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1. 发明申请

WO2009002034A2 REAL-TIME PCR MONITORING APPARATUS 审中-公开
标题翻译：实时PCR监测装置
公开(公告)号：WO2009002034A2
公开(公告)日：2008-12-31
申请号：PCT/KR2008003408
申请日：2008-06-17
申请人： BIONEER CORP , PARK HANEE , CHOI IL KYU , PARK HAN OH
发明人： PARK HANEE , CHOI IL KYU , PARK HAN OH
IPC分类号： C12Q1/68
CPC分类号： G01N21/6445 , G01J3/0224 , G01J3/4406 , G01N21/6452 , G01N2021/6478 , G01N2021/6484 , G01N2201/0631 , G01N2201/0636
摘要： The present invention relates to a real-time PCR monitoring apparatus for real-time monitoring production of reaction product produced during the reaction while performing nucleic acid amplification such as PCR for various kinds of trace samples. Specifically, the present invention relates to an apparatus for real-time monitoring biochemical reaction for efficiently dividing interference between an excitation light and a fluorescence, which includes a polarizer, a polarizing beam splitter, a polarization converter and so on.
摘要翻译：本发明涉及一种用于实时监测在反应期间产生的反应产物的实时PCR监测装置，同时进行各种痕量样品的PCR等核酸扩增。具体地说，本发明涉及一种用于实时监测激发光和荧光之间的干扰的生物化学反应的装置，其包括偏振器，偏振分束器，偏振转换器等。

2. 发明申请

WO2009157695A3 THERMAL CYCLING REACTION BLOCK AND CONTINUOUS REAL-TIME MONITORING APPARATUS USING THE SAME 审中-公开
标题翻译：热循环反应块和连续实时监测装置
公开(公告)号：WO2009157695A3
公开(公告)日：2010-03-25
申请号：PCT/KR2009003376
申请日：2009-06-23
申请人： BIONEER CORP , PARK HAN OH , PARK HANEE , CHOI IL KYU
发明人： PARK HAN OH , PARK HANEE , CHOI IL KYU
IPC分类号： C12M1/38
CPC分类号： B01L7/525 , B01L2300/0838 , B01L2300/0861 , B01L2300/1805 , G01N21/64 , G01N2021/6467
摘要： Provided is a real-time monitoring apparatus, including a thermal cycling reaction block having heating block which is formed of a hollow part and divided by an insulating layer, and a capillary tube through which a sample is flowed in and/or out and which is wound on the heating block so that different temperatures are transferred and thus reaction cycle is repeatedly performed a light source; a band pass filter; a condensing lens; a beam splitter a reflecting mirror which is rotatably connected with a motor so as to transfer the excitation light reflected from the beam splitter to the capillary tube and reflect the fluorescence generated from the sample in the capillary tube; and a fluorescence detecting part.
摘要翻译：提供了一种实时监测装置，包括具有由中空部分形成并被绝缘层分隔的加热块的热循环反应块和毛细管，样品通过该毛细管流出和/或流出，缠绕在加热块上，从而转移不同的温度，从而反复进行光源的反应循环; 带通滤波器; 聚光透镜; 分束器，与电动机可旋转地连接以将从分束器反射的激发光转移到毛细管并将从样品产生的荧光反射到毛细管中的反射镜; 和荧光检测部。

3. 发明申请

WO2012108672A3 REVERSE TRANSCRIPTASE HAVING IMPROVED THERMOSTABILITY 审中-公开
标题翻译：逆转录酶具有改善的热稳定性
公开(公告)号：WO2012108672A3
公开(公告)日：2012-12-20
申请号：PCT/KR2012000894
申请日：2012-02-07
申请人： BIONEER CORP , PARK HAN OH , YANG SUNG JUN , JOO SUNG MO , HWANG BYOUNG OH
发明人： PARK HAN OH , YANG SUNG JUN , JOO SUNG MO , HWANG BYOUNG OH
IPC分类号： C12N9/12 , C12N15/54 , C12N15/63
CPC分类号： C12N9/1276 , C12N1/20 , C12N9/12 , C12N15/70 , C12P19/34 , Y02P20/52
摘要： The present invention relates to a reverse transcriptase having improved thermostability, more precisely a mutant reverse transcriptase with improved thermostability by substitution of one or more amino acids selected from the group consisting of the 63rd glutamine (Q63), the 264th lysine (K264), the 295th lysine (K295), the 306th threonine (T306), the 346th glutamic acid (E346), the 408th proline (P408), the 438th histidine (H438), and the 454th asparagin (N454) of the amino acid sequence of M-MLV originated reverse transcriptase represented by SEQ. ID. NO: 1 with other amino acids. The mutant reverse transcriptase of the present invention demonstrates excellent thermostability, compared with the wild type reverse transcriptase. Therefore, it is advantageous to obtain the target cDNA with stable reverse transcription activity even in the presence of RNA that can form the stable secondary structure at a high temperature.
摘要翻译：本发明涉及具有改善的热稳定性的逆转录酶，更准确地说是通过取代选自第63位谷氨酰胺（Q63），第264位赖氨酸（K264），第63位赖氨酸 M-氨基酸序列的第295位赖氨酸（K295），第306位苏氨酸（T306），第346位谷氨酸（E346），第408位脯氨酸（P408），第438位组氨酸（H438）和第454位天冬酰胺（N454） MLV来源于SEQ.ID.No.1所示的逆转录酶。 ID。 NO：1与其他氨基酸。与野生型逆转录酶相比，本发明的突变逆转录酶显示出优异的热稳定性。因此，即使在能够在高温下形成稳定的二级结构的RNA的存在下获得具有稳定逆转录活性的靶cDNA也是有利的。

4. 发明申请

WO2012023722A3 LOW HEAT CAPACITY COMPOSITE FOR THERMAL CYCLER 审中-公开
标题翻译：用于热循环的低热容复合材料
公开(公告)号：WO2012023722A3
公开(公告)日：2012-05-24
申请号：PCT/KR2011005756
申请日：2011-08-08
申请人： BIONEER CORP , PARK HAN OH , KIM JAE HA
发明人： PARK HAN OH , KIM JAE HA
IPC分类号： C09K5/14 , B01L7/00 , C22C26/00
CPC分类号： B01L7/52 , B22F2998/10 , B22F2999/00 , C09K5/14 , C22C1/0416 , C22C1/0425 , C22C1/0466 , C22C1/0483 , C22C13/00 , C22C13/02 , C22C26/00 , C22C1/1084 , B22F3/14 , B22F3/18 , C22C1/02
摘要： Provided is a low heat capacity composite for a thermal cycler. The low heat capacity composite of the present invention is a low heat capacity composite for a thermal cycler capable of overcoming difficulty in manufacture and reproducibility due to uniqueness of the existing PCR thermal cycler only. The low heat capacity composite of the present invention can reduce the cost of raw material and retain excellent heat property due to the improvement in low heat capacity and physical and mechanical properties, thereby remarkably shortening PCR reaction time and saving energy when used as a thermal block for a thermal cycler.
摘要翻译：提供了用于热循环仪的低热容复合材料。本发明的低热容复合材料是用于热循环仪的低热容复合材料，其能够仅克服现有的PCR热循环仪的唯一性，从而克服制造难度和重复性。本发明的低热容复合材料可以降低原料的成本，并且由于低热容量和物理机械性能的改善而保持优异的热性能，从而显着缩短PCR反应时间并在用作热块时节省能量用于热循环仪。

5. 发明申请

WO2010131916A3 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译： SIRNA结合物及其制备方法
公开(公告)号：WO2010131916A3
公开(公告)日：2011-04-07
申请号：PCT/KR2010003039
申请日：2010-05-13
申请人： BIONEER CORP , HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C12N15/87
CPC分类号： A61K47/48215 , A61K9/1075 , A61K47/34 , A61K47/60 , B82Y5/00 , C07F7/0836 , C07H21/02 , C08G65/3356 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/30 , C12N2320/51 , Y10S977/773 , Y10S977/906
摘要： The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.
摘要翻译：本发明涉及siRNA-聚合物缀合物及其制备方法，更具体地说，涉及通过共价键合siRNA和用于提高siRNA生物稳定性的高分子化合物形成的杂合共轭体的制备方法，杂交缀合物。本发明的缀合物可以改善siRNA的生物稳定性，从而实现将治疗性siRNA有效地递送到细胞中，并且即使以较低浓度的小剂量也显示出siRNA的活性。因此，缀合物不仅可以有效地用作癌症和其他感染性疾病的siRNA治疗工具，而且可以用作新型的siRNA递送系统。

6. 发明申请

WO2010104345A3 APPARATUS FOR INTEGRATED REAL-TIME NUCLEIC ACID ANALYSIS, AND METHOD FOR DETECTING A TARGET NUCLEIC ACID USING SAME 审中-公开
标题翻译：用于综合实时核酸分析的装置和使用其检测目标核酸的方法
公开(公告)号：WO2010104345A3
公开(公告)日：2011-01-13
申请号：PCT/KR2010001530
申请日：2010-03-11
申请人： BIONEER CORP , KIM YU-JEONG , KOO WAN-LIM , KIM JONG-HOON , JANG DAE-JIN , SEO JIN-CHEOL , KIM SEONG-YOUL , PARK HAE-JOON , PARK HAN OH
发明人： KIM YU-JEONG , KOO WAN-LIM , KIM JONG-HOON , JANG DAE-JIN , SEO JIN-CHEOL , KIM SEONG-YOUL , PARK HAE-JOON , PARK HAN OH
IPC分类号： C12Q1/68 , C12M1/38 , C12N15/09
CPC分类号： B03C1/01 , B03C1/288 , B03C1/30 , C12Q1/6844 , G01N35/0098 , Y02A90/26 , C12Q2561/113 , C12Q2537/143
摘要： The present invention relates to an integrated real-time nucleic acid analysis apparatus and to a method using same. More particularly, the present invention relates to an integrated real-time nucleic acid analysis apparatus which performs a qualitative analysis and a quantitative analysis at the same time on genes corresponding to a plurality of biological samples of various types, and to a method for detecting a target nucleic acid using same. The integrated real-time nucleic acid analysis apparatus and the method for detecting a target nucleic acid using same according to the present invention perform just a single test on a variety of targets, requested for a variety of analytes, in a quick and accurate manner, and thus can be efficiently used in a hospital or the like where diagnoses for diseases are required.
摘要翻译：本发明涉及一种综合实时核酸分析装置及其使用方法。更具体地，本发明涉及一种对与多种生物样品相对应的基因同时进行定性分析和定量分析的综合实时核酸分析装置，以及一种检测方法靶核酸使用相同的。综合实时核酸分析装置和根据本发明的用于检测目标核酸的方法仅以对快速和准确的方式对各种分析物要求的各种靶标进行单次测试，因此能够有效地用于需要诊断疾病的医院等中。

7. 发明申请

WO2012157955A3 OIL PURIFICATION METHOD AND APPARATUS WITH POROUS MEMBRANE 审中-公开
标题翻译：油多孔方法和装置
公开(公告)号：WO2012157955A3
公开(公告)日：2013-01-24
申请号：PCT/KR2012003836
申请日：2012-05-16
申请人： BIONEER CORP , PARK HAN OH , KIM JAE HA , KIM JUN PYO
发明人： PARK HAN OH , KIM JAE HA , KIM JUN PYO
IPC分类号： B01D71/02 , C10M175/00
CPC分类号： B01D69/12 , B01D71/021 , B01D71/022 , B01D71/024 , B01D2311/04 , C10M175/0091 , B01D2311/103
摘要： Provided is a method of purifying oil by which nano particles are effectively removed from the oil. According to the oil purifying method, oil is effectively purified at a high temperature using a carbon nanostructure-metal or -metal oxide composite nano porous membrane composed of a carbon nanostructure-metal composite.
摘要翻译：提供了一种净化油的方法，通过该方法可以有效地从油中除去纳米颗粒。根据油净化方法，使用由碳纳米结构金属复合材料构成的碳纳米结构金属或金属氧化物复合纳米多孔膜，在高温下有效地纯化油。

8. 发明申请

WO2012108672A9 REVERSE TRANSCRIPTASE HAVING IMPROVED THERMOSTABILITY 审中-公开
公开(公告)号：WO2012108672A9
公开(公告)日：2012-11-01
申请号：PCT/KR2012000894
申请日：2012-02-07
申请人： BIONEER CORP , PARK HAN OH , YANG SUNG JUN , JOO SUNG MO , HWANG BYOUNG OH
发明人： PARK HAN OH , YANG SUNG JUN , JOO SUNG MO , HWANG BYOUNG OH
IPC分类号： C12N9/12 , C12N15/54 , C12N15/63
CPC分类号： C12N9/1276 , C12N1/20 , C12N9/12 , C12N15/70 , C12P19/34 , Y02P20/52
摘要： The present invention relates to a reverse transcriptase having improved thermostability, more precisely a mutant reverse transcriptase with improved thermostability by substitution of one or more amino acids selected from the group consisting of the 63rd glutamine (Q63), the 264th lysine (K264), the 295th lysine (K295), the 306th threonine (T306), the 346th glutamic acid (E346), the 408th proline (P408), the 438th histidine (H438), and the 454th asparagin (N454) of the amino acid sequence of M-MLV originated reverse transcriptase represented by SEQ. ID. NO: 1 with other amino acids. The mutant reverse transcriptase of the present invention demonstrates excellent thermostability, compared with the wild type reverse transcriptase. Therefore, it is advantageous to obtain the target cDNA with stable reverse transcription activity even in the presence of RNA that can form the stable secondary structure at a high temperature.

9. 发明申请

WO2012115464A2 COMPOSITION FOR HOT-START PCR COMPRISING BLOCKING OLIGONUCLEOTIDE 审中-公开
标题翻译：包含阻断寡核苷酸的热启动PCR组合物
公开(公告)号：WO2012115464A2
公开(公告)日：2012-08-30
申请号：PCT/KR2012001387
申请日：2012-02-23
申请人： BIONEER CORP , LEE JUN HEE , CHOI SO RA , KIM NAM IL , PARK HAN OH
发明人： LEE JUN HEE , CHOI SO RA , KIM NAM IL , PARK HAN OH
IPC分类号： C12Q1/68 , C12N15/11 , C12Q1/48
CPC分类号： C12Q1/686 , C12Q1/6848 , C12Q2527/107 , C12Q2537/161 , C12Q2537/163 , C12Q2549/101 , C12Q2525/204 , C12Q2525/186
摘要： The present invention relates to a composition for hot-start PCR, more precisely a composition for hot-start PCR characteristically prepared by adding the blocking oligonucleotide having the hydroxyl group at 3'-end blocked and the nucleotide sequence complementary to the primer to the conventional PCR composition containing reaction buffer, MgCl2, 4 kinds of dNTP, and DNA polymerase. The composition for hot-start PCR of the present invention can give more authentic PCR results by inhibiting smear band of PCR amplification product caused by non-specific reaction or primer-dimer formation at low temperature since the blocking oligonucleotide included therein can be dissociated at the lower temperature than melting temperature of the primer.
摘要翻译：本发明涉及用于热启动PCR的组合物，更确切地说是一种用于热启动PCR的组合物，其特征在于通过将3'末端具有羟基的封闭寡核苷酸添加到与常规引物互补的核苷酸序列含有反应缓冲液，MgCl 2，4种dNTP和DNA聚合酶的PCR组合物。本发明的热启动PCR用组合物通过在低温下抑制非特异性反应或引物二聚体形成引起的PCR扩增产物的涂片带，可以得到更加真实的PCR结果，因为其中包含的封闭寡核苷酸可以在低于底漆的熔化温度。

10. 发明申请

WO2012030196A3 OLIGONUCLEOTIDE MARKER AND METHOD FOR IDENTIFYING THE SAME 审中-公开
标题翻译：寡核苷酸标记及鉴定相同方法
公开(公告)号：WO2012030196A3
公开(公告)日：2012-05-31
申请号：PCT/KR2011006540
申请日：2011-09-02
申请人： BIONEER CORP , PARK HAN OH , LEE JAE-DON , SONG GU-YOUNG , OH JONG WAK , KIM HYUN-BAE , BYUN SANG-JIN , JANG JIN-WONG , JANG WON-SEOK , CHOI JONG-DEOK
发明人： PARK HAN OH , LEE JAE-DON , SONG GU-YOUNG , OH JONG WAK , KIM HYUN-BAE , BYUN SANG-JIN , JANG JIN-WONG , JANG WON-SEOK , CHOI JONG-DEOK
IPC分类号： C12N15/11 , C12Q1/68 , G01N33/58
CPC分类号： G01N33/58 , C12Q1/68 , C12Q2531/113 , C12Q2561/113 , C12Q2563/185
摘要： Provided are an oligonucleotide marker and a method of identifying a material using the same. The oligonucleotide marker makes it possible to analyze a trace amount of the material with high precision within a short time, has improved solubility in an oily solvent, and can improve a detection method such that the oligonucleotide marker can be detected within 2 hours. The oligonucleotide marker can label various products, including oil products and petroleum products, works of art and collections, and can also be used to conduct criminal investigations.
摘要翻译：提供了一种寡核苷酸标记物和使用其鉴定材料的方法。该寡核苷酸标记物可以在短时间内高精度地分析微量的该物质，提高在油性溶剂中的溶解性，并且可以改进在2小时内检测寡核苷酸标记物的检测方法。寡核苷酸标记可标记各种产品，包括石油产品和石油产品，艺术品和收藏品，也可用于进行刑事调查。

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