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1. 发明申请

WO2004016200A1 IMPLANTABLE VASCULAR DEVICE 审中-公开
标题翻译：可植入血管装置
公开(公告)号：WO2004016200A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025794
申请日：2003-08-15
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY , MED INSTITUTE, INC. , WILLIAM COOK EUROPE ApS
发明人： PAVCNIK, Dusan , CASE, Brian, L. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Raymond, B., II , OSBORNE, Thomas, A. , PAUL, Ram, H., Jr. , SCHAEFFER, Darin, G. , SISKEN, Richard, B.
IPC分类号： A61F2/06
CPC分类号： C25F3/24 , A61F2/2418 , A61F2/2439 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0091 , A61F2230/0095
摘要： A valve prosthesis (43), such as an artificial venous valve, having a support frame (11) and leaf structure comprising one or more leaflets (78, 79) in which the outer edge (112) of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements (31, 32) can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure (164) comprises a second or third expandable frames (31, 32) attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：具有支撑框架（11）和叶结构的瓣膜假体（43），例如人造静脉瓣，叶片结构包括一个或多个传单（78,79），其中每个小叶的外边缘（112）沿着蛇形路径的身体通道通过可扩张的框架被推靠在通道上，而内边缘响应于流体而移动以限制逆行流动。可选地，一个或多个元件（31,32）可以从支撑框架/叶片结构延伸，以提供定位支撑和/或保护免受附着在血管壁上的小叶。在一个实施例中，定心支撑结构（164）包括附接到主阀结构和支撑框架的近端和/或远端并从其延伸的第二或第三可膨胀框架（31,32）。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

2. 发明申请

WO2004024032A1 RETRIEVABLE FILTER 审中-公开
标题翻译：可检索过滤器
公开(公告)号：WO2004024032A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/028679
申请日：2003-09-12
申请人： COOK INCORPORATED , WILLIAM COOK EUROPE APS
发明人： PAVCNIK, Dusan , CASE, Brian, C. , KAUFMAN, John, A. , GARRISON, Michael, L. , FLAGLE, Jacob, A.
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067
摘要： A long-term retrievable, permanent blood filtration unit is to be implanted in a vessel of a patient's body, particularly for capturing blood clots, comprising a filter, a stent and a locking mechanism for releasably attaching the filter to the stent.
摘要翻译：将长期可回收的永久性血液过滤单元植入患者身体的容器中，特别是用于捕获血块，包括过滤器，支架和用于将过滤器可释放地附接到支架的锁定机构。

3. 发明申请

WO2004016201A2 STENT AND METHOD OF FORMING A STENT WITH INTEGRAL BARBS 审中-公开
标题翻译：形成具有综合棒的手套的方法和方法
公开(公告)号：WO2004016201A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025827
申请日：2003-08-15
申请人： COOK INCORPORATED , WILLIAM COOK EUROPE APS , WILLIAM A. COOK AUSTRALIA PTY. LTD.
发明人： CASE, Brian, L. , COOK, William, A. , DEBRYUYNE, Michael, P. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , KELLER, Frederick, S. , LEONARD, Raymond, B., II , MEAD, Jason, A. , NICKLESS, Benjamin , OSBORNE, Thomas, A. , PAUL, Ram, H., Jr. , PAVCNIK, Dusan , ROSCH, Josef , SHAEFFER, Darin, G. , SISKEN, Richard, B.
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/07 , A61F2/2412 , A61F2/2418 , A61F2/848 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/005 , A61F2230/0054 , A61F2230/0058 , A61F2230/0091 , A61F2230/0095 , A61F2250/0031 , C25F3/24
摘要： A method for manufacturing a barbed stent includes providing a sheet of stent material, cutting the sheet to form a stent wire with integral barbs extending therefrom, and forming the stent wire into a final stent shape having a longitudinal axis. A stent for deployment within the body of a patient includes integral barbs.
摘要翻译：一种用于制造有肋的支架的方法包括提供支架材料的片材（152），切割片材以形成具有从其延伸的整体倒钩（124）的支架丝线，并将支架丝线形成为具有纵向轴线的最终支架形状。用于在患者体内展开的支架包括一体倒钩。

4. 发明申请

WO2003045275A2 MEDICAL DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：医疗器械输送系统
公开(公告)号：WO2003045275A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/038289
申请日：2002-11-27
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.
摘要翻译：一种用于将诸如静脉瓣的医疗装置（30）植入患者脉管系统的输送系统（10）。递送系统包括具有与其远端（14）相邻的装置容纳部分（15）的输送导管（11）和延伸穿过导管并超出其远端的内部构件（16）到无创伤远端尖端部分（17）在导管远端的前方。内部构件在包含装置的区域中延伸通过医疗装置，包括具有足够大直径的近端部分（18），以在导管在展开期间缩回时防止装置的纵向移动，并且使得装置在从远端导管在部署期间结束。内部构件优选地是设备下方的射线可透以与装置的不透射线标记（43）形成对比。内部构件优选地包括从装置容纳部分延伸到近端（22）的平坦部分（35），以与输送导管形成通道或内腔（21），以将保湿流体传送到装置，例如包含在患者植入之前立即需要水合的冻干组织。

5. 发明申请

WO2009029261A1 SPIDER PFO CLOSURE DEVICE 审中-公开
标题翻译： SPIDER PFO封闭装置
公开(公告)号：WO2009029261A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/010109
申请日：2008-08-26
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY , TEKULVE, Kurt, J. , PAVCNIK, Dusan
发明人： TEKULVE, Kurt, J. , PAVCNIK, Dusan
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00623 , A61B2017/00867
摘要： A device for occluding septal defects or other bodily passageways including PFOs, includes an occluding body formed from a plurality of flexible outwardly radiating occluding wires connected to one or more biocompatible sheet materials. The occluding wires are joined together at proximal wire ends. Linking members connectively link the occluding body to a flexible, substantially linear anchor formed from at least one tube, coil, or bar. The anchor is configured for placement on one side of bodily passageway, whereby the longitudinal axis of at least one anchor extends across a transverse cross-section of the bodily passageway, anchoring the occluding body in place against the other side of a bodily passageway to close, occlude, or fill at least a lumenal portion of a bodily passageway. The anchor may include one or more grasping member(s) integrally formed or connected to the tube, coil, or bar for releasable attachment to an anchor engaging member, such as a biopsy forceps. In a further aspect, a closure device assembly includes a delivery catheter housing a collapsibly disposed closure device linked to a biopsy forceps. The biopsy forceps may be positioned in a locking catheter, which is configured to prevent inadvertent release of the closure device when held in a compressed state inside the delivery catheter. By positioning the catheter near a bodily passageway, such as a PFO, and disengaging the anchor engaging member from the grasping member, the closure device may be released so as to facilitate stable closure of the bodily passageway.
摘要翻译：用于阻塞间隔缺损或其他身体通道（包括PFO）的装置包括由连接到一个或多个生物相容性片材的多个柔性向外辐射阻塞线形成的闭塞体。封闭线在近端线端连接在一起。连接构件将闭塞体连接到由至少一个管，线圈或杆形成的柔性基本线性的锚固件。该锚固件构造成用于放置在身体通道的一侧上，由此至少一个锚固件的纵向轴线延伸穿过身体通道的横向横截面，将闭塞体固定在身体通道的另一侧以封闭，闭塞或填充身体通道的至少腔内部分。锚固件可以包括一个或多个整体形成或连接到管，线圈或杆的抓握构件，用于可释放地附接到锚固件接合构件，例如活检钳。在另一方面，闭合装置组件包括输送导管，其容纳与活检钳连接的可折叠地设置的闭合装置。活检钳可以定位在锁定导管中，该锁定导管被配置成防止当将其保持在输送导管内部的压缩状态时封闭装置的意外释放。通过将导管定位在诸如PFO的身体通道附近，并且将锚定接合构件与抓握构件分离，则可以释放闭合装置，以便于身体通道的稳定关闭。

6. 发明申请

WO2008094691A3 CLOSURE DEVICE AND METHOD FOR OCCLUDING A BODILY PASSAGEWAY 审中-公开
公开(公告)号：WO2008094691A3
公开(公告)日：2008-08-07
申请号：PCT/US2008/001376
申请日：2008-02-01
申请人： COOK INCORPORATED , OREGON HEALTH & SCIENCE UNIVERSITY , PAVCNIK, Dusan , TEKULVE, Kurt, J.
发明人： PAVCNIK, Dusan , TEKULVE, Kurt, J.
IPC分类号： A61B17/00
摘要： A device (10) for occluding septal defects or other bodily passageways includes two anchors (14, 16) connected to an occluding body (18). The occluding body may be formed as a plug (32) or tube of biocompatible material configured to occlude a bodily passageway. At least one of the anchors includes a grasping member (30) in the form of a loop or suitably shaped structure, which is configured for releasable attachment to an anchor engaging member, such as a biopsy forceps (66). In a further aspect, a closure device assembly (40) includes a closure device linked to the biopsy forceps and collapsibly disposed in a catheter (62). By positioning the catheter near a bodily passageway, such as a PFO, and disengaging the forceps from the grasping member, the closure device may be released so as to facilitate stable closure of a septal opening, such as a PFO.

7. 发明申请

WO2006050460A1 VASCULAR VALVES HAVING IMPLANTED AND TARGET CONFIGURATIONS AND METHODS OF PREPARING THE SAME 审中-公开
标题翻译：具有植入物和目标配置的血管瓣及其制备方法
公开(公告)号：WO2006050460A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/039835
申请日：2005-10-27
申请人： COOK INCORPORATED , CASE, Brian, C. , FLAGLE, Jacob, A. , GARRISON, Michael, L. , OBERMILLER, F., Joseph , PAVCNIK, Dusan
发明人： CASE, Brian, C. , FLAGLE, Jacob, A. , GARRISON, Michael, L. , OBERMILLER, F., Joseph , PAVCNIK, Dusan
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

8. 发明申请

WO2005053547A2 VASCULAR OCCLUSION METHODS, SYSTEMS AND DEVICES 审中-公开
标题翻译：血管造影方法，系统和装置
公开(公告)号：WO2005053547A2
公开(公告)日：2005-06-16
申请号：PCT/US2004/039840
申请日：2004-11-29
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , PAVCNIK, Dusan , KAUFMAN, John, A. , OSBORNE, Thomas , BATES, Brian , PATEL, Umesh , FETTE, Clay, D. , CHIN, Likang , MCALEXANDER, Chad, S. , SHAH, Bhavin
发明人： PAVCNIK, Dusan , KAUFMAN, John, A. , OSBORNE, Thomas , BATES, Brian , PATEL, Umesh , FETTE, Clay, D. , CHIN, Likang , MCALEXANDER, Chad, S. , SHAH, Bhavin
IPC分类号： A61B17/12
CPC分类号： A61B17/12109 , A61B17/00008 , A61B17/12022 , A61B17/12181 , A61B17/32053 , A61B2017/12054 , A61L2430/36
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures are used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment of one or more vascular occlusion devices via a through-and-through percutaneous procedure that leaves the vascular occlusion device or devices in a through-and-through condition.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括经由通过经皮操作的一个或多个血管闭塞装置的部署，其使得血管闭塞装置或穿通状态离开。

9. 发明申请

WO2001056500A3 IMPLANTABLE VASCULAR DEVICE 审中-公开
公开(公告)号：WO2001056500A3
公开(公告)日：2001-08-09
申请号：PCT/US2001/003766
申请日：2001-02-05
申请人： COOK INCORPORATED , COOK BIOTECH, INC.
发明人： PAVCNIK, Dusan , KELLER, Frederick, S. , ROSCH, Josef , OSBORNE, Thomas, A. , BATES, Brian, L. , DEFORD, John, A. , DIXON, Christopher, G. , HOFFA, Andrew, K. , LEONARD, Raymond, B., II , OBERMILLER, Joseph, F.
IPC分类号： A61F2/24
摘要： A multiple-sided medical device (10) comprises a frame (11) comprising wire or other resilient material and having a series of bends (12) and interconnecting sides. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs (16) for anchoring purposes. A full or partial covering (45) of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device (51), a stent graft (75), or an implantable, intraluminal valve (43) such as for correcting incompetent veins in the lower legs and feet.

10. 发明授权

EP1465546B1 MEDICAL DEVICE DELIVERY SYSTEM 有权
标题翻译：医疗设备输送系统
公开(公告)号：EP1465546B1
公开(公告)日：2007-07-18
申请号：EP02799890.5
申请日：2002-11-27
申请人： Cook Incorporated , Oregon Health and Science University
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.

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