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1. 发明授权

US06216538B1 Particle handling apparatus for handling particles in fluid by acoustic radiation pressure 失效
标题翻译：用于通过声辐射压力处理流体中的颗粒的颗粒处理装置
公开(公告)号：US06216538B1
公开(公告)日：2001-04-17
申请号：US08742695
申请日：1996-11-04
申请人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
发明人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
IPC分类号： G01H1700
CPC分类号： B01D21/283 , G10K15/00
摘要： An ultrasonic manipulation apparatus has a plurality of ultrasonic wave oscillators arranged in two dimensions to trap, fix or move particles to an optional position in the solution or perform cell fusion by using a gradient force obtained by superposing one over another the gradient force fields generated by ultrasonic waves produced by a plurality of ultrasonic wave oscillators. The ultrasonic wave oscillators, functioning independently of one another, can emit ultrasonic waves with optional intensities and phases, and by using an external force produced by superposed gradient force fields generated by ultrasonic waves, particles are handled easily.
摘要翻译：超声波操作装置具有多个超声波振荡器，其被设置成二维排列，以将颗粒捕获，固定或移动到溶液中的可选位置，或者通过使用通过将颗粒叠加在另一个上而产生的梯度力场而获得的梯度力进行细胞融合由多个超声波振荡器产生的超声波。彼此独立起作用的超声波振荡器可以发射具有可选强度和相位的超声波，并且通过使用由超声波产生的叠加梯度力场产生的外力，可以容易地处理颗粒。

2. 发明授权

US5523058A Ultrasonic irradiation apparatus and processing apparatus based thereon 失效
标题翻译：超声波照射装置及其处理装置
公开(公告)号：US5523058A
公开(公告)日：1996-06-04
申请号：US240733
申请日：1994-05-12
申请人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
发明人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
IPC分类号： A61B17/22 , A61N7/00 , A61N7/02 , B01F11/02 , A61B8/00 , B06B1/00
CPC分类号： A61N7/02 , A61B17/22004 , A61N2007/006 , A61N2007/0078 , A61N2007/0095
摘要： By providing an ultrasonic irradiation apparatus for generating acoustic cavitation efficiently, it is intended to realize an ultrasonic therapeutic apparatus for generating the action of cavitation on a living body suitable for medical treatment of malignant tumors and medical treatment of thrombi and calculi, an ultrasonic diagnostic apparatus for generating cavitation for emphasizing an ultrasonic echo image such as a blood flow and utilizing the reflection capability of the cavitation, an ultrasonic chemical reaction accelerating apparatus, an ultrasonic cleaning apparatus or an ultrasonic sterilizing apparatus. Irradiation focus/code signals for defining irradiated acoustic fields of a fundamental wave and a second harmonic wave as well as focus positions/acoustic pressure distribution forms of the respective waves are applied from an irradiation unit main control circuit to drive phase generating circuits. Generated drive phases are applied to drive signal generating circuits, generated drive signals are applied to element drive circuits and a group of fundamental frequency elements and a group of second harmonic elements are driven. The drive phases are controlled such that the fundamental wave and second harmonic wave are superimposed on each other in a medium near a focal point, thus generating acoustic caviation locally and efficiently.
摘要翻译： PCT No.PCT / JP93 / 01310 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年9月14日PCT公布。公开号WO94 / 06380 日期为1994年3月31日。通过提供用于有效产生声孔的超声波照射装置，旨在实现用于产生适于恶性肿瘤治疗的生物体上的空化作用的超声波治疗装置和血栓的治疗和结石，用于产生用于强调超声波回波图像如血流并利用空化反射能力的超声波诊断装置，超声波化学反应加速装置，超声波清洗装置或超声波消毒装置。用于定义基波和二次谐波的辐射声场以及各波的聚焦位置/声压分布形式的照射焦点/码信号从照射单元主控制电路施加到驱动相位产生电路。产生的驱动相位被施加到驱动信号发生电路，所产生的驱动信号被施加到元件驱动电路，并且一组基频元件和一组二次谐波元件被驱动。控制驱动相位使得基波和二次谐波在焦点附近的介质中彼此叠加，从而局部且有效地产生声空化。

3. 发明授权

US09834806B2 Microbe-collecting carrier cartridge, carrier treating apparatus, and method of measuring microbes 有权
公开(公告)号：US09834806B2
公开(公告)日：2017-12-05
申请号：US13001465
申请日：2009-06-25
申请人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
发明人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/06 , C12Q1/00 , B01L3/00 , G01N1/22
CPC分类号： C12Q1/008 , B01L3/502 , B01L2300/0681 , B01L2300/069 , B01L2300/1805 , B01L2400/0487 , G01N1/2208 , G01N1/2273
摘要： A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped. The contact with the warm water causes the carrier to be solated filtered through the filter.

4. 发明授权

US08040515B2 Fluorescence detection apparatus and method, and prism used therein 有权
标题翻译：荧光检测装置和方法以及其中使用的棱镜
公开(公告)号：US08040515B2
公开(公告)日：2011-10-18
申请号：US12051245
申请日：2008-03-19
申请人： Tsuyoshi Sonehara , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
发明人： Tsuyoshi Sonehara , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
IPC分类号： G01N21/25
CPC分类号： G01N21/6452 , G02B2207/113
摘要： In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.
摘要翻译：为了提供具有高灵敏度，高处理能力和成本方面的竞争优势的荧光检测装置，根据本发明的荧光检测装置用光照射样品，使得照射区域的形式的纵横比由样品排列表面上的光可能为1±0.1。照射区域的优选形式不限于一个，并且根据要优化的项目而在一定程度上变化。照射区域的形式可以是例如圆形，等边三角形，正方形，正六边形等。

5. 发明授权

US07932486B2 Mass spectrometer system 有权
标题翻译：质谱仪系统
公开(公告)号：US07932486B2
公开(公告)日：2011-04-26
申请号：US12330374
申请日：2008-12-08
申请人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
发明人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
IPC分类号： H01J49/26
CPC分类号： G01N33/6851 , G01N33/6848 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
摘要翻译：在通过串联质谱法对蛋白质或肽进行结构分析期间，作为串联质谱目标，可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。迄今为止难以分析的，从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。关于已经测量的蛋白质和来自蛋白质的肽的数据被自动存储在内部数据库中。存储的数据与测量数据高精度对照以确定同位素峰。以这种方式，可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程，并且可以避免衍生自相同蛋白质的肽的冗余测量。包含在MSn谱中的信息在涉及多级解离和质谱（MSn）的MSn的每个步骤中被有效地利用，使得用于确定下一个分析内容的流程和为母体离子的选择例如，MSn + 1分析可以在实时测量和高效率和精确度下进行优化。因此，用户关注的目标可以进行串联质谱，无需浪费测量。

6. 发明授权

US07798981B2 Living body inspection apparatus 有权
标题翻译：生活检查仪器
公开(公告)号：US07798981B2
公开(公告)日：2010-09-21
申请号：US12267056
申请日：2008-11-07
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Kenko Uchida , Hideo Kawaguchi , Minoru Sakairi
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Kenko Uchida , Hideo Kawaguchi , Minoru Sakairi
IPC分类号： A61B5/103 , A61B5/05
CPC分类号： A61B5/1101 , A61B5/4082 , A61B5/6824 , A61B5/6826 , A61B5/6828 , A61B5/6838 , A61B5/7239
摘要： A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.
摘要翻译：一种生物体检查装置，包括通过交流电流的振荡线圈，检测由检测线圈产生的交流磁场的检测线圈，放大电路，放大电路，放大由检测线圈感应出的磁场产生的电压，用于检测放大电路的输出信号的单元，输入检测单元的输出信号的低通滤波器，用于在生物体的第一和第二区域设置振荡线圈和检测线圈的单元，记录单元用于在活体的第一区域和第二区域移动时记录低通滤波器的输出，以及用于显示记录在记录单元中的数据的显示单元或记录数据的分析结果。

7. 发明授权

US07231241B2 Probe for optical measurement instrument for living body and optical measurement instrument for living body using the same 失效
标题翻译：探头用于生物体光学测量仪器和使用其的活体光学测量仪器
公开(公告)号：US07231241B2
公开(公告)日：2007-06-12
申请号：US11070816
申请日：2005-03-03
申请人： Yukiko Hirabayashi , Kenko Uchida
发明人： Yukiko Hirabayashi , Kenko Uchida
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0042 , A61B5/0261 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： Disclosed is a probe for biomeasurement by use of light capable of adjusting positions of incident points and detection points without changing the distance between the incident point and the detection point in accordance with the size of a subject's head, and an optical bioinstrumentation for living body using the probe. The distances between the incident points and the detection points are approximately the same. A gap is formed by removing part of connecting members, rotatable about the incident point and the detection point, around the subject head top portion. The size of the probe is changed by changing the distance between the incident points or the detection points around the gap.
摘要翻译：公开了一种用于通过使用能够调整入射点和检测点的位置的光而不改变入射点与检测点之间的距离的光的探针，该探针根据受检者的头部的尺寸和使用的生物体的光学生物仪器探针。入射点和检测点之间的距离大致相同。通过将围绕入射点和检测点旋转的连接构件的一部分围绕被检体顶部部分去除而形成间隙。通过改变入射点或间隙周围的检测点之间的距离来改变探头的尺寸。

8. 发明授权

US08680483B2 Fluorescence detector 失效
标题翻译：荧光检测器
公开(公告)号：US08680483B2
公开(公告)日：2014-03-25
申请号：US13141127
申请日：2009-12-22
申请人： Takanobu Haga , Tsuyoshi Sonehara , Kenko Uchida , Tomoyuki Sakai , Satoshi Takahashi
发明人： Takanobu Haga , Tsuyoshi Sonehara , Kenko Uchida , Tomoyuki Sakai , Satoshi Takahashi
IPC分类号： G01J1/58
CPC分类号： G01N21/6452 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478
摘要： A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.
摘要翻译：一种荧光检测器，其中样品基板设置有包括棱镜或衍射光栅的结构单元。落在样品基板上的激发光在位于结构单元的相对侧的生物分子固定面全面反射，结构单元允许从其发射反射光。为了确保多个视野测量，提供了样品基板驱动单元以扫描样品基板。

9. 发明申请

US20140065704A1 CELL COLLECTION SYSTEM 审中-公开
标题翻译：细胞收集系统
公开(公告)号：US20140065704A1
公开(公告)日：2014-03-06
申请号：US14111036
申请日：2012-04-10
申请人： Masataka Shirai , Hiroyuki Tsunoda , Hiroko Matsunaga , Kenko Uchida
发明人： Masataka Shirai , Hiroyuki Tsunoda , Hiroko Matsunaga , Kenko Uchida
IPC分类号： C12M1/26
CPC分类号： C12M33/04 , C12M47/04
摘要： The present invention provides a simple and highly reliable cell collection system with high throughput and improved in cell collection efficiency. In the present invention, one or more pores are formed in a cell collection plate. One surface of the plate can be directly introduced in e.g., a petri dish, so as to be in contact with a solution containing cells. In this case, means for obtaining an optical image of collected cells from its rear surface is provided to improve reliability and convenience during a cell collection process. Alternatively, the vicinities of the pores in the cell collection plate are only hydrophilized and the other region is made water repellent to improve the efficiency of cell collection.
摘要翻译：本发明提供了一种具有高通量并提高了细胞收集效率的简单且高度可靠的细胞收集系统。在本发明中，在细胞收集板中形成一个以上的孔。板的一个表面可以直接引入例如陪替氏培养皿中，以便与含有细胞的溶液接触。在这种情况下，提供用于从其后表面获得收集的细胞的光学图像的装置，以提高细胞收集过程中的可靠性和便利性。或者，细胞收集板中的孔附近仅被亲水化，另一区域被制成防水剂，以提高细胞收集的效率。

10. 发明授权

US08293191B2 Method for transferring droplet 有权
标题翻译：液滴转移方法
公开(公告)号：US08293191B2
公开(公告)日：2012-10-23
申请号：US11675749
申请日：2007-02-16
申请人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
发明人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
IPC分类号： B01L3/00 , G01N21/03
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译：本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。为了合并两个液滴，它们被接触。为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。设置通过液滴的光路以进行光学测量。本发明可实现廉价的简单的液滴转印。根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。

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