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1. 发明申请

WO2018035249A1 COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE AMINOCYCLOPROPANES 审中-公开
标题翻译：用于制备立体异构纯氨基环丙烷的组合物和方法
公开(公告)号：WO2018035249A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047192
申请日：2017-08-16
申请人： IMAGO BIOSCIENCES, INC. , TAPPER, Amy, E. , CELATKA, Cassandra , ROMERO, Arthur, Glenn , MCCALL, John, M. , CHANCELLOR, Toni , ZHAO, He , BIOLATTO, Betina , CHEN, Jian-xie , BROT, Elisabeth, C.A. , MICHELS, Peter, C. , CHARI, Venkat, K. , COTTERILL, Ian, C.
发明人： TAPPER, Amy, E. , CELATKA, Cassandra , ROMERO, Arthur, Glenn , MCCALL, John, M. , CHANCELLOR, Toni , ZHAO, He , BIOLATTO, Betina , CHEN, Jian-xie , BROT, Elisabeth, C.A. , MICHELS, Peter, C. , CHARI, Venkat, K. , COTTERILL, Ian, C.
IPC分类号： C12P17/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12P13/04
摘要： The present disclosure relates to compositions and methods for producing stereoisomerically pure aminocyclopropanes.
摘要翻译：本公开涉及用于生产立体异构纯的氨基环丙烷的组合物和方法。

2. 发明申请

WO2016123689A1 DIAGNOSTIC METHOD AND APPARATUS FOR BRAIN INJURY BASED ON EMG FREQUENCY POWER SPECTRA ANALYSIS 审中-公开
标题翻译：基于肌电频率功率谱分析的脑损伤诊断方法及装置
公开(公告)号：WO2016123689A1
公开(公告)日：2016-08-11
申请号：PCT/CA2015/051377
申请日：2015-12-29
申请人： CHEN, Jian
发明人： CHEN, Jian
IPC分类号： A61B5/0488 , A61B5/16
CPC分类号： A61B5/0488 , A61B5/112 , A61B5/4064 , A61B5/4076
摘要： A method and a device for diagnosing brain injury (e.g. concussion) based on analysis of electromyogram (EMG) signals and presence of neurological modulation impairment of motor activity are described. The method consists of recording specific EMG signals under defined conditions, processing the acquired EMG signals, extracting the relevant information, and making diagnosis of brain injury and disorders that are associated with brain pathology. Specifically, the steps and device involved in the method include placing an EMG electrode set on the subject's body area, acquiring EMG signals from a subject's muscle(s) undergoing contraction, processing the acquired EMG signals using a signal processing algorithm that includes Fourier transformation. The resulting EMG data with a frequency domain (frequency power spectra) are then analyzed in comparison with databases stored in the device and used to determine anomaly of diagnostic value in the EMG power spectra from subjects. A diagnosis can be made based the altered EMG frequency power spectra that reflect the neurological modulation impairment of motor neurons. The diagnostic value, determination, management suggestions are displayed on the device.
摘要翻译：描述了基于肌电图（EMG）信号的分析和运动活动的神经调节障碍的存在来诊断脑损伤（例如脑震荡）的方法和装置。该方法包括在规定的条件下记录特定的EMG信号，处理所获得的EMG信号，提取相关信息，以及对与脑病理学相关的脑损伤和病症的诊断。具体地说，该方法所涉及的步骤和装置包括将EMG电极置于受试者的身体区域，从受试者的肌肉收缩EMG信号，使用包含傅里叶变换的信号处理算法处理获取的EMG信号。然后与存储在设备中的数据库相比较，分析与频域（频率功率谱）所得到的EMG数据，并用于确定受试者的EMG功率谱中诊断值的异常。可以基于反映运动神经元的神经调节障碍的改变的EMG频率功率谱进行诊断。诊断值，确定，管理建议显示在设备上。

3. 发明申请

WO2014182420A3 GPS AND WLAN HYBRID POSITION DETERMINATION 审中-公开
标题翻译： GPS和WLAN混合位置确定
公开(公告)号：WO2014182420A3
公开(公告)日：2015-04-09
申请号：PCT/US2014034568
申请日：2014-04-17
申请人： LIU BOCHIH , JIA ZHIKE , ZHOU FAGEN , CHEN JIAN , YU JING
发明人： LIU BOCHIH , JIA ZHIKE , ZHOU FAGEN , CHEN JIAN , YU JING
IPC分类号： G01S19/00
CPC分类号： H04W64/00 , G01S19/48 , H04W4/02
摘要： The present disclosure provides a method for determining a real-time position of a mobile device using a global positioning system (GPS) and wireless local area network (WLAN) hybrid positioning mode. The method includes determining, by a mobile device, the mobile devices environment area based on GPS satellite signals; determining an absolute position of the mobile device based on the GPS satellite signals while the mobile device is moving from an outdoor area to an indoor area; estimating a reference position of the mobile device based on the determined absolute position and WLAN access point signals while moving to a shadow area; and while moving to an indoor area, determining an estimated position of the mobile device based on calculated regressive coefficients and the WLAN access point signals, and updating the estimated position of the mobile device based on motion information and indoor floor map information.
摘要翻译：本公开提供了一种使用全球定位系统（GPS）和无线局域网（WLAN）混合定位模式来确定移动设备的实时位置的方法。该方法包括：基于GPS卫星信号，由移动设备确定移动设备环境区域; 在移动设备从户外区域移动到室内区域的同时，基于GPS卫星信号确定移动设备的绝对位置; 在移动到阴影区域的同时，基于所确定的绝对位置和WLAN接入点信号来估计移动设备的参考位置; 并且在移动到室内的同时，基于计算的回归系数和WLAN接入点信号来确定移动设备的估计位置，并且基于运动信息和室内楼层地图信息更新移动设备的估计位置。

4. 发明申请

WO2013043602A3 HIGH ENDURANCE NON-VOLATILE STORAGE 审中-公开
标题翻译：高耐久性非挥发性储存
公开(公告)号：WO2013043602A3
公开(公告)日：2013-07-11
申请号：PCT/US2012055919
申请日：2012-09-18
申请人： SANDISK TECHNOLOGIES INC , CHEN JIAN , GOROBETS SERGEI , SPROUSE STEVEN , KUO TIEN-CHIEN , LI YAN , LEE SEUNGPIL , MAK ALEX , DUTTA DEEPANSHU , HIGASHITANI MASAAKI
发明人： CHEN JIAN , GOROBETS SERGEI , SPROUSE STEVEN , KUO TIEN-CHIEN , LI YAN , LEE SEUNGPIL , MAK ALEX , DUTTA DEEPANSHU , HIGASHITANI MASAAKI
IPC分类号： G11C16/10 , G11C5/06 , G11C11/56
CPC分类号： G11C16/10 , G11C5/063 , G11C11/5628 , G11C2211/5641
摘要： A non-volatile storage system is disclosed that includes non-volatile memory cells designed for high endurance and lower retention than other non-volatile memory cells. A method for programming a non-volatile memory is disclosed in which the floating gate is saturated with electrons. The non-volatile storage system may comprise first and second sets of storage elements having different pitches.
摘要翻译：公开了一种非易失性存储系统，其包括设计用于高耐久性和比其他非易失性存储器单元更低保持性的非易失性存储器单元。公开了一种用于编程非易失性存储器的方法，其中浮动栅极被电子饱和。非易失性存储系统可以包括具有不同间距的第一组和第二组存储元件。

5. 发明申请

WO2012177893A3 TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译： TRPM8拮抗剂及其在治疗中的使用
公开(公告)号：WO2012177893A3
公开(公告)日：2013-06-13
申请号：PCT/US2012043566
申请日：2012-06-21
申请人： AMGEN INC , BISWAS KAUSTAV , BROWN JAMES , CHEN JIAN J , GORE VIJAY KESHAV , HARRIED SCOTT , HORNE DANIEL B , KALLER MATTHEW R , LIU QINGYIAN , MA VU VAN , MONENSCHEIN HOLGER , NGUYEN THOMAS T , YUAN CHESTER CHENGUANG , ZHONG WENGE , ST JEAN DAVID J JR
发明人： BISWAS KAUSTAV , BROWN JAMES , CHEN JIAN J , GORE VIJAY KESHAV , HARRIED SCOTT , HORNE DANIEL B , KALLER MATTHEW R , LIU QINGYIAN , MA VU VAN , MONENSCHEIN HOLGER , NGUYEN THOMAS T , YUAN CHESTER CHENGUANG , ZHONG WENGE , ST JEAN DAVID J JR
IPC分类号： C07D213/40 , A61K31/45 , A61P29/00 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula I are useful as antagonists of transient receptor potential melastatin 8 (TRPM8). They are useful in treating disorders and conditions such as migraines and neuropathic pain. Compounds of Formula I have the following structure: where in particular X1 and X 2 may be C or N, and R1 is a ring.
摘要翻译：式I的化合物可用作瞬时受体潜力melastatin 8（TRPM8）的拮抗剂。它们可用于治疗疾病和病症如偏头痛和神经性疼痛。式I的化合物具有以下结构：其中特别地，X 1和X 2可以是C或N，并且R 1是环。

6. 发明申请

WO2013079085A1 CASE SYSTEM, BATTERY AND BATTERY RACK WITH IMPROVED STACKING 审中-公开
标题翻译：案例系统，电池和电池架与改进的堆叠
公开(公告)号：WO2013079085A1
公开(公告)日：2013-06-06
申请号：PCT/EP2011/071158
申请日：2011-11-28
申请人： ZHEJIANG NARADA POWER SOURCE CO. LTD. , WANG, De Li , CHEN, Jian
发明人： WANG, De Li , CHEN, Jian
IPC分类号： H01M2/02
CPC分类号： H01M2/1077 , H01M2/0242 , H01M2/305
摘要： A case system for lead batteries is provided. The case system has an essentially six sided cuboid shape comprising two pairs of parallel sidewalls (110, 110', 111, 111') perpendicular to each other. Each pair of sidewalls defines two opposite surfaces of the essentially cuboid shape and further defines an interior volume inside the case system. The case system comprises a further pair of parallel sidewalls, each of them perpendicular to the sidewalls above and each with a surface area larger than that of any one of the surface areas of the above sidewalls. One of the sidewalls is arranged as a separate cover wall (106) for sealing the case system. At least one division plane is further comprised in the case system. The division plane divides said interior volume, such as to form a plurality of compartments (104), each for storing an electrical cell (105). All division planes are perpendicular to the cover wall (106). Further, an electrical cell, a lead battery and a lead battery layout comprising the above are shown. The case allows the positioning of the electrode plates horizontally.
摘要翻译：提供了一种用于铅蓄电池的壳体系统。壳体系统具有包括彼此垂直的两对平行侧壁（110,110'，111,111'）的基本上六边形的长方体形状。每一对侧壁限定了基本长方体形状的两个相对表面，并进一步限定了壳体系内的内部容积。壳体系统包括另外一对平行的侧壁，它们中的每一个垂直于上面的侧壁并且每个具有比上述侧壁的任何一个表面区域大的表面积。一个侧壁被布置为用于密封壳体系统的单独的盖壁（106）。在壳体系统中进一步包括至少一个分割平面。划分平面将所述内部体积分开，以便形成多个隔室（104），每个隔间用于存储电池（105）。所有分割平面垂直于盖壁（106）。此外，示出了包括上述的电池，铅电池和铅电池布局。这种情况允许电极板水平定位。

7. 发明申请

WO2013066756A2 SOFTWARE DIGITAL FRONT END (SoftDFE) SIGNAL PROCESSING 审中-公开
标题翻译：软件数字前端（SoftDFE）信号处理
公开(公告)号：WO2013066756A2
公开(公告)日：2013-05-10
申请号：PCT/US2012/062179
申请日：2012-10-26
申请人： LSI CORPORATION , AZADET, Kameran , LI, Chengzhou , MOLINA, Albert , OTHMER, Joseph, H. , PINAULT, Steven, C. , YU, Meng-Lin , WILLIAMS, Joseph , PEREZ, Ramon, Sanchez , CHEN, Jian-Guo
发明人： AZADET, Kameran , LI, Chengzhou , MOLINA, Albert , OTHMER, Joseph, H. , PINAULT, Steven, C. , YU, Meng-Lin , WILLIAMS, Joseph , PEREZ, Ramon, Sanchez , CHEN, Jian-Guo
CPC分类号： G06F9/3001 , G06F5/01 , G06F9/30036 , G06F17/15 , H03F1/0288 , H03F1/3241 , H03F1/3258 , H03F3/189 , H03F3/24 , H03F2200/336 , H03F2201/3209 , H03F2201/3212 , H03F2201/3224 , H03F2201/3233 , H03H17/06 , H03M3/30 , H04B1/0003 , H04B1/0475 , H04B1/62 , H04B2001/0408 , H04L1/0054 , H04L25/02 , H04L25/03 , H04L25/03178 , H04L25/03216 , H04L25/4917 , H04L27/2334
摘要： Software Digital Front End (SoftDFE) signal processing techniques are provided. One or more digital front end (DFE) functions are performed on a signal in software by executing one or more specialized instructions on a processor to perform the one or more digital front end (DFE) functions on the signal, wherein the processor has an instruction set comprised of one or more of linear and non-linear instructions. A block of samples comprised of a plurality of data samples is optionally formed and the digital front end (DFE) functions are performed on the block of samples. The specialized instructions can include a vector convolution function, a complex exponential function, an x k function, a vector compare instruction, a vector max() instruction, a vector multiplication instruction, a vector addition instruction, a vector sqrt() instruction, a vector 1/x instruction, and a user-defined non-linear instruction.
摘要翻译：提供了软件数字前端（SoftDFE）信号处理技术。通过在处理器上执行一个或多个专用指令来对信号执行一个或多个数字前端（DFE）功能，以对信号执行一个或多个数字前端（DFE）功能，其中处理器具有指令由一个或多个线性和非线性指令组成。可选地形成由多个数据样本组成的样本块，并且在该样本块上执行数字前端（DFE）功能。专用指令可以包括矢量卷积函数，复指数函数，xk函数，矢量比较指令，矢量max（）指令，矢量乘法指令，矢量加法指令，矢量sqrt（）指令，矢量1 / x指令和用户定义的非线性指令。

8. 发明申请

WO2012177893A2 TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译： TRPM8拮抗剂及其在治疗中的应用
公开(公告)号：WO2012177893A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043566
申请日：2012-06-21
申请人： AMGEN INC. , BISWAS, Kaustav , BROWN, James , CHEN, Jian, J. , GORE, Vijay, Keshav , HARRIED, Scott , HORNE, Daniel, B. , KALLER, Matthew, R. , LIU, Qingyian , MA, Vu, Van , MONENSCHEIN, Holger , NGUYEN, Thomas, T. , YUAN, Chester, Chenguang , ZHONG, Wenge , ST. JEAN, David, J., Jr.
发明人： BISWAS, Kaustav , BROWN, James , CHEN, Jian, J. , GORE, Vijay, Keshav , HARRIED, Scott , HORNE, Daniel, B. , KALLER, Matthew, R. , LIU, Qingyian , MA, Vu, Van , MONENSCHEIN, Holger , NGUYEN, Thomas, T. , YUAN, Chester, Chenguang , ZHONG, Wenge , ST. JEAN, David, J., Jr.
IPC分类号： C07D213/40
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have a structure where the definitions of the variables are provided herein.
摘要翻译：式（I）的化合物可用作TRPM8的拮抗剂。这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。这些疾病的实例包括但不限于偏头痛和神经性疼痛。式（I）的化合物具有这里提供变量的定义的结构。

9. 发明申请

WO2012039867A1 SYSTEM AND METHOD FOR VOLTAGE-BASED PLASMA EXCURSION DETECTION 审中-公开
标题翻译：基于电压等离子体检测的系统和方法
公开(公告)号：WO2012039867A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/048553
申请日：2011-08-22
申请人： APPLIED MATERIALS, INC. , CHEN, Jian (Janson) , AYOUB, Mohamad
发明人： CHEN, Jian (Janson) , AYOUB, Mohamad
IPC分类号： H05H1/46 , H01L21/3065 , C23C16/50
CPC分类号： H01J37/32183 , H01J37/32935
摘要： The present invention provides a system and method for the detection of plasma excursions, such as arcs, micro-arcs, or other plasma instability, during plasma processing by directly monitoring direct current (DC) bias voltage on an RF power electrode of a plasma processing chamber. The monitored DC bias voltage is then passed through a succession of analog filters and amplifiers to provide a plasma excursion signal. The plasma excursion signal is compared to a preset value, and at points where the plasma excursion signal exceeds the preset value, an alarm signal is generated. The alarm signal is then fed back into a system controller so that an operator can be alerted and/or the processing system can be shut down. In certain embodiments, multiple processing regions can be monitored by a single detection control unit.
摘要翻译：本发明提供了一种用于在等离子体处理期间通过直接监视等离子体处理的RF功率电极上的直流（DC）偏置电压来检测诸如电弧，微弧或其它等离子体不稳定性的等离子体偏移的系统和方法室。监控的直流偏置电压然后通过一系列模拟滤波器和放大器，以提供等离子体偏移信号。将等离子体偏移信号与预设值进行比较，并且在等离子体偏移信号超过预设值的点处，产生报警信号。然后将报警信号反馈回系统控制器，以便可以警告操作员和/或处理系统被关闭。在某些实施例中，多个处理区域可以由单个检测控制单元监视。

10. 发明申请

WO2011143365A1 NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS 审中-公开
标题翻译：硝基杂环化合物作为PDE10抑制剂有用
公开(公告)号：WO2011143365A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/036148
申请日：2011-05-11
申请人： AMGEN INC. , ALLEN, Jennifer R. , CHEN, Jian J. , FROHN, Michael J. , HU, Essa , LIU, Qingyian , PICKRELL, Alexander J. , RUMFELT, Shannon , RZASA, Robert M. , ZHONG, Wenge
发明人： ALLEN, Jennifer R. , CHEN, Jian J. , FROHN, Michael J. , HU, Essa , LIU, Qingyian , PICKRELL, Alexander J. , RUMFELT, Shannon , RZASA, Robert M. , ZHONG, Wenge
IPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61P25/00 , A61K31/497 , A61K31/4439 , C07D471/08 , C07D491/08
CPC分类号： C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
摘要： Unsaturated nitrogen heterocyclic compounds of formula (I): (I), as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：式（I）的不饱和氮杂环化合物：（I），如说明书中所定义的含有它们的组合物，以及制备这些化合物的方法。本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，亨廷顿氏病，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。

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