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1. 发明申请

WO2006086551A2 MICROFLUIDIC LASERS 审中-公开
标题翻译：微流感激光
公开(公告)号：WO2006086551A2
公开(公告)日：2006-08-17
申请号：PCT/US2006004577
申请日：2006-02-08
申请人： HARVARD COLLEGE , MASSACHUSETTS INST TECHNOLOGY , MAYERS BRIAN T , CONROY RICHARD S , VEZENOV DMITRI V , SNEE PRESTON , CHAN YINTHAI , BAWENDI MOUNGI G , WHITESIDES GEORGE M
发明人： MAYERS BRIAN T , CONROY RICHARD S , VEZENOV DMITRI V , SNEE PRESTON , CHAN YINTHAI , BAWENDI MOUNGI G , WHITESIDES GEORGE M
CPC分类号： H01S3/05 , H01S3/213
摘要： The present invention generally relates to lasers comprising fluidic channels, such as microfluidic channels. In some instances, the channel contains two or more fluids. The fluids may remain non-mixed within the channel, for example, due to immiscibility and/or laminar flow within the channel. The fluids may be arranged in the channel such that light propagating in a first fluid is prevented by the second fluid from exiting the first fluid, for example, due to differences in the indexes of refraction (e.g., causing internal reflection of the fluid to occur). Thus, in one embodiment, a first fluid may be at least partially surrounded by a second fluid having a second index of refraction lower than the index of refraction of the first fluid. In some embodiments, the fluidic channel is used as a laser, for instance, a dye laser, i.e., a laser created by directing light at a dye to produce coherent light. The dye may be present in one or more fluids within the fluidic channel. The incident light (for example, created by another laser) may be directed at the channel from any angle. In some cases, laser light may be produced in a direction substantially aligned with the longitudinal axis of the channel. In some embodiments, the laser is free of mirrors, prisms, or gratings, or the laser may produce coherent light using a non-resonant photonic pathway. However, in other cases, mirrors, prisms, or gratings may be used to reflect light along the channel to enhance stimulated emission of coherent light. Another aspect of the invention includes optical diffractors, such as prisms or gratings, which can contain a fluid. The optical diffractors, in certain embodiments, are positioned to diffract light, such as coherent light, emanating from the fluidic channel. Still other aspects of the invention provide devices, kits, and methods of making and using such lasers.
摘要翻译：本发明一般涉及包括流体通道的激光器，例如微流体通道。在一些情况下，通道包含两种或更多种流体。流体可以在通道内保持不混合，例如，由于通道内的不混溶和/或层流。流体可以布置在通道中，使得通过第二流体从第一流体中排出的光例如由于折射率的差异（例如，引起流体的内部反射）而被阻止在第一流体中传播的光）。因此，在一个实施例中，第一流体可以至少部分地被具有低于第一流体的折射率的第二折射率的第二流体包围。在一些实施例中，流体通道用作激光器，例如染料激光器，即通过在染料处引导光以产生相干光而产生的激光。染料可存在于流体通道内的一种或多种流体中。入射光（例如，由另一激光产生的）可以从任何角度指向通道。在一些情况下，可以在与通道的纵向轴线基本对准的方向上产生激光。在一些实施例中，激光器不含镜子，棱镜或光栅，或者激光可以使用非共振光子通道产生相干光。然而，在其他情况下，可以使用反射镜，棱镜或光栅来沿着通道反射光以增强相干光的受激发射。本发明的另一方面包括可以包含流体的光学衍射器，例如棱镜或光栅。在某些实施例中，光衍射器被定位成衍射从流体通道发出的光，例如相干光。本发明的其它方面提供了制造和使用这种激光器的装置，套件和方法。

2. 发明申请

WO9954786A9 ELASTOMERIC MASK AND USE IN FABRICATION OF DEVICES, INLCUDING PIXELATED ELECTROLUMINESCENT DISPLAYS 审中-公开
标题翻译：弹性掩模和在器件制造中的应用，嵌入像素电致发光显示器
公开(公告)号：WO9954786A9
公开(公告)日：2000-02-03
申请号：PCT/US9908623
申请日：1999-04-20
申请人： HARVARD COLLEGE , MASSACHUSETTS INST TECHNOLOGY , JACKMAN REBECCA J , DUFFY DAVID C , WHITESIDES GEORGE M , VAETH KATHLEEN M , JENSEN KLAVS F
发明人： JACKMAN REBECCA J , DUFFY DAVID C , WHITESIDES GEORGE M , VAETH KATHLEEN M , JENSEN KLAVS F
IPC分类号： B41C1/14 , B05D1/32 , G03F1/00 , G03F7/00 , G03F7/12 , H01L27/32 , H01L51/50 , H05B33/10
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/32 , H01L27/3211 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain unshielded, while other openings of the lower mask are shielded. A first deposition step, followed by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.
摘要翻译：提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。然后可以从掩模的表面简单地剥离掩模，留下图案化材料。描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。第一沉积步骤，随后重新取向上掩模以暴露不同组的下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。通过所述技术提供像素化的有机电致发光器件。

3. 发明申请

WO2008070088A3 EDGE-EMITTING LIGHT-EMITTING DIODE ARRAYS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：边发射发光二极管阵列及其制造和使用方法
公开(公告)号：WO2008070088A3
公开(公告)日：2008-09-25
申请号：PCT/US2007024855
申请日：2007-12-05
申请人： NANO TERRA INC , MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
发明人： MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
IPC分类号： H01L33/20 , H01L33/24
CPC分类号： H01L33/24 , H01L33/20
摘要： The present invention is directed to edge-emitting light-emitting diode arrays, a process to prepare the edge-emitting light-emitting diode arrays, and process products prepared by the process.
摘要翻译：本发明涉及边缘发射型发光二极管阵列，制备边缘发射型发光二极管阵列的工艺以及由该工艺制备的工艺产品。

4. 发明申请

WO2009158039A8 PATTERNING PROCESSES COMPRISING AMPLIFIED PATTERNS 审中-公开
标题翻译：包含放大图案的图案处理方法
公开(公告)号：WO2009158039A8
公开(公告)日：2010-03-11
申请号：PCT/US2009003861
申请日：2009-06-29
申请人： NANO TERRA INC , MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
发明人： MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
IPC分类号： B05D1/28 , H01L21/70
CPC分类号： B05D5/00 , B82Y10/00 , B82Y40/00 , G03F7/0002 , H01L21/306
摘要： The present invention is directed to substrates comprising amplified patterns, methods for making the amplified patterns, and methods of using the amplified patterns to form surface features on the substrates.
摘要翻译：本发明涉及包括放大图案的基板，用于制作放大图案的方法，以及使用放大图案在基板上形成表面特征的方法。

5. 发明申请

WO2008070087A3 METHOD FOR PATTERNING A SURFACE 审中-公开
标题翻译：表面方法
公开(公告)号：WO2008070087A3
公开(公告)日：2009-04-30
申请号：PCT/US2007024854
申请日：2007-12-05
申请人： NANO TERRA INC , MERCK KGAA , MAYERS BRIAN T , CARBECK JEFF , SAADI WAJEEH , WHITESIDES GEORGE M , KUGLER RALF , KURSAWE MONIKA , CANISIUS JOHANNES
发明人： MAYERS BRIAN T , CARBECK JEFF , SAADI WAJEEH , WHITESIDES GEORGE M , KUGLER RALF , KURSAWE MONIKA , CANISIUS JOHANNES
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： The present invention is directed to methods for patterning surfaces using contact printing and pastes, pastes for use with the processes, and products formed therefrom.
摘要翻译：本发明涉及使用接触印刷和糊剂，用于该方法的浆料以及由其形成的产品来图案化表面的方法。

6. 发明申请

WO2009121037A3 THREE-DIMENSIONAL MICROFLUIDIC DEVICES 审中-公开
标题翻译：三维微流体器件
公开(公告)号：WO2009121037A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038693
申请日：2009-03-27
申请人： HARVARD COLLEGE , CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
发明人： CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
IPC分类号： G01N35/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括由多个图案化的多孔亲水层和设置在每两个相邻的图案化多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有流体不可渗透的屏障，其基本上渗透多孔亲水层的厚度并限定图案化多孔亲水层内的一个或多个亲水区域的边界。不透流体层具有与至少一个相邻图案化多孔亲水层内的亲水区域的至少一部分对齐的开口。还描述了微流体测定装置，微流体混合器，微流体控制装置。

7. 发明申请

WO2008127649A3 SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION 审中-公开
标题翻译：通过接触电气组装的系统和方法
公开(公告)号：WO2008127649A3
公开(公告)日：2009-06-04
申请号：PCT/US2008004704
申请日：2008-04-11
申请人： HARVARD COLLEGE , WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
发明人： WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
IPC分类号： C08J5/12 , B05D1/04 , C08J7/00
CPC分类号： C08J5/12 , B05D3/14 , B05D7/02 , B05D2401/32 , C08J7/047 , C08J2327/18 , C08J2433/12
摘要： The present invention generally relates to the charging of materials via contact electrification, including systems and methods of assembly using contact electrification. One aspect of the present invention is directed to systems and methods of identifying and synthesizing nonionic polymeric materials that can be charged using contact electrification. Another aspect of the present invention is directed to methods of localizing charged particles or other materials on such surfaces, for example, in the presence of a controlled humidity environment. Yet another aspect of the present invention is directed to a surface comprising positively and negatively charged regions. Oppositely charged materials may be attracted to those regions. Other aspects of the invention are directed to methods of making, using, and promoting such materials, or kits containing such materials.
摘要翻译：本发明一般涉及通过接触带电充电材料，包括使用接触带电装配的系统和组装方法。本发明的一个方面涉及鉴定和合成可以使用接触带电充电的非离子聚合物材料的系统和方法。本发明的另一方面涉及将带电粒子或其它材料定位在这些表面上的方法，例如在受控湿度环境的存在下。本发明的另一方面涉及包括正带电和带负电荷的区域的表面。对这些区域可能会吸引相反电荷的材料。本发明的其它方面涉及制造，使用和促进这些材料或包含这种材料的试剂盒的方法。

8. 发明申请

WO2008051432A3 PATTERNING OF IONIC POLYMERS 审中-公开
标题翻译：离子聚合物的构图
公开(公告)号：WO2008051432A3
公开(公告)日：2009-04-09
申请号：PCT/US2007022219
申请日：2007-10-18
申请人： HARVARD COLLEGE , LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
发明人： LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与解决方案。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

9. 发明申请

WO2007061448A3 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：微流控网络中导电路径，微型计算机和微结构的制造
公开(公告)号：WO2007061448A3
公开(公告)日：2008-08-28
申请号：PCT/US2006019787
申请日：2006-05-18
申请人： HARVARD COLLEGE , BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
发明人： BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
IPC分类号： H05K3/10 , B01F13/00 , B01L3/00 , B29C39/12
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

10. 发明申请

WO2008060449A2 MICROFLUIDIC DETECTOR 审中-公开
标题翻译：微流体检测器
公开(公告)号：WO2008060449A2
公开(公告)日：2008-05-22
申请号：PCT/US2007023595
申请日：2007-11-09
申请人： HARVARD COLLEGE , BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
发明人： BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/54373 , G01N2333/16 , G01N2333/70503 , G01N2800/24
摘要： Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.
摘要翻译：提供了用于确定指示疾病状况的分析物的文章和方法。在一些实施方案中，本文描述的制品和方法可以用于确定流体样品中组分（例如特定类型的细胞）的定性或定量存在。在一个特定实施例中，提供了用于快速检测T细胞的低成本微流体系统。微流体系统可以在通道中使用固定的抗体和粘附分子以从流体样本（例如小体积血液）捕获T细胞。捕获的T细胞可以使用对T细胞受体（TCR）特异性的抗体用金属胶体（例如金纳米颗粒）标记，并且可以将金属银催化沉淀到细胞上。捕获的T细胞的数量可以被计数，并且可以指示患者的疾病状况，例如严重的联合免疫缺陷或人类免疫缺陷病毒。

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