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1. 发明申请

WO2009060350A1 MICROELECTRONIC SENSOR DEVICE 审中-公开
标题翻译：微电子传感器装置
公开(公告)号：WO2009060350A1
公开(公告)日：2009-05-14
申请号：PCT/IB2008/054493
申请日：2008-10-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten, M.J.W. , VOSSEN, Dirk, L.J , GILLIES, Murray, F. , KLUNDER, Derk, J.W. , JOHNSON, Mark, T. , PONJEE, Marc, W.G.
发明人： VAN HERPEN, Maarten, M.J.W. , VOSSEN, Dirk, L.J , GILLIES, Murray, F. , KLUNDER, Derk, J.W. , JOHNSON, Mark, T. , PONJEE, Marc, W.G.
IPC分类号： G01N21/55 , G01N21/64 , G01N33/551
CPC分类号： G01N21/7743 , G01N21/13 , G01N21/554 , G01N21/6452 , G01N21/648 , G01N33/5438
摘要： The invention concerns a microelectronic sensor device (100) for the detection of target components (19) near a binding surface (12). The sensor (100) comprises an aperture defining structure (20), at least one aperture (4) having a smallest in plane aperture dimension (W1) smaller than a diffraction limit defined by the radiation wavelength and a medium for containing the target components (10). A source (21) is provided for emitting a beam of radiation (101) having a wavelength incident at the aperture defining structure (20), for providing evanescent radiation, in response to the radiation (101) incident at the structure (20), in a detection volume (13) formed in the aperture (14). In addition a detector (31) is provided for determining radiation (102) from the target component (10) present in the detection volume (13), in response to the emitted incident radiation (101) from the source (21). An electrode (112) is provided near the aperture defining structure (20), so as to transport the target components (10) in between the apertures (4) by applying an electric field; and a charging circuit (113) for charging the electrode (112).
摘要翻译：本发明涉及用于检测接合表面（12）附近的目标部件（19）的微电子传感器装置（100）。传感器（100）包括孔限定结构（20），具有小于由辐射波长限定的衍射极限的平面孔尺寸（W1）最小的至少一个孔（4）和用于容纳目标成分的介质 10）。源（21）被提供用于发射具有入射在孔限定结构（20）处的波长的辐射束（101），用于响应于在结构（20）处入射的辐射（101）来提供渐逝辐射，在形成在孔（14）中的检测体积（13）中。此外，响应于来自源（21）的发射入射辐射（101），提供检测器（31），用于根据存在于检测体积（13）中的目标成分（10）来确定辐射（102）。在孔限定结构（20）附近设置电极（112），以便通过施加电场将目标部件（10）传送到孔（4）之间; 以及用于对电极（112）充电的充电电路（113）。

2. 发明申请

WO2007072293A2 BIOSENSOR WITH ONE-DIMENSIONAL SUB-DIFFRACTION-LIMITED APERTURES COMPOSED OF A GRID AND A POLARIZER 审中-公开
标题翻译：具有一个网格和一个偏振器的一维亚衍射极限孔径生物传感器
公开(公告)号：WO2007072293A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054750
申请日：2006-12-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , VAN HERPEN, Maarten , BROER, Dirk J. , PEETERS, Emiel , KLUNDER, Derk J.W. , STAPERT, Hendrik R.
发明人： VAN HERPEN, Maarten , BROER, Dirk J. , PEETERS, Emiel , KLUNDER, Derk J.W. , STAPERT, Hendrik R.
IPC分类号： G01N21/00
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译：公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。在本发明的上下文中，生物传感器包括被限定为孔阵列的网格（120），其中孔径具有在介质中的激发光（102）的衍射极限以下的第一维度和第二维度，偏振器（（120）的体积，狭缝阵列（120）和偏振器（115）之间的体积以及一个或多个发光体（117），所述发光体（117）位于从由以下各项组成的组中选择的体积中：其中所述栅格（120）提供在第一方向上延伸的透射轴并且所述偏振器（115）提供在第二方向上延伸的透射轴，所述第一方向和所述第二方向基本上是相对于彼此垂直，其中所述激发辐射（102）被极化，使得所述激发辐射（102）基本上被所述至少一个栅格（120）和偏振器（115）中的一个抑制并且基本上不被所述o 至少一个格栅（120）和偏振器（115）的一部分。

3. 发明申请

WO2009083884A1 MICROELECTRONIC SENSOR DEVICE. 审中-公开
标题翻译：微电子传感器装置。
公开(公告)号：WO2009083884A1
公开(公告)日：2009-07-09
申请号：PCT/IB2008/055417
申请日：2008-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk J.W.
发明人： KLUNDER, Derk J.W.
IPC分类号： G01N21/64 , G01N21/55
CPC分类号： G01N21/553 , G01N21/648
摘要： The invention concerns an optical device for providing evanescent radiation, in response to incident radiation, in a detection volume for containing a target component in a medium, the detection volume having at least one in-plane dimension (W1) smaller than a diffraction limit. The diffraction limit is defined by the radiation wavelength and the medium. The evanescent radiation is provided by aperture defining structures having a smallest in plane aperture dimension W1 smaller than the diffraction limit. The detection volume is provided between said aperture defining structures. The aperture defining structures in addition define a largest in plane aperture dimension W2; wherein said largest in plane aperture dimension is larger than the diffraction limit. A source is provided for emitting a beam of radiation having a wavelength incident at the optical device and having a direction of incidence non parallel to an out of plane normal direction, for providing evanescent radiation in the detection volume, in response to the radiation incident at the optical device. The plane of incidence is parallel to the largest in plane aperture dimension.
摘要翻译：本发明涉及一种光学装置，用于响应于入射辐射，在用于在介质中容纳目标成分的检测体积中提供ev逝辐射，所述检测体积具有小于衍射极限的至少一个面内尺寸（W1）。衍射极限由辐射波长和介质决定。 ev逝辐射由具有小于衍射极限的最小平面孔径尺寸W1的孔限定结构提供。检测体积设置在所述孔限定结构之间。孔限定结构另外限定最大的平面孔尺寸W2; 其中所述最大的平面孔径尺寸大于衍射极限。提供源，用于发射具有入射在光学装置处的波长并具有不平行于外部平面法线方向的入射方向的辐射束，用于响应于入射在...的辐射而在检测体积中提供渐逝辐射光学装置。入射平面平行于最大的平面孔径尺寸。

4. 发明申请

WO2008078264A1 WIREGRID WAVEGUIDE 审中-公开
公开(公告)号：WO2008078264A1
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055160
申请日：2007-12-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J.W. , VAN HERPEN, Maarten, M.J.W. , VERSCHUUREN, Marcus, A.
发明人： KLUNDER, Derk, J.W. , VAN HERPEN, Maarten, M.J.W. , VERSCHUUREN, Marcus, A.
IPC分类号： G01N21/64
CPC分类号： G01N21/774 , G01N21/648 , G01N2021/6467
摘要： There is provided a wave guide comprising: a wave guiding medium, having an index of refraction and provided between first and second wave propagating planar structures at least said first planar structure comprises a plurality of slitted-apertures defining a length axis of the first reflective structure; the slitted apertures constructed and arranged to reflect a R-polarized component of said radiation oriented parallel to said length axis; and wherein said first planar structure is arranged between said wave guiding medium and an adjacent medium having an index of refraction equal or larger than the wave guiding medium. In one aspect of the invention, a waveguide is proposed to limit an excitation region wherein luminophores are excited; substantially independent from the surrounding media of the waveguide. Preferentially, the waveguide is used in a luminescence sensor.
摘要翻译：提供了一种波导，包括：波导介质，其具有折射率并且设置在第一和第二波传播平面结构之间，至少所述第一平面结构包括限定第一反射结构的长度轴的多个狭缝孔 ; 所述切割孔被构造和布置成反射平行于所述长度轴线定向的所述辐射的R偏振分量; 并且其中所述第一平面结构布置在所述波导介质和具有等于或大于所述波导介质的折射率的相邻介质之间。在本发明的一个方面，提出了一种波导来限制其中发光体被激发的激发区域; 基本上独立于波导的周围介质。优选地，波导用于发光传感器。

5. 发明申请

WO2009022246A1 SENSOR ARRAY FOR SPR-BASED DETECTION. 审中-公开
标题翻译：传感器阵列进行基于SPR的检测。
公开(公告)号：WO2009022246A1
公开(公告)日：2009-02-19
申请号：PCT/IB2008/053029
申请日：2008-07-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MUSKENS, Otto L. , GOMEZ RIVAS, Jaime , VAN DIJK, Erik, M. H. P. , KLUNDER, Derk J.W.
发明人： MUSKENS, Otto L. , GOMEZ RIVAS, Jaime , VAN DIJK, Erik, M. H. P. , KLUNDER, Derk J.W.
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , G01N2021/258
摘要： The invention relates to a sensor array for detecting the presence of a target, where a target is detected based on a detection of a surface plasmon resonance (SPR). The sensor array (30) comprises a carrier substrate (31), and a plurality of nano-sized particles (32) disposed on the carrier substrate. The surface plasmon resonance (SPR) for each of the nano-sized particles is correlated to a structural parameter of the nano-sized particles or group of nano-sized particles. The structural parameter and thereby the surface plasmon resonance is varied in a pre-defined way in at least a first area of the carrier substrate. The target is detected based on detecting intensity variations in the radiation resulting from the sensor array, the intensity variations being correlated to the pre-defined variation in the structural parameter. In embodiments, the sensor array may be a bio-sensor for the detection of bio-molecules.
摘要翻译：本发明涉及一种用于检测靶的存在的传感器阵列，其中基于表面等离子体共振（SPR）的检测来检测目标。传感器阵列（30）包括载体衬底（31）和设置在载体衬底上的多个纳米尺寸颗粒（32）。每个纳米尺寸颗粒的表面等离子体共振（SPR）与纳米尺寸颗粒或纳米尺寸颗粒组的结构参数相关。结构参数以及由此的表面等离子体共振在载体衬底的至少第一区域中以预定义的方式变化。基于检测由传感器阵列产生的辐射的强度变化来检测目标，强度变化与结构参数中的预定变化相关。在实施例中，传感器阵列可以是用于检测生物分子的生物传感器。

6. 发明申请

WO2008078263A1 APERTURE BIOSENSOR WITH TRENCHES 审中-公开
标题翻译：带孔的APERTURE生物传感器
公开(公告)号：WO2008078263A1
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055159
申请日：2007-12-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J.W. , VAN HERPEN, Maarten, M.J.W. , STAPERT, Hendrik, R.
发明人： KLUNDER, Derk, J.W. , VAN HERPEN, Maarten, M.J.W. , STAPERT, Hendrik, R.
IPC分类号： G01N21/64 , B01L3/00
CPC分类号： G01N21/648 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/025 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , C12Q1/6837 , G01N21/47 , G01N21/554 , G01N21/658 , G01N2021/95676
摘要： A luminescence sensor, comprising a non-transparent substrate structure (2) having at least one aperture (5) intended to comprise an analyte and a transparent substrate structure (3), which is arranged to or adjacent said first structure (2). The aperture has a smallest lateral dimension, which is smaller than half the effective wavelength of an excitation radiation, such as light at a wavelength of 700nm, resulting in an effective wavelength in water of about 538nm. The transparent structure has a trench (4) with a surface portion provided with ligands with an affinity towards a target molecule. The trench results in that a luminophore attached to the target molecule will be positioned at the entrance surface of the aperture, where the excitation energy is largest.
摘要翻译：发光传感器，包括具有至少一个孔（5）的非透明衬底结构（2），所述孔旨在包括被分析物和透明衬底结构（3），所述透明衬底结构（3）布置在所述第一结构（2）上或邻近所述第一结构（2）。孔径具有最小的横向尺寸，其小于激发辐射的有效波长的一半，例如波长为700nm的光，导致在约538nm的水中的有效波长。透明结构具有沟槽（4），其表面部分具有对靶分子具有亲和性的配体。沟槽导致附着到靶分子的发光体将位于孔的入射表面处，其中激发能最大。

7. 发明申请

WO2008075289A1 SUB WAVELENGTH APERTURE 审中-公开
标题翻译：子波长孔径
公开(公告)号：WO2008075289A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055208
申请日：2007-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten, M.J.W. , KLUNDER, Derk, J.W.
发明人： VAN HERPEN, Maarten, M.J.W. , KLUNDER, Derk, J.W.
IPC分类号： G01J3/44 , G01N21/64
CPC分类号： G01N21/64 , G01N21/6445
摘要： There is provided a method of detecting a presence of a luminophore in a detection volume comprising providing excitation radiation in said detection volume. A luminophore is provided in said detection volume being excitable by said excitation radiation. The luminescent radiation is detected to identify the presence of said luminophore in said detection volume. In one aspect of the invention, said luminophore is selected to emit luminescent radiation having a wavelength in said medium that is larger than twice said smallest dimension; and wherein said luminophore is selected to be excitable by excitation radiation having a wavelength in said medium that is smaller than twice said smallest dimension. Accordingly, luminescent radiation is blocked from entering the detector but for the portion present on an interface of the aperture.
摘要翻译：提供了一种检测检测体积中的发光体的存在的方法，包括在所述检测体积中提供激发辐射。在所述检测体积中提供发光体，所述发光体可被所述激发辐射激发。检测发光辐射以识别所述检测体积中所述发光体的存在。在本发明的一个方面，所述发光体选择为发射具有大于所述最小尺寸的两倍的所述介质中的波长的发光辐射; 并且其中所述发光体被选择为通过所述介质中具有小于所述最小尺寸的两倍的波长的激发辐射来激发。因此，阻挡发光辐射进入检测器，但是阻挡存在于孔的界面上的部分。

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