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1. 发明申请

WO2009157695A3 THERMAL CYCLING REACTION BLOCK AND CONTINUOUS REAL-TIME MONITORING APPARATUS USING THE SAME 审中-公开
标题翻译：热循环反应块和连续实时监测装置
公开(公告)号：WO2009157695A3
公开(公告)日：2010-03-25
申请号：PCT/KR2009003376
申请日：2009-06-23
申请人： BIONEER CORP , PARK HAN OH , PARK HANEE , CHOI IL KYU
发明人： PARK HAN OH , PARK HANEE , CHOI IL KYU
IPC分类号： C12M1/38
CPC分类号： B01L7/525 , B01L2300/0838 , B01L2300/0861 , B01L2300/1805 , G01N21/64 , G01N2021/6467
摘要： Provided is a real-time monitoring apparatus, including a thermal cycling reaction block having heating block which is formed of a hollow part and divided by an insulating layer, and a capillary tube through which a sample is flowed in and/or out and which is wound on the heating block so that different temperatures are transferred and thus reaction cycle is repeatedly performed a light source; a band pass filter; a condensing lens; a beam splitter a reflecting mirror which is rotatably connected with a motor so as to transfer the excitation light reflected from the beam splitter to the capillary tube and reflect the fluorescence generated from the sample in the capillary tube; and a fluorescence detecting part.
摘要翻译：提供了一种实时监测装置，包括具有由中空部分形成并被绝缘层分隔的加热块的热循环反应块和毛细管，样品通过该毛细管流出和/或流出，缠绕在加热块上，从而转移不同的温度，从而反复进行光源的反应循环; 带通滤波器; 聚光透镜; 分束器，与电动机可旋转地连接以将从分束器反射的激发光转移到毛细管并将从样品产生的荧光反射到毛细管中的反射镜; 和荧光检测部。

2. 发明申请

WO2006086382A2 SYSTEM AND METHODS FOR USE IN DETECTING HARMFUL AEROSOL PARTICLES 审中-公开
标题翻译：用于检测有害气溶胶颗粒的系统和方法
公开(公告)号：WO2006086382A2
公开(公告)日：2006-08-17
申请号：PCT/US2006004279
申请日：2006-02-08
申请人： NORTHROP GRUMMAN CORP , HAIRSTON PETER P , FREIDHOFF CARL B
发明人： HAIRSTON PETER P , FREIDHOFF CARL B
IPC分类号： G01J1/58
CPC分类号： G01J3/32 , G01J3/02 , G01J3/0218 , G01J3/10 , G01J3/36 , G01J3/427 , G01J3/4406 , G01J2003/1213 , G01J2003/1217 , G01N15/1459 , G01N15/1463 , G01N21/53 , G01N21/645 , G01N21/6486 , G01N21/65 , G01N21/85 , G01N2015/0088 , G01N2015/144 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6467 , G01N2021/6482 , G01N2021/6484 , G01N2021/8592
摘要： The invention provides systems and methods for detecting aerosols. The systems and methods can be used to detect harmful aerosols, such as, bio-aerosols.
摘要翻译：本发明提供了用于检测气溶胶的系统和方法。系统和方法可用于检测有害气溶胶，如生物气溶胶。

3. 发明申请

WO2005001436A8 IMPROVEMENTS TO FLUID BORNE PARTICLE ANALYSERS 审中-公开
标题翻译：流体颗粒分析仪的改进
公开(公告)号：WO2005001436A8
公开(公告)日：2005-04-14
申请号：PCT/GB2004002761
申请日：2004-06-28
申请人： SECR DEFENCE , KAYE PAUL HENRY , HIRST EDWIN
发明人： KAYE PAUL HENRY , HIRST EDWIN
IPC分类号： G01J1/04 , G01J1/42 , G01J3/44 , G01N1/24 , G01N15/02 , G01N21/05 , G01N21/53 , G01N21/64 , G01N15/14
CPC分类号： G01N21/645 , G01J3/4406 , G01N1/24 , G01N15/0211 , G01N21/05 , G01N21/53 , G01N21/6486 , G01N2021/6467 , G01N2201/065
摘要： This invention describes an improved method and apparatus for the analysis of fluid borne particles and which is especially suitable for the detection of airborne biological particles. In one aspect the invention provides an apparatus for the detection of fluid borne particles which comprises: a zone through which a fluid to be analysed flows, in use; a source of illumination to illuminate / irradiate fluid borne particles present in said zone; and a detector to detect light from the particles as an indicator of the presence or characteristics of the particles, wherein the apparatus comprises an integrating sphere and the zone is within the integrating sphere. The apparatus is highly sensitive and can be used for detecting airborne particles even where the particles are present at very low particle concentrations in the air.
摘要翻译：本发明描述了用于分析流体颗粒的改进方法和装置，其特别适用于检测空气传播的生物颗粒。在一个方面，本发明提供了一种用于检测流体传播颗粒的装置，其包括：待使用的待分析流体在其中流动的区域; 用于照亮/照射存在于所述区域中的流体颗粒的照明源; 以及检测器，用于检测来自颗粒的光作为颗粒的存在或特性的指示，其中所述设备包括积分球，并且所述区域在积分球内。该装置高度灵敏，并且可用于检测空气中的颗粒，即使颗粒以非常低的颗粒浓度存在于空气中。

4. 发明申请

WO2010007386A3 SPECTROMETER AND METHOD OF OPERATING A SPECTROMETER 审中-公开
标题翻译：光谱仪和操作光谱仪的方法
公开(公告)号：WO2010007386A3
公开(公告)日：2010-06-10
申请号：PCT/GB2009001782
申请日：2009-07-15
申请人： ASSAYMETRICS LTD , GRAVES PIERRE ROBERT
发明人： GRAVES PIERRE ROBERT
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01J3/02 , G01J3/0213 , G01J3/4406 , G01J2003/1243 , G01N2021/6421 , G01N2021/6467 , G01N2021/6491
摘要： A photoluminescence spectrometer (100) is provided comprising; (i) a source of electromagnetic radiation (2) for exciting photoluminescence in a sample (16); (ii) a site (1) for location of the sample (iii) a detector (8) for detecting photoluminescence emitted from the sample and (iv) located in the optical path between the site for location of a sample and the detector, a means (10) of varying the intensity received by the detector of electromagnetic radiation having the same wavelength as the excitation radiation. The mean of varying the intensity may be formed by a tiltable interference filter or by a plurality of movable attenuating filters. A method of using such a spectrometer is also provided.
摘要翻译：提供了一种光致发光光谱仪（100），包括：（i）用于在样品（16）中激发光致发光的电磁辐射源（2）; （ii）用于样本位置的位置（1）（iii）用于检测从样品发射的光致发光的检测器（8）和（iv）位于样品位置与检测器的位置之间的光路中的检测器，用于改变由检测器接收的具有与激发辐射相同波长的电磁辐射的强度的装置（10）。改变强度的平均值可以由可倾斜干涉滤光器或多个可移动的衰减滤光器形成。还提供了使用这种光谱仪的方法。

5. 发明申请

WO2009157695A2 THERMAL CYCLING REACTION BLOCK AND CONTINUOUS REAL-TIME MONITORING APPARATUS USING THE SAME 审中-公开
标题翻译：热循环反应块和连续实时监测装置
公开(公告)号：WO2009157695A2
公开(公告)日：2009-12-30
申请号：PCT/KR2009/003376
申请日：2009-06-23
申请人： BIONEER CORPORATION , PARK, Han Oh , PARK, Hanee , CHOI, il kyu
发明人： PARK, Han Oh , PARK, Hanee , CHOI, il kyu
IPC分类号： C12M1/38
CPC分类号： B01L7/525 , B01L2300/0838 , B01L2300/0861 , B01L2300/1805 , G01N21/64 , G01N2021/6467
摘要： Provided is a real-time monitoring apparatus, including a thermal cycling reaction block having heating block which is formed of a hollow part and divided by an insulating layer, and a capillary tube through which a sample is flowed in and/or out and which is wound on the heating block so that different temperatures are transferred and thus reaction cycle is repeatedly performed a light source; a band pass filter; a condensing lens; a beam splitter a reflecting mirror which is rotatably connected with a motor so as to transfer the excitation light reflected from the beam splitter to the capillary tube and reflect the fluorescence generated from the sample in the capillary tube; and a fluorescence detecting part.
摘要翻译：提供了一种实时监测装置，包括具有由中空部分形成并被绝缘层分隔的加热块的热循环反应块和毛细管，样品通过该毛细管流出和/或流出，缠绕在加热块上，从而转移不同的温度，从而反复进行光源的反应循环; 带通滤波器; 聚光透镜; 分束器，与电动机可旋转地连接以将从分束器反射的激发光转移到毛细管并将从样品产生的荧光反射到毛细管中的反射镜; 和荧光检测部。

6. 发明申请

WO2003006964A1 SUBMERSIBLE LIGHT-DIRECTING MEMBER FOR MATERIAL EXCITATION IN MICROFUIDIC DEVICES 审中-公开
标题翻译：用于微型设备中材料激发的不可见光指向器
公开(公告)号：WO2003006964A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/019494
申请日：2002-06-19
申请人： ACLARA BIOSCIENCES, INC. , BJORNSON, Torleif O. , MAHER, Kevin , GLUSZCZAK, Michael, Robert
发明人： BJORNSON, Torleif O. , MAHER, Kevin , GLUSZCZAK, Michael, Robert
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N21/05 , G01N21/645 , G01N21/8507 , G01N27/44721 , G01N27/44791 , G01N2021/0346 , G01N2021/058 , G01N2021/6439 , G01N2021/6467 , G01N2021/6482
摘要： A system for material excitation in microfluidic devices is described. Aspects of the invention resemble a submerged periscope when in use. A reflecting surface (20) may be provided in connection with a simple support (18). The reflecting surface (20) is used to direct a laser beam (22) along one or more microfluidic trenches or channels (6). Alternately, a reflecting surface (20) may be provided on a prism. Directing a beam (22) along multiple paths is preferably accomplished by scanning a single laser across or around the reflecting surface (20) provided. Provision may be made for at least a portion of the support (18) to be used as an electrode to assist in electrokinetically driving fluids and/or ions within the mocrofluidic device.
摘要翻译：描述了微流体装置中材料激发的系统。本发明的方面在使用时类似于浸没潜望镜。反射表面（20）可以与简单支撑件（18）相关联地设置。反射表面（20）用于沿着一个或多个微流体沟槽或通道（6）引导激光束（22）。或者，反射表面（20）可以设置在棱镜上。优选地通过沿着所提供的反射表面（20）或其周围扫描单个激光器来实现沿着多个路径引导光束（22）。可以提供用于支撑件（18）的至少一部分用作电极以辅助电动驱动流体装置内的流体和/或离子。

7. 发明申请

WO2010111508A1 FIBER OPTICAL ASSEMBLY FOR FLUORESCENCE SPECTROMETRY 审中-公开
标题翻译：用于荧光光谱的光纤组件
公开(公告)号：WO2010111508A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028692
申请日：2010-03-25
申请人： PILTCH, Martin, S. , GRAY, Perry, Clayton , RUBENSTEIN, Richard , LOS ALAMOS NATIONAL SECURITY, LLC , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： PILTCH, Martin, S. , GRAY, Perry, Clayton , RUBENSTEIN, Richard
IPC分类号： G01N33/00
CPC分类号： G01N21/645 , G01N21/65 , G01N33/4833 , G01N2021/6467 , G01N2021/6484
摘要： System is provided for detecting the presence of an analyte of interest in a sample, said system comprising an elongated, transparent container for a sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the sample, and wherein the radiation induces a signal which is emitted from the sample; and, at least two linear arrays disposed about the sample holder, each linear array comprising a plurality of optical fibers having a first end and a second end, wherein the first ends of the fibers are disposed along the length of the container and in proximity thereto; the second ends of the fibers of each array are bundled together to form a single end port.
摘要翻译：提供用于检测样品中感兴趣分析物的存在的系统，所述系统包括用于样品的细长透明容器; 与所述样品光学通信的激发源，其中来自所述激发源的辐射沿着所述样品的长度被引导，并且其中所述辐射诱导从所述样品发射的信号; 以及围绕所述样品保持器布置的至少两个线性阵列，每个线性阵列包括具有第一端和第二端的多根光纤，其中所述纤维的所述第一端沿着所述容器的长度并且在其附近设置 ; 每个阵列的纤维的第二端被捆绑在一起以形成单个端口。

8. 发明申请

WO2010007386A2 SPECTROMETER AND METHOD OF OPERATING A SPECTROMETER 审中-公开
标题翻译：光谱仪和操作光谱仪的方法
公开(公告)号：WO2010007386A2
公开(公告)日：2010-01-21
申请号：PCT/GB2009/001782
申请日：2009-07-15
申请人： ASSAYMETRICS LIMITED , GRAVES, Pierre, Robert
发明人： GRAVES, Pierre, Robert
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01J3/02 , G01J3/0213 , G01J3/4406 , G01J2003/1243 , G01N2021/6421 , G01N2021/6467 , G01N2021/6491
摘要： A photoluminescence spectrometer is provided comprising; (i) a source of electromagnetic radiation for exciting photoluminescence in a sample; (ii) a site for location of the sample (iii) a detector for detecting photoluminescence emitted from the sample and (iv) located in the optical path between the site for location of a sample and the detector, a means of varying the intensity received by the detector of electromagnetic radiation having the same wavelength as the excitation radiation. A method of using such a spectrometer is also provided.
摘要翻译：提供了一种光致发光光谱仪，包括：（i）用于激发样品中的光致发光的电磁辐射源; （ii）用于样品位置的位置（iii）用于检测从样品发射的光致发光的检测器和（iv）位于样品位置与检测器的位置之间的光路中的检测器，改变接收到的强度的方法通过具有与激发辐射相同波长的电磁辐射的检测器。还提供了使用这种光谱仪的方法。

9. 发明申请

WO2008078264A1 WIREGRID WAVEGUIDE 审中-公开
公开(公告)号：WO2008078264A1
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055160
申请日：2007-12-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J.W. , VAN HERPEN, Maarten, M.J.W. , VERSCHUUREN, Marcus, A.
发明人： KLUNDER, Derk, J.W. , VAN HERPEN, Maarten, M.J.W. , VERSCHUUREN, Marcus, A.
IPC分类号： G01N21/64
CPC分类号： G01N21/774 , G01N21/648 , G01N2021/6467
摘要： There is provided a wave guide comprising: a wave guiding medium, having an index of refraction and provided between first and second wave propagating planar structures at least said first planar structure comprises a plurality of slitted-apertures defining a length axis of the first reflective structure; the slitted apertures constructed and arranged to reflect a R-polarized component of said radiation oriented parallel to said length axis; and wherein said first planar structure is arranged between said wave guiding medium and an adjacent medium having an index of refraction equal or larger than the wave guiding medium. In one aspect of the invention, a waveguide is proposed to limit an excitation region wherein luminophores are excited; substantially independent from the surrounding media of the waveguide. Preferentially, the waveguide is used in a luminescence sensor.
摘要翻译：提供了一种波导，包括：波导介质，其具有折射率并且设置在第一和第二波传播平面结构之间，至少所述第一平面结构包括限定第一反射结构的长度轴的多个狭缝孔 ; 所述切割孔被构造和布置成反射平行于所述长度轴线定向的所述辐射的R偏振分量; 并且其中所述第一平面结构布置在所述波导介质和具有等于或大于所述波导介质的折射率的相邻介质之间。在本发明的一个方面，提出了一种波导来限制其中发光体被激发的激发区域; 基本上独立于波导的周围介质。优选地，波导用于发光传感器。

10. 发明申请

WO2004059312A1 CAPILLARY ASSAY DEVICE AND METHOD 审中-公开
标题翻译：毛细测定装置和方法
公开(公告)号：WO2004059312A1
公开(公告)日：2004-07-15
申请号：PCT/US2003/040753
申请日：2003-12-19
申请人： CORNING INCORPORATED
发明人： MARTIN, Gregory, R. , TANNER, Allison, J.
IPC分类号： G01N27/447
CPC分类号： G01N21/6452 , G01N21/03 , G01N21/05 , G01N21/253 , G01N21/552 , G01N2021/0346 , G01N2021/0357 , G01N2021/6467
摘要： A device and method for detecting a signal from an analytical sample is provided. The device comprises a platen with a first and second surface, a number of collection structures extending from the second surface. Each collection structure has a capillary channel running along a common axis as the collection structure from the platen to a terminal end of the structure. Within the capillary channel are sample analytes of interest. On the first surface is disposed a number of optical elements, corresponding to each collection structure, each centered on a capillary channel. Each collection structure has a geometry that can concentrate an optical emission from within the capillary channel, along the entire length of the capillary channel, towards the first surface and optical elements, to a detection device, by means of either mirrored surface reflection or total internal reflection. The collection structure may also direct a light beam into the capillary channel. The present device can be used for non-imaging optical applications from the generated signal.
摘要翻译：提供了一种用于检测来自分析样品的信号的装置和方法。该装置包括具有第一和第二表面的压板，多个收集结构从第二表面延伸。每个收集结构具有沿着公共轴线延伸的毛细通道，作为从压盘到结构的终端的收集结构。在毛细管通道内是感兴趣的样品分析物。在第一表面上设置多个对应于每个收集结构的光学元件，每个光学元件均以毛细通道为中心。每个收集结构具有几何形状，其可以将毛细管道内的光发射沿着毛细管通道的整个长度朝向第一表面和光学元件集中到检测装置，通过镜面反射或总内部反射。收集结构还可以将光束引导到毛细通道中。本装置可以用于来自产生的信号的非成像光学应用。

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