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1. 发明申请

WO2010014469A3 SUBCUTANEOUS IMPLANTABLE LEAD WITH LEADING END 审中-公开
标题翻译：具有领先优势的轻便可伸缩领先
公开(公告)号：WO2010014469A3
公开(公告)日：2010-07-22
申请号：PCT/US2009051371
申请日：2009-07-22
申请人： MEDTRONIC INC , HAVEL WILLIAM J , LAZEROMS MARKUS J , RUTTEN JEAN JOSEPH GERARDUS , SMITS KAREL F A A
发明人： HAVEL WILLIAM J , LAZEROMS MARKUS J , RUTTEN JEAN JOSEPH GERARDUS , SMITS KAREL F A A
IPC分类号： A61N1/39 , A61N1/05
CPC分类号： A61N1/0504 , A61N1/3962
摘要： A subcutaneous implantable device is provided that includes a defibrillation electrode disposed along a portion of a lead, and a lead tip connected to the lead. The lead tip includes a trailing end coupled to a distal end of the lead, and first and second non-parallel sides extending from the trailing end that converge to a leading end that is configured to wedge between tissue layers as the lead is advanced subcutaneously.
摘要翻译：提供了一种皮下可植入装置，其包括沿引线的一部分设置的除颤电极和连接到引线的引线头。引导尖端包括联接到引线的远端的尾端以及从后端延伸的第一和第二非平行侧，所述后端会聚到前端，当引导皮下进行时，构造成在组织层之间楔入。

2. 发明申请

WO03020364A2 IMPLANTABLE MEDICAL DEVICE FOR TREATING CARDIAC MECHANICAL DYSFUNCTION BY ELECTRICAL STIMULATION 审中-公开
标题翻译：通过电刺激治疗心脏机械性功能障碍的可植入医疗器械
公开(公告)号：WO03020364A2
公开(公告)日：2003-03-13
申请号：PCT/US0227924
申请日：2002-08-28
申请人： MEDTRONIC INC
发明人： DENO CURTIS D , HAVEL WILLIAM J , BENNETT TOM D , STEIN PAUL M , EULER DAVID E
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/0408 , A61B5/0478 , A61B5/0492 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/37 , A61N1/39 , A61N1/00
CPC分类号： A61N1/3956 , A61N1/36014 , A61N1/36114 , A61N1/3625 , A61N1/3627 , A61N1/36585 , A61N1/3706
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction.
摘要翻译：据信上述方法和装置对患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益被指示。应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。本发明提供用于递送心脏血液动力学功能障碍治疗的系统和方法。

3. 发明申请

WO2004041354A8 RESPIRATORY NERVE STIMULATION 审中-公开
标题翻译：呼吸神经刺激
公开(公告)号：WO2004041354A8
公开(公告)日：2005-04-07
申请号：PCT/US0333901
申请日：2003-10-27
申请人： MEDTRONIC INC
发明人： CASAVANT DAVID A , HAVEL WILLIAM J
IPC分类号： A61N1/05 , A61N1/36 , A61N1/365
CPC分类号： A61N1/3601 , A61N1/365 , A61N2001/0585
摘要： The invention is directed to an implantable medical device that stimulates a nerve associated with respiration. The nerve may, for example be a phrenic nerve, and the stimulation may cause a diaphragm of the patient to contract. The implantable medical device receives a signal that indicates a need for increased cardiac output and stimulates the nerve in response to the signal. The implantable medical device may receive such a signal by, for example, detecting a ventricular tachyarrhythmia, sensing a pressure that indicates a need for increased cardiac output, or receiving a signal from a patient via a patient activator. Stimulation of the nerve may increase cardiac output of a beating or defibrillating heart
摘要翻译：本发明涉及刺激与呼吸相关的神经的可植入医疗装置。神经可能例如是膈神经，并且刺激可能导致患者的隔膜收缩。该可植入医疗装置接收一信号，该信号指示需要增加心输出量并响应信号刺激神经。可植入医疗装置可以通过例如检测心室快速性心律失常，感测指示增加心输出量的需要的压力或者经由患者激活器从患者接收信号来接收这种信号。刺激神经可能会增加心脏输出的跳动或除颤心脏

4. 发明申请

WO2006105458A8 METHOD OF OPTIMIZING MECHANICAL HEART RATE DURING DELIVERY OF COUPLED OR PAIRED PACING 审中-公开
标题翻译：联动或配对交付期间优化机械心率的方法
公开(公告)号：WO2006105458A8
公开(公告)日：2007-02-08
申请号：PCT/US2006012129
申请日：2006-03-30
申请人： MEDTRONIC INC , HAVEL WILLIAM J , KRAUSE PAUL G , KLECKNER KAREN J , DENO D CURTIS
发明人： HAVEL WILLIAM J , KRAUSE PAUL G , KLECKNER KAREN J , DENO D CURTIS
IPC分类号： A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/37

5. 发明申请

WO03047685B1 CONTROL OF ARBITRARY WAVEFORMS FOR CONSTANT DELIVERED ENERGY 审中-公开
公开(公告)号：WO03047685B1
公开(公告)日：2003-10-30
申请号：PCT/US0240037
申请日：2002-12-03
申请人： MEDTRONIC INC
发明人： HAVEL WILLIAM J , DEGROOT PAUL J , SINNER THOMAS W , KUEHN KEVIN , KEMMETMUELLER GARY , WOLD WARREN W
IPC分类号： A61B5/05 , A61N1/04 , A61N1/08 , A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrary waveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.

6. 发明申请

WO2009088745A3 APPARATUS AND METHOD FOR NON-INVASIVE INDUCTION OF VENTRICULAR FIBRILLATION 审中-公开
标题翻译：用于非侵入性诱发静脉穿刺的装置和方法
公开(公告)号：WO2009088745A3
公开(公告)日：2009-09-11
申请号：PCT/US2008088008
申请日：2008-12-22
申请人： MEDTRONIC INC , NIKOLSKI VLADIMIR P , HAVEL WILLIAM J , SULLIVAN JOSEPH L , PIRAINO DANIEL W , WILLIAMS ERIC R
发明人： NIKOLSKI VLADIMIR P , HAVEL WILLIAM J , SULLIVAN JOSEPH L , PIRAINO DANIEL W , WILLIAMS ERIC R
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/3943 , A61N1/3962
摘要： An apparatus and method for delivering an external shock pulse receive pacing pulses generated by a first device and a shock pulse generated by a second device. An output of the apparatus is coupled to patient electrodes and the apparatus controls delivery of the received pacing pulses to the output and delivery of the received shock pulse to the output. A control module, pacing control and shock control included in the apparatus cooperatively control delivery of the received shock pulse to the output at a predetermined delay after one of the received pacing pulses.
摘要翻译：用于递送外部冲击脉冲的装置和方法接收由第一装置产生的起搏脉冲和由第二装置产生的冲击脉冲。该装置的输出耦合到患者电极，并且该装置控制接收到的起搏脉冲的输出并输出接收到的冲击脉冲。装置中包括的控制模块，起搏控制和冲击控制协调地控制接收到的冲击脉冲在一个接收的起搏脉冲之后以预定延迟输出到输出端。

7. 发明申请

WO03020364A9 IMPLANTABLE MEDICAL DEVICE FOR TREATING CARDIAC MECHANICAL DYSFUNCTION BY ELECTRICAL STIMULATION 审中-公开
标题翻译：通过电刺激治疗心脏机械性功能障碍的可植入医疗设备
公开(公告)号：WO03020364A9
公开(公告)日：2004-04-08
申请号：PCT/US0227924
申请日：2002-08-28
申请人： MEDTRONIC INC
发明人： DENO CURTIS D , HAVEL WILLIAM J , BENNETT TOM D , STEIN PAUL M , EULER DAVID E
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/0408 , A61B5/0478 , A61B5/0492 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/37 , A61N1/39 , A61N1/368
CPC分类号： A61N1/3956 , A61N1/36014 , A61N1/36114 , A61N1/3625 , A61N1/3627 , A61N1/36585 , A61N1/3706
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction.
摘要翻译：据信上述方法和设备对于患有心力衰竭的患者特别有益，所述患者包括心脏功能障碍，慢性HF等，以及本文所述的所有变体，包括本发明所属领域的技术人员已知的那些是指示。应该理解，本发明提供了监测和治疗各种急性和慢性心脏功能障碍的可能性。本发明提供了用于治疗心脏血液动力学功能障碍的系统和方法。

8. 发明申请

WO03047685A2 CONTROL OF ARBITRARY WAVEFORMS FOR CONSTANT DELIVERED ENERGY 审中-公开
标题翻译：用于恒定供应能量的仲裁波的控制
公开(公告)号：WO03047685A2
公开(公告)日：2003-06-12
申请号：PCT/US0240037
申请日：2002-12-03
申请人： MEDTRONIC INC
发明人： HAVEL WILLIAM J , DEGROOT PAUL J , SINNER THOMAS W , KUEHN KEVIN , KEMMETMUELLER GARY , WOLD WARREN W
IPC分类号： A61B5/05 , A61N1/04 , A61N1/08 , A61N1/39 , A61N
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrary waveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.
摘要翻译：本发明概述了通过自动补偿由可植入式心律转复除颤器（ICD）检测的负载阻抗来向患者传送可控量的能量的结构和方法。本发明采用高速，开关电源转换器技术，高效生成高能量，任意波形。与线性放大器不同，开关电源转换器提供高能量波形，效率与所需波形的大小和幅度无关。使用开关功率转换器将期望的能量递送到患者的ICD存储要在存储电容器中传递的能量。然后，转换器通过以高速率切换存储电容器输入和输出输出电路，将该能量转换成任意形状的输出电压控制或电流控制波形。优选地，波形包括斜坡型波形。

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