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1. 发明申请

WO2016011134A1 MICROFLUIDICS CARTRIDGE WITH PIPETTING GUIDE 审中-公开
标题翻译：具有导管指导的微流控盒
公开(公告)号：WO2016011134A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040534
申请日：2015-07-15
申请人： TECAN TRADING AG , LAY, Tiffany , HOFFMEYER, Daniel , KOPF-SILL, Anne, R. , PERROUD, Thomas
发明人： LAY, Tiffany , HOFFMEYER, Daniel , KOPF-SILL, Anne, R. , PERROUD, Thomas
IPC分类号： B01L3/02 , B81B1/00 , G01N27/447 , G01N27/453
CPC分类号： B01L3/502792 , B01L3/0275 , B01L3/50273 , B01L2200/027 , B01L2300/0816 , B01L2300/161 , B01L2400/0427
摘要： A disposable cartridge (1) is configured for use in a digital microfluidics system (3) for manipulating samples in liquid portions or droplets (4). The digital microfluidics system (3) comprises a cartridge accommodation site (2) and a central control unit (7) for controlling the selection of individual electrodes (8) of an electrode array (5) located at said cartridge accommodation site (2) and for providing a number of said electrodes (8) with individual voltage pulses for manipulating liquid portions or droplets (4) by electrowetting. The disposable cartridge (1) comprises a hydrophobic working surface (10) and a rigid cover (11 ) with a second hydrophobic surface (12), the hydrophobic surfaces (10,12) facing each other and being separated or being separable in essentially parallel planes by a gap (13) with a gap height (14).
摘要翻译：一次性盒（1）被配置用于数字微流体系统（3），用于操纵液体部分或液滴中的样品（4）。数字微流体系统（3）包括用于控制位于所述盒容纳位置（2）的电极阵列（5）的各个电极（8）的选择的盒容纳部位（2）和中央控制单元（7），以及用于通过电润湿来提供多个具有用于通过电润湿操纵液体部分或液滴（4）的各个电压脉冲的所述电极（8）。一次性药筒（1）包括具有第二疏水表面（12）的疏水性工作表面（10）和刚性覆盖物（11），所述疏水性表面（10,12）彼此面对并且基本平行地分离或可分离通过具有间隙高度（14）的间隙（13）。

2. 发明申请

WO2020150528A1 METHOD FOR DIGITAL QUANTIFICATION OF A NUCLEIC ACID WITHOUT PHYSICALLY PARTITIONING THE REACTION MIXTURE 审中-公开
公开(公告)号：WO2020150528A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/013955
申请日：2020-01-16
申请人： QIAGEN SCIENCES LLC , QIAGEN, GmbH , PERROUD, Thomas Daniel , TONG, Yanhong
发明人： PERROUD, Thomas Daniel , TONG, Yanhong
IPC分类号： C12Q1/6844 , C12Q1/6851 , C12Q1/6876 , C12Q1/68
摘要： The invention is directed to a method for digital quantification of individual sample molecules in vitro without physically partitioning the reaction mixture and to a kit adapted for carrying out said method.

3. 发明申请

WO2017040818A1 BEAD SEPARATION IN MICROFLUIDICS 审中-公开
标题翻译：微流控珠粒分离
公开(公告)号：WO2017040818A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049952
申请日：2016-09-01
申请人： TECAN TRADING AG , PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： In a separation method, a digital microfluidics system (1) with electrodes (2) attached to a substrate or PCB (3), a control unit (7) for manipulating liquid droplets (8-1) by electrowetting, a cartridge accommodation site (18) for taking up a disposable cartridge (17) which comprises a working gap (4) in-between two hydrophobic surfaces (5,6), and a magnetic conduit (9)/backing magnet (10) combination is provided. A barrier element (40) is provided on an individual electrode (2) of the PCB (3) for narrowing the working gap (4). A disposable cartridge (17) is positioned at the cartridge accommodation site (18), its flexible working film (19) touching there and of the barrier element (40) an uppermost surface (22). In the working gap (4) and above a path of selected electrodes (2') a liquid portion (8-2) or liquid droplet (8- 1) with magnetically responsive beads (11) is provided and moved by electrowetting on the electrode path (2') until a magnetic field of the magnetic conduit (9) is reached. The backing magnet (10) is activated before and during moving by electrowetting the liquid portion (8-2) or liquid droplet (8- 1) with the magnetically responsive beads (11) over and/or around the barrier element (40), thereby attracting and substantially removing magnetically responsive beads (11) therefrom. A suspending method, a digital microfluidics system (1), and a disposable cartridge (17) are disclosed too.
摘要翻译：在分离方法中，具有连接到基板或PCB（3）上的电极（2）的数字微流体系统（1），用于通过电润湿来操纵液滴（8-1）的控制单元（7）提供了一种包括在两个疏水表面（5,6）之间的工作间隙（4）和一个磁性导管（9）/背衬磁体（10）组合）的一次性盒式存储器（17）。阻挡元件（40）设置在PCB（3）的单独电极（2）上，用于使工作间隙（4）变窄。一次性盒（17）定位在盒容纳位置（18）处，其柔性工作膜（19）接触其上和屏障元件（40）最上表面（22）。在工作间隙（4）及以上，提供具有磁响应珠（11）的液体部分（8-2）或液滴（8-1）的选定电极（2'）的路径，并通过电润湿移动到电极路径（2'），直到达到磁导管（9）的磁场。背衬磁体（10）在通过电磁润湿液体部分（8-2）或液滴（8-1）与磁性响应珠子（11）在屏障元件（40）之上和/或周围的移动之前和期间被激活，从而吸引并基本上去除其上的磁响应珠（11）。还公开了悬挂方法，数字微流体系统（1）和一次性盒（17）。

4. 发明申请

WO2017039654A1 MAGNETIC CONDUITS IN MICROFLUIDICS 审中-公开
标题翻译：微流控磁流体
公开(公告)号：WO2017039654A1
公开(公告)日：2017-03-09
申请号：PCT/US2015/048141
申请日：2015-09-02
申请人： TECAN TRADING AG , PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： A method comprises the steps of: providing a digital microfluidics system (1) with electrodes (2) attached to a substrate (3) and covered by a hydrophobic surface (5), and a control unit (7) for manipulating liquid droplets (8-1) by electrowetting; providing in close proximity to electrodes (2) a magnetic conduit (9) for directing a magnetic field of a backing magnet to the first hydrophobic surface (5); providing on the hydrophobic surface (5) a liquid droplet (8-1) that comprises magnetically responsive beads (11); moving by electrowetting the liquid droplet (8-1) with the magnetically responsive beads (11) until at least a part of which is placed atop of the magnetic conduit (9); actuating the backing magnet (10) of the magnetic conduit (9) and attracting/concentrating magnetically responsive beads (11); and while actuating the backing magnet (10), moving by electrowetting the liquid droplet (8-1)' with decreased number of magnetically responsive beads (11) away from the specific magnetic conduit (9). Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge (17) to carry out the methods therein.
摘要翻译：一种方法包括以下步骤：提供数字微流体系统（1），电极（2）连接到基底（3）并被疏水表面（5）覆盖;以及控制单元（7），用于操纵液滴 -1）通过电润湿; 提供靠近电极（2）的磁导管（9），用于将背衬磁体的磁场引导到第一疏水表面（5）; 在疏水表面（5）上提供包含磁响应珠（11）的液滴（8-1）; 通过用磁响应珠（11）电润湿液滴（8-1）直到其至少一部分放置在磁导管（9）的顶部来移动; 启动磁导管（9）的背衬磁体（10）并吸引/集中磁响应珠（11）; 并且在致动所述背衬磁体（10）时，通过以较少数量的磁响应珠（11）远离所述特定磁导管（9）的方式电润湿所述液滴（8-1）来移动。还公开了一种在数字微流体中的液体部分或液滴中悬浮磁响应珠的方法和用于执行其中的方法的一次性盒（17）。

5. 发明申请

WO2009126352A3 NOVEL MICROPORES AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：新型微孔及其制造和使用方法
公开(公告)号：WO2009126352A3
公开(公告)日：2009-12-23
申请号：PCT/US2009031516
申请日：2009-01-21
申请人： SANDIA NAT LAB , PERROUD THOMAS D , PATEL KAMLESH D , MEAGHER ROBERT J
发明人： PERROUD THOMAS D , PATEL KAMLESH D , MEAGHER ROBERT J
IPC分类号： H01L21/311 , H01L21/02 , H01L21/70
CPC分类号： G01N33/5005 , B01F3/0807 , B01F5/0471 , B01F13/0059 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0688 , B81B2201/058 , B81C1/00047 , B81C1/00087 , B81C1/00119 , B81C1/00404 , B81C2201/0133 , B81C2201/0142 , Y10T137/9464 , Y10T428/24479
摘要： Disclosed herein are methods of making micropores of a desired height and/or width between two isotropic wet etched features in a substrate which comprises single-level isotropic wet etching the two features using an etchant and a mask distance that is less than 2X a set etch depth. Also disclosed herein are methods using the micropores and microfluidic devices comprising the micropores.
摘要翻译：本文公开了制造基底中的两个各向同性湿蚀刻特征之间的期望高度和/或宽度的微孔的方法，其包括使用蚀刻剂和掩模距离的单级各向同性湿法蚀刻两个特征，掩模距离小于集蚀刻的2X 深度。本文还公开了使用包含微孔的微孔和微流体装置的方法。

6. 发明申请

WO2009131722A3 METHODS AND DEVICES FOR IMMOBILIZATION OF SINGLE PARTICLES 审中-公开
标题翻译：用于单颗粒固定的方法和装置
公开(公告)号：WO2009131722A3
公开(公告)日：2009-12-17
申请号：PCT/US2009031515
申请日：2009-01-21
申请人： SANDIA NAT LAB , PERROUD THOMAS D , PATEL KAMLESH D
发明人： PERROUD THOMAS D , PATEL KAMLESH D
IPC分类号： G01N1/28 , G01N35/10
CPC分类号： G01N33/5005 , B01F3/0807 , B01F5/0471 , B01F13/0059 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0688 , B81B2201/058 , B81C1/00047 , B81C1/00087 , B81C1/00119 , B81C1/00404 , B81C2201/0133 , B81C2201/0142 , Y10T137/9464 , Y10T428/24479
摘要： Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.
摘要翻译：本文公开了固定颗粒的方法，其包括将含有颗粒的样品流体的流聚焦到虚流道中，所述虚流道朝向微流体通道中的未被占据的流体动力捕集器流动，使得颗粒流入流体动力捕集器并且固定在其中。还公开了微流体装置，其包括具有至少一个流体动力捕集器的至少一个微通道，至少一个聚焦流体入口，所述聚焦流体入口在流体动力捕集器的上游，使得引入其中的聚焦流体导致样品的虚拟通道存在时流体优先流向流体动力捕集器。

7. 发明申请

WO2009131722A2 METHODS AND DEVICES FOR IMMOBILIZATION OF SINGLE PARTICLES 审中-公开
标题翻译：用于固定单颗颗粒的方法和装置
公开(公告)号：WO2009131722A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/031515
申请日：2009-01-21
申请人： SANDIA NATIONAL LABORATORIES , PERROUD, Thomas, D. , PATEL, Kamlesh, D.
发明人： PERROUD, Thomas, D. , PATEL, Kamlesh, D.
IPC分类号： G01N1/28 , G01N35/10
CPC分类号： G01N33/5005 , B01F3/0807 , B01F5/0471 , B01F13/0059 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0688 , B81B2201/058 , B81C1/00047 , B81C1/00087 , B81C1/00119 , B81C1/00404 , B81C2201/0133 , B81C2201/0142 , Y10T137/9464 , Y10T428/24479
摘要： Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.
摘要翻译：本文公开了固定颗粒的方法，其包括将含有颗粒的样品流体的流动聚焦到虚拟通道中，该虚拟通道朝向微流体通道中的未占据的流体动力阱捕获，使得颗粒流入流体动力阱并固定在其中。还公开了微流体装置，其包括具有至少一个流体动力捕集器，至少一个聚焦流体入口的至少一个微通道，所述聚焦流体入口在流体动力捕集器的上游，使得其中引入的聚焦流体导致样品的虚拟通道存在时优先流向流体动力阱的流体。

8. 发明申请

WO2009126352A2 NOVEL MICROPORES AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：新型微波炉及其制造和使用方法
公开(公告)号：WO2009126352A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/031516
申请日：2009-01-21
申请人： SANDIA NATIONAL LABORATORIES , PERROUD, Thomas, D. , PATEL, Kamlesh, D. , MEAGHER, Robert, J.
发明人： PERROUD, Thomas, D. , PATEL, Kamlesh, D. , MEAGHER, Robert, J.
IPC分类号： H01L21/311 , H01L21/02 , H01L21/70
CPC分类号： G01N33/5005 , B01F3/0807 , B01F5/0471 , B01F13/0059 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0688 , B81B2201/058 , B81C1/00047 , B81C1/00087 , B81C1/00119 , B81C1/00404 , B81C2201/0133 , B81C2201/0142 , Y10T137/9464 , Y10T428/24479
摘要： Disclosed herein are methods of making micropores of a desired height and/or width between two isotropic wet etched features in a substrate which comprises single-level isotropic wet etching the two features using an etchant and a mask distance that is less than 2X a set etch depth. Also disclosed herein are methods using the micropores and microfluidic devices comprising the micropores.
摘要翻译：这里公开的方法是在衬底中的两个各向同性湿蚀刻特征之间制造所需高度和/或宽度的微孔的方法，其包括使用蚀刻剂和小于2X的蚀刻剂的掩模距离的单层各向同性湿法蚀刻两个特征深度。本文还公开了使用包括微孔的微孔和微流体装置的方法。

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