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1. 发明申请

WO2004016200A1 IMPLANTABLE VASCULAR DEVICE 审中-公开
标题翻译：可植入血管装置
公开(公告)号：WO2004016200A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025794
申请日：2003-08-15
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY , MED INSTITUTE, INC. , WILLIAM COOK EUROPE ApS
发明人： PAVCNIK, Dusan , CASE, Brian, L. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Raymond, B., II , OSBORNE, Thomas, A. , PAUL, Ram, H., Jr. , SCHAEFFER, Darin, G. , SISKEN, Richard, B.
IPC分类号： A61F2/06
CPC分类号： C25F3/24 , A61F2/2418 , A61F2/2439 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0091 , A61F2230/0095
摘要： A valve prosthesis (43), such as an artificial venous valve, having a support frame (11) and leaf structure comprising one or more leaflets (78, 79) in which the outer edge (112) of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements (31, 32) can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure (164) comprises a second or third expandable frames (31, 32) attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：具有支撑框架（11）和叶结构的瓣膜假体（43），例如人造静脉瓣，叶片结构包括一个或多个传单（78,79），其中每个小叶的外边缘（112）沿着蛇形路径的身体通道通过可扩张的框架被推靠在通道上，而内边缘响应于流体而移动以限制逆行流动。可选地，一个或多个元件（31,32）可以从支撑框架/叶片结构延伸，以提供定位支撑和/或保护免受附着在血管壁上的小叶。在一个实施例中，定心支撑结构（164）包括附接到主阀结构和支撑框架的近端和/或远端并从其延伸的第二或第三可膨胀框架（31,32）。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

2. 发明申请

WO2003045275A2 MEDICAL DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：医疗器械输送系统
公开(公告)号：WO2003045275A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/038289
申请日：2002-11-27
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.
摘要翻译：一种用于将诸如静脉瓣的医疗装置（30）植入患者脉管系统的输送系统（10）。递送系统包括具有与其远端（14）相邻的装置容纳部分（15）的输送导管（11）和延伸穿过导管并超出其远端的内部构件（16）到无创伤远端尖端部分（17）在导管远端的前方。内部构件在包含装置的区域中延伸通过医疗装置，包括具有足够大直径的近端部分（18），以在导管在展开期间缩回时防止装置的纵向移动，并且使得装置在从远端导管在部署期间结束。内部构件优选地是设备下方的射线可透以与装置的不透射线标记（43）形成对比。内部构件优选地包括从装置容纳部分延伸到近端（22）的平坦部分（35），以与输送导管形成通道或内腔（21），以将保湿流体传送到装置，例如包含在患者植入之前立即需要水合的冻干组织。

3. 发明申请

WO2003045275A3 MEDICAL DEVICE DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2003045275A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/038289
申请日：2002-11-27
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/06
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.

4. 发明授权

EP1465546B1 MEDICAL DEVICE DELIVERY SYSTEM 有权
标题翻译：医疗设备输送系统
公开(公告)号：EP1465546B1
公开(公告)日：2007-07-18
申请号：EP02799890.5
申请日：2002-11-27
申请人： Cook Incorporated , Oregon Health and Science University
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.

5. 发明公开

EP1465546A2 MEDICAL DEVICE DELIVERY SYSTEM 有权
标题翻译：医疗设备输送系统
公开(公告)号：EP1465546A2
公开(公告)日：2004-10-13
申请号：EP02799890.5
申请日：2002-11-27
申请人： Cook Incorporated , Oregon Health and Science University
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.

6. 发明申请

WO2004016201A2 STENT AND METHOD OF FORMING A STENT WITH INTEGRAL BARBS 审中-公开
标题翻译：形成具有综合棒的手套的方法和方法
公开(公告)号：WO2004016201A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025827
申请日：2003-08-15
申请人： COOK INCORPORATED , WILLIAM COOK EUROPE APS , WILLIAM A. COOK AUSTRALIA PTY. LTD.
发明人： CASE, Brian, L. , COOK, William, A. , DEBRYUYNE, Michael, P. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , KELLER, Frederick, S. , LEONARD, Raymond, B., II , MEAD, Jason, A. , NICKLESS, Benjamin , OSBORNE, Thomas, A. , PAUL, Ram, H., Jr. , PAVCNIK, Dusan , ROSCH, Josef , SHAEFFER, Darin, G. , SISKEN, Richard, B.
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/07 , A61F2/2412 , A61F2/2418 , A61F2/848 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/005 , A61F2230/0054 , A61F2230/0058 , A61F2230/0091 , A61F2230/0095 , A61F2250/0031 , C25F3/24
摘要： A method for manufacturing a barbed stent includes providing a sheet of stent material, cutting the sheet to form a stent wire with integral barbs extending therefrom, and forming the stent wire into a final stent shape having a longitudinal axis. A stent for deployment within the body of a patient includes integral barbs.
摘要翻译：一种用于制造有肋的支架的方法包括提供支架材料的片材（152），切割片材以形成具有从其延伸的整体倒钩（124）的支架丝线，并将支架丝线形成为具有纵向轴线的最终支架形状。用于在患者体内展开的支架包括一体倒钩。

7. 发明申请

WO2008036314A2 APPARATUS AND METHODS FOR IN SITU EMBOLIC PROTECTION 审中-公开
标题翻译：装置和方法用于疫苗保护
公开(公告)号：WO2008036314A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/020300
申请日：2007-09-19
申请人： COOK INCORPORATED , DEBRUYNE, Michael, P. , HOFFA, Andrew, K. , MELSHEIMER, Jeffry, S. , REEVES, Sarah, E.
发明人： DEBRUYNE, Michael, P. , HOFFA, Andrew, K. , MELSHEIMER, Jeffry, S. , REEVES, Sarah, E.
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84
CPC分类号： A61F2/013 , A61F2/07 , A61F2/95 , A61F2/958 , A61F2002/011 , A61F2002/075 , A61F2002/8486 , A61F2250/0048
摘要： The present invention provides apparatus and methods for treating a vascular condition by restoring patency to a vessel while reducing the likelihood that emboli become dislodged into the bloodstream. In a first embodiment, the apparatus comprises a graft having proximal and distal regions, a first support member attached to the distal region of the graft, and a second support member attached to the proximal region of the graft. The first and second support members may comprise first and second stents, respectively. The first stent is deployed distal to a vascular condition, and the second stent is deployed proximal to a vascular condition, such that the graft spans the length of the vascular condition to entrap emboli during treatment of the vascular condition. In an alternative embodiment, the first stent is adapted to be deployed within a vessel at a location distal to the vascular condition, and the graft is adapted to be everted to form a pocket adapted to entrap emboli dislodged during treatment of the vascular condition. The second stent then may be subsequently deployed proximal to the vascular condition, such that emboli trapped within the graft pocket are effectively sealed off from the bloodstream.
摘要翻译：本发明提供了通过恢复对血管的通畅来治疗血管病变的装置和方法，同时降低栓塞进入血流的可能性。在第一实施例中，该装置包括具有近端区域和远端区域的移植物，附接到移植物的远侧区域的第一支撑构件和附接到移植物的近端区域的第二支撑构件。第一和第二支撑构件可以分别包括第一和第二支架。第一个支架部署在血管状态的远端，第二个支架部署在血管状态附近，使得移植物跨越血管状态的长度，以在治疗血管疾病期间截留栓塞。在替代实施例中，第一支架适于在位于远离血管状态的位置处的血管内展开，并且移植物适于被转动以形成适于在治疗血管状况期间阻塞栓塞移出的口袋。然后第二支架随后可以部署在血管状态附近，使得捕获在移植物袋内的栓塞被有效地从血流中密封。

8. 发明申请

WO2004093745A1 DEVICES KITS, AND METHODS FOR PLACING MULTIPLE INTRALUMINAL MEDICAL DEVICES IN A BODY VESSEL 审中-公开
标题翻译：装置套件以及用于在身体容器中放置多个内部医疗装置的方法
公开(公告)号：WO2004093745A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/012685
申请日：2004-04-23
申请人： COOK INCORPORATED , HOFFA, Andrew, K. , FLAGLE, Jacob, A. , GARRISON, Michael, L.
发明人： HOFFA, Andrew, K. , FLAGLE, Jacob, A. , GARRISON, Michael, L.
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/2412 , A61F2/2436 , A61F2/2475 , A61F2002/826
摘要： Devices, kits, and methods for delivering multiple intraluminal medical devices into a body vessel are provided.
摘要翻译：提供了将多个管腔内医疗装置输送到体内容器中的装置，试剂盒和方法。

9. 发明申请

WO2001056500A3 IMPLANTABLE VASCULAR DEVICE 审中-公开
公开(公告)号：WO2001056500A3
公开(公告)日：2001-08-09
申请号：PCT/US2001/003766
申请日：2001-02-05
申请人： COOK INCORPORATED , COOK BIOTECH, INC.
发明人： PAVCNIK, Dusan , KELLER, Frederick, S. , ROSCH, Josef , OSBORNE, Thomas, A. , BATES, Brian, L. , DEFORD, John, A. , DIXON, Christopher, G. , HOFFA, Andrew, K. , LEONARD, Raymond, B., II , OBERMILLER, Joseph, F.
IPC分类号： A61F2/24
摘要： A multiple-sided medical device (10) comprises a frame (11) comprising wire or other resilient material and having a series of bends (12) and interconnecting sides. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs (16) for anchoring purposes. A full or partial covering (45) of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device (51), a stent graft (75), or an implantable, intraluminal valve (43) such as for correcting incompetent veins in the lower legs and feet.

10. 发明申请

WO2011017423A1 FLEXIBLE MEDICAL DEVICE FOR CLOT REMOVAL FROM SMALL VESSELS 审中-公开
标题翻译：灵活的医疗设备，用于从小容器中取出衣物
公开(公告)号：WO2011017423A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/044398
申请日：2010-08-04
申请人： COOK INCORPORATED , HOFFA, Andrew, K.
发明人： HOFFA, Andrew, K.
IPC分类号： A61M25/00
CPC分类号： A61M25/0023 , A61B17/22 , A61B2017/22038 , A61B2017/22079 , A61B2017/22084 , A61M25/0045 , A61M25/0053 , A61M25/0054 , A61M2025/0042
摘要： A medical device for applying drugs and to remove thrombus or soft tissue clots from vascular or other lumens in a patient is presented. The medical device generally comprises an elongated tubular delivery member having a proximal portion and a distal portion that differ in rigidity and a leak-free connector that is in contact with the proximal portion of the delivery member and is compatible for use with fibrinolytic agents and application of a vacuum. The delivery member includes a metal core made out of multiple shaped-wire strands and a polymer overlay disposed about the core. The wire strands, which have both an A-side and a B-side, are helically wound to form a polygonal shaped lumen whose inner diameter is defined by the A-side of the strands.
摘要翻译：提出了一种用于施用药物并从患者血管或其他腔内去除血栓或软组织血块的医疗装置。医疗装置通常包括细长的管状递送构件，其具有刚性差异的近端部分和远端部分，以及与输送构件的近端部分接触并且与纤维蛋白溶解剂和应用相容的渗漏连接器的真空。递送构件包括由多个成形线股线制成的金属芯和围绕芯部设置的聚合物覆层。具有A侧和B侧的线股线被螺旋缠绕以形成其内径由股线的A侧限定的多边形管腔。

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