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1822 , B01L2400/0427 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
摘要翻译：在一个实施例中，多路复用流体处理盒包括样品井，可变形流体室，其中设置有混合器的混合井，包括裂解混合器的裂解室，用于微滴处理的电润湿网格，以及被配置为检测分析物的电传感器阵列出于兴趣。用于处理药筒的器械被配置为接收药筒并且选择性地将热能，磁力和电连接施加到药筒上的一个或多个离散位置，并且还被配置为以特定顺序压缩可变形腔室。

9. 发明申请

WO2017087940A1 NON-INVASIVE MONITORING CANCER USING INTEGRATED MICROFLUIDIC PROFILING OF CIRCULATING MICROVESICLES 审中-公开
标题翻译：循环微创综合微流控技术在非侵袭性监测中的应用
公开(公告)号：WO2017087940A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/063044
申请日：2016-11-21
申请人： UNIVERSITY OF KANSAS , KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
发明人： ZHAO, Zheng , ZENG, Yong , HE, Mei
IPC分类号： B01L3/00 , G01N27/00 , G01N33/543 , G01N33/574
CPC分类号： G01N33/57449 , B01L3/502761 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , G01N33/5308 , G01N33/543 , G01N2333/4725 , G01N2333/70596
摘要： A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from plasma samples with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyses of intravesicular biomarkers in the selected subpopulation. The expression of IGF-IR and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed as a non-invasive alternative to the conventional biopsy and immunohistochemistry. Detection of ovarian cancer also is assessed. The microfluidic chip, which may be fabricated of a glass substrate and a layer of poly(dimethylsiloxane), includes a serpentine microchannel to mix a fluid and a microchamber for the collection and detection of exosomes.
摘要翻译：公开了整合外来体分离和靶向蛋白质组分析的微流体外泌体分布平台。该平台能够直接从血浆样品中定量外泌体生物标志物分析，其灵敏度和特异性显着提高。通过探测选定亚群中的表面蛋白和囊内生物标志物的多参数分析来证明从患者衍生的外来体的不同亚群的鉴定。评估非小细胞肺癌（NSCLC）患者血浆中IGF-1R及其磷酸化水平的表达作为常规活检和免疫组织化学的非侵入性替代。还评估了卵巢癌的检测。微流控芯片可由玻璃基板和聚（二甲基硅氧烷）层制成，包括蛇形微通道以混合流体和微型腔室以收集和检测外来体。

10. 发明申请

WO2017066884A1 FLUIDIC CIRCUITS AND METHODS FOR BACTERIAL SCREENING 审中-公开
标题翻译：流动电路和细菌筛选方法
公开(公告)号：WO2017066884A1
公开(公告)日：2017-04-27
申请号：PCT/CA2016/051232
申请日：2016-10-24
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
发明人： JUNCKER, David , OLANREWAJU, Ayokunle
IPC分类号： G01N1/00 , B33Y10/00 , B33Y80/00 , B81B1/00 , B81C1/00
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502761 , B01L2200/0621 , B01L2200/0668 , B01L2200/12 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/126 , B01L2400/0406 , B01L2400/0688 , B33Y80/00
摘要： A microfluidic device and method for performing an assay for detecting bacteria in a fluid sample are described. The microfluidic device includes a capillaric circuit having a main channel and a sample reservoir which are fluidicly connected and separated from each other by a sample-release valve integrally formed with the capillaric circuit. The main channel has a suspension of functionalized microbeads therein, which form a microbead column portion receiving the plurality of functionalized microbeads therein to create a self-packing microbead column created autonomously during operation of the microfluidic device by flow of the suspension of the functionalized microbeads. A capillary pump is operable to drive fluid motion through the fluidic circuit by capillary action only, and one or more reagent reservoirs are fluidicly connected with the main channel and separated by respective reagent-release valves integrally formed with the capillaric circuit. The capillaric circuit may be formed by three-dimensional printing.
摘要翻译：描述了用于执行用于检测流体样品中的细菌的分析的微流体装置和方法。微流体装置包括具有主通道和样品池的毛细管电路，所述主通道和样品池通过与毛细管电路整体形成的样品释放阀而彼此流体连接和分离。主通道中具有悬浮的功能化微珠，其形成微珠柱部分，其中接收多个官能化微珠以产生在微流体装置通过官能化微珠悬浮液的流动操作期间自主产生的自填充微珠柱。毛细管泵可操作以仅通过毛细管作用驱动通过流体回路的流体运动，并且一个或多个试剂储存器与主通道流体连接并且通过与毛细管电路整体形成的相应试剂释放阀分隔开。毛细管电路可以通过三维印刷形成。

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