专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008051432A3 PATTERNING OF IONIC POLYMERS 审中-公开
标题翻译：离子聚合物的构图
公开(公告)号：WO2008051432A3
公开(公告)日：2009-04-09
申请号：PCT/US2007022219
申请日：2007-10-18
申请人： HARVARD COLLEGE , LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
发明人： LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与解决方案。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

2. 发明申请

WO2009006409A2 DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 审中-公开
标题翻译：基于密度的方法分离材料，监测固体支撑反应和测量小液体体积和固体密度
公开(公告)号：WO2009006409A2
公开(公告)日：2009-01-08
申请号：PCT/US2008068797
申请日：2008-06-30
申请人： HARVARD COLLEGE , PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
发明人： PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
IPC分类号： G01N33/53
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译：描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。

3. 发明申请

WO2006113727A3 FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS 审中-公开
标题翻译：流体结构包括测量和宽频道
公开(公告)号：WO2006113727A3
公开(公告)日：2007-02-15
申请号：PCT/US2006014583
申请日：2006-04-19
申请人： HARVARD COLLEGE , LINDER VINCENT , SIA SAMUEL K , WHITESIDES GEORGE M , NAROVLYANSKY MAX , SIEGEL ADAM
发明人： LINDER VINCENT , SIA SAMUEL K , WHITESIDES GEORGE M , NAROVLYANSKY MAX , SIEGEL ADAM
IPC分类号： G01N21/59 , B01L3/00 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54366 , B01L3/502746 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0883 , B01L2400/0406 , G01N21/01 , G01N21/82 , G01N33/54373
摘要： The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.
摘要翻译：本发明一般涉及微流体结构，更具体地涉及包括曲折和宽通道的微流体结构和方法。微流控系统可以提供用于执行各种反应和分析的有利环境，这是由于与常规系统相比所需的样品和试剂量的减少，操作系统尺寸的减小以及反应时间的减少。不幸的是，微量流体通道的小尺寸有时会导致在不放大光学器件（例如显微镜或光电倍增管）的情况下检测物质的困难。一系列紧密包装的微通道，即曲折区域或具有大约毫米数量级的宽通道可以通过创建宽的测量区域来解决这个问题。尽管本发明主要描述了在微流体芯片上的异源免疫测定中使用曲折和宽通道，但是本发明可用于放大用于其他类型反应和/或测定的光学信号。

4. 发明申请

WO2006125176A8 MICROSYSTEM SPECTROSCOPY 审中-公开
标题翻译：微结构光谱
公开(公告)号：WO2006125176A8
公开(公告)日：2007-03-01
申请号：PCT/US2006019533
申请日：2006-05-19
申请人： HARVARD COLLEGE , DAMEAN NICOLAE , SIA SAMUEL K , LINDER VINCENT , NAROVLYANSKY MAX , WHITESIDES GEORGE M
发明人： DAMEAN NICOLAE , SIA SAMUEL K , LINDER VINCENT , NAROVLYANSKY MAX , WHITESIDES GEORGE M
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N21/255 , B01L3/5027 , G01J3/02 , G01J3/0208 , G01J3/0256 , G01N21/05 , G01N2021/0346 , G01N2201/0638 , G02B21/0032
摘要： The present invention generally relates to systems and methods for acquiring multiple spectra from a sample, for example, a microfluidic sample. In some aspects of the invention, spectra from a series of locations within a sample are recorded and analyzed, and optionally correlated with an image of the sample. The spectra can be obtained by passing a plurality of light beams through a sample, e.g., using an array of microlenses, diffracting the light beams passing through the sample with a transmission grating, before or after passing the light through the sample, and detecting the resulting light, e.g., as an image. The light beams may pass through the sample before or after passing through the transmission grating. The image can appear as an array of discrete spectra, where each spectrum is associated with a region of the sample where a light beam passed through the sample. The spectra can be analyzed to determine information about the region where the light beam passed through the sample. In some cases, the array of microlenses may be movable and/or replaceable with a second array of microlenses. Also, in some instances, the transmission grating may be movable and/or replaceable with a second transmission grating.
摘要翻译：本发明一般涉及用于从样品例如微流体样品获取多个光谱的系统和方法。在本发明的一些方面，记录和分析来自样品中的一系列位置的光谱，并且可选地与样品的图像相关。可以通过使多个光束通过样品获得光谱，例如使用微透镜阵列，在通过样品之前或之后通过透射光栅衍射穿过样品的光束，并且检测产生光，例如，作为图像。光束可以在通过透射光栅之前或之后通过样品。该图像可以显示为离散光谱阵列，其中每个光谱与光束通过样品的样品区域相关联。可以分析光谱以确定关于光束通过样品的区域的信息。在一些情况下，微透镜阵列可以是可移动的和/或可替代的第二阵列的微透镜。此外，在一些情况下，透射光栅可以是可移动的和/或可以用第二透射光栅代替。

5. 发明申请

WO2008045745A2 CHEMICALLY-DIRECTED ELECTROSTATIC SELF-ASSEMBLY OF MATERIALS 审中-公开
标题翻译：化学静电自组装材料
公开(公告)号：WO2008045745A2
公开(公告)日：2008-04-17
申请号：PCT/US2007080392
申请日：2007-10-04
申请人： HARVARD COLLEGE , MCCARTY LOGAN S , WHITESIDES GEORGE M , WINKLEMAN ADAM
发明人： MCCARTY LOGAN S , WHITESIDES GEORGE M , WINKLEMAN ADAM
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , Y10T156/10 , Y10T428/24942
摘要： A self-assembled article includes a surface comprising an chemical functionality having an immobilized charge; and a plurality of particles assembled on the surface of the core, said particles having a surface comprising an immobilized chemical functionality of a charge opposite that of the core.
摘要翻译：自组装制品包括包含具有固定电荷的化学官能团的表面; 以及组装在芯的表面上的多个颗粒，所述颗粒具有表面，其包含电荷相对于芯的电荷的固定化学官能团。

6. 发明申请

WO2009121037A3 THREE-DIMENSIONAL MICROFLUIDIC DEVICES 审中-公开
标题翻译：三维微流体器件
公开(公告)号：WO2009121037A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038693
申请日：2009-03-27
申请人： HARVARD COLLEGE , CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
发明人： CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
IPC分类号： G01N35/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括由多个图案化的多孔亲水层和设置在每两个相邻的图案化多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有流体不可渗透的屏障，其基本上渗透多孔亲水层的厚度并限定图案化多孔亲水层内的一个或多个亲水区域的边界。不透流体层具有与至少一个相邻图案化多孔亲水层内的亲水区域的至少一部分对齐的开口。还描述了微流体测定装置，微流体混合器，微流体控制装置。

7. 发明申请

WO2008127649A3 SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION 审中-公开
标题翻译：通过接触电气组装的系统和方法
公开(公告)号：WO2008127649A3
公开(公告)日：2009-06-04
申请号：PCT/US2008004704
申请日：2008-04-11
申请人： HARVARD COLLEGE , WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
发明人： WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
IPC分类号： C08J5/12 , B05D1/04 , C08J7/00
CPC分类号： C08J5/12 , B05D3/14 , B05D7/02 , B05D2401/32 , C08J7/047 , C08J2327/18 , C08J2433/12
摘要： The present invention generally relates to the charging of materials via contact electrification, including systems and methods of assembly using contact electrification. One aspect of the present invention is directed to systems and methods of identifying and synthesizing nonionic polymeric materials that can be charged using contact electrification. Another aspect of the present invention is directed to methods of localizing charged particles or other materials on such surfaces, for example, in the presence of a controlled humidity environment. Yet another aspect of the present invention is directed to a surface comprising positively and negatively charged regions. Oppositely charged materials may be attracted to those regions. Other aspects of the invention are directed to methods of making, using, and promoting such materials, or kits containing such materials.
摘要翻译：本发明一般涉及通过接触带电充电材料，包括使用接触带电装配的系统和组装方法。本发明的一个方面涉及鉴定和合成可以使用接触带电充电的非离子聚合物材料的系统和方法。本发明的另一方面涉及将带电粒子或其它材料定位在这些表面上的方法，例如在受控湿度环境的存在下。本发明的另一方面涉及包括正带电和带负电荷的区域的表面。对这些区域可能会吸引相反电荷的材料。本发明的其它方面涉及制造，使用和促进这些材料或包含这种材料的试剂盒的方法。

8. 发明申请

WO2007061448A3 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：微流控网络中导电路径，微型计算机和微结构的制造
公开(公告)号：WO2007061448A3
公开(公告)日：2008-08-28
申请号：PCT/US2006019787
申请日：2006-05-18
申请人： HARVARD COLLEGE , BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
发明人： BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
IPC分类号： H05K3/10 , B01F13/00 , B01L3/00 , B29C39/12
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

9. 发明申请

WO2008060449A2 MICROFLUIDIC DETECTOR 审中-公开
标题翻译：微流体检测器
公开(公告)号：WO2008060449A2
公开(公告)日：2008-05-22
申请号：PCT/US2007023595
申请日：2007-11-09
申请人： HARVARD COLLEGE , BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
发明人： BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/54373 , G01N2333/16 , G01N2333/70503 , G01N2800/24
摘要： Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.
摘要翻译：提供了用于确定指示疾病状况的分析物的文章和方法。在一些实施方案中，本文描述的制品和方法可以用于确定流体样品中组分（例如特定类型的细胞）的定性或定量存在。在一个特定实施例中，提供了用于快速检测T细胞的低成本微流体系统。微流体系统可以在通道中使用固定的抗体和粘附分子以从流体样本（例如小体积血液）捕获T细胞。捕获的T细胞可以使用对T细胞受体（TCR）特异性的抗体用金属胶体（例如金纳米颗粒）标记，并且可以将金属银催化沉淀到细胞上。捕获的T细胞的数量可以被计数，并且可以指示患者的疾病状况，例如严重的联合免疫缺陷或人类免疫缺陷病毒。

10. 发明申请

WO2004002627A2 METHOD AND APPARATUS FOR FLUID DISPERSION 审中-公开
标题翻译：流体分散方法及装置
公开(公告)号：WO2004002627A2
公开(公告)日：2004-01-08
申请号：PCT/US0320542
申请日：2003-06-30
申请人： HARVARD COLLEGE , STONE HOWARD A , ANNA SHELLY L , BONTOUX NATHALIE , LINK DARREN ROY , WEITZ DAVID A , GITLIN IRINA , GARSTECKI PIOTR , DILUZIO WILLOW , WHITESIDES GEORGE M , KUMACHEVA EUGENIA
发明人： STONE HOWARD A , ANNA SHELLY L , BONTOUX NATHALIE , LINK DARREN ROY , WEITZ DAVID A , GITLIN IRINA , GARSTECKI PIOTR , DILUZIO WILLOW , WHITESIDES GEORGE M , KUMACHEVA EUGENIA
IPC分类号： B01F3/08 , B01F5/06 , B01F13/00 , B01L3/00 , B05B7/04
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式