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1. 发明申请

WO2016040306A1 METALLIC GRATINGS AND MEASUREMENT METHODS THEREOF 审中-公开
标题翻译：金属镀层及其测量方法
公开(公告)号：WO2016040306A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/048913
申请日：2015-09-08
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： O'MULLANE, Sam , DIEBOLD, Alain , PETERSON, Brennan , KELLER, Nicholas
IPC分类号： H01L29/78 , H01L21/28 , H01L21/768
CPC分类号： G01N21/211 , G01B11/02 , G01N21/9501 , G01N21/956 , G01N2021/213 , G01N2201/0683
摘要： There is set forth herein in one embodiment, a structure including a metallic grating having a grating pattern, the metallic grating including a critical dimension. The metallic grating can output a spectral profile when exposed to electromagnetic radiation, the spectral profile having a feature. The grating pattern can be configured so that a change of the critical dimension produces a shift in a value of the feature of the spectral profile. A method can include propagating input electromagnetic radiation onto a metallic grating having a two dimensional periodic grating pattern and measuring a critical dimension of the metallic grating using output electromagnetic radiation from the metallic grating.
摘要翻译：这里在一个实施例中阐述了包括具有光栅图案的金属光栅的结构，金属光栅包括临界尺寸。当暴露于电磁辐射时，金属光栅可以输出光谱轮廓，光谱轮廓具有特征。光栅图案可被配置成使得临界尺寸的变化产生光谱轮廓特征值的偏移。一种方法可以包括将输入电磁辐射传播到具有二维周期性光栅图案的金属光栅上，并使用来自金属光栅的输出电磁辐射来测量金属光栅的临界尺寸。

2. 发明申请

WO2015066726A1 METHODS, SYSTEMS, AND DEVICES FOR DETERMINING AND VISUALLY INDICATING DEMYELINATED PATHWAYS 审中-公开
标题翻译：方法，系统和装置，用于确定和可视化地指示脱乙酰化途径
公开(公告)号：WO2015066726A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063956
申请日：2014-11-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： MACCABEE, Paul, Jacob , EBERLE, Lawrence, Philip
IPC分类号： A61N1/36
CPC分类号： A61B5/4041 , A61B5/04012 , A61B5/0488 , A61B5/0492 , A61B5/1107 , A61B5/162 , A61B5/4052 , A61B5/6877 , A61B5/742
摘要： A method includes receiving multiple compound muscle action potential values (CMAPs), wherein each CMAP is an onset latency, a peak latency, a conduction velocity, or a response amplitude measured from a baseline; for each of the CMAPs and for each of a number parameters calculated from the CMAPs, determining a corresponding demyelinating boundary value using a normal value from a preselected population; determining whether each of the CMAPs and each of the parameters exceeds the corresponding demyelinating boundary value; determining one or more demyelinated nerve pathways based on which of the CMAPs and the parameters exceeds the corresponding demyelinating boundary value; indicating on a display which of the CMAPs and the parameters exceed the corresponding demyelinating boundary value; and displaying, in pictorial form, an anatomical diagram indicating the demyelinated nerve pathways.
摘要翻译：一种方法包括接收多个复合肌肉动作电位值（CMAP），其中每个CMAP是从基线测量的起始潜伏期，峰值潜伏期，传导速度或响应幅度; 对于每个CMAP和针对从CMAP计算的每个参数，使用来自预选群体的正常值确定相应的脱髓鞘边界值; 确定每个CMAP和每个参数是否超过相应的脱髓鞘边界值; 基于哪个CMAP和参数超过相应的脱髓鞘边界值来确定一个或多个脱髓鞘神经通路; 在显示器上指示哪个CMAP和参数超过相应的脱髓鞘边界值; 并以图示形式显示指示脱髓鞘神经通路的解剖图。

3. 发明申请

WO2014022741A1 PAA NANOPARTICLES FOR PET IMAGING AND PDT TREATMENT 审中-公开
标题翻译：用于PET成像和PDT处理的PAA纳米颗粒
公开(公告)号：WO2014022741A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/053349
申请日：2013-08-02
申请人： HEALTH RESEARCH, INC. , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： PANDEY, Ravindra, K. , KOPELMAN, Raoul , GUPTA, Anurag , SAJJAD, Munawwar
IPC分类号： A61K51/00 , C07D487/22
CPC分类号： A61K41/0071 , A61K51/0451 , C07D487/22
摘要： PAA (polyacrylic acid and its derivatives at the carboxy groups, e.g. polyacrylamide) nanoparticles containing a photosensitizer and an imaging enhancing agent are provided. The imaging agent is preferably a PET imaging agent and more preferably an 1241 labeled compound. The photosensitizer is preferably selected from chlorins, bacteriochlorins, pyropheophorbides, and mixtures thereof. The nanoparticles preferably contain at least one photosensitizer comprises a moiety containing 1241 and also acts as an imaging agent. The photosensitizer and imaging agent are preferably post loaded onto the nanoparticle after nanoparticle formation.
摘要翻译：提供了包含光敏剂和成像增强剂的PAA（聚丙烯酸及其在羧基上的衍生物，例如聚丙烯酰胺）纳米颗粒。成像剂优选为PET成像剂，更优选为1241标记化合物。光敏剂优选选自二氢卟酚，细菌二氢卟酚，焦偏微生物及其混合物。纳米颗粒优选包含至少一种光敏剂，其包含含有1241的部分，并且还用作显像剂。光敏剂和成像剂优选在纳米颗粒形成之后负载于纳米颗粒上。

4. 发明申请

WO2013142326A1 5-CARBONYLAMINO-/(SULFONAMIDO-) SUBSTITUTED BENZ IMIDAZOLES AND USE THEREOF TREATMENT OF TUBERCULOSIS 审中-公开
标题翻译： 5-亚苄氨基 - /（磺酰氨基）取代的苯并咪唑及其用于治疗结肠癌的用途
公开(公告)号：WO2013142326A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/032083
申请日：2013-03-15
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： OJIMA, Iwao
IPC分类号： C07D235/08 , C07D235/18 , C07D405/04 , A61K31/4184 , A61P31/06
CPC分类号： C07D235/18 , C07D235/08 , C07D405/04
摘要： The present invention discloses novel 5-/6- or 5-/7- substituded benzimidazoles and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to their use in treating a patient infected by Mycobacterium tuberculosis or Francisella tularensis.
摘要翻译：本发明公开了新颖的5- / 6-或5- / 7-取代苯并咪唑及其药学上可接受的盐。本发明的另一方面涉及其用于治疗感染结核分枝杆菌或土拉弗朗西斯氏菌的患者。

5. 发明申请

WO2013116823A1 BENZIMIDAZOLES AND USES THEREOF 审中-公开
标题翻译：苯并咪唑及其用途
公开(公告)号：WO2013116823A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024601
申请日：2013-02-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： OJIMA, Iwao
IPC分类号： C07D235/08 , A61K31/4184 , A61P31/06
CPC分类号： C07D235/08
摘要： The present invention relates to novel 2,5,6-benzimidazole derivatives of formula I and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis or Mycobacterium avium complex by administering to the patient a 2,5,6- benzimidazole derivative or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式I的新的2,5,6-苯并咪唑衍生物及其药学上可接受的盐。本发明的另一方面涉及通过向患者施用2,5,6-苯并咪唑衍生物或其药学上可接受的盐来治疗由结核分枝杆菌或鸟分枝杆菌复合物感染的患者的方法。

6. 发明申请

WO2013112201A1 PLASMONIC INTERFEROMETER BIOSENSORS 审中-公开
标题翻译：等离子干扰仪生物传感器
公开(公告)号：WO2013112201A1
公开(公告)日：2013-08-01
申请号：PCT/US2012/053882
申请日：2012-09-06
申请人： LEHIGH UNIVERSITY , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , BARTOLI, Filbert , GAN, Qiaoqiang , GAO, Yongkang
发明人： BARTOLI, Filbert , GAN, Qiaoqiang , GAO, Yongkang
IPC分类号： G01B9/02 , G02B26/00 , G02F1/00
CPC分类号： G02B5/008
摘要： An optical device includes a transparent substrate and a conductive layer disposed over an upper surface of the transparent substrate. The conductive layer defines at least one groove inwardly extending from an upper surface and includes an aperture that is spaced apart from the at least one groove. An interface between the upper surface of the conductive layer and an ambient medium defines an optical branch along which surface plasmon polariton modes are excited in response to at least partially coherent light being received by the optical device.
摘要翻译：光学装置包括透明基板和设置在透明基板的上表面上的导电层。导电层限定从上表面向内延伸的至少一个凹槽，并且包括与所述至少一个凹槽间隔开的孔。导电层的上表面和环境介质之间的界面限定了光学分支，响应于由光学装置接收的至少部分相干的光，表面等离子体激元模式被激发。

7. 发明申请

WO2013070362A1 COMPOSITIONS AND METHODS FOR IMMUNE TOLERANCE INDUCTION 审中-公开
标题翻译：用于免疫耐受诱导的组合物和方法
公开(公告)号：WO2013070362A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/059223
申请日：2012-10-08
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： BALU-IYER, Sathy, V.
IPC分类号： A61K9/127 , A61K9/38 , A61K38/37
CPC分类号： A61K39/0005 , A61K9/127 , A61K38/37 , A61K38/47 , A61K47/6911 , A61K2039/577 , A61K2039/6018 , C12Y302/0102
摘要： Methods and compositions to reduce immunogenicity of proteins are disclosed. Compositions comprising therapeutic proteins (such as Factor VIII or any other protein or peptide) complexed with liposomes comprising PS and PC (PS liposomes), or comprising PS, PI and PC and, optionally, cholesterol (PS/PI liposomes) may be used.
摘要翻译：公开了降低蛋白质免疫原性的方法和组合物。可以使用包含与包含PS和PC（PS脂质体）或包含PS，PI和PC以及任选的胆固醇（PS / PI脂质体）的脂质体复合的治疗性蛋白质（例如因子VIII或任何其它蛋白质或肽）的组合物。

8. 发明申请

WO2013066606A1 PHOTONIC BANDGAP STRUCTURES FOR MULTISPECTRAL IMAGING DEVICES 审中-公开
标题翻译：用于多图像成像装置的光子带结构
公开(公告)号：WO2013066606A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/060142
申请日：2012-10-12
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： GAN, Qiaoqiang , CARTWRIGHT, Alexander, N. , LIU, Ke , XU, Huina
IPC分类号： G02B5/32 , G02B6/12
CPC分类号： G02B1/005 , B82Y20/00 , G01J3/0256 , G01J3/18 , G01J3/32 , G01J2003/1213 , G02B5/1857 , G02B6/02133 , G02B6/1225 , G02B6/138 , H04N5/23238 , H04N5/332
摘要： The invention discloses methods for making photonic bandgap structures and photonic bandgap structures made by those processes. In one embodiment, the photonic bandgap structure is flexible. In another photonic bandgap structure, the structure has a graded, periodic grating. One embodiment of a method according to the present invention comprises the steps of preparing a pre-polymer mixture, positioning that mixture between two slides, exposing the mixture to electromagnetic radiation, curing the mixture, and discarding at least one of the slides. In another embodiment of the method, the pre-polymer mixture is exposed to the electromagnetic radiation through a prism. In one embodiment of the method, the pre-polymer mixture is exposed to the electromagnetic radiation through a lens. In one embodiment of the invention, the photonic bandgap structure is used as a filter in a multispectral imaging device comprising a imaging device, the filter, a processor, and an electronic image storage device.
摘要翻译：本发明公开了由这些工艺制造的光子带隙结构和光子带隙结构的方法。在一个实施例中，光子带隙结构是柔性的。在另一个光子带隙结构中，该结构具有渐变的周期性光栅。根据本发明的方法的一个实施方案包括以下步骤：制备预聚物混合物，将混合物定位在两个载玻片之间，将混合物暴露于电磁辐射，固化混合物，以及丢弃载玻片中的至少一个。在该方法的另一个实施方案中，预聚合物混合物通过棱镜暴露于电磁辐射。在该方法的一个实施方案中，预聚合物混合物通过透镜暴露于电磁辐射。在本发明的一个实施例中，光子带隙结构在包括成像装置，滤光器，处理器和电子图像存储装置的多光谱成像装置中用作滤光器。

9. 发明申请

WO2013040190A1 LOW CONCENTRATION AMMONIA NANOSENSOR 审中-公开
标题翻译：低浓度氨氮纳米传感器
公开(公告)号：WO2013040190A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/055134
申请日：2012-09-13
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , SAMUILOV, Vladimir
发明人： SAMUILOV, Vladimir
IPC分类号： G01N27/26 , G01N27/28 , G01N27/30 , G01N27/407 , B82Y15/00
CPC分类号： G01N27/126 , B82Y15/00 , B82Y30/00 , G01N27/127 , G01N27/30 , G01N33/0054 , Y02A50/246
摘要： An electrochemical sensor for sensing a gaseous analyte includes a substrate having at least two electrodes disposed thereon, and a carbon nanotube-polyaniline (CNT/PANI) film disposed on the substrate and in contact with at least two electrodes. The CNT/PANI film includes carbon nanotubes coated with a thin layer of polyaniline. The thickness of the polyaniline coating is such that electron transport can occur along and/or between the carbon nanotubes.
摘要翻译：用于感测气态分析物的电化学传感器包括其上设置有至少两个电极的基板和设置在基板上并与至少两个电极接触的碳纳米管 - 聚苯胺（CNT / PANI）膜。 CNT / PANI膜包括涂覆有聚苯胺薄层的碳纳米管。聚苯胺涂层的厚度使得电子传输可以沿着碳纳米管和/或碳纳米管发生。

10. 发明申请

WO2012139023A2 DEVICE AND METHOD FOR DETERMINING PROCESSING CAPACITY 审中-公开
标题翻译：用于确定加工能力的装置和方法
公开(公告)号：WO2012139023A2
公开(公告)日：2012-10-11
申请号：PCT/US2012/032557
申请日：2012-04-06
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , LUNDGREN, Clas, E. , OKUPSKI, Ronald, M.
发明人： LUNDGREN, Clas, E. , OKUPSKI, Ronald, M.
IPC分类号： B01D53/62 , B01D43/00
CPC分类号： G01N21/78 , A61M16/22 , A61M2205/18 , A61M2205/276 , A61M2205/3306 , A61M2205/50 , A61M2205/52 , A61M2205/583 , A61M2205/8206 , A61M2209/02 , A62B27/00 , B01D53/0454 , B01D53/62 , B01D2251/302 , B01D2251/304 , B01D2251/306 , B01D2251/404 , B01D2251/602 , B01D2251/604 , B01D2253/102 , B01D2253/112 , B01D2253/1124 , B01D2255/1021 , B01D2255/1025 , B01D2257/504 , B01D2259/40084 , B01D2259/4533 , B01D2259/4541 , B63C11/24 , Y02C10/04 , Y02C10/08
摘要： A system and method for determining a remaining processing capacity of a scrubber having a flow path and a processing material disposed along the flow path. A device may comprise a plurality of optical sensors disposed within the processing material and arranged along the flow path, a light source, and a processor for determining the capacity according to signals received from the optical sensor. The device may be used to illuminate processing material adjacent to each optical sensor using the light source, measure a light value reflected by the processing material at each optical sensor, and determine the remaining processing capacity of the scrubber, using the processor, based on the measured light value. Devices may comprise a memory, such as a non-volatile memory to allow multiple uses of a scrubber without reloading with fresh processing material.
摘要翻译：一种用于确定具有沿着流动路径布置的流动路径和处理材料的洗涤器的剩余处理能力的系统和方法。设备可以包括设置在处理材料内并且沿着流动路径布置的多个光学传感器，光源和用于根据从光学传感器接收的信号确定容量的处理器。该装置可以用于使用光源照亮与每个光学传感器相邻的处理材料，测量由每个光学传感器处理材料反射的光值，并且基于该处理器确定洗涤器的剩余处理能力测量光值。设备可以包括存储器，例如非易失性存储器，以允许多次使用洗涤器，而不用新鲜的处理材料重新装载。

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