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1. 发明申请

WO2007061448A3 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：微流控网络中导电路径，微型计算机和微结构的制造
公开(公告)号：WO2007061448A3
公开(公告)日：2008-08-28
申请号：PCT/US2006019787
申请日：2006-05-18
申请人： HARVARD COLLEGE , BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
发明人： BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
IPC分类号： H05K3/10 , B01F13/00 , B01L3/00 , B29C39/12
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

2. 发明申请

WO2007061448A9 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：导电路径的制造，微流控网络中的微处理器和微结构
公开(公告)号：WO2007061448A9
公开(公告)日：2007-07-26
申请号：PCT/US2006019787
申请日：2006-05-18
申请人： HARVARD COLLEGE , BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
发明人： BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
IPC分类号： H05K3/10
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，所形成的装置包括通过固化存在于一个或多个微流体通道中的液体金属形成的导电通路（以下称为“微溶体”装置）。在某些这样的器件中，其中可以在微流体结构中的区域之间形成和/或重组电连接; 在一些情况下，形成的器件/电路可以是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其他微流体通道附近，该流体通道携带流动的流体，使得导电路径可产生与其相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，所形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

3. 发明申请

WO2006083833A3 VALVES AND RESERVOIRS FOR MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：微流体系统的阀门和储存器
公开(公告)号：WO2006083833A3
公开(公告)日：2007-02-22
申请号：PCT/US2006003354
申请日：2006-01-31
申请人： HARVARD COLLEGE , WEIBEL DOUGLAS B , LEE ANDREW , POTENTA SCOTT , SIEGEL ADAM , KRUITHOF MAARTEN , WHITESIDES GEORGE M
发明人： WEIBEL DOUGLAS B , LEE ANDREW , POTENTA SCOTT , SIEGEL ADAM , KRUITHOF MAARTEN , WHITESIDES GEORGE M
IPC分类号： F16K3/24
CPC分类号： F15B1/04 , B01L3/502738 , B01L3/502746 , B01L2200/0636 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F15B2201/21 , F15B2201/305 , F15B2201/4053 , F16K99/0001 , F16K99/0026 , F16K99/0034 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T137/0318 , Y10T137/0396 , Y10T137/2213 , Y10T137/4824 , Y10T137/6161
摘要： A microfluidic valve assembly includes a structure defining a microfluidic fluid path and an actuator that can be moved between different positions controlling flow through the channel. In one embodiment, the actuator can be threaded into at least a portion of the structure, and can be moved rotationally between a first position, causing relatively greater constriction of a microfluidic fluid path, and a second position causing relatively lesser constriction of the fluid path. Actuating the actuator, e.g., by rotation, can deform material between the valve and the fluid path, thereby constricting at least a portion of the underlying fluid path and regulating the flow of a fluid in the fluid path. In another aspect, the invention provides a reservoir into which fluid can be placed and from which fluid can be introduced into a microfluidic system. In one embodiment, the reservoir is expandable and thereby able to store fluid under pressure for delivery to a microfluidic system.
摘要翻译：微流体阀组件包括限定微流体流体路径的结构和可以在控制流过通道的不同位置之间移动的致动器。在一个实施例中，致动器可以被螺纹连接到结构的至少一部分中，并且可以在第一位置和第二位置之间旋转地移动，第一位置引起微流体流体路径的相对较大的收缩，并且引起相对较小的流体路径收缩的第二位置。例如通过旋转来致动致动器可以在阀和流体路径之间变形材料，从而收缩下面的流体路径的至少一部分并且调节流体路径中的流体的流动。在另一方面，本发明提供了一种储存器，流体可以放置在该储存器中，并且可以从该储存器将流体引入到微流体系统中。在一个实施例中，储存器是可膨胀的并且因此能够在压力下存储流体以递送到微流体系统。

4. 发明申请

WO2009006409A2 DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 审中-公开
标题翻译：基于密度的方法分离材料，监测固体支撑反应和测量小液体体积和固体密度
公开(公告)号：WO2009006409A2
公开(公告)日：2009-01-08
申请号：PCT/US2008068797
申请日：2008-06-30
申请人： HARVARD COLLEGE , PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
发明人： PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
IPC分类号： G01N33/53
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译：描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。

5. 发明申请

WO2009121037A3 THREE-DIMENSIONAL MICROFLUIDIC DEVICES 审中-公开
标题翻译：三维微流体器件
公开(公告)号：WO2009121037A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038693
申请日：2009-03-27
申请人： HARVARD COLLEGE , CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
发明人： CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
IPC分类号： G01N35/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括由多个图案化的多孔亲水层和设置在每两个相邻的图案化多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有流体不可渗透的屏障，其基本上渗透多孔亲水层的厚度并限定图案化多孔亲水层内的一个或多个亲水区域的边界。不透流体层具有与至少一个相邻图案化多孔亲水层内的亲水区域的至少一部分对齐的开口。还描述了微流体测定装置，微流体混合器，微流体控制装置。

6. 发明申请

WO2009121041A3 PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：基于纸张的微流体系统
公开(公告)号：WO2009121041A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038699
申请日：2009-03-27
申请人： HARVARD COLLEGE , SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W
发明人： SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W
IPC分类号： G01N35/00 , G01N27/26 , G01N33/48
CPC分类号： B01L3/502707 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/025 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2300/0819 , B01L2300/087 , B01L2300/12 , B01L2300/126 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , Y10T436/25 , Y10T436/2575
摘要： The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.
摘要翻译：本发明的特征在于测定装置，微流体装置和检测流体样品中高电解质浓度的存在的方法。测定装置包括多孔亲水底物; 限定测定区域和主通道区域边界的流体不渗透屏障，主通道区域与流体连接到测定区域的主通道区域; 以及设置在多孔亲水基底上的导电材料条。微流体装置包括多孔的亲水基底; 流体不可渗透的屏障，所述屏障渗透所述多孔亲水基底的厚度，并且在所述多孔亲水基底内限定具有第一和第二侧壁的开放式通道的边界; 以及设置在所述多孔亲水基底上的导电通路，所述导电路径包括（i）在桥接所述第一和第二侧壁的导电材料不存在的情况下形成开路的导电材料条; 以及（ii）电池，电响应指示器和电连接到导电材料条的电阻器。

7. 发明申请

WO2008051265A9 ENGINEERED CELL GROWTH ON POLYMERIC FILMS AND BIOTECHNOLOGICAL APPLICATIONS THERE OF 审中-公开
标题翻译：在聚合物薄膜上生长的细胞生长及其生物技术应用
公开(公告)号：WO2008051265A9
公开(公告)日：2008-06-26
申请号：PCT/US2007003051
申请日：2007-02-05
申请人： HARVARD COLLEGE , PARKER KEVIN KIT , FEINBERG ADAM W , WHITESIDES GEORGE M , SHEVKOPLYAS SERGEY S , FEIGEL ALEXANDER
发明人： PARKER KEVIN KIT , FEINBERG ADAM W , WHITESIDES GEORGE M , SHEVKOPLYAS SERGEY S , FEIGEL ALEXANDER
IPC分类号： C12N5/071 , C12N5/077
CPC分类号： G01N33/5061 , C12N5/0062 , C12N5/0657 , C12N2533/30 , C12N2533/52 , C12N2539/10 , G01N2500/10
摘要： A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
摘要翻译：独立式薄膜由包括涂覆有牺牲聚合物层的基层的结构制成，所述牺牲聚合物层又涂覆有柔性聚合物层。然后将细胞接种到柔性聚合物层上并培养形成组织。然后从基层释放柔性聚合物层以在柔性聚合物层上产生包含组织的独立式薄膜。在一个实施方案中，细胞是肌细胞，其可以被启动以推动或置换自立式膜。在另一个实施例中，自立式膜用于治疗受伤的人体组织。

8. 发明申请

WO2012088119A3 THREE DIMENSIONAL ASSEMBLY OF DIAMAGNETIC MATERIALS USING MAGNETIC LEVITATION 审中-公开
标题翻译：用磁悬浮法测量三维磁性材料的组装
公开(公告)号：WO2012088119A3
公开(公告)日：2012-10-26
申请号：PCT/US2011066169
申请日：2011-12-20
申请人： HARVARD COLLEGE , WHITESIDES GEORGE M , ILIEVSKI FILIP , ELLERBEE AUDREY , SHEVKOPLYAS SERGEY S , MIRICA KATHERINE A
发明人： WHITESIDES GEORGE M , ILIEVSKI FILIP , ELLERBEE AUDREY , SHEVKOPLYAS SERGEY S , MIRICA KATHERINE A
IPC分类号： B81C3/00 , B03C1/01 , B03C1/28
CPC分类号： B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
摘要： The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (aset of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
摘要翻译：描述了使用反磁性粒子悬浮在含有顺磁性阳离子的溶液中组装三维结构的能力。该分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）在固定结构之后，组装好的结构可以从顺磁性溶液中去除以进一步处理; iii）组装速度快; 和iv）它小巧便携。

9. 发明申请

WO2008051265A3 ENGINEERED CELL GROWTH ON POLYMERIC FILMS AND BIOTECHNOLOGICAL APPLICATIONS THERE OF 审中-公开
标题翻译：聚合物膜上的工程细胞生长和生物技术应用
公开(公告)号：WO2008051265A3
公开(公告)日：2008-08-28
申请号：PCT/US2007003051
申请日：2007-02-05
申请人： HARVARD COLLEGE , PARKER KEVIN KIT , FEINBERG ADAM W , WHITESIDES GEORGE M , SHEVKOPLYAS SERGEY S , FEIGEL ALEXANDER
发明人： PARKER KEVIN KIT , FEINBERG ADAM W , WHITESIDES GEORGE M , SHEVKOPLYAS SERGEY S , FEIGEL ALEXANDER
IPC分类号： C12N5/071 , C12N5/077
CPC分类号： G01N33/5061 , C12N5/0062 , C12N5/0657 , C12N2533/30 , C12N2533/52 , C12N2539/10 , G01N2500/10
摘要： A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
摘要翻译：独立的薄膜由包括涂覆有牺牲聚合物层的基层的结构制成，牺牲聚合物层又被柔性聚合物层涂覆。然后将细胞接种到柔性聚合物层上并进行培养以形成组织。然后将柔性聚合物层从基底层释放出来，以产生包含柔性聚合物层上的组织的自立薄膜。在一个实施方案中，细胞是肌细胞，其可以被致动以推动或置换自立膜。在另一个实施方案中，自立膜用于治疗受损的人体组织。

10. 发明申请

WO2008049083A3 LATERAL FLOW AND FLOW-THROUGH BIOASSAY BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME 审中-公开
标题翻译：基于图形多孔介质的横向流动和流动性生物多样性，其制造方法及其使用方法
公开(公告)号：WO2008049083A3
公开(公告)日：2009-03-12
申请号：PCT/US2007081848
申请日：2007-10-18
申请人： HARVARD COLLEGE , WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN
发明人： WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
摘要翻译：本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。

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