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1. 发明申请

WO2017106683A3 CONCATEMERIC RNA MOLECULES, COMPOSITIONS, AND METHODS AND USES THEREOF 审中-公开
标题翻译： CONCATEMERIC RNA分子，组合物和方法及其用途
公开(公告)号：WO2017106683A3
公开(公告)日：2017-07-27
申请号：PCT/US2016067233
申请日：2016-12-16
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： HAMMOMD-CUNNINGHAM PAULA T , WU CONNIE , SHOPSOWITZ KEVIN E
IPC分类号： C12N15/11 , C12N15/113 , C12P19/34
CPC分类号： C12N15/111 , C12N2310/14 , C12N2310/51 , C12N2310/531
摘要： The present invention relates to concatemeric RNA molecules, compositions, particles, and methods of uses thereof.
摘要翻译：本发明涉及多聚体RNA分子，组合物，颗粒及其使用方法。

2. 发明申请

WO2017099817A8 PRESSURE DRIVEN FLOW CRYSTALLIZER 审中-公开
标题翻译：压力驱动流动结晶器
公开(公告)号：WO2017099817A8
公开(公告)日：2017-07-27
申请号：PCT/US2016000122
申请日：2016-12-08
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： MYERSON ALLAN STUART , O'MAHONY MARCUS , STELZER TORSTEN , CUI YUQING
IPC分类号： B01J8/00 , B01J8/20 , B01J8/22 , B01J19/00 , B01J19/26
CPC分类号： C07H17/08 , B01D9/0004 , B01D9/0013 , B01D9/0031 , B01D9/0036 , B01D9/0054 , C07B2200/13 , C07C213/10
摘要： The present invention generally relates to systems and methods for pressure driven flow crystallization. In some embodiments, the system comprises a comprising a cavity and a mixing mechanism. In some embodiments, one or more inlets facilitate the transfer of one or more reagent streams to the cavity. In some such embodiments, the mixing mechanism mixes the first and second reagent streams such that a continuous crystallization and/or generation of a product (e.g., solid particles) in the fluid.
摘要翻译：本发明总体上涉及用于压力驱动流动结晶的系统和方法。在一些实施例中，该系统包括包含空腔和混合机构的系统。在一些实施例中，一个或多个入口有利于将一个或多个试剂流传送到空腔。在一些这样的实施例中，混合机构混合第一和第二试剂流，使得流体中的产物（例如固体颗粒）的连续结晶和/或产生。

3. 发明申请

WO2016100975A8 MOLECULAR BIOMARKERS FOR CANCER IMMUNOTHERAPY 审中-公开
标题翻译：癌症免疫治疗的分子生物标志物
公开(公告)号：WO2016100975A8
公开(公告)日：2017-06-22
申请号：PCT/US2015067143
申请日：2015-12-21
申请人： MASSACHUSETTS INST TECHNOLOGY , MASSACHUSETTS GEN HOSPITAL
发明人： HACOHEN NIR , ROONERY MICHAEL S
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/57407 , G01N2333/96436 , G01N2800/52
摘要： In one aspect, provided herein is a method comprising: (a) (i) determining cytolytic activity in a tumor from the subject; and/or (ii) determining genetic alterations associated with cytolytic activity in the tumor; and (b) administering an immunotherapeutic agent to the subject if (i) cytolytic activity is detected in the tumor and/or (ii) a genetic alteration associated with induction of cytolytic activity, tumor resistance to cytolytic activity and/or suppression of cytolytic activity is detected in the tumor.
摘要翻译：在一个方面，本文提供了一种方法，其包括：（a）（i）确定来自受试者的肿瘤中的细胞溶解活性; 和/或（ii）确定与肿瘤中细胞溶解活性相关的遗传改变; 和（b）如果（i）在肿瘤中检测到溶细胞活性和/或（ii）与诱导细胞溶解活性相关的基因改变，肿瘤对细胞溶解活性的抗性和/或抑制细胞溶解活性，则向受试者施用免疫治疗剂在肿瘤中被检测到。

4. 发明申请

WO2016057855A8 METHODS AND APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE 审中-公开
标题翻译：用于刺激生物组织的方法和设备
公开(公告)号：WO2016057855A8
公开(公告)日：2017-04-20
申请号：PCT/US2015054796
申请日：2015-10-08
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： GROSSMAN NIR , BONO DAVID , BOYDEN EDWARD
IPC分类号： A61N1/36
CPC分类号： A61N1/36017 , A61N1/0529 , A61N1/36014 , A61N1/36125 , A61N1/36146 , A61N1/36185
摘要： In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.
摘要翻译：在本发明的说明性实施中，干涉刺激精确地指向脑中的任意区域。目标区域不限于电极正下方的区域，但可以是任何浅表，中等深度或深度的大脑结构。通过定位最大包络振幅的区域以使其位于目标组织处来实现靶向。通过使至少一个电流通道反相，即，至少一个电流通道的电极对在两个电极之间具有基本上等于180度的相位差，电流通道之间的泄漏大大减少。成对的刺激电极并排放置，而不是以传统的十字形图案，因此只产生一个最大包络振幅的区域。通常，电流源用于驱动干扰电流。

5. 发明申请

WO2016201174A3 GENE EXPRESSION IN BACTEROIDES 审中-公开
标题翻译：细菌中的基因表达
公开(公告)号：WO2016201174A3
公开(公告)日：2017-04-13
申请号：PCT/US2016036811
申请日：2016-06-10
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： LU TIMOTHY KUAN-TA , MIMEE MARK K , VOIGT CHRISTOPHER , TUCKER ALEX C
IPC分类号： A61K39/02 , C12N1/21 , C12N7/01 , C12N15/70 , C12N15/74
CPC分类号： C12N15/63 , C12N9/12 , C12N9/16
摘要： Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
摘要翻译：在这里，在一些方面，是用于构建拟杆菌属和拟杆菌属细菌中的遗传回路以及含有遗传回路的细菌的工具（例如，方法，组合物和核酸）。

6. 发明申请

WO2017023384A3 APPARATUS AND METHODS FOR RECONFIGURABLE OPTICAL RECEIVERS 审中-公开
标题翻译：用于可重构光学接收器的装置和方法
公开(公告)号：WO2017023384A3
公开(公告)日：2017-03-16
申请号：PCT/US2016031136
申请日：2016-05-06
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： CAPLAN DAVID O , WATTS MICHAEL R , SU ZHAN
IPC分类号： G01J3/18
CPC分类号： H04B10/677 , G02B6/12007 , G02B6/2938 , G02B6/29395 , G02F1/011 , G02F1/0147 , G02F2201/16 , G02F2203/055 , G02F2203/15 , G02F2203/58 , G02F2203/585 , H04B10/67 , H04B10/671 , H04J14/02
摘要： An optical receiver includes a cascade of optical filtering elements, each of which selects spectral components from incoming optical signals at a wavelengths aligned to filter passbands. The selected spectral components may be optically combined to form k pairs of intermediary signals, where k= log2(M). By comparing the k pairs of intermediary signals, k bits of a digital signal representing the incident signal may be generated. The filtering elements may be configured to perform demultiplexing and demodulation simultaneously, increasing functionality and reducing excess losses. The filtering elements may also be tuned so that the optical receiver may be reconfigured to accommodate different combinations of wavelengths and modulation formats, such as wavelength division multiplexed (WDM) on off keying (OOK), M-ary orthogonal formats including frequency shift keying (FSK) and pulse position modulation (PPM), differential phase shift keying, and hybrid combinations - providing rate and format flexibility and WDM scalability.
摘要翻译：一种光学接收器包括级联的光学滤波元件，其中的每一个从对准的波长的输入光信号中选择光谱分量以对通带进行滤波。所选择的频谱分量可以被光学组合以形成k对中间信号，其中k = log2（M）。通过比较k对中间信号，可以生成表示入射信号的数字信号的k位。滤波元件可以被配置为同时执行解复用和解调，增加功能并减少额外损耗。滤波元件也可以被调谐，使得光接收机可以被重新配置以适应波长和调制格式的不同组合，例如波分多路复用（WDM）开关键控（OOK），M元正交格式，包括频移键控（ FSK）和脉冲位置调制（PPM），差分相移键控和混合组合 - 提供速率和格式灵活性以及WDM可扩展性。

7. 发明申请

WO2016081409A8 FLOW CONTROL IN MULTI-STEP FILTRATION, AND ASSOCIATED SYSTEMS 审中-公开
标题翻译：多步骤过滤中的流量控制及相关系统
公开(公告)号：WO2016081409A8
公开(公告)日：2017-03-02
申请号：PCT/US2015060990
申请日：2015-11-17
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： MCGOVERN RONAN K , LIENHARD V JOHN H
IPC分类号： B01D61/02 , B01D61/12 , B01D61/14 , B01D61/22 , C12G3/08
CPC分类号： B01D61/022 , B01D61/025 , B01D61/12 , B01D61/145 , B01D61/22 , B01D2311/25 , B01D2313/50 , C12C11/11 , C12G3/085
摘要： Flow control in multi-step filtration systems and associated methods are generally described. Certain embodiments are related to methods in which a single filter is used to perform multiple, separate filtration steps. In some cases, a diluted permeate from a first filtration step can be recycled back through the filter, as part of a separate filtration step, to produce a second retentate and a second permeate. Subsequent filtration steps can also be performed. Systems configured to perform multiple, separate filtration steps using a single filter are also described.
摘要翻译：一般来说，描述了多步骤过滤系统和相关方法中的流量控制。某些实施方案涉及使用单个过滤器来执行多个单独的过滤步骤的方法。在一些情况下，来自第一过滤步骤的稀释的渗透物可以作为单独的过滤步骤的一部分通过过滤器再循环回来，以产生第二渗余物和第二渗透物。还可以执行随后的过滤步骤。还描述了配置为使用单个过滤器执行多个单独过滤步骤的系统。

8. 发明申请

WO2016019391A8 MODIFIED ALGINATES FOR ANTI-FIBROTIC MATERIALS AND APPLICATIONS 审中-公开
标题翻译：用于抗纤维材料和应用的改性助剂
公开(公告)号：WO2016019391A8
公开(公告)日：2017-03-02
申请号：PCT/US2015043495
申请日：2015-08-03
申请人： MASSACHUSETTS INST TECHNOLOGY , THE CHILDREN'S MEDICAL CENTER CORP
发明人： VEGAS ARTURO J , DOLOFF JOSHUA C , VEISEH OMID , MA MINGLIN , LANGER ROBERT S , ANDERSON DANIEL G
IPC分类号： C08B37/00 , A61K47/36 , C12N5/00 , C12N5/071
CPC分类号： A61K9/5036 , A61K9/0024 , A61K35/39 , A61L29/085 , A61L31/10 , A61L33/08 , C08B37/0084 , C12N5/0012 , C12N5/0677 , C08L5/04
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
摘要翻译：本文公开了具有增强的生物相容性和定制的理化性质的共价改性的藻酸盐聚合物，以及其制备和使用方法。共价修饰的藻酸盐可用作涂覆需要减少纤维化的任何材料的基质，例如用于移植的包封细胞和植入或用于体内的医疗装置。

9. 发明申请

WO2016114844A3 MESSAGE FRACTIONATION AND PHYSICAL LAYER CHANNEL ASSIGNMENT FOR MULTIUSER DETECTION-ENABLED WIRELESS COMMUNICATION AMONG ADAPTIVE INTERFERENCE 审中-公开
标题翻译：用于多用户检测的消息分段和物理层信道分配 - 自适应干扰中的无线通信
公开(公告)号：WO2016114844A3
公开(公告)日：2016-09-22
申请号：PCT/US2015058586
申请日：2015-11-02
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： LEARNED RACHEL E , BASU PRABAHAN
IPC分类号： H04W72/08
CPC分类号： H04W16/04 , H04W16/14 , Y02D70/00 , Y02D70/1262 , Y02D70/1264 , Y02D70/142 , Y02D70/146
摘要： A cognitive coexistence radio utilizes message fractionation and physical layer channel assignment to achieve co-existence communications in the presence of interferers. A transmit signal is split into a plurality of streams for transmission in occupied channels according to power allocation and modulation scheme. A near-optimal selfish power allocation scheme is based on the water-filling solution. A receiver can receive and decode the streams using parallel MUDs.
摘要翻译：认知共存无线电利用消息分级和物理层信道分配来实现存在干扰源的共存通信。根据功率分配和调制方案，发射信号被分成多个流，用于在被占用信道中传输。近乎最优的自私权力分配方案是基于灌水解决方案。接收机可以使用并行MUD接收和解码流。

10. 发明申请

WO2016115537A3 SYSTEMS, METHODS, AND APPARATUS FOR IN VITRO SINGLE-CELL IDENTIFICATION AND RECOVERY 审中-公开
标题翻译：用于体外单细胞鉴定和回收的系统，方法和装置
公开(公告)号：WO2016115537A3
公开(公告)日：2016-09-09
申请号：PCT/US2016013724
申请日：2016-01-15
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： ADALSTEINSSON VIKTOR A , LOGINOV DENIS , LOVE J CHRISTOPHER , STOCKDALE ALAN , GIERAHN TODD
IPC分类号： B01L3/00
CPC分类号： G06K9/00147 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/0896 , B01L2300/12 , G01N15/1425 , G01N15/1463 , G01N33/4833 , G01N35/00029 , G01N35/00871 , G01N2015/0065 , G01N2015/1006 , G01N2035/00148 , G02B21/16 , G02B21/26 , G06K9/0014 , G06K9/036 , G06K9/4647 , G06K9/4652 , G06K9/4661 , H04N5/2256
摘要： Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
摘要翻译：本文描述了用于从生物物质样本例如生物流体中自动识别和回收感兴趣的单个细胞的系统，方法和设备。还描述了丰富感兴趣的细胞类型的方法。这些系统，方法和装置允许以下两种或更多种的协调表现，例如全部使用相同的装置，从而实现高通量：细胞富集，细胞鉴定和单个细胞回收用于进一步分析（例如测序）的个体回收细胞。

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