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1. 发明申请

WO2010041875A3 ULTRA HIGH SPEED AND HIGH SENSITIVITY BASE SEQUENCE ANALYSIS SYSTEM AND ANALYSIS METHOD FOR SAME 审中-公开
标题翻译：超高速高灵敏度基准序列分析系统及其分析方法
公开(公告)号：WO2010041875A3
公开(公告)日：2010-08-05
申请号：PCT/KR2009005742
申请日：2009-10-08
申请人： NAT UNIV CHUNGBUK IND ACAD , CHOI JUNG BUM , LEE JONG JIN
发明人： CHOI JUNG BUM , LEE JONG JIN
IPC分类号： G01N33/68
CPC分类号： G01N33/588 , B01L3/502761 , B82Y5/00 , B82Y15/00 , C12Q1/6869 , G01N27/00 , G01N27/414 , G01N33/48721 , Y10S436/806 , C12Q2565/631 , C12Q2565/629 , C12Q2565/607
摘要： The present system relates to a system architecture that uses a single electron transistor (SET) to analyze base sequences of deoxyribonucleic acid (DNA) at ultra high speed in real time. DNA represents the entire body of genetic information and consists of nucleotide units. There are a total of four types of nucleotides, and each nucleotide consists of an identical pentose (deoxyribose), and four types of bases that differ in their phosphate groups (Adenine: A, Guanine: G, Cytosine: C, Thymine: T). A and G are purines having a bicyclic structure while C and T are pyrimidines having a monocyclic structure. Each has a different atomic arrangement, which signifies a different charge distribution from one another. Therefore, a system comprising a single electron transistor that is very sensitive to charges, a probe of a very small size that reacts to one nucleotide very effectively, and an extended gate that connects the SET with the probe, can be used to analyze DNA base sequences at ultra high speed in real time.
摘要翻译：本系统涉及使用单电子晶体管（SET）以超高速实时分析脱氧核糖核酸（DNA）的碱基序列的系统架构。 DNA代表遗传信息的整体，由核苷酸单位组成。总共有四种类型的核苷酸，每种核苷酸由相同的戊糖（脱氧核糖）和四种类型的磷酸基团不同的碱基组成（腺嘌呤：A，鸟嘌呤：G，胞嘧啶：C，胸腺嘧啶：T）。 A和G是具有双环结构的嘌呤，而C和T是具有单环结构的嘧啶。每种元素都有不同的原子排列，表示不同的电荷分布。因此，可以使用包含对电荷非常敏感的单电子晶体管，非常有效地与一个核苷酸反应的非常小尺寸的探针以及将SET与探针连接的扩展门的系统来分析DNA碱基实时超高速序列。

2. 发明申请

WO2009091589A1 DEVICES USING ADDRESSABLE MAGNETIC TUNNEL JUNCTION ARRAY TO DETECT MAGNETIC PARTICLES 审中-公开
标题翻译：使用可寻址磁性连接阵列检测磁性颗粒的装置
公开(公告)号：WO2009091589A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/000302
申请日：2009-01-16
申请人： MAGIC TECHNOLOGIES, INC. , SHI, Xizeng , WANG, Po, Kang , YANG, Hsu, Kai
发明人： SHI, Xizeng , WANG, Po, Kang , YANG, Hsu, Kai
IPC分类号： G01R33/00
CPC分类号： G01R33/098 , G01R33/1269 , Y10S436/806
摘要： A magnetic sensor for identifying small superparamagnetic particles bonded to a substrate contains a regular orthogonal array of MTJ cells formed beneath that substrate. A magnetic field imposed on the particle, perpendicular to the substrate, induces a magnetic field that has a component within the MTJ cells that is along the plane of the MTJ free layer. If that free layer has a low switching threshold, the induced field of the particle will create resistance changes in a group of MTJ cells that lie beneath it. These resistance changes will be distributed in a characteristic formation or signature that will indicate the presence of the particle. If the particle's field is insufficient to produce the free layer switching, then a biasing field can be added in the direction of the hard axis and the combination of this field and the induced field allows the presence of the particle to be determined.
摘要翻译：用于识别结合到衬底的小超顺磁性颗粒的磁传感器包含在该衬底下面形成的MTJ电池的规则正交阵列。垂直于衬底施加在颗粒上的磁场诱导磁场，该磁场在MTJ单元内具有沿着MTJ自由层的平面的分量。如果自由层具有低切换阈值，则颗粒的感应场将在其下面的一组MTJ细胞中产生电阻变化。这些电阻变化将分布在表征粒子存在的特征形成或特征中。如果粒子的场不足以产生自由层切换，则可以在硬轴的方向上添加偏置场，并且该场与感应场的组合允许确定粒子的存在。

3. 发明申请

WO2008075285A1 MEASURING AGGLUTINATION PARAMETERS 审中-公开
标题翻译：测量参数
公开(公告)号：WO2008075285A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055195
申请日：2007-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, U. , DE KIEVIT, Peggy , NIEUWENHUIS, Jeroen, H. , PRINS, Menno, W., J. , VAN IJZENDOORN, Leonardus, J. , JANSSEN, Xander, J., A.
发明人： DITTMER, Wendy, U. , DE KIEVIT, Peggy , NIEUWENHUIS, Jeroen, H. , PRINS, Menno, W., J. , VAN IJZENDOORN, Leonardus, J. , JANSSEN, Xander, J., A.
IPC分类号： G01N15/02 , G01N33/543 , G01R33/12
CPC分类号： G01N15/0266 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N2015/0092 , G01R33/093 , G01R33/1269 , Y10S436/806
摘要： A method and system are described for measuring agglutination in a target- induced agglutination assay with one or more magnetic particles performed in a reaction chamber. After the magnetic particles (3, 15), which are capable of binding to a target (5) are provided in the assay, an agglutination process resulting in agglutinated particles (100) comprising at least one magnetic particle is performed. The method then further comprises applying an alternating current magnetic field (H AC ) to the assay and- measuring an effect of the H AC on the one or more magnetic particles (3,15) unattached to any surface. The measured effect is indicative of one or more agglutination parameters.
摘要翻译：描述了用于在反应室中进行的一种或多种磁性颗粒测量靶诱导的凝集测定中的凝集的方法和系统。在测定中提供能够结合靶（5）的磁性颗粒（3,15）之后，进行产生包含至少一个磁性颗粒的凝集颗粒（100）的凝集过程。该方法然后还包括向测定中施加交流磁场（H SUB AC），并且测量一个或多个磁性颗粒（3）上的H AC的影响，15）不附着在任何表面上。测量的效果表示一个或多个凝集参数。

4. 发明申请

WO2004102176A1 センサ审中-公开
标题翻译：传感器
公开(公告)号：WO2004102176A1
公开(公告)日：2004-11-25
申请号：PCT/JP2004/006618
申请日：2004-05-11
申请人：松下電器産業株式会社 , 山本智浩
发明人：山本智浩
IPC分类号： G01N27/327
CPC分类号： B01L3/50273 , B01L3/502753 , B01L2200/0684 , B01L2300/0663 , B01L2300/0681 , B01L2300/0825 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , C12Q1/002 , G01N33/48707 , Y10S435/817 , Y10S436/806
摘要：　本発明は、センサが略水平状態になかったとしても、少量の試料液を迅速かつ的確に濾過部に供給することのできるセンサを実現するため、毛細管現象により試料液を濾過部に手段を有することを特徴とするセンサを提供する。
摘要翻译：即使传感器不位于大致水平状态，也能够将少量的试样液体迅速且准确地供给到过滤部的传感器，其特征在于，包括用于通过毛细管现象将试样液供给到过滤部的装置。

5. 发明申请

WO9005910A3 WHOLLY MICROFABRICATED BIOSENSORS AND PROCESS FOR THE MANUFACTURE AND USE THEREOF 审中-公开
标题翻译：专用微生物传感器及其制造及其使用过程
公开(公告)号：WO9005910A3
公开(公告)日：2004-04-22
申请号：PCT/US8905227
申请日：1989-11-13
申请人： I STAT CORP
发明人： COZZETTE STEPHEN N , DAVIS GRAHAM , ITAK JEANNE A , LAUKS IMANTS R , MIER RANDALL M , PIZNIK SYLVIA , SMIT NICOLAAS , STEINER SUSAN J , VAN DER WERF PAUL , WIECK HENRY J
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00 , G01N27/26 , B01D61/00 , B01D63/00 , B67D5/00
CPC分类号： B01L3/0268 , B01L3/5027 , B01L3/5088 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01N35/109 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01V9/00 , G10K11/006 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using a substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxyde.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法为批量生产均匀的全微生物传感器提供了有效的手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理学意义的新方法，其产生选自由二氧和过氧化氢组成的组中的电活性物质的浓度的变化。

6. 发明申请

WO2004021005A1 FLOW-THROUGH ASSAY WITH AN INTERNAL CALIBRATION SYSTEM USING___MAGNETIC PARTICLES 审中-公开
标题翻译：使用__磁性颗粒进行内部校准系统的流量测量
公开(公告)号：WO2004021005A1
公开(公告)日：2004-03-11
申请号：PCT/US2003/021522
申请日：2003-07-10
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： SONG, Xuedong , KAYLOR, Rosann
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device uses a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用自校准的磁性结合测定格式（例如，夹心，竞争性等），其包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能产生校准信号的校准探针（例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

7. 发明申请

WO03068913A2 SYNTHESIS OF 2H- AND 13C- SUBSTITUTED DITHIANES 审中-公开
标题翻译： 2H-和13C-取代的DITHIANES的合成
公开(公告)号：WO03068913A2
公开(公告)日：2003-08-21
申请号：PCT/US0303525
申请日：2003-02-06
申请人： UNIV CALIFORNIA
发明人： MARTINEZ RODOLFO A , ALVAREZ MARC A , SILKS LOUIS A III , UNKEFER CLIFFORD J
IPC分类号： C07C319/14 , C07C323/12 , G01N33/543 , C12N
CPC分类号： G01N33/54373 , C07B2200/05 , C07C319/14 , G01N33/5438 , G01N33/54386 , Y10S435/808 , Y10S435/966 , Y10S436/805 , Y10S436/806 , Y10S436/808 , Y10S436/823 , Y10S530/811 , Y10S530/812 , C07C323/12
摘要： The present invention is directed to labeled compounds, [2-13C]dithiane wherein the 13C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2-13C]dithiane wherein the 13C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e.g., [2H1-2, 13C]methanol (arylthio)-, acetates wherein the 13C atom is directly bonded to exactly one or two deuterium atoms.
摘要翻译：本发明涉及标记的化合物[2-13C]二噻烷，其中13 C原子直接键合到一个或两个氘原子上。本发明还涉及制备[2-13C]二噻烷的方法，其中13 C原子直接键合到一个或两个氘原子上。本发明还涉及标记的化合物，例如[2H1-2,13C]甲醇（芳硫基） - 乙酸酯，其中13 C原子直接键合到正好一个或两个氘原子。

8. 发明申请

WO02044327A2 METHOD AND APPARATUS FOR PROTEIN MANIPULATION 审中-公开
标题翻译：蛋白质操作的方法和装置
公开(公告)号：WO02044327A2
公开(公告)日：2002-06-06
申请号：PCT/US2001/044269
申请日：2001-11-28
IPC分类号： G01N33/553 , B01D43/00 , B01D57/00 , B03C1/00 , B03C1/28 , C07K1/22 , C07K1/24 , C07K1/36 , C07K17/08 , C07K17/14 , C12N
CPC分类号： C07K1/24 , B03C1/286 , C07K1/22 , C07K1/36 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S977/914 , Y10T428/298 , Y10T436/25 , Y10T436/25375
摘要： A method and apparatus for extracting, identifying, and manipulating proteins or peptides from a solution uses paramagnetic beads having a coating with an affinity for the target component. In one embodiment, paramagnetic beads coated with C18 are used to adsorb proteins and peptides. The beads can be used to purify, immobilize and assay antibodies. By cycling the beads, many times greater molar amount of binding partner may be separated from a solution. A magnetic probe is used to capture the beads and transfer the beads to selected processing stages.
摘要翻译：从溶液中提取，鉴定和操作蛋白质或肽的方法和装置使用具有对靶组分具有亲和力的涂层的顺磁珠。在一个实施方案中，用C18涂覆的顺磁珠用于吸附蛋白质和肽。珠可用于纯化，固定和测定抗体。通过循环珠，可以将多次摩尔量的结合配偶体与溶液分离。使用磁性探针捕获珠并将珠转移到选定的处理阶段。

9. 发明申请

WO02029076A1 METHODS AND COMPOSITIONS FOR DIRECTED MICROWAVE CHEMISTRY 审中-公开
标题翻译：用于方向微波化学的方法和组合物
公开(公告)号：WO02029076A1
公开(公告)日：2002-04-11
申请号：PCT/US2001/030617
申请日：2001-10-02
IPC分类号： G01N33/53 , B01J19/00 , C01B39/00 , C07C209/62 , C07C211/52 , C12M1/00 , C12N11/00 , C12N13/00 , C12N15/09 , G01N33/566 , G01N37/00 , C12P1/00 , C12N11/02 , C12N11/08 , C12N11/14
CPC分类号： C12N11/00 , C12N13/00 , Y10S436/806 , Y10T436/115831 , Y10T436/116664 , Y10T436/24
摘要： Chemical reactions are accelerated by applying an electromagnetic field to result in dielectric heating of a solid material containing a bound retractant. A composite is provided containing a solid dielectric material susceptibl to dielectric heating and a specific binding molecule for the reactant. Microwaves are applied to the composite to result in dielectric heating of the solid material to accelerate reaction of the reactant. In another embodiment, the composite is contacted with a reactant-containing solution to bind the reactant to the composite, a composite-reactant complex to result in dielectric heating of the solid material and accelerating conversion of the reactant to a product. Binding molecules include molecularly imprinted polymers, zeolites, antibodies, enzymes, cavitands, receptors, ligands, and nucleic acids. Dielectric materials include inorganic titanates, niobates, ferroelectric polymers, clays and oxides.
摘要翻译：化学反应通过施加电磁场而加速，导致包含结合的回缩物的固体材料的电介质加热。提供了一种复合材料，其包含易于电介质加热的固体介电材料和用于反应物的特异性结合分子。将微波施加到复合材料上以导致固体材料的介电加热以加速反应物的反应。在另一个实施方案中，复合材料与含反应物的溶液接触以将反应物结合到复合材料复合材料 - 反应物复合物上，导致固体材料的介电加热并促进反应物转化成产物。结合分子包括分子印迹聚合物，沸石，抗体，酶，空穴，受体，配体和核酸。介电材料包括无机钛酸盐，铌酸盐，铁电聚合物，粘土和氧化物。

10. 发明申请

WO00060125A3 HIGH RESOLUTION DNA DETECTION METHODS AND DEVICES 审中-公开
标题翻译：高分辨率DNA检测方法和设备
公开(公告)号：WO00060125A3
公开(公告)日：2002-02-21
申请号：PCT/US2000/009389
申请日：2000-04-07
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/25 , C12Q1/37 , C12Q1/68 , C12Q1/70 , C40B40/06 , G01N1/02 , G01N33/569 , G01N37/00 , H01L51/30 , B01L7/00 , G01N27/00
CPC分类号： C12Q1/6825 , B01J2219/00529 , B01J2219/00653 , B01J2219/00722 , B82Y10/00 , C12Q1/6816 , C12Q1/6883 , C12Q1/689 , C12Q1/70 , C40B40/06 , G01N2001/021 , H01L51/0093 , Y10S436/806 , Y10S436/807 , C12Q2565/607 , C12Q2523/313 , C12Q2565/543
摘要： The present invention provides methods and devices for detecting a target nucleic acid molecule. A set of oligonucleotide probes integrated into an electric circuit, where the oligonucleotide probes are positioned such that they can not come into contact with one another, are contacted with a sample. If the sample contains a target nucleic acid molecule, one which has sequences complementary to both probes, the target nucleic acid molecule can bridge the gap between the probes. The resulting bridge can then carry electrical current between the two probes, indicating the presence of the target nucleic acid molecule.
摘要翻译：本发明提供了用于检测靶核酸分子的方法和装置。集成到电路中的寡核苷酸探针的集合，其中寡核苷酸探针被定位成使得它们不能彼此接触，与样品接触。如果样品含有靶核酸分子，其具有与两个探针互补的序列，则靶核酸分子可以桥接探针之间的间隙。所得到的桥可以在两个探针之间携带电流，表明靶核酸分子的存在。

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