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1. 发明授权

US11609162B2 Facing and quality control in microtomy 有权
公开(公告)号：US11609162B2
公开(公告)日：2023-03-21
申请号：US17451516
申请日：2021-10-20
申请人： Clarapath, Inc.
发明人： Partha P. Mitra , Charles Cantor , Baris Yagci , David Kleinfeld , Cong Zhang
IPC分类号： G02B21/34 , B01L9/00 , G01N1/28 , G06T7/00 , G01N1/36 , G01B11/22 , G06T7/521 , G01N1/06 , G01N1/31 , G01N35/00 , G01N21/64
摘要： The present disclosure also relates to systems and methods for quality control in histology systems. In some embodiments, a method is provided that includes receiving a tissue block comprising a tissue sample embedded in an embedding material, imaging the tissue block to create a first imaging data of the tissue sample in a tissue section on the tissue block, removing the tissue section from the tissue block, the tissue section comprising a part of the tissue sample, imaging the tissue section to create a second imaging data of the tissue sample in the tissue section, and comparing the first imaging data to the second imaging data to confirm correspondence in the tissue sample in the first imaging data and the second imaging data based on one or more quality control parameters.

2. 发明申请

US20230046748A1 AUTOMATED TISSUE SECTION TRANSFER SYSTEM WITH HIGH THROUGHPUT 有权
公开(公告)号：US20230046748A1
公开(公告)日：2023-02-16
申请号：US17866725
申请日：2022-07-18
申请人： Clarapath, Inc.
发明人： Baris Yagci , Eric Feinstein , Partha P. Mitra , Janak Sewkarran , Cong Zhang , Robert Shusko
IPC分类号： G01N1/06 , B01L3/00 , G01N1/36
摘要： There is provided an automated system for preparing tissue samples that comprises one or more microtomes, a hydration system, and a processor, the processor being programmed to initiate facing, by one or more microtomes, of a first tissue block comprising a first tissue sample embedded in an embedding material, and cause the first tissue block to be hydrated by the hydration system for a first predetermined time, and initiate facing, by one or more microtomes, of a second tissue block while the first tissue block is being hydrated, the second tissue block comprising a second tissue sample embedded in an embedding material, and cause the second tissue block to be hydrated by the hydration system for a second predetermined time, and to initiate the one or more microtomes to begin sectioning of the first tissue block while the second tissue block is being hydrated.

3. 发明申请

US20230040801A1 SECTIONABLE CASSETTE AND EMBEDDING FRAME WITH CONNECTORS, AND METHODS FOR PREPARING BIOPSY TISSUE SAMPLES 有权
公开(公告)号：US20230040801A1
公开(公告)日：2023-02-09
申请号：US17970007
申请日：2022-10-20
申请人： BioPath Automation, L.L.C.
发明人： Warren P. Williamson, IV
IPC分类号： B01L9/00 , G01N33/483 , G01N1/36 , G01N1/06
摘要： A histologic tissue sample support device includes a tissue cassette, a frame, and a lid. The tissue cassette has a recess including at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The lid is coupled to the frame and includes a platen configured to be received within the recess of the tissue cassette. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

4. 发明申请

US20230035804A1 SECTIONABLE CASSETTE AND EMBEDDING FRAME WITH CONNECTORS, AND METHODS FOR PREPARING BIOPSY TISSUE SAMPLES 有权
公开(公告)号：US20230035804A1
公开(公告)日：2023-02-02
申请号：US17967485
申请日：2022-10-17
申请人： BioPath Automation, L.L.C.
发明人： Warren P. Williamson, IV
IPC分类号： B01L9/00 , G01N1/36 , G01N1/06 , G01N33/483
摘要： A histologic tissue sample support device includes a tissue cassette, a frame, a lid, and a frame-cassette connector. The tissue cassette formed of a first material has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid is coupled to the frame. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

5. 发明申请

US20220404359A1 DEVICE FOR EVALUATING NEUROVIRULENCE OF MUMPS VIRUS 有权
公开(公告)号：US20220404359A1
公开(公告)日：2022-12-22
申请号：US17755664
申请日：2020-11-03
申请人： SHANGHAI KING-CELL BIOTECHNOLOGY CO. LTD. , BEIJING CELL-FUSION BIOTECHNOLOGY CO., LTD.
发明人： Dayong TIAN , Juncheng RUAN , Zhenfang FU , Yajing ZHANG , Yulin GU , Qi AN
IPC分类号： G01N33/569 , G01N1/28 , G01N1/36 , G01N1/30
摘要： A device for evaluating the neurovirulence of a mumps virus, comprising: (I) a virus inoculation module, which is used for performing virus inoculation of a mumps virus to be evaluated on the lateral ventricle of a rat; (II) a processing module, which is used for performing vibration slicing on the fixed rat brain; (III) an imaging module, which is used for scanning and imaging the obtained rat brain slices; and (IV) an analysis module, which is used in the obtained imaging for calculating a neurovirulence index by using a formula I: the neurovirulence index=S1/S0×100 (formula I) according to the cross-sectional area S1 of a cavity formed by hydrocephalus in the longitudinal section of the rat brain and the total cross-sectional area S0 of the rat brain. Multiple results show that the results are stable, repeatability is high, and a wild strain may be distinguished from a vaccine strain. In addition, relative to a current monkey body neurovirulence model, animal cost and difficulty of operation are greatly reduced.

6. 发明申请

US20220404241A1 Integrated System for Preparation of Pathology Samples 有权
公开(公告)号：US20220404241A1
公开(公告)日：2022-12-22
申请号：US17845763
申请日：2022-06-21
申请人： Clarapath, Inc.
发明人： Baris Yagci , Partha P. Mitra , Charles Cantor , Eric Feinstein
IPC分类号： G01N1/28 , G01N1/36 , G01N1/31 , G01N1/06 , B01L9/00
摘要： An integrated pathology system includes a tissue embedding module configured to embed a tissue sample into an embedding material to prepare a tissue block, a sectioning and slide creating module configured to remove one or more tissue sections from the tissue block and place the one or more tissue sections onto one or more slides, a staining module configured to stain the one or more tissue sections on the slides, and a cover-slipper module configured to place a cover onto the one or more stained tissue sections. The system further includes one or more transfer devices configured to integrate the modules and a processor in communication with the modules for controlling one or more processes performed by the modules and the one or more transfer devices for controlling the integration of the modules.

7. 发明申请

US20220373438A1 TISSUE PIECE TREATING APPARATUS 有权
公开(公告)号：US20220373438A1
公开(公告)日：2022-11-24
申请号：US17771795
申请日：2020-10-13
申请人： SAKURA SEIKI CO., LTD. , SAKURA FINETEK JAPAN CO., LTD.
发明人： TADASHI TOFUKUJI , MOE OKABE
IPC分类号： G01N1/31 , G01N1/36 , G01N1/44
摘要： The present invention addresses the problem of a tissue piece treating apparatus in which drying in an inside of a treating tank is promoted, compared with conventional tissue piece treating apparatuses, and the gas in the inside of the treating tank is discharged so that a risk of inflammation can be prevented. As a solution, a tissue piece treating apparatus (10) according to the present invention includes: a treating tank (18) in which a tissue piece is housed, and immersion of the tissue piece is performed by a chemical solution being supplied thereto; a communication passage (34) that is connected to the treating tank (18); one or a plurality of chemical solution bottles (24) that are connected to the treating tank (18) through the communication passage (34), and store chemical solutions to be supplied to the treating tank (18); and a pump (60) that causes an inside of the treating tank (18)to be a negative pressure to supply the chemical solution from the chemical solution bottle (24) to the inside of the treating tank (18), and causes the inside of the treating tank (18) to be a positive pressure to discharge the chemical solution from the inside of the treating tank (18) to the chemical solution bottle (24), in which the communication passage (34), which partially branches, includes an outside air port (42) that communicates with an outside air, and is thus configured to be able to supply and discharge the outside air to and from the inside of the treating tank (18) by receiving an action of the pump (60).

8. 发明授权

US11486801B2 Mounting press and closing device for a mounting press 有权
公开(公告)号：US11486801B2
公开(公告)日：2022-11-01
申请号：US16610740
申请日：2018-03-12
申请人： ATM GmbH
发明人： Jochen Bongartz
IPC分类号： G01N1/28 , B29C43/02 , B29C43/56 , B30B15/04 , G01N1/36 , G01N1/44
摘要： The present disclosure relates to a mounting press for hot mounting a sample, comprising: a mounting cylinder for receiving the sample, having a main cylinder axis and a cylinder opening, the main cylinder axis extending inside the mounting cylinder and out through the cylinder opening, a sliding closure with a sliding carriage, an upper piston and a closing lever that is operatively connected to the upper piston, wherein the sliding carriage is configured so as to be displaceable in a direction transverse to the main cylinder axis, for example by means of the closing lever, and wherein in a position of use of the sliding carriage the upper piston can be driven to or into the cylinder opening of the mounting cylinder, wherein the closing lever has at least one open position and one closed position and can be transferred from the open position into the closed position, and wherein the closing lever cooperates with the upper piston such that the upper piston closes the cylinder opening when guiding the closing lever from the open position into the closed position when the sliding carriage is in the position of use.

9. 发明申请

US20220307950A1 Hard Tissue Slice Anti-Falling Pretreatment Device And Anti-Falling Pretreatment Method 有权
公开(公告)号：US20220307950A1
公开(公告)日：2022-09-29
申请号：US17558144
申请日：2021-12-21
申请人： Shanghai Sixth People's Hospital
发明人： Junhui YIN , Changqing ZHANG
IPC分类号： G01N1/31 , G01N1/36 , G01N1/04
摘要： The invention discloses a hard tissue slice anti-falling pretreatment device which comprises a box and a slice frame, a buffer plate is arranged in the box, and a plurality of small holes are evenly formed in the buffer plate; the bottom of the box is communicated with a liquid discharge pipe through a liquid outlet, and the liquid discharge pipe is provided with a valve; the slice frame is arranged on the buffer plate and comprises two longitudinal support frames and a plurality of layers of transverse support frames fixed between the two longitudinal support frames; each layer of transverse support frame comprises a plurality of first support rods, the gradient of each first support rod relative to the horizontal plane is 0-15 degrees.

10. 发明授权

US11422121B2 Device, method and kit for dissolution testing 有权
公开(公告)号：US11422121B2
公开(公告)日：2022-08-23
申请号：US16330004
申请日：2017-09-05
申请人： NANOFORM FINLAND OY
发明人： Jenni Pessi , Sami Svanbäck , Ilkka Lassila , Jouko Yliruusi
IPC分类号： G01N33/15 , G01N13/00 , G01N1/36 , G01N35/00 , G01N1/28
摘要： Disclosed are devices and methods for dissolving sample substances such as drug molecules. Also disclosed is use of the method for device for testing dissolution rates of the sample substances. It utilizes lyophilic matrices that create conditions for discriminating the dissolved sample substance from undissolved sample substances. This is aimed at preventing dispersion of the undissolved sample substance to avoid any substantial membrane effects.

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