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1. 发明申请

WO2004016200A1 IMPLANTABLE VASCULAR DEVICE 审中-公开
标题翻译：可植入血管装置
公开(公告)号：WO2004016200A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025794
申请日：2003-08-15
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY , MED INSTITUTE, INC. , WILLIAM COOK EUROPE ApS
发明人： PAVCNIK, Dusan , CASE, Brian, L. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Raymond, B., II , OSBORNE, Thomas, A. , PAUL, Ram, H., Jr. , SCHAEFFER, Darin, G. , SISKEN, Richard, B.
IPC分类号： A61F2/06
CPC分类号： C25F3/24 , A61F2/2418 , A61F2/2439 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0091 , A61F2230/0095
摘要： A valve prosthesis (43), such as an artificial venous valve, having a support frame (11) and leaf structure comprising one or more leaflets (78, 79) in which the outer edge (112) of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements (31, 32) can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure (164) comprises a second or third expandable frames (31, 32) attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：具有支撑框架（11）和叶结构的瓣膜假体（43），例如人造静脉瓣，叶片结构包括一个或多个传单（78,79），其中每个小叶的外边缘（112）沿着蛇形路径的身体通道通过可扩张的框架被推靠在通道上，而内边缘响应于流体而移动以限制逆行流动。可选地，一个或多个元件（31,32）可以从支撑框架/叶片结构延伸，以提供定位支撑和/或保护免受附着在血管壁上的小叶。在一个实施例中，定心支撑结构（164）包括附接到主阀结构和支撑框架的近端和/或远端并从其延伸的第二或第三可膨胀框架（31,32）。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

2. 发明申请

WO2003045275A2 MEDICAL DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：医疗器械输送系统
公开(公告)号：WO2003045275A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/038289
申请日：2002-11-27
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.
摘要翻译：一种用于将诸如静脉瓣的医疗装置（30）植入患者脉管系统的输送系统（10）。递送系统包括具有与其远端（14）相邻的装置容纳部分（15）的输送导管（11）和延伸穿过导管并超出其远端的内部构件（16）到无创伤远端尖端部分（17）在导管远端的前方。内部构件在包含装置的区域中延伸通过医疗装置，包括具有足够大直径的近端部分（18），以在导管在展开期间缩回时防止装置的纵向移动，并且使得装置在从远端导管在部署期间结束。内部构件优选地是设备下方的射线可透以与装置的不透射线标记（43）形成对比。内部构件优选地包括从装置容纳部分延伸到近端（22）的平坦部分（35），以与输送导管形成通道或内腔（21），以将保湿流体传送到装置，例如包含在患者植入之前立即需要水合的冻干组织。

3. 发明申请

WO2003045275A3 MEDICAL DEVICE DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2003045275A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/038289
申请日：2002-11-27
申请人： COOK INCORPORATED , OREGON HEALTH AND SCIENCE UNIVERSITY
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/06
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.

4. 发明授权

EP1465546B1 MEDICAL DEVICE DELIVERY SYSTEM 有权
标题翻译：医疗设备输送系统
公开(公告)号：EP1465546B1
公开(公告)日：2007-07-18
申请号：EP02799890.5
申请日：2002-11-27
申请人： Cook Incorporated , Oregon Health and Science University
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.

5. 发明申请

WO2004024032A1 RETRIEVABLE FILTER 审中-公开
标题翻译：可检索过滤器
公开(公告)号：WO2004024032A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/028679
申请日：2003-09-12
申请人： COOK INCORPORATED , WILLIAM COOK EUROPE APS
发明人： PAVCNIK, Dusan , CASE, Brian, C. , KAUFMAN, John, A. , GARRISON, Michael, L. , FLAGLE, Jacob, A.
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067
摘要： A long-term retrievable, permanent blood filtration unit is to be implanted in a vessel of a patient's body, particularly for capturing blood clots, comprising a filter, a stent and a locking mechanism for releasably attaching the filter to the stent.
摘要翻译：将长期可回收的永久性血液过滤单元植入患者身体的容器中，特别是用于捕获血块，包括过滤器，支架和用于将过滤器可释放地附接到支架的锁定机构。

6. 发明公开

EP1465546A2 MEDICAL DEVICE DELIVERY SYSTEM 有权
标题翻译：医疗设备输送系统
公开(公告)号：EP1465546A2
公开(公告)日：2004-10-13
申请号：EP02799890.5
申请日：2002-11-27
申请人： Cook Incorporated , Oregon Health and Science University
发明人： PAVCNIK, Dusan , CASE, Brian, C. , DIXON, Christopher, G. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , LEONARD, Ray, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.

7. 发明申请

WO2004016201A2 STENT AND METHOD OF FORMING A STENT WITH INTEGRAL BARBS 审中-公开
标题翻译：形成具有综合棒的手套的方法和方法
公开(公告)号：WO2004016201A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025827
申请日：2003-08-15
申请人： COOK INCORPORATED , WILLIAM COOK EUROPE APS , WILLIAM A. COOK AUSTRALIA PTY. LTD.
发明人： CASE, Brian, L. , COOK, William, A. , DEBRYUYNE, Michael, P. , FLAGLE, Jacob, A. , GARRISON, Mike , HOFFA, Andrew, K. , KELLER, Frederick, S. , LEONARD, Raymond, B., II , MEAD, Jason, A. , NICKLESS, Benjamin , OSBORNE, Thomas, A. , PAUL, Ram, H., Jr. , PAVCNIK, Dusan , ROSCH, Josef , SHAEFFER, Darin, G. , SISKEN, Richard, B.
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/07 , A61F2/2412 , A61F2/2418 , A61F2/848 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/005 , A61F2230/0054 , A61F2230/0058 , A61F2230/0091 , A61F2230/0095 , A61F2250/0031 , C25F3/24
摘要： A method for manufacturing a barbed stent includes providing a sheet of stent material, cutting the sheet to form a stent wire with integral barbs extending therefrom, and forming the stent wire into a final stent shape having a longitudinal axis. A stent for deployment within the body of a patient includes integral barbs.
摘要翻译：一种用于制造有肋的支架的方法包括提供支架材料的片材（152），切割片材以形成具有从其延伸的整体倒钩（124）的支架丝线，并将支架丝线形成为具有纵向轴线的最终支架形状。用于在患者体内展开的支架包括一体倒钩。

8. 发明申请

WO2009009466A1 TUBULAR DEVICES HAVING REVERSIBLE COMPONENTS FOR DEPLOYMENT OF ENDOLUMINAL OCCLUDERS AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：具有用于分泌内分泌系统的可逆组分的管状装置及相关方法和系统
公开(公告)号：WO2009009466A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069290
申请日：2008-07-07
申请人： COOK INCORPORATED , PAUL, Ram, H., Jr. , FLAGLE, Jacob, A. , CASE, Brian, C.
发明人： PAUL, Ram, H., Jr. , FLAGLE, Jacob, A. , CASE, Brian, C.
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12136 , A61B17/12181 , A61B17/1219 , A61B17/3468 , A61B2017/1205
摘要： Described are devices, methods, and systems useful for deploying one or more occlusive prostheses within the vasculature of a patient. Illustrative devices can include a deployment tube or sheath that contains an occlusive prosthesis, wherein a segment of the sheath is reversible by a user so as to deploy the prosthesis from the sheath lumen within a bodily lumen of a patient.
摘要翻译：描述了用于在患者的脉管系统内部署一个或多个闭塞假体的装置，方法和系统。示例性装置可以包括包含闭塞假体的展开管或护套，其中护套的一部分可由使用者逆转，以便将该假体从皮肤内腔部署到患者体内。

9. 发明申请

WO2006028821A1 DELIVERY SYSTEM WHICH FACILITATES HYDRATION OF AN INTRALUMINAL MEDICAL DEVICE 审中-公开
标题翻译：促进肝内医疗器械水分化的输送系统
公开(公告)号：WO2006028821A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/030861
申请日：2005-08-31
申请人： COOK INCORPORATED , CASE, Brian, C. , FLAGLE, Jacob, A. , RAM, Paul, H. , SCHAEFFER, Darin, G.
发明人： CASE, Brian, C. , FLAGLE, Jacob, A. , RAM, Paul, H. , SCHAEFFER, Darin, G.
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/2436 , A61F2/95 , A61F2002/011 , A61F2002/9583
摘要： Delivery systems and methods of making delivery systems are provided. A delivery system facilitates hydration of an intraluminal medical device disposed within a device chamber of the delivery system.
摘要翻译：提供了交付系统和交付系统的方法。递送系统促进置于输送系统的装置室内的管腔内医疗装置的水合。

10. 发明申请

WO2006113863A2 MEDICAL APPARATUS FOR RAPID INSERTION 审中-公开
标题翻译：医疗器械用于快速插入
公开(公告)号：WO2006113863A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014864
申请日：2006-04-20
申请人： COOK INCORPORATED , PAL, Dharmendra , AGNEW, Charles, W. , FLAGLE, Jacob, A. , LENTZ, D., Christian , MELSHEIMER, Jeffry, S. , OSBORNE, Thomas, A. , PARKER, Fred, T.
发明人： PAL, Dharmendra , AGNEW, Charles, W. , FLAGLE, Jacob, A. , LENTZ, D., Christian , MELSHEIMER, Jeffry, S. , OSBORNE, Thomas, A. , PARKER, Fred, T.
CPC分类号： A61M25/0662 , A61F2/95 , A61F2002/9517 , A61M25/0045 , A61M25/005 , A61M25/0053
摘要： Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.
摘要翻译：提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其他医疗器械通过的后膛位置开口的过渡区域附近。外部构件相对于内部构件可轴向滑动以展开自扩张装置。还提供了使用和制造方法。

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