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1. 发明授权

US5902489A Particle handling method by acoustic radiation force and apparatus therefore 失效
标题翻译：因此，通过声辐射力和装置进行颗粒处理
公开(公告)号：US5902489A
公开(公告)日：1999-05-11
申请号：US745656
申请日：1996-11-08
申请人： Kenji Yasuda , Shin-ichiro Umemura , Kazuo Takeda , Mitsuru Tamura , Norio Shimizu
发明人： Kenji Yasuda , Shin-ichiro Umemura , Kazuo Takeda , Mitsuru Tamura , Norio Shimizu
IPC分类号： G01N1/36 , B01D21/00 , B01D43/00 , B01J19/10 , B01D17/06 , B01D35/06
CPC分类号： B01J19/10 , B01D21/283 , B01D21/34 , B01D43/00
摘要： A chamber for exerting an ultrasound beam on a sample solution containing particles to be concentrated, separated or arranged is provided with a view toward arbitrarily controlling the shape of a spatial distribution of potential energy created by the ultrasound beam and concentrating, separating or periodically arranging the particles. In contrast to the chamber, irradiation ultrasound sources for generating ultrasound beams are provided to create an ultrasonic intensity distribution for producing a position potential energy distribution used to exert a force forwarded in a predetermined direction or a force staying at a predetermined region to each particle. Thus, a specific spatial distribution of potential energy can be realized by ultrasound beams each having a specific intensity, a specific frequency and a specific phase or an ultrasound beam formed by superimposing these on one another. Further, at least one suction hole for recovering separated solvents or particles is defined in a wall surface of the tube, which is orthogonal to the flow of the sample solution.
摘要翻译：在包含要集中，分离或排列的颗粒的样品溶液上施加超声波束的腔室设置有任意控制由超声波束产生的势能空间分布的形状的集中，分离或周期性排列粒子。与腔室相反，提供用于产生超声波束的照射超声波源以产生用于产生用于施加沿预定方向传递的力的位置势能分布的超声波强度分布或者保持在每个粒子的预定区域的力。因此，可以通过每个具有特定强度，特定频率和特定相位的超声波束或通过将它们彼此叠加而形成的超声波束来实现势能的特定空间分布。此外，在管的壁表面中限定用于回收分离的溶剂或颗粒的至少一个吸孔，其与样品溶液的流动正交。

2. 发明授权

US06216538B1 Particle handling apparatus for handling particles in fluid by acoustic radiation pressure 失效
标题翻译：用于通过声辐射压力处理流体中的颗粒的颗粒处理装置
公开(公告)号：US06216538B1
公开(公告)日：2001-04-17
申请号：US08742695
申请日：1996-11-04
申请人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
发明人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
IPC分类号： G01H1700
CPC分类号： B01D21/283 , G10K15/00
摘要： An ultrasonic manipulation apparatus has a plurality of ultrasonic wave oscillators arranged in two dimensions to trap, fix or move particles to an optional position in the solution or perform cell fusion by using a gradient force obtained by superposing one over another the gradient force fields generated by ultrasonic waves produced by a plurality of ultrasonic wave oscillators. The ultrasonic wave oscillators, functioning independently of one another, can emit ultrasonic waves with optional intensities and phases, and by using an external force produced by superposed gradient force fields generated by ultrasonic waves, particles are handled easily.
摘要翻译：超声波操作装置具有多个超声波振荡器，其被设置成二维排列，以将颗粒捕获，固定或移动到溶液中的可选位置，或者通过使用通过将颗粒叠加在另一个上而产生的梯度力场而获得的梯度力进行细胞融合由多个超声波振荡器产生的超声波。彼此独立起作用的超声波振荡器可以发射具有可选强度和相位的超声波，并且通过使用由超声波产生的叠加梯度力场产生的外力，可以容易地处理颗粒。

3. 发明授权

US08951474B2 Disposable chip-type flow cell and flow cytometer using same 有权
标题翻译：一次性片式流动池和流式细胞仪使用它
公开(公告)号：US08951474B2
公开(公告)日：2015-02-10
申请号：US13148271
申请日：2010-02-05
申请人： Kazuo Takeda
发明人： Kazuo Takeda
IPC分类号： B01L3/00 , G01N21/64 , G01N21/00 , G01N15/14
CPC分类号： G01N15/1404 , G01N15/1427 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N21/6486 , G01N33/4833 , G01N33/5005 , G01N2015/1409 , G01N2015/149 , Y10T436/101666
摘要： The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.
摘要翻译：本发明提供了一种用于分析溶液中的颗粒的装置，包括：单元，被配置为放置具有用于流动含有颗粒的样品溶液的流动路径的流通池; 被配置为照亮流过所述流动池的流路的样品溶液的单元; 检测从样品溶液中的颗粒产生的散射光和/或荧光的光电检测器; 以及基于由所述光检测器检测出的信号强度来分析所述粒子的单元，其中所述流通池具有形成在基板中的流路，在所述流路的侧面形成有反射面，所述反射面将所述在流动池的流路中产生的光并且在基板的面内方向前进到流动池的表面的特定区域，并且光检测器将从指定区域射出的光检测到外部。

4. 发明授权

US08714290B2 Grille shutter device 有权
标题翻译：格栅快门装置
公开(公告)号：US08714290B2
公开(公告)日：2014-05-06
申请号：US13551791
申请日：2012-07-18
申请人： Masayuki Kitashiba , Chiharu Totani , Minoru Shibata , Kazuo Takeda
发明人： Masayuki Kitashiba , Chiharu Totani , Minoru Shibata , Kazuo Takeda
IPC分类号： B60K11/08
CPC分类号： B60K11/085 , Y02T10/88
摘要： A grille shutter device selectively opening and closing a grille opening in the front grille of a vehicle. The grille shutter device includes a fin, a motor, a transmission mechanism, a first switch, and a second switch. The fin has a support shaft, which is rotatably supported by the front grille. When supplied with electricity, the motor rotates its output shaft in one direction. The transmission mechanism converts the rotation of the output shaft to a swinging motion of the fin, thereby swinging the fin between a closed position, where the fin closes the grille opening, and an open position, where the fin opens the grille opening. When the fin is swung to the closed position, the first switch stops the motor. When the fin is swung to the open position, the second switch stops the motor.
摘要翻译：格栅快门装置选择性地打开和关闭车辆前格栅中的格栅开口。格栅快门装置包括翅片，马达，传动机构，第一开关和第二开关。翅片具有由前格栅可旋转地支撑的支撑轴。当电力供电时，电机将其输出轴沿一个方向旋转。传动机构将输出轴的旋转转换成翅片的摆动运动，从而使翅片在翅片关闭格栅开口的关闭位置和打开格栅开口的打开位置之间摆动。当翅片摆动到关闭位置时，第一个开关停止电机。当翅片摆动到打开位置时，第二个开关停止电机。

5. 发明申请

US20130302828A1 METHOD FOR DETECTING LOW CONCENTRATIONS OF SPECIFIC CELL FROM HIGH CONCENTRATIONS OF CELL POPULATIONS, AND METHOD FOR COLLECTING AND ANALYZING DETECTED CELL 有权
标题翻译：用于检测细胞群体高浓度特定细胞浓度低的方法，以及收集和分析检测细胞的方法
公开(公告)号：US20130302828A1
公开(公告)日：2013-11-14
申请号：US13885570
申请日：2011-11-21
申请人： Kazuo Takeda , Fumie Jimma , Masashi Takao
发明人： Kazuo Takeda , Fumie Jimma , Masashi Takao
IPC分类号： G01N1/30
CPC分类号： G01N33/57492 , G01N1/30 , G01N15/1436 , G01N15/1459 , G01N21/6428 , G01N33/54333 , G01N33/574 , G01N2015/1006 , G01N2015/1477 , G01N2021/6439 , G01N2201/06113 , G01N2333/705 , G01N2333/70596
摘要： Conventional CTC detection methods have been problematic in that 1) there is no technique for automatically determining and counting live CTCs in a brief period of time, 2) no process has been developed for detecting, counting, and thereafter collecting and culturing live CTCs, and 3) there exists no flow cytometer that is contamination free and is capable of measuring an entire sample. Provided is a CTC detection method which comprises a pre-treatment step for concentrating and fluorescence staining CTCs, and a step for identifying and counting CTCs. The pre-treatment step includes attaching magnetic beads to EpCAM antibodies expressed by epithelial cell-derived CTCs and concentrating the CTCs through the use of a magnet, fluorescently labeling an epithelia cell surface marker of the CTCs through the use of EpCAM antibodies or 5E11 antibodies, and performing two types of nuclear staining, one being cell membrane-permeable and the other being cell membrane-impermeable. The identifying and counting step includes evaluating the respective absolute concentrations of live and dead CTCs in a volume of blood by automatically identifying CTCs by the ratio of a plurality of fluorescence signal intensities using a flow cytometer, and differentiating between and counting the live CTCs and the dead CTCs. In the cytometer, an entire liquid-feeding system that includes a flow cell can be replaced for each sample, and the total amount of a liquid sample can be measured.
摘要翻译：传统的CTC检测方法存在问题，即1）在短时间内没有自动确定和计数活CTC的技术，2）没有开发检测，计数，之后收集和培养活的CTC的过程， 3）不存在无污染的流式细胞仪，能够测量整个样品。提供了一种CTC检测方法，其包括用于浓缩和荧光染色CTC的预处理步骤，以及用于鉴定和计数CTC的步骤。预处理步骤包括将磁珠附着到由上皮细胞衍生的CTC表达的EpCAM抗体中，并通过使用磁体浓缩CTC，通过使用EpCAM抗体或5E11抗体荧光标记CTC的上皮细胞表面标志物，并进行两种类型的核染色，一种是细胞膜可渗透的，另一种是细胞膜不可渗透的。识别和计数步骤包括通过使用流式细胞仪自动识别多个荧光信号强度的比例来自动识别CTC，并且区分和计数活CTC和死了四氯化碳。在血细胞计数器中，可以为每个样品更换包括流通池的整个液体供给系统，并且可以测量液体样品的总量。

6. 发明授权

US07232716B2 Display device and method for manufacturing the same 有权
标题翻译：显示装置及其制造方法
公开(公告)号：US07232716B2
公开(公告)日：2007-06-19
申请号：US10891522
申请日：2004-07-15
申请人： Hironaru Yamaguchi , Kiyoshi Ogata , Takuo Tamura , Jun Gotoh , Masakazu Saito , Kazuo Takeda
发明人： Hironaru Yamaguchi , Kiyoshi Ogata , Takuo Tamura , Jun Gotoh , Masakazu Saito , Kazuo Takeda
IPC分类号： H01L21/66 , H01L21/268
CPC分类号： H01L21/02686 , G02F1/13454 , H01L21/02595 , H01L21/2026 , H01L27/1285 , H01L29/04 , H01L29/66757 , H01L29/78675
摘要： The average film thickness of an amorphous silicon film formed on a substrate is measured. Then, the amorphous silicon film is irradiated with a laser beam to form a polysilicon film, and the grain size distribution of the polysilicon film is measured. An optimum value of energy density of laser beam irradiation is calculated on the basis of grain size values measured at two points A and B of the polysilicon film. Then, the average film thickness of an amorphous silicon film formed on a subsequent substrate is measured. A value of energy density of laser beam irradiation for the subsequent amorphous silicon film is calculated on the basis of the two average film thicknesses. Accordingly, a uniform polysilicon film of large grain sizes is formed on the whole surface of a large-size substrate to provide polysilicon TFTs in a large area.
摘要翻译：测量在基板上形成的非晶硅膜的平均膜厚。然后，用激光束照射非晶硅膜以形成多晶硅膜，并测量多晶硅膜的晶粒尺寸分布。基于在多晶硅膜的两点A和B测量的晶粒尺寸值来计算激光束照射的能量密度的最佳值。然后，测量形成在随后的基板上的非晶硅膜的平均膜厚。基于两个平均膜厚度计算随后的非晶硅膜的激光束照射的能量密度值。因此，在大尺寸基板的整个表面上形成均匀的大晶粒尺寸的多晶硅膜，以提供大面积的多晶硅TFT。

7. 发明授权

US07230389B2 Metal halide lamp having function for suppressing abnormal discharge 有权
标题翻译：具有抑制异常放电功能的金属卤化物灯
公开(公告)号：US07230389B2
公开(公告)日：2007-06-12
申请号：US10660929
申请日：2003-09-12
申请人： Kazuo Takeda , Isao Ota , Kazushige Sakamoto , Yoshiharu Nishiura
发明人： Kazuo Takeda , Isao Ota , Kazushige Sakamoto , Yoshiharu Nishiura
IPC分类号： H05B37/02 , H01J1/88
CPC分类号： H01J61/544 , H01J9/247 , H01J61/34 , H01J61/50 , H01J61/547 , H01J61/56 , H01J61/827
摘要： A metal halide lamp includes a ceramic arc tube that is composed of a main body and two narrow tube parts provided at respective ends of the main body; a pair of electrodes provided inside the main body; two feeders, each being connected at one end thereof to a different one of the electrodes inside the main body, and extending through a different one of the narrow tube parts, so as to be external to the arc tube at another end; a starting wire that is connected to one of the feeders, and that is in a vicinity of or contacts an outer surface of the arc tube; and a current suppressing unit that is on a current path of the starting wire, and suppresses or cuts off current on the path.
摘要翻译：金属卤化物灯包括：陶瓷电弧管，由主体和设在主体各端的两个细管部分组成; 设置在主体内的一对电极; 两个进料器各自在其一端连接到主体内的不同的一个电极，并且延伸通过不同的一个窄管部分，以便在另一端处于电弧管的外部; 起动线，其连接到所述馈电线中的一个，并且在所述电弧管的外表面附近或接触所述电弧管; 以及电流抑制单元，其在起始线的电流路径上，并且抑制或切断路径上的电流。

8. 发明授权

US07151046B2 Semiconductor thin film decomposing method, decomposed semiconductor thin film, decomposed semiconductor thin film evaluation method, thin film transistor made of decomposed semiconductor thin film, and image display device having circuit constituted of thin film transistors 失效
标题翻译：半导体薄膜分解方法，分解半导体薄膜，分解半导体薄膜评估方法，由分解的半导体薄膜制成的薄膜晶体管，以及具有由薄膜晶体管构成的电路的图像显示装置
公开(公告)号：US07151046B2
公开(公告)日：2006-12-19
申请号：US10900365
申请日：2004-07-28
申请人： Kazuo Takeda , Takeshi Sato , Masakazu Saito , Jun Gotoh
发明人： Kazuo Takeda , Takeshi Sato , Masakazu Saito , Jun Gotoh
IPC分类号： H01L21/20
CPC分类号： H01L21/02686 , B23K26/066 , B23K26/0738 , H01L21/02678 , H01L21/2026 , H01L27/1285 , H01L29/66757 , H01L29/78675
摘要： A surface roughness of a polycrystalline semiconductor film to be formed by a laser annealing method is reduced. A transmittance distribution filter is disposed at the optical system of a laser annealing apparatus. The transmittance distribution filter controls an irradiation light intensity distribution along a scanning direction of a substrate formed with an amorphous silicon semiconductor thin film to have a distribution having an energy part equal to or higher than a fine crystal threshold on a high energy light intensity side and an energy part for melting and combining only a surface layer. This transmittance distribution filter is applied to an excimer laser annealing method, a phase shift stripe method or an SLS method respectively using a general line beam to thereby reduce the height of protrusions on a polycrystalline surface.
摘要翻译：通过激光退火法形成的多晶半导体膜的表面粗糙度降低。透射率分布滤光器设置在激光退火装置的光学系统中。透射率分布滤光器控制沿着形成有非晶硅半导体薄膜的基板的扫描方向的照射光强度分布，以具有在高能量光强度侧具有等于或高于精细晶体阈值的能量分布的分布，以及用于熔化和组合仅表面层的能量部分。该透射率分布滤波器分别应用于准分子激光退火方法，相移条纹法或SLS法，使用通用线束，从而降低多晶表面上的突起的高度。

9. 发明申请

US20060118036A1 Semiconductor thin film and process for production thereof 有权
公开(公告)号：US20060118036A1
公开(公告)日：2006-06-08
申请号：US11342602
申请日：2006-01-31
申请人： Kazuo Takeda , Jun Gotou , Masakazu Saito , Makoto Ohkura , Takeshi Satou , Hiroshi Fukuda , Takeo Shiba
发明人： Kazuo Takeda , Jun Gotou , Masakazu Saito , Makoto Ohkura , Takeshi Satou , Hiroshi Fukuda , Takeo Shiba
IPC分类号： C30B23/00 , C30B25/00 , C30B28/12 , C30B28/14
CPC分类号： C30B29/06 , C30B13/00 , Y10S117/904
摘要： To improve the laser annealing process for polycrystallizing amorphous silicon to form silicon thin films having large crystal particle diameters at a high throughput, the present invention is directed to a process of crystallization by irradiation of a semiconductor thin film formed on a substrate with pulsed laser light. The process comprises having a means to shape laser light into a linear beam and a means to periodically and spatially modulate the intensity of pulsed laser in the direction of the long axis of the linear beam by passing through a phase-shifting stripy pattern perpendicular to the long axis, and collectively forming for each shot a polycrystalline film composed of crystals which have grown in a certain direction over the entire region irradiated with the linear beam.

10. 发明授权

US07022183B2 Semiconductor thin film and process for production thereof 有权
公开(公告)号：US07022183B2
公开(公告)日：2006-04-04
申请号：US10462792
申请日：2003-06-17
申请人： Kazuo Takeda , Jun Gotou , Masakazu Saito , Makoto Ohkura , Takeshi Satou , Hiroshi Fukuda , Takeo Shiba
发明人： Kazuo Takeda , Jun Gotou , Masakazu Saito , Makoto Ohkura , Takeshi Satou , Hiroshi Fukuda , Takeo Shiba
IPC分类号： C30B23/00
CPC分类号： C30B29/06 , C30B13/00 , Y10S117/904
摘要： To improve the laser annealing process for polycrystallizing amorphous silicon to form silicon thin films having large crystal particle diameters at a high throughput, the present invention is directed to a process of crystallization by irradiation of a semiconductor thin film formed on a substrate with pulsed laser light. The process comprises having a means to shape laser light into a linear beam and a means to periodically and spatially modulate the intensity of pulsed laser in the direction of the long axis of the linear beam by passing through a phase-shifting stripy pattern perpendicular to the long axis, and collectively forming for each shot a polycrystalline film composed of crystals which have grown in a certain direction over the entire region irradiated with the linear beam.

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