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1. 发明申请

US20230139821A1 FLOW CELLS AND METHODS FOR MAKING THE SAME 有权
公开(公告)号：US20230139821A1
公开(公告)日：2023-05-04
申请号：US17739964
申请日：2022-05-09
申请人： ILLUMINA, INC.
发明人： Jeffrey S. Fisher , Anthony Flannery , Sahngki Hong , Brinda Kodira Cariappa , Lewis J. Kraft
IPC分类号： B01L3/00 , G03F7/039 , G03F7/038 , G03F7/00
摘要： In an example method, a first functionalized layer is deposited over a resin layer including multi-depth depressions separated by interstitial regions, each depression including a deep portion and a shallow portion adjacent to the deep portion; a photoresist is deposited over the first functionalized layer; an ultraviolet light dosage is directed, through the resin layer, whereby a first photoresist portion generates an insoluble photoresist and a second photoresist portion becomes a soluble photoresist; the soluble photoresist is removed to expose a portion of the first functionalized layer; the portion of the first functionalized layer is removed to expose a portion of the resin layer; a second functionalized layer is deposited over the insoluble photoresist, and over the exposed portion of the resin layer; the insoluble photoresist is removed to expose the first functionalized layer; and the first functionalized layer or the second functionalized layer is removed from the interstitial regions.

2. 发明申请

US20230139694A1 PREPARING SUBSTANCES IN A MEDICAL DIAGNOSTIC SYSTEM 有权
公开(公告)号：US20230139694A1
公开(公告)日：2023-05-04
申请号：US17519351
申请日：2021-11-04
申请人： Instrumentation Laboratory Company
发明人： Demetrio Sanchez-Martinez , Joshua Shreve
IPC分类号： B01L3/00 , G01N1/28
摘要： Operations performed according to the example techniques described herein include controlling a probe to pierce a stopper of a container containing a substance, where the stopper provides an air-tight seal for the container, and where the air-tight seal supports an internal pressure in the container. The operations also include detecting the internal pressure based on information from a pressure sensor; determining that the internal pressure is not at a target pressure and, based on determining that the internal pressure is not at the target pressure, controlling the probe either to aspirate air from the container or to dispense air into the container in order to move the internal pressure toward the target pressure.

3. 发明申请

US20230133224A1 A SWAB AND CASE THEREOF, AND METHODS OF USING THE SAME 有权
公开(公告)号：US20230133224A1
公开(公告)日：2023-05-04
申请号：US17918843
申请日：2021-04-14
申请人： Daniel SHAHAF , Eyal BRESSLER
发明人： Daniel SHAHAF , Eyal BRESSLER
IPC分类号： G01N1/10 , B01L3/00
摘要： The present invention discloses, inter alia, swab, kit and a case, disclose a swab as defined above, administrable either or both into and onto a sample in a method comprising steps of providing the pouch-like envelope (1) with the opening (2), the inner surface (1i) and the at least one external surface (1e) with the at last one swabbing portion; inserting a handle into the swabbing portion; applying the swabbing portion either or both onto and into the substance; in-out rolling up the envelope so that the external portion hereto applied either or both onto and into the substance is position within the envelope; wherein at least one of the following s held true: the envelope characterized as a sleeve-like or sock-like elongated member having a main longitudinal axis, configured to be in-out rolled-up along the main longitudinal axis; and the envelope characterized as flexible pouch-like envelope, further characterized by being width-wise squeezable along an axis perpendicular to the main longitudinal axis thereby tightly encapsulated within at least two external case's walls. The present invention discloses a method for both sampling a substance and storing the same, characterized by steps: providing a pouch-like envelope (1), configured to be in-out rolled-up having an opening (2); the pouch comprises an inner surface (1i); and at least one external surface (1e) with at last one swabbing portion (3); the envelope either or both (a) characterized as a sleeve-like or sock-like elongated member having a main longitudinal axis, configured to be in-out rolled-up along the main longitudinal axis; and (b) flexible pouch-like envelope, characterized by being width-wise squeezable along an axis perpendicular to the main longitudinal axis thereby tightly encapsulated within two case's walls; inserting a handle into the swabbing portion; applying the swabbing portion either or both onto and into the substance; in-out rolling up the envelope so that the external portion hereto applied either or both onto and into the substance is position within the envelope; wherein at least one of the following is held true: the envelope characterized as a sleeve-like or sock-like elongated member having a main longitudinal axis, configured to be in-out rolled-up along the main longitudinal axis; and the envelope characterized as flexible pouch-like envelope, further characterized by being width-wise squeezable along an axis perpendicular to the main longitudinal axis thereby tightly encapsulated within at least two external case's walls.

4. 发明授权

US11639888B2 Microfluidic system and method with focused energy apparatus 有权
公开(公告)号：US11639888B2
公开(公告)日：2023-05-02
申请号：US17851319
申请日：2022-06-28
申请人： ABS Global, Inc.
发明人： David Appleyard , Jeff Betthauser , Marjorie Faust , John Larsen , Guocheng Shao , Zheng Xia , Yu Zhou
IPC分类号： G01N15/14 , G01N33/483 , G01N21/01 , B01L3/00 , C12N13/00 , G01N1/44 , G01N21/64 , G01N15/10
摘要： A method of inseminating an animal including flowing a stream of a population of sperm cells through a channel, differentiating the sperm cells into two subpopulations of X-chromosome containing sperm cells and Y-chromosome containing sperm cells, selecting a desired subpopulation, ablating an undesired subpopulation, and collecting both the subpopulations of sperm cells including the desired subpopulation and the ablated undesired subpopulation together, wherein the collected population of sperm cells is used to fertilize an egg.

5. 发明申请

US20230130689A1 IN VITRO DIAGNOSTIC SAMPLE TUBES AND METHODS OF USE THEREOF 有权
公开(公告)号：US20230130689A1
公开(公告)日：2023-04-27
申请号：US17655044
申请日：2022-03-16
申请人： Frank Allen Cable, JR. , Orion Franceso CABLE , Sotirios GERAGONIS
发明人： Frank Allen Cable, JR. , Orion Franceso CABLE , Sotirios GERAGONIS
IPC分类号： B01L3/00 , A61B10/00
摘要： A diagnostic sample tube, comprising a tube body having a tube cavity to receive a test sample; and a tube body lid; the tube body and the tube body lid are formed as a single piece; a mechanical fastening mechanism formed with the single piece, the mechanical fastening mechanism comprising an engagement protrusion and an engagement protrusion receiver; wherein, when the mechanical fastening mechanism is fastened, the mechanical fastening mechanism holds the tube body and the tube body lid in a closed position relative to one another with the cavity closed; and wherein, when the mechanical fastening mechanism is fastened, the engagement protrusion receiver surrounds a longitudinal length of the engagement protrusion.

6. 发明申请

US20230127798A1 Multi-Well Plates for Creation of High-Density Arrays of Compartmentalized Cell Cultures for Usage in High Capacity Applications 有权
公开(公告)号：US20230127798A1
公开(公告)日：2023-04-27
申请号：US17907712
申请日：2021-04-08
申请人： CELLECTRICON AB
发明人： Johan PIHL , Mathias KARLSSON , Paul KARILA
IPC分类号： B01L3/00 , C12M1/32 , C12M1/00 , G01N33/543
摘要： The disclosure relates to multi-well plates having fluidic connections between neighboring wells that are useful to produce a cell culture substrate and compliant with American National Standards Institute of the Society for Laboratory Automation and Screening (ANSI/SLAS) microplate standards

7. 发明授权

US11635356B2 Slide staining assembly and cover member 有权
公开(公告)号：US11635356B2
公开(公告)日：2023-04-25
申请号：US16910368
申请日：2020-06-24
申请人： LEICA BIOSYSTEMS MELBOURNE PTY LTD
发明人： Kenneth Heng-Chong Ng , Mark Brian Dockrill , Peter Toogood , Martin Limon , Daniel Dobrogorsky , Mark Wilcock , Greg Boyes , Brendyn Rodgers , Stephen John Bagnato , Ashan Chiranga Perera
IPC分类号： G01N1/00 , G01N1/31 , B01L3/00
摘要： A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.

8. 发明授权

US11634746B2 Portable genetic detection and analysis system and method 有权
公开(公告)号：US11634746B2
公开(公告)日：2023-04-25
申请号：US16540769
申请日：2019-08-14
申请人： Illumina, Inc.
发明人： Robert C. Kain , Min-Jui Richard Shen , John A. Moon , Helmy A. Eltoukhy
IPC分类号： C12Q1/68 , C12Q1/6837 , C12Q1/6869 , G01N33/487 , B01L3/00 , G01N35/00
摘要： A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed.

9. 发明授权

US11633740B2 Reagent vessel for storing a liquid reagent 有权
公开(公告)号：US11633740B2
公开(公告)日：2023-04-25
申请号：US15950620
申请日：2018-04-11
申请人： Roche Diagnostics Operations, Inc.
发明人： Reinhold Kraemer , Stephan Sattler
IPC分类号： B01L3/00 , B29C45/33 , B29C45/44 , B29C45/26 , G01N35/04 , B29K23/00 , B29L31/00
摘要： A reagent vessel, an apparatus and a method for manufacturing a lower part of a reagent vessel for an analytical instrument are disclosed. The reagent vessel is configured to store a liquid reagent. The reagent vessel comprises a cover and a lower part. The lower part comprises a bottom wall, a front wall, a rear wall, two opposing side walls and at least one connection wall. The cover, bottom wall, front wall, rear wall and two opposing side walls define at least one internal volume for storing at least one liquid reagent. The two opposing side walls are at least partially connected to one another by the at least one connection wall located within the at least one internal volume. The connection wall is spaced apart from the bottom wall. The connection wall and at least the two opposing side walls can be injection-molded and are monolithically formed.

10. 发明授权

US11633738B2 Devices and methods for sample analysis 有权
公开(公告)号：US11633738B2
公开(公告)日：2023-04-25
申请号：US15724203
申请日：2017-10-03
申请人： ABBOTT LABORATORIES
发明人： Jeffrey B. Huff , Mark A. Hayden , Peter J. Karabatsos , Andrew Fischer , John M. Robinson , Shelley R. Holets-McCormack , Sophie Laurenson
IPC分类号： B01L3/00 , G01N33/543 , G01N33/53
摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.

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