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    • 4. 发明申请
    • DETECTION OF INTERACTING CELLULAR BODIES
    • WO2023085925A1
    • 2023-05-19
    • PCT/NL2022/050632
    • 2022-11-09
    • LUMICKS CA HOLDING B.V.
    • VAN DER HORST, JelleROZEMULLER, Willem Mathijs
    • G06V10/44G06V20/69G01N15/14G02B21/36G06T7/00G01N33/00
    • Methods and systems for selecting cellular bodies are disclosed. The method comprises determining or receiving a first image and a second image. The first image and the second image may be images of first cellular bodies interacting with second cellular bodies in a holding space. The holding space may include a functionalised wall surface comprising the first cellular bodies. The first image represents at least the first cellular bodies, and the second image represent at least the second cellular bodies. The first image is obtained with a first imaging modality and the second image is obtained with a second imaging modality. At least one of the first and second imaging modalities may provide images on which the first respectively second cellular bodies can be uniquely determined. Each pixel in the first image may be associated with a pixel in the second image. The method further comprises detecting a set of first pixels representing first cellular bodies in the first image, and detecting groups of second pixels representing the second cellular bodies in the second image, and determining, for each second cellular body represented by a respective group of second pixels, an interaction parameter between the respective second cellular body and one or more of the first cellular bodies based on the detected first and second pixels. The interaction parameter may represent a contact surface between the respective second cellular body and the first cellular bodies. The method may further comprise selecting groups of second pixels for which the determined interaction parameter is greater than or smaller than an interaction threshold.