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1. 发明专利

JP2008029866A TUBULAR GRAFT FROM PURIFIED SUBMUCOSA 审中-公开
公开(公告)号：JP2008029866A
公开(公告)日：2008-02-14
申请号：JP2007264711
申请日：2007-10-10
申请人： COOK BIOTECH INC , MED INST INC
发明人： FEARNOT NEAL E , HILES MICHAEL C
IPC分类号： A61F2/07 , A61F2/00 , A61F2/06 , A61L27/00 , A61L27/24 , A61L27/36
摘要： PROBLEM TO BE SOLVED: To provide a graft prosthesis, which is easily produced and mechanically strong. SOLUTION: The prosthesis is manufactured in any desired length, wall thickness or diameter. The construct produced by the method of the invention can be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the graft prosthesis generally involves wrapping a plurality of sheets of matrix structure of purified collagen-base, around a mandrel, compressing and drying the tissue on the mandrel, and removing the construct from the mandrel for eventual use. COPYRIGHT: (C)2008,JPO&INPIT

2. 发明专利

JP2007521884A Casting bioremodelable graft 有权
公开(公告)号：JP2007521884A
公开(公告)日：2007-08-09
申请号：JP2006552348
申请日：2005-02-09
申请人：クック・インコーポレイテッドCook Incorporated , クック・バイオテック・インコーポレイテッドCook Biotech, Inc.
发明人：イールズ，スコット・イー , オズボーン，トーマス・エイ , ヒルズ，マイケル・シィ
IPC分类号： A61L31/00 , A61F2/06 , A61L27/36 , A61L27/50 , A61L27/58
CPC分类号： A61L27/507 , A61L27/3629 , A61L27/3633 , A61L27/58
摘要：生体再造形可能物質（３４）の鋳造管状構造物（３３）を備えた鋳造生体再造形可能グラフト（２２）。生体再造形可能物質を型上に鋳造または塗布し、次に真空プレスして物質を乾燥または硬化させる。拡張可能部材（１８）を鋳造管状構造物上、中、下または近辺に配置して、グラフトが腔内送達システムから放出されるときこれを拡張させる。第２層（３９）を第１層（３８）および拡張可能ステントを覆って塗布して、接着手段を別途に必要とせずにステントをこれらの間に封入することができる。グラフトを脱水および好ましくは真空プレスして生体再造形可能物質を硬化させる。型を除去して、グラフト内に１つ以上の内腔（２３、２５）を形成し、次にグラフトを腔内送達システムに装着する。

3. 发明专利

JP2009261955A Graft prosthesis, materials and methods 审中-公开
标题翻译： GRAFT PROSTHESIS，材料和方法
公开(公告)号：JP2009261955A
公开(公告)日：2009-11-12
申请号：JP2009112403
申请日：2009-05-06
申请人： Cook Biotech Inc , Cook Inc , Med Inst Inc , エムイーディーインスティチュート,インコーポレイティド , クックインコーポレイティッド , クックバイオテクインコーポレイティド
发明人： COOK WILLIAM A , HILES MICHAEL C , KOZMA THOMAS G , PATEL UMESH H
IPC分类号： A61L27/00 , C12N5/06 , A61F2/00 , A61F2/06 , A61F2/08 , A61F2/30 , A61K35/38 , A61L2/00 , A61L27/24 , A61L27/36 , A61L29/00 , A61L31/00
CPC分类号： A61L27/24 , A61F2/06 , A61F2/07 , A61L2/0088 , A61L27/3604 , A61L27/3662 , A61L27/3683 , A61L27/3695 , A61L27/3839 , A61L27/3843 , A61L27/386 , A61L29/005 , A61L31/005 , Y10S623/925
摘要： PROBLEM TO BE SOLVED: To provide a method for obtaining a purified collagen-based matrix from a tissue source. SOLUTION: A graft prostheses 11, materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis 11 includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供从组织来源获得纯化的基于胶原的基质的方法。解决方案：移植假体11，用于植入，移植，替换或修复患者的一部分的材料和方法。移植假体11包括从粘膜下层组织源移除的纯化的基于胶原的基质结构。通过消毒和去除步骤来净化粘膜下组织来源，以去活化和去除污染物，从而使纯化的结构生物相容并适于在患者和/或患者中接枝。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2015006420A 増強した成分プロファイルを有する加工したＥＣＭ材料有权
标题翻译：加工ECM材料具有增强的组件配置文件
公开(公告)号：JP2015006420A
公开(公告)日：2015-01-15
申请号：JP2014178012
申请日：2014-09-02
申请人：クック・バイオテック・インコーポレーテッド , Cook Biotech Inc
发明人： CHAD E JOHNSON
IPC分类号： A61L27/00
CPC分类号： A61L27/3633 , A61L27/3604 , A61L27/3695
摘要：【課題】望ましい成分を保持しつつ、望ましくない成分が減少した独創的な成分プロファイルを有する細胞外マトリックス移植片材料の提供。【解決手段】コラーゲン成分及び非コラーゲン成分を含む滅菌の、非細胞化した細胞外マトリックス材料から成り、前記非コラーゲン成分が、(i)約20μg/g以下のレベルの天然IgAと、(ii)重量比にて約4%以下のレベルの天然脂質と、(iii)少なくとも約10ng/gのレベルの天然FGF−2と、(iv)少なくとも約50μg/gのレベルの天然ヒアルロン酸と、(v)少なくとも約500μg/gのレベルの天然硫酸化グリコサミノグリカンと、を含む医療用移植片材料。【選択図】なし
摘要翻译：要解决的问题：提供具有减少量的不期望成分的独特组分分布的细胞外基质植入物材料，同时保留所需的成分。解决方案：医用植入材料由包括胶原组分和非胶原的灭菌的，细胞外的细胞外基质材料组成组件。非胶原成分包括：（i）约20μg/ g或更低水平的天然IgA; （ii）重量比约4％或更少的天然脂质; （iii）水平至少约10ng / g的天然FGF-2; （iv）天然透明质酸含量至少约为50μg/ g; 和（v）至少约500μg/ g水平的天然硫酸化糖胺聚糖。

5. 发明专利

JP2010253285A Tissue graft product, its use, and method of manufacturing the same 审中-公开
标题翻译：组织砂粒产品，其使用及其制造方法
公开(公告)号：JP2010253285A
公开(公告)日：2010-11-11
申请号：JP2010141546
申请日：2010-06-22
申请人： Cook Biotech Inc , クック・バイオテック・インコーポレーテッド
发明人： BLEYER MARK W , PATEL UMESH H
IPC分类号： A61L27/00 , A61F2/10 , A61L15/40 , A61L15/42 , A61L27/36 , A61L27/50 , A61L27/60 , A61L31/00
CPC分类号： A61L27/3683 , A61F2/105 , A61L15/40 , A61L15/42 , A61L27/3604 , A61L27/3633 , A61L27/3666 , A61L27/50 , A61L27/60 , A61L31/005
摘要： PROBLEM TO BE SOLVED: To provide a tissue graft product useful for treatment of exudative open skin damage.
SOLUTION: The tissue graft product includes at least one collagen layer 11 comprising submucosa or renal capsule tissue having slits 12 formed therein to provide a mesh pattern which establishes a graft structure that is highly deformable. The slits 11 and the mesh pattern provide improved characteristics when utilized as a tissue graft and in particular an external wound care. Preferred devices have multiple submucosa, renal capsule or other collagenous extracellular matrix layers, providing a substantial and lasting scaffold for tissue ingrowth during a whole period of wound treatment.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于治疗渗出性皮肤损伤的组织移植物产品。解决方案：组织移植产品包括至少一个包含粘膜下层或肾胶囊组织的胶原层11，其具有形成在其中的狭缝12，以提供形成高度可变形的移植结构的网状图案。当用作组织移植物，特别是外部伤口护理时，狭缝11和网状图案提供改进的特性。优选的装置具有多个粘膜下层，肾胶囊或其他胶原细胞外基质层，为整个伤口治疗期间的组织向内生长提供了基本和持久的支架。版权所有（C）2011，JPO＆INPIT

6. 发明专利

GB2583231A Sterilized tissue products and related methods 未知
公开(公告)号：GB2583231A
公开(公告)日：2020-10-21
申请号：GB202008991
申请日：2018-11-14
申请人： COOK BIOTECH INC
发明人： UMESH H PATEL , MICHAEL L TAYLOR , CARA MCCAMMON , RAE RITCHIE
IPC分类号： A61L27/36 , A61L31/00 , A61M5/00
摘要： Disclosed are products having animal tissue packed within the lumen of a device such as a needle cannula. The needle cannula or other device can be received in a capsule and/or other container. Methods of use of the products are also described and can include ejecting the animal tissue from the lumen of device using pressurized liquid passed through the lumen, potentially to deliver the animal tissue directly into a patient. Methods of manufacture of the products are also described.

7. 发明专利

AU2018294247A1 Implantable medical devices for tissue repositioning 未知
公开(公告)号：AU2018294247A1
公开(公告)日：2020-01-23
申请号：AU2018294247
申请日：2018-06-28
申请人： COOK BIOTECH INC , COOK MEDICAL TECHNOLOGIES LLC
发明人： O'CONNOR PETER , COLBURN WADE , MCKIERNAN CHELSEA , ISCH ANDREW P , BRETHAUER ALEXANDER
IPC分类号： A61F5/56
摘要： A medical device for repositioning tissue within an animal has a main body with a first end portion, a second end portion, and a middle portion. The first end portion defines a series of passageways and the second end portion defines a bulbous shape, a slot, and a tab portion. Methods of treating obstructive sleep apnea are also described.

8. 发明专利

AU2014227794B2 Drug eluting graft constructs and methods 未知
公开(公告)号：AU2014227794B2
公开(公告)日：2018-03-01
申请号：AU2014227794
申请日：2014-03-14
申请人： COOK BIOTECH INC , COOK MEDICAL TECHNOLOGIES LLC
发明人： PECK RHONDA , SHAH BHAVIN , PATEL UMESH H , GEARHART KRISTA , CHARLEBOIS STEVEN , MILNER KEITH , RODENBERG ERIC J
IPC分类号： A61L31/00 , A61L31/14 , A61L31/16
摘要： The present invention provides, in certain aspects, medical graft products that incorporate multiple drug depots in and/or on the products. One such product is a sheet graft construct, for example for tissue support that includes a sheet graft material with a plurality of drug depots. The drug depots can be hardened deposits formed directly onto the sheet graft material and/or can be capable of eluting a drug for a minimum of 72 hours.

9. 发明专利

AU2014227561C1 ECM implant compositions and methods 未知
公开(公告)号：AU2014227561C1
公开(公告)日：2017-12-14
申请号：AU2014227561
申请日：2014-03-14
申请人： COOK BIOTECH INC
发明人： CHUTKA MICHELLE , HILES MICHAEL C
IPC分类号： A61L27/36 , A61L27/50
摘要： Described our medical compositions and methods including a particulate extracellular matrix tissue in admixture with sugar. Such medical compositions, dried forms, can demonstrate enhanced rehydration properties. Medical compositions and products as described herein find particular use in treating diseased and/or damaged tissue, such as wound repair. Related methods of manufacture and use are also described.

10. 发明专利

CA2728553C ISOLATED EXTRACELLULAR MATRIX MATERIAL INCLUDING SUBSEROUS FASCIA 未知
公开(公告)号：CA2728553C
公开(公告)日：2016-08-16
申请号：CA2728553
申请日：2009-06-29
申请人： COOK BIOTECH INC
发明人： SHAH BHAVIN , HARRIGAN KATIE L
IPC分类号： A61L27/36 , A61L27/50
摘要： Described are purified extracellular matrix materials isolated from the abdominal wall of animals and including the subserous fascia layer of the abdominal wall. Such medical materials can find use in treating damaged tissue and in certain aspects in providing tissue support for the repair of hernias. Related methods of manufacture and use are also described.

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