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1. 发明申请

US20190234876A1 FLUORESCENCE IMMUNOASSAY DEVICE BASED ON INTEGRATION OF PHOTONIC CRYSTAL AND MAGNETIC BEADS AND METHOD THEREOF 审中-公开
公开(公告)号：US20190234876A1
公开(公告)日：2019-08-01
申请号：US15955002
申请日：2018-04-17
申请人： NATIONAL CHIAO TUNG UNIVERSITY
发明人： CHENG-SHENG HUANG , WEN-SYANG HSU , LIN-YUN SU , YING-BIN WANG , YANG CHEN
IPC分类号： G01N21/64 , G01N33/543
CPC分类号： G01N21/6428 , G01N21/648 , G01N33/54326 , G01N33/54373 , G01N2021/6439
摘要： A fluorescence immunoassay device based on integration of a photonic crystal and magnetic beads and a method thereof are provided. Magnetic beads with high surface-to-volume ratio are used as carriers of fluorescent molecules to obtain higher fluorescence density. The electric field on the surface of the photonic crystal is enhanced through excitation of photonic crystal resonance. The intensity of the fluorescence signal excited by the enhanced electric field is increased. Moreover, through interaction with the photonic crystal, some fluorescent signals that originally cannot be received by the fluorescent sensor are coupled to the photonic crystal resonant modes and reradiate toward the fluorescent sensor, thereby increasing collection efficiency. The fluorescence signals generated by fluorescent molecules on the magnetic beads are significantly intensified, which could lower the detection limit. Furthermore, the magnetic beads aggregation method can achieve the detection capability that cannot be achieved by the current fluorescent immunoassay.

2. 发明申请

US20190212271A1 SHAPED-EXCITATION FLUORESCENCE (SEF) MICROSCOPY 审中-公开
公开(公告)号：US20190212271A1
公开(公告)日：2019-07-11
申请号：US16245241
申请日：2019-01-10
申请人： Mikhail Zamkov
发明人： Mikhail Zamkov
IPC分类号： G01N21/64 , G02B21/16
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6447 , G01N2021/6439 , G01N2021/6471 , G02B21/16
摘要： A method and apparatus for detecting more than one fluorophore in a sample. A broad spectrum excitation light is passed through a shaping filter before illuminating the target sample with more than one fluorophore to be detected, where the optical density of the shaping filter changes based on the wavelength of the broad-spectrum excitation light passing through it.

3. 发明申请

US20190204227A1 LIGHT ENERGY FLUORESCENCE EXCITATION 审中-公开
公开(公告)号：US20190204227A1
公开(公告)日：2019-07-04
申请号：US16206574
申请日：2018-11-30
申请人： Illumina, Inc.
发明人： Rui JIANG , Joseph PINTO
IPC分类号： G01N21/64 , C12Q1/6869
CPC分类号： G01N21/6428 , C12Q1/6869 , G01J3/10 , G01N21/64 , G01N21/6452 , G01N21/6456 , G01N2021/6439 , G01N2201/0638 , G01N2201/08 , G02B27/0994 , H01L27/14612 , H01L27/14623 , H01L27/14625 , H01L27/14636
摘要： There is set forth herein a light energy exciter that can include one or more light sources. A light energy exciter can emit excitation light directed toward a detector surface that can support biological or chemical samples.

4. 发明申请

US20190194738A1 KEY-VALUE STORE THAT HARNESSES LIVE MICRO-ORGANISMS TO STORE AND RETRIEVE DIGITAL INFORMATION 审中-公开
公开(公告)号：US20190194738A1
公开(公告)日：2019-06-27
申请号：US15855294
申请日：2017-12-27
申请人： Anjali CHAKRADHAR
发明人： Anjali CHAKRADHAR
IPC分类号： C12Q1/6869 , C12Q1/6876 , C12N15/10 , G01N21/64 , G01N15/14
CPC分类号： C12Q1/6869 , C12N15/1086 , C12Q1/6876 , G01N15/1429 , G01N15/1434 , G01N21/6428 , G01N2015/149 , G01N2021/6439
摘要： A digital store comprising of a method to store digital data in live micro-organisms, and a method to selectively retrieve subsets of stored data, is disclosed. Digital data is represented as a plurality of key-value pairs. The proposed system stores copies of key-value pairs in a plurality of live micro-organisms. Upon presentation of a retrieval key, the proposed digital store retrieves the value associated with the retrieval key. Storage method for a key-value pair comprises of (a) mapping the key to a gene that expresses a unique fluorescent protein so that no two keys map to the same gene, (b) encoding the key-value pair as base-pair sequences, (c) synthesizing oligonucleotide chains from base-pairs for the key-value pair and the gene, (d) synthesizing recombinant DNA plasmids that have oligonucleotide chains for the key-value pair, the gene, and two primers, as foreign DNA inserts, (e) incorporation of recombinant DNA plasmids into live micro-organisms, (f) isolation of live micro-organisms that have absorbed the recombinant DNA plasmids, and (g) safe storage of population of live micro-organisms with embedded key-value pairs in a common pool. Retrieval of the value paired with a key comprises of (a) taking as input the retrieval key, and mapping the key to the specific gene for fluorescent protein, (b) taking a sample from the safe storage pool that contains live micro-organisms embedded with key-value pairs, (c) isolating the live micro-organisms that have expressed the gene by using high-speed fluorescence activated cell sorting or flow cytometry, (d) extracting DNA from the recombinant DNA plasmid in the isolated live micro-organisms, (d) selectively amplifying and sequencing only those DNA strands that contain the value for the key, and (e) decoding the base-pair sequence obtained after DNA sequencing to yield the value associated with the retrieval key.We also disclose two important variations. The first variation relates to the storage step. The recombinant DNA plasmid is constructed to include additional non-fluorescent oligonucleotides and genes so that during the data retrieval step, the live micro-organisms that have absorbed the said plasmid can be sorted by cell sorters based on parameters of individual cells such as cell size, cell complexity, cell phenotype, cell structure, cell function, and magnetic or electrical properties. The second variation relates to both storage and retrieval of key-value pairs with large values. To store such a key-value pair, the large value is split into smaller blocks so that a block can fit into a recombinant DNA plasmid, and a distinct pair of primers is used for each block. A block's primer pair is used to selectively amplify and sequence only the DNA that encodes the data in the block, thereby enabling the retrieval of a specific block of the value, as opposed to retrieving the entire value associated with a key.

5. 发明申请

US20190119315A1 Methods And Compositions For Incorporating Nucleotides 审中-公开
公开(公告)号：US20190119315A1
公开(公告)日：2019-04-25
申请号：US16193639
申请日：2018-11-16
申请人： Qiagen Wal Tham, Inc.
发明人： Steven Gordon , Jerzy Olejnik
IPC分类号： C07H19/00 , G01N21/64 , C12Q1/6874 , C12Q1/6869 , G01N21/05
CPC分类号： C12Q1/6869 , C07H19/00 , C12Q1/6874 , C12Q2535/101 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6471 , G01N2201/062 , G01N2201/0627 , G01N2201/12
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable Media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

6. 发明申请

US20190064066A1 FLUORESCENT SUPRAMOLECULAR BIOSENSOR AND PREPARATION METHOD THEREOF 审中-公开
公开(公告)号：US20190064066A1
公开(公告)日：2019-02-28
申请号：US15988616
申请日：2018-05-24
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
发明人： Yong-beom LIM , Woo-jin Jeong
IPC分类号： G01N21/64 , C07K14/00
CPC分类号： G01N21/6428 , C07K1/13 , C07K14/003 , C07K19/00 , C12Q1/04 , C12Q1/6834 , G01N33/542 , G01N33/56911 , G01N2021/6439
摘要： The present disclosure relates to a fluorescent supramolecular biosensor, more particularly to a fluorescent supramolecular biosensor which shows change in fluorescence signal through binding to a specific bacterium and a method for preparing the same. The fluorescent supramolecular biosensor is advantageous in that it exhibits remarkably superior affinity and selectivity for a target bacterium.In addition, because a secondary coiled coil stereostructure is highly stabilized as the supramolecular building block is self-assembled to form the fluorescent supramolecular biosensor, the fluorescent supramolecular biosensor can be stored for a long period of time without structural change even at high temperatures.

7. 发明申请

US20190041331A1 Turn-On Near Infrared Fluorescent Probes for Imaging Lysosomal ROS in Live Cells at Subcellular Resolution 审中-公开
公开(公告)号：US20190041331A1
公开(公告)日：2019-02-07
申请号：US15764819
申请日：2016-10-04
申请人： University of Massachusetts
发明人： Maolin GUO
IPC分类号： G01N21/64 , C07D405/06
CPC分类号： G01N21/6428 , A61K49/0019 , C07D405/06 , G01N31/228 , G01N2021/6439
摘要： This invention is in the field of fluorescence imaging and relates to a new near infrared (NIR) reactive oxygen species (ROS) sensor designed with controlled fluorescence on-off switching mechanism.

8. 发明申请

US20180328846A1 METHOD OF DETERMINING AN OXYGEN CONCENTRATION INSIDE A GAS SHIELD 审中-公开
公开(公告)号：US20180328846A1
公开(公告)日：2018-11-15
申请号：US15973629
申请日：2018-05-08
申请人： ROLLS-ROYCE plc
发明人： Clive GRAFTON-REED
IPC分类号： G01N21/64
CPC分类号： G01N21/643 , G01N2021/6439
摘要： Method of determining an oxygen level inside a gas shield:providing a surface;positioning a gas shield over a portion of the surface;applying a pressure sensitive paint to the portion of the surface;flowing oxygen through the gas shield onto the portion of the surface;illuminating the portion of the surface;measuring a first fluorescent emission from the portion of the surface while oxygen is flowing through the gas shield;determining an oxygen saturation level across the portion of the surface in dependence on the magnitude of the first fluorescent emission;flowing a shield gas through the gas shield;illuminating the portion of the surface;measuring a second fluorescent emission from the portion of the surface while the shield gas is flowing through the gas shield; anddetermining an oxygen level across the portion of the surface in dependence on the relative magnitudes of first and second fluorescent emission.

9. 发明申请

US20180321269A1 DETECTION METHOD, DETECTION APPARATUS AND TEST KIT 审中-公开
公开(公告)号：US20180321269A1
公开(公告)日：2018-11-08
申请号：US15776297
申请日：2016-10-28
申请人： Konica Minolta, Inc.
发明人： Mami TAKEUCHI , Masataka MATSUO
IPC分类号： G01N35/08 , G01N21/64
CPC分类号： G01N35/08 , G01N21/64 , G01N21/6428 , G01N37/00 , G01N2021/6439
摘要： Supplying a liquid to a detection chip including a housing having an opening portion and internally housing the liquid and including an elastic sheet covering the opening portion and having a penetrating portion providing communicating between the inside and the outside of the housing, specifically by inserting a liquid delivery nozzle to the housing via the penetrating portion and supplying the liquid into the housing in a state where the nozzle is in contact with the elastic sheet so as to close the penetrating portion. The penetrating portion is one of a hole and a notch. One of the maximum length of the opening of the hole and the maximum length of the notch is smaller than the outer diameter of the nozzle at a portion coming in contact with the elastic sheet when the nozzle is inserted to close the penetrating portion when a liquid is supplied into the housing.

10. 发明申请

US20180321218A1 Medical Toilet with Aptamer Sensors to Analyze Urine 审中-公开
公开(公告)号：US20180321218A1
公开(公告)日：2018-11-08
申请号：US15589403
申请日：2017-05-08
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
IPC分类号： G01N33/493 , G01N33/53 , G01N33/487 , G01N33/543 , G01N33/542 , G01N27/327 , G01N21/64 , G01N21/78 , A61B5/00 , A61B5/20
CPC分类号： G01N33/493 , A61B5/0071 , A61B5/207 , G01N21/6428 , G01N21/78 , G01N27/3276 , G01N33/48792 , G01N33/5308 , G01N33/542 , G01N33/5438 , G01N2021/6417 , G01N2021/6432 , G01N2021/6439
摘要： We disclose an in-toilet urinalysis system which includes a system for collection urine and for analysis of urine components using aptamer technology. Urine collection system may dispense urine into cuvettes, channels, or other containers that include aptamers. The aptamers may detect target molecules in urine. The aptamers may measure urine analytes, detect excreted drugs or drug metabolites, or disease markers. Upon binding to the target molecule, the aptamers may produce a signal which a sensor in the toilet may detect. In some embodiments, the signal may be electrochemical, fluorescent, or colorimetric. The measurements obtained from analysis of the urine may be used to assess a user's health or diagnose disease. In some embodiments, the measurements are stored in a controller which may transmit the measurements to a healthcare provider for assessment.

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