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1. 发明申请

WO2022271192A1 SUSTAINABLE FOUNDATION SYSTEM 审中-公开
公开(公告)号：WO2022271192A1
公开(公告)日：2022-12-29
申请号：PCT/US2021/040886
申请日：2021-07-08
申请人： FORGENIE, Darryl M. , LEZAMA MARTINEZ, Andres Antonio
发明人： FORGENIE, Darryl M. , LEZAMA MARTINEZ, Andres Antonio
IPC分类号： E02D27/01
摘要： Provided herein is an amphibious foundation system for mitigating the impact of water currents on coastal erosion and deep-water machinery. The system is modular in design and is made up of tires stacked in a columnar arrangement, where adjacent tires are secured with at least three polyester straps. A geotextile bag filled with a filler is placed within the core at the center of the column to stabilize the column in the vertical direction. The foundation system may have any shape such as a hexagon and a wedge and is deployable in the deep-water zone or the surf zone.

2. 发明申请

WO2011097412A1 DEVICES AND METHODS FOR MULTIPLEXED ASSAYS 审中-公开
标题翻译：多重测试的设备和方法
公开(公告)号：WO2011097412A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023647
申请日：2011-02-03
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WHITESIDES, George, M. , MIRICA, Katherine, A. , MARTINEZ, Andres, W. , CHENG, Chao-Min , PHILLIPS, Scott, T. , MASCAREÑAS, Monica , LIU, Xinyu , LI, Xiujun
发明人： WHITESIDES, George, M. , MIRICA, Katherine, A. , MARTINEZ, Andres, W. , CHENG, Chao-Min , PHILLIPS, Scott, T. , MASCAREÑAS, Monica , LIU, Xinyu , LI, Xiujun
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译：本公开提供了用于执行多重测定的低成本便携式三维装置。这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

3. 发明申请

WO2009121041A3 PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：基于纸张的微流体系统
公开(公告)号：WO2009121041A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038699
申请日：2009-03-27
申请人： HARVARD COLLEGE , SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W
发明人： SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W
IPC分类号： G01N35/00 , G01N27/26 , G01N33/48
CPC分类号： B01L3/502707 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/025 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2300/0819 , B01L2300/087 , B01L2300/12 , B01L2300/126 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , Y10T436/25 , Y10T436/2575
摘要： The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.
摘要翻译：本发明的特征在于测定装置，微流体装置和检测流体样品中高电解质浓度的存在的方法。测定装置包括多孔亲水底物; 限定测定区域和主通道区域边界的流体不渗透屏障，主通道区域与流体连接到测定区域的主通道区域; 以及设置在多孔亲水基底上的导电材料条。微流体装置包括多孔的亲水基底; 流体不可渗透的屏障，所述屏障渗透所述多孔亲水基底的厚度，并且在所述多孔亲水基底内限定具有第一和第二侧壁的开放式通道的边界; 以及设置在所述多孔亲水基底上的导电通路，所述导电路径包括（i）在桥接所述第一和第二侧壁的导电材料不存在的情况下形成开路的导电材料条; 以及（ii）电池，电响应指示器和电连接到导电材料条的电阻器。

4. 发明申请

WO2007061448A2 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：微流控网络中导电通路，微环境和微结构的制作
公开(公告)号：WO2007061448A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/019787
申请日：2006-05-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BRUZEWICZ, Derek, A. , BONCHEVA-BETTEX, Mila , WHITESIDES, George, M. , SIEGEL, Adam , WEIBEL, Douglas, B. , SHEVKOPLYAS, Sergey , MARTINEZ, Andres
发明人： BRUZEWICZ, Derek, A. , BONCHEVA-BETTEX, Mila , WHITESIDES, George, M. , SIEGEL, Adam , WEIBEL, Douglas, B. , SHEVKOPLYAS, Sergey , MARTINEZ, Andres
IPC分类号： H05K3/10
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：这里公开了各种微流体装置和固体，典型地导电装置，其可以使用诸如模具的装置形成。在某些实施例中，形成的器件包括通过凝固存在于一个或多个微流体通道中的液态金属（以下称为“微型固态”器件）形成的导电通路。在某些这样的装置中，其中可以在微流体结构中的区域之间形成和/或重新形成电连接; 在一些情况下，形成的器件/电路可以是柔性的和/或涉及柔性电子部件。在某些实施方案中，在微流体通道中形成的固体金属丝/导电通路可保持包含在微流体结构内。在某些这样的实施例中，所形成的导电通路可位于承载流动流体的结构的其他微流体通道附近，使得导电通路可产生与其相互作用的能量（例如电磁能和/或热能），并且 /或影响流动的流体和/或包含在其中或由其承载的组件。在其他实施例中，可以将微观结构从微流体模具移除以形成独立结构。在某些实施方案中，所形成的固体金属结构可与入射在结构上的光能相互作用或可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电通路/连接的自组装结构的形成。

5. 发明申请

WO2010102294A1 METHODS OF MICROPATTERNING PAPER-BASED MICROFLUIDICS 审中-公开
标题翻译：基于纸张微流控的方法
公开(公告)号：WO2010102294A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026547
申请日：2010-03-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CARRILHO, Emanuel , MARTINEZ, Andres W. , WHITESIDES, George M.
发明人： CARRILHO, Emanuel , MARTINEZ, Andres W. , WHITESIDES, George M.
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L2300/126 , B01L2300/161 , B01L2300/165 , Y10T29/4998
摘要： Methods of patterning hydrophobic regions onto hydrophilic substrates are described.
摘要翻译：描述了将疏水区域图案化到亲水基底上的方法。

6. 发明申请

WO2009121041A2 PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：基于纸张的微流体系统
公开(公告)号：WO2009121041A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038699
申请日：2009-03-27
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , SIEGEL, Adam, C. , PHILLIPS, Scott, T. , DICKEY, Michael, D. , ROZKIEWICZ, Dorota , WILEY, Benjamin , WHITESIDES, George, M. , MARTINEZ, Andres, W.
发明人： SIEGEL, Adam, C. , PHILLIPS, Scott, T. , DICKEY, Michael, D. , ROZKIEWICZ, Dorota , WILEY, Benjamin , WHITESIDES, George, M. , MARTINEZ, Andres, W.
IPC分类号： G01N35/00 , G01N33/48 , G01N27/26
CPC分类号： B01L3/502707 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/025 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2300/0819 , B01L2300/087 , B01L2300/12 , B01L2300/126 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , Y10T436/25 , Y10T436/2575
摘要： Paper-based microfluidic systems and methods of making the same are described.
摘要翻译：描述了基于纸的微流体系统及其制备方法。

7. 发明申请

WO2009121037A2 THREE-DIMENSIONAL MICROFLUIDIC DEVICES 审中-公开
标题翻译：三维微流体装置
公开(公告)号：WO2009121037A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038693
申请日：2009-03-27
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CARRILHO, Emanuel , MARTINEZ, Andres, W. , MIRICA, Katherine, A. , PHILLIPS, Scott, T. , SIEGEL, Adam, C. , WILEY, Benjamin , WHITESIDES, George, M.
发明人： CARRILHO, Emanuel , MARTINEZ, Andres, W. , MIRICA, Katherine, A. , PHILLIPS, Scott, T. , SIEGEL, Adam, C. , WILEY, Benjamin , WHITESIDES, George, M.
IPC分类号： G01N35/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括多个图案化的多孔亲水层和设置在每两个相邻的图案化的多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定图案化的多孔亲水层内的一个或多个亲水区域的边界。流体不可渗透层具有与至少一个相邻的图案化的多孔亲水层内的亲水区域的至少一部分对准的开口。还描述了微流控测定装置，微流体混合器，微流控流量控制装置。

8. 发明申请

WO2008049083A3 LATERAL FLOW AND FLOW-THROUGH BIOASSAY BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME 审中-公开
标题翻译：基于图形多孔介质的横向流动和流动性生物多样性，其制造方法及其使用方法
公开(公告)号：WO2008049083A3
公开(公告)日：2009-03-12
申请号：PCT/US2007081848
申请日：2007-10-18
申请人： HARVARD COLLEGE , WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN
发明人： WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
摘要翻译：本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。

9. 发明申请

WO2008049083A2 LATERAL FLOW AND FLOW-THROUGH BIOASSAY BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME 审中-公开
标题翻译：基于图形多孔介质的横向流动和流动性生物多样性，其制造方法及其使用方法
公开(公告)号：WO2008049083A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/081848
申请日：2007-10-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WHITESIDES, George, M. , PHILLIPS, Scott, T. , MARTINEZ, Andres, W. , BUTTE, Manish, J. , WONG, Amy , THOMAS, Samuel , SINDI, Hayat , VELLA, Sarah, Jane , CARRILHO, Emanuel , MIRICA, Katherine, A. , LIU, Yanyan
发明人： WHITESIDES, George, M. , PHILLIPS, Scott, T. , MARTINEZ, Andres, W. , BUTTE, Manish, J. , WONG, Amy , THOMAS, Samuel , SINDI, Hayat , VELLA, Sarah, Jane , CARRILHO, Emanuel , MIRICA, Katherine, A. , LIU, Yanyan
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
摘要翻译：本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。

10. 发明申请

WO2003097166A1 DISPOSITIVO PARA LA EVACUACION DE PERSONAS DESDE ALTURAS DIFERENCIADAS 审中-公开
标题翻译：用于从不同高度取出个人的设备
公开(公告)号：WO2003097166A1
公开(公告)日：2003-11-27
申请号：PCT/ES2003/000233
申请日：2003-05-21
申请人： LUQUE MARTINEZ, Andres , PEREZ GUIRAL, Antonio
发明人： LUQUE MARTINEZ, Andres , PEREZ GUIRAL, Antonio
IPC分类号： A62B1/06
CPC分类号： A62B1/10
摘要： Dispositivo (1) para la evacuación de personas desde alturas diferenciadas, está constituido a partir de la fijación en el interior de un habitáculo (2) instalado en un edificio de un cuerpo (3) que forma una estructura que se fija al forjado del edificio por la parte inferior, presentando un brazo retráctil (4) en el extremo del cual se incorpora una polea, con objeto de que pase a través de la misma un cable (7) que se encuentra arrollado sobre un carrete (6), disponiendo el cuerpo (3) de una palanca bloqueante.
摘要翻译：本发明涉及一种用于从不同高度撤离个体的装置（1）。本发明的装置包括固定在设置在建筑物内并形成固定到建筑物的板坯的下部的结构的空间（2）内的主体（3）。所述装置包括在其末端具有滑轮的可伸缩臂（4）。根据本发明，绕卷轴（6）卷绕的电缆（7）穿过所述滑轮，所述主体（3）包括锁定杆。

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