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1. 发明申请

WO2008094706A3 CLOSURE DEVICE AND METHOD OF CLOSING A BODILY OPENING 审中-公开
公开(公告)号：WO2008094706A3
公开(公告)日：2008-08-07
申请号：PCT/US2008/001422
申请日：2008-02-01
申请人： COOK INCORPORATED , OREGON HEALTH & SCIENCE UNIVERSITY , PAVCNIK, Dusan , TEKULVE, Kurt, J.
发明人： PAVCNIK, Dusan , TEKULVE, Kurt, J.
IPC分类号： A61B17/00
摘要： In one embodiment, a device (10) for closing or occluding ASDs and PFOs, or other bodily passageways, includes a circumferential frame (14), a sheet (18) of biocompatible material attached to the frame, and at least one anchor (22) attached to the sheet of biocompatible material. In another embodiment, the closure device includes a circumferential frame, at least one crossbar (20) extending across and attached to the frame, at least one anchor connected to at least one crossbar; and at least one sheet of biocompatible material (such as ECM material) attached to the frame. The anchor includes at least one grasping member (34) having a structure, such as a wired loop, which is configured for releasable attachment to a delivery release member, which facilitates delivery of a closure device collapsibly disposed in a delivery catheter. Alternatively, one or more anchor end pairs may be connected to a delivery bar (36) enhancing delivery and retrieval of the device.

2. 发明申请

WO2008094691A3 CLOSURE DEVICE AND METHOD FOR OCCLUDING A BODILY PASSAGEWAY 审中-公开
公开(公告)号：WO2008094691A3
公开(公告)日：2008-08-07
申请号：PCT/US2008/001376
申请日：2008-02-01
申请人： COOK INCORPORATED , OREGON HEALTH & SCIENCE UNIVERSITY , PAVCNIK, Dusan , TEKULVE, Kurt, J.
发明人： PAVCNIK, Dusan , TEKULVE, Kurt, J.
IPC分类号： A61B17/00
摘要： A device (10) for occluding septal defects or other bodily passageways includes two anchors (14, 16) connected to an occluding body (18). The occluding body may be formed as a plug (32) or tube of biocompatible material configured to occlude a bodily passageway. At least one of the anchors includes a grasping member (30) in the form of a loop or suitably shaped structure, which is configured for releasable attachment to an anchor engaging member, such as a biopsy forceps (66). In a further aspect, a closure device assembly (40) includes a closure device linked to the biopsy forceps and collapsibly disposed in a catheter (62). By positioning the catheter near a bodily passageway, such as a PFO, and disengaging the forceps from the grasping member, the closure device may be released so as to facilitate stable closure of a septal opening, such as a PFO.

3. 发明申请

WO2009029261A1 SPIDER PFO CLOSURE DEVICE 审中-公开
标题翻译： SPIDER PFO封闭装置
公开(公告)号：WO2009029261A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/010109
申请日：2008-08-26
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY , TEKULVE, Kurt, J. , PAVCNIK, Dusan
发明人： TEKULVE, Kurt, J. , PAVCNIK, Dusan
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00623 , A61B2017/00867
摘要： A device for occluding septal defects or other bodily passageways including PFOs, includes an occluding body formed from a plurality of flexible outwardly radiating occluding wires connected to one or more biocompatible sheet materials. The occluding wires are joined together at proximal wire ends. Linking members connectively link the occluding body to a flexible, substantially linear anchor formed from at least one tube, coil, or bar. The anchor is configured for placement on one side of bodily passageway, whereby the longitudinal axis of at least one anchor extends across a transverse cross-section of the bodily passageway, anchoring the occluding body in place against the other side of a bodily passageway to close, occlude, or fill at least a lumenal portion of a bodily passageway. The anchor may include one or more grasping member(s) integrally formed or connected to the tube, coil, or bar for releasable attachment to an anchor engaging member, such as a biopsy forceps. In a further aspect, a closure device assembly includes a delivery catheter housing a collapsibly disposed closure device linked to a biopsy forceps. The biopsy forceps may be positioned in a locking catheter, which is configured to prevent inadvertent release of the closure device when held in a compressed state inside the delivery catheter. By positioning the catheter near a bodily passageway, such as a PFO, and disengaging the anchor engaging member from the grasping member, the closure device may be released so as to facilitate stable closure of the bodily passageway.
摘要翻译：用于阻塞间隔缺损或其他身体通道（包括PFO）的装置包括由连接到一个或多个生物相容性片材的多个柔性向外辐射阻塞线形成的闭塞体。封闭线在近端线端连接在一起。连接构件将闭塞体连接到由至少一个管，线圈或杆形成的柔性基本线性的锚固件。该锚固件构造成用于放置在身体通道的一侧上，由此至少一个锚固件的纵向轴线延伸穿过身体通道的横向横截面，将闭塞体固定在身体通道的另一侧以封闭，闭塞或填充身体通道的至少腔内部分。锚固件可以包括一个或多个整体形成或连接到管，线圈或杆的抓握构件，用于可释放地附接到锚固件接合构件，例如活检钳。在另一方面，闭合装置组件包括输送导管，其容纳与活检钳连接的可折叠地设置的闭合装置。活检钳可以定位在锁定导管中，该锁定导管被配置成防止当将其保持在输送导管内部的压缩状态时封闭装置的意外释放。通过将导管定位在诸如PFO的身体通道附近，并且将锚定接合构件与抓握构件分离，则可以释放闭合装置，以便于身体通道的稳定关闭。

4. 发明申请

WO2005053547A2 VASCULAR OCCLUSION METHODS, SYSTEMS AND DEVICES 审中-公开
标题翻译：血管造影方法，系统和装置
公开(公告)号：WO2005053547A2
公开(公告)日：2005-06-16
申请号：PCT/US2004/039840
申请日：2004-11-29
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , PAVCNIK, Dusan , KAUFMAN, John, A. , OSBORNE, Thomas , BATES, Brian , PATEL, Umesh , FETTE, Clay, D. , CHIN, Likang , MCALEXANDER, Chad, S. , SHAH, Bhavin
发明人： PAVCNIK, Dusan , KAUFMAN, John, A. , OSBORNE, Thomas , BATES, Brian , PATEL, Umesh , FETTE, Clay, D. , CHIN, Likang , MCALEXANDER, Chad, S. , SHAH, Bhavin
IPC分类号： A61B17/12
CPC分类号： A61B17/12109 , A61B17/00008 , A61B17/12022 , A61B17/12181 , A61B17/32053 , A61B2017/12054 , A61L2430/36
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures are used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment of one or more vascular occlusion devices via a through-and-through percutaneous procedure that leaves the vascular occlusion device or devices in a through-and-through condition.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括经由通过经皮操作的一个或多个血管闭塞装置的部署，其使得血管闭塞装置或穿通状态离开。

5. 发明申请

WO2006050460A1 VASCULAR VALVES HAVING IMPLANTED AND TARGET CONFIGURATIONS AND METHODS OF PREPARING THE SAME 审中-公开
标题翻译：具有植入物和目标配置的血管瓣及其制备方法
公开(公告)号：WO2006050460A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/039835
申请日：2005-10-27
申请人： COOK INCORPORATED , CASE, Brian, C. , FLAGLE, Jacob, A. , GARRISON, Michael, L. , OBERMILLER, F., Joseph , PAVCNIK, Dusan
发明人： CASE, Brian, C. , FLAGLE, Jacob, A. , GARRISON, Michael, L. , OBERMILLER, F., Joseph , PAVCNIK, Dusan
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

6. 发明申请

WO2004082530A2 DELIVERY SYSTEMS AND METHODS FOR DEPLOYING EXPANDABLE INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：用于配置可扩展的内镜医疗装置的递送系统和方法
公开(公告)号：WO2004082530A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/008507
申请日：2004-03-19
申请人： COOK INCORPORATED , GARRISON, Michael, L. , CASE, Brian, C. , HOFFA, Andrew, K. , FLAGLE, Jacob, A. , PAVCNIK, Dusan
发明人： GARRISON, Michael, L. , CASE, Brian, C. , HOFFA, Andrew, K. , FLAGLE, Jacob, A. , PAVCNIK, Dusan
IPC分类号： A61F
CPC分类号： A61F2/95 , A61F2/013 , A61F2/966 , A61F2002/011 , A61F2002/015 , A61F2230/0006 , A61F2230/005
摘要： Methods and devices for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. A portion of a delivery device is spaced from an interior wall surface of the body vessel prior to deployment of the expandable intraluminal device.
摘要翻译：提供了用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置的方法和装置。在部署可膨胀的管腔内装置之前，输送装置的一部分与身体血管的内壁表面间隔开。

7. 发明申请

WO2004103187A1 BODILY LUMEN CLOSURE APPARATUS AND METHOD 审中-公开
标题翻译：身体闭合装置和方法
公开(公告)号：WO2004103187A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/014847
申请日：2004-05-12
申请人： COOK BIOTECH INCORPORATED , OREGON HEALTH and SCIENCE UNIVERSITY , PAVCNIK, Dusan , KAUFMAN, John , FETTE, Clay, D.
发明人： PAVCNIK, Dusan , KAUFMAN, John , FETTE, Clay, D.
IPC分类号： A61B17/00
CPC分类号： A61F2/07 , A61B17/00234 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12118 , A61B17/1219 , A61B2017/00004 , A61B2017/0053 , A61B2017/00637 , A61B2017/00641 , A61B2017/00654 , A61F2/89 , A61F6/225 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/077 , A61F2230/005 , A61F2230/0054
摘要： An absorbable and expandable closure member used to occlude or exclude a body lumen or cavity, such as a blood vessel, fallopian tube, duct, aneurysmal sac, etc., comprising a closure member comprising one of more sheets of a biomaterial that are rolled, stacked, or folded to form a multilayer construct of a generally cylindrical configuration for deployment through a delivery system, either as a singularly or part of a multiplicity of closure members. The biomaterial is derived from a source material, such as small intestinal submucosa or another remodelable material (e.g., an extracellular matrix) having properties for stimulating ingrowth of adjacent tissue into the biomaterial deployed within the bodily lumen. The closure member is deployed to the bodily lumen from a delivery sheath, cartridge, and/or over a inner guiding member, such as a wire guide or catheter.
摘要翻译：一种可吸收和可膨胀的封闭构件，其用于闭塞或排除体腔或腔体，例如血管，输卵管，导管，动脉瘤囊等，其包括封闭构件，该闭合构件包括多个生物材料片材中的一个，堆叠或折叠以形成大致圆柱形构造的多层构造，用于通过输送系统进行部署，作为单个或多个闭合构件的一部分。生物材料衍生自源材料，例如小肠粘膜下层或具有用于刺激相邻组织的向内生长进入体内部署的生物材料的特性的另一种可重塑材料（例如细胞外基质）。封闭构件从输送护套，药筒和/或内部引导构件（例如电线引导件或导管）部署到身体管腔。

8. 发明授权

EP0614342B1 CLOSURE PROSTHESIS FOR TRANSCATHETER PLACEMENT 失效转让
标题翻译：闭幕移植导管放置
公开(公告)号：EP0614342B1
公开(公告)日：1999-07-14
申请号：EP92925402.7
申请日：1992-11-25
申请人： WILLIAM COOK EUROPE A/S , PAVCNIK, Dusan , WALLACE, Sidney , WRIGHT, Kenneth C.
发明人： PAVCNIK, Dusan , WALLACE, Sidney , WRIGHT, Kenneth C.
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/0057 , A61B17/12109 , A61B17/12172 , A61B2017/00637 , A61B2017/00659
摘要： A closure prosthesis and transcatheter delivery system are disclosed, wherein the closure prosthesis seals across an opening of a fluid passageway within a living body. The closure prosthesis is a flexible disk (10) including a flexible ring (12) and diaphragm (14) having a plurality of hollow flexible wire segments (18) attached thereto. Delivery of the closure prosthesis is accomplished using a hollow sheath (26) and a pusher catheter (28) slidable within the sheath, wherein filaments are looped through the wire segments to releasably connect the disk to the pusher catheter. The disk is resiliently compressed within the sheath and, upon release therefrom, the disk resiliently expands into a larger, unrestrained shape. Tension applied to the filaments resiliently bends the wire segments so that they may be drawn through the opening of the defect. Upon releasing the filaments from the disk, the wire segements resiliently expand to trap the disk in place to seal across the opening.

9. 发明授权

EP2627265B8 OCCLUSION DEVICE FOR BLOCKING FLUID FLOW THROUGH BODILY PASSAGES 有权
公开(公告)号：EP2627265B8
公开(公告)日：2019-02-20
申请号：EP11774164.5
申请日：2011-10-14
申请人： Cook Medical Technologies LLC , Oregon Health & Science University
发明人： SHIRLEY, Brad , RANDOLPH, J., R. , PAVCNIK, Dusan , KELLER, Frederick , THEOBALD, Elizabeth , CHAMBERS, Sean , PAUL, Ram
IPC分类号： A61B17/12

10. 发明公开

EP0614342A1 CLOSURE PROSTHESIS FOR TRANSCATHETER PLACEMENT 失效转让
标题翻译：闭幕移植导管放置。
公开(公告)号：EP0614342A1
公开(公告)日：1994-09-14
申请号：EP92925402.0
申请日：1992-11-25
申请人： WILLIAM COOK EUROPE A/S , PAVCNIK, Dusan , WALLACE, Sidney , WRIGHT, Kenneth C.
发明人： PAVCNIK, Dusan , WALLACE, Sidney , WRIGHT, Kenneth C.
IPC分类号： A61B17
CPC分类号： A61B17/12022 , A61B17/0057 , A61B17/12109 , A61B17/12172 , A61B2017/00637 , A61B2017/00659
摘要： Prothèse de fermeture et système de mise en place par l'intermédiaire d'un cathéter, selon lesquels la prothèse de fermeture ferme hermétiquement l'ouverture d'un passage de liquide dans un corps vivant. Ladite prothèse de fermeture est un disque souple (10) comportant un anneau souple (12) et un diaphragme (14) doté d'une pluralité de segments de fil souple creux (18) attachés audit diaphragme. La mise en place de la prothèse de fermeture s'effectue à l'aide d'une gaine creuse (26) et d'un cathéter poussoir (28) coulissant à l'intérieur de la gaine, des filaments étant disposés en boucle à travers les segments de fil de manière à relier de façon libérable le disque au cathéter poussoir. Le disque est comprimé de manière souple au sein de la gaine et lorsqu'il est libéré de ladite gaine, il s'étend pour prendre une forme plus grande et non comprimée. La tension appliquée sur les filaments courbe de manière souple les segments de fil de façon à ce qu'ils puissent être passés à travers l'ouverture défectueuse. Lorsque les filaments sont détachés du disque, les segments de fil s'étendent de manière souple afin de coincer le disque en place de façon à obstruer l'ouverture.

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