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1. 发明申请

WO2004026397A8 PREFERRED ADI/R: A PERMANENT PACING MODE TO ELIMINATE VENTRICULAR PACING WHILE MAINTAINING BACKUP SUPPORT 审中-公开
标题翻译：优先ADI / R：在维护备份支持时消除静脉瓣的永久开放模式
公开(公告)号：WO2004026397A8
公开(公告)日：2004-06-24
申请号：PCT/US0329154
申请日：2003-09-16
申请人： MEDTRONIC INC
发明人： CASAVANT DAVID A , MULLEN THOMAS J , BELK PAUL , STROEBEL JOHN C
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3688
摘要： A preferred atrial-based pacing method and apparatus is provided using an intelligent cardiac pacing system to having the ability to continue atrial-based pacing as long as relatively reliable AV conduction is present. In the event that such relatively reliable AV conduction is not present, mode switching to a DDD/R or a DDI/R pacing mode while continually biased to mode switch back to atrial-based pacing. The standard or relatively reliable AV conduction may be changed either automatically or manually. This increases pacing that utilizes natural AV conduction however possible so as to gain all the benefits of cardiac contractile properties resulting therefrom, while tolerating the occasional missed ventricular depolarization (i.e., non-conducted P-wave). In the event where relatively reliable AV conduction is not present, the pacing mode is switched to a DDD/R mode while detecting a return of the relatively reliable AV conduction (and resulting mode switch to preferred atrial based pacing).
摘要翻译：只要存在相对可靠的AV传导，使用智能心脏起搏系统提供优选的基于心房的起搏方法和装置，以具有继续心房起搏的能力。在不存在这种相对可靠的AV传导的情况下，模式切换到DDD / R或DDI / R起搏模式，同时不断偏向模式切换回基于心房的起搏。标准或相对可靠的AV传导可以自动或手动改变。这增加了使用自然AV传导的起搏，尽可能地获得心脏收缩性质的所有益处，同时容忍偶尔的心室去极化（即，未传导的P波）。在不存在相对可靠的AV导通的情况下，起搏模式被切换到DDD / R模式，同时检测相对可靠的AV导通的返回（并且导致的模式切换到优选的基于心房的起搏）。

2. 发明申请

WO2006057754A2 SELF LIMITED RATE RESPONSE 审中-公开
标题翻译：自我有限的速度反应
公开(公告)号：WO2006057754A2
公开(公告)日：2006-06-01
申请号：PCT/US2005038419
申请日：2005-10-25
申请人： MEDTRONIC INC , BELK PAUL A , CASAVANT DAVID A
发明人： BELK PAUL A , CASAVANT DAVID A
IPC分类号： A61N1/37
CPC分类号： A61N1/37 , A61N1/368
摘要： Rate responsive pacing is limited in an atrial based pacing mode by the AV interval in order to avoid or minimize ventricular encroachment of atrial pacing. The AV or VA interval is used to permit rate responsiveness; modulate rate responsiveness or to determine a dynamic upper sensor rate.
摘要翻译：心房起搏模式下房速反应性起搏受AV间期限制，以避免或最小化心房起搏的心室侵犯。 AV或VA间隔用于允许速率响应; 调制速率响应性或确定动态上传感器速率。

3. 发明申请

WO03103767B1 METHOD TO PREVENT PACEMAKER INDUCED NON-REENTRANT VA SYNCHRONY USING ADAPTIVE ATRIAL PACING OUTPUT 审中-公开
标题翻译：使用自适应ATRIAL PAC输出的方法预防诱导型非依赖性VA同步物
公开(公告)号：WO03103767B1
公开(公告)日：2004-03-04
申请号：PCT/US0318329
申请日：2003-06-10
申请人： MEDTRONIC INC
发明人： CASAVANT DAVID A , SWEENEY MICHAEL D , BETZOLD ROBERT A
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3688
摘要： The present invention is directed to the problem of preventing episodes of "AV Desynchronization Arrhythmia" (AVDA), a dual-chamber pacing behavior that is initiated by a PVC or other ventricular event that is not closely preceded by an atrial depolarization event. If the initiating PVC creates retrograde conduction resulting in an atrial refractory-sensed event, and should the succeeding AP fail to capture due to pacing within the atrial (physiological) refractory period (ARP) a repetitive AVDA pattern (of APineffectual - VP - ARrefractory) can persist for an extended period of time during which symptoms of pacemaker syndrome can occur. According to the present invention, after detection of AVDA, the following may occur: an dynamically increased magnitude of delivered atrial pacing energy, a delay interval may be increased to allow the atrial myocardial tissue to recover, a pacing modality mode-switch, a patient notification, record or process a histogram, and/or a combination thereof may be used in response to detection of a deleterious AVDA sequence.
摘要翻译：本发明涉及防止“AV脱相同步心律失常”（AVDA）发作的问题，这是双室起搏行为，其由PVC或其他心室事件发起，其不紧密地在心房去极化事件之前。如果引发的PVC产生逆行传导，导致心房难治性感觉事件，并且如果后续AP由于心房（生理）不应期（ARP）中的起搏而不能捕获，则重复的AVDA模式（APineffective-VP-ARRPractory）可以持续长时间的时间，在此期间可能发生起搏器综合征的症状。根据本发明，在检测到AVDA后，可能发生以下情况：动态地增加递送的心房起搏能量的幅度，可以增加延迟间隔以允许心房心肌组织恢复，起搏模式切换，患者响应于有害AVDA序列的检测，可以使用通知，记录或处理直方图和/或其组合。

4. 发明申请

WO03030988A2 LEAD SYSTEM FOR PROVIDING ELECTRICAL STIMULATION TO THE BUNDLE OF HIS 审中-公开
标题翻译：为他提供电子刺激的引线系统
公开(公告)号：WO03030988A2
公开(公告)日：2003-04-17
申请号：PCT/US0233662
申请日：2002-10-07
申请人： MEDTRONIC INC
发明人： ALINDER JASON , CASAVANT DAVID A , HESS DOUGLAS N , GRENZ DAVID A , FREIBORG MIKE , CLEMENS WILLIAM J , RUFF MICHAEL A
IPC分类号： A61N1/05 , A61N1/00
CPC分类号： A61N1/0573
摘要： Methods and endocardial screw-in leads for enabling provision of electrical stimulation to the heart, particularly the His Bundle in the intraventricular septal wall. An endocardial screw-in lead having a distal end coupled to a retractable fixation helix wherein a distal portion of the fixation helix extends beyond the lead distal end when the fixation helix is fully retracted or partially extended is positioned in proximity to the His Bundle in the septal wall. The lead body is rotated to attach the distal portion of the fixation helix into the septal wall. The fixation helix is rotated with respect to the lead body to fully extend the fixation helix so that a portion of the fixation helix is in proximity to the His Bundle, enabling provision of electrical stimulation to the His Bundle and/or to sense electrical signals of the heart traversing the His Bundle through the fixation helix.
摘要翻译：方法和心内膜旋入导致使得能够向心脏提供电刺激，特别是心室间隔壁中的His束。具有联接到可缩回固定螺旋的远端的心内膜旋入式引线，其中当固定螺旋完全缩回或部分延伸时，固定螺旋的远端部分延伸超出远端，位于接近His束的隔壁。旋转导线主体以将固定螺旋的远端部分附接到隔壁。固定螺旋相对于导线主体旋转以完全延伸固定螺旋，使得固定螺旋的一部分接近His束，使得能够向His束提供电刺激和/或感测电信号的心脏穿过固定螺旋穿过祂的束。

5. 发明申请

WO2005113065A3 VENTRICULAR DEVICE EVENT FILTERING FOR AN IMPLANTABLE MEDICAL 审中-公开
标题翻译：用于可植入医疗的静脉内装置事件过滤
公开(公告)号：WO2005113065A3
公开(公告)日：2005-12-22
申请号：PCT/US2005019125
申请日：2005-05-21
申请人： MEDTRONIC INC , BETZHOLD ROBERT A , CASAVANT DAVID A , BELK PAUL A , MULLEN THOMAS J , STROEBEL JOHN C , HORNBERGER STEVEN R , SHELDON TODD J , PETERSON DOUGLAS A
发明人： BETZHOLD ROBERT A , CASAVANT DAVID A , BELK PAUL A , MULLEN THOMAS J , STROEBEL JOHN C , HORNBERGER STEVEN R , SHELDON TODD J , PETERSON DOUGLAS A
IPC分类号： A61N1/36 , A61N1/368 , A61N1/37
CPC分类号： A61N1/368 , A61N1/3688 , A61N1/3702
摘要： Pacing parameters are provided to address cross talk and intrinsic ventricular events occurring within a predefined blanking period following an atrial event. The parameters are used in conjunction with protocol for minimizing or reducing ventricular pacing, wherein ignoring intrinsic ventricular events during the blanking period might otherwise affect the performance of the protocol.
摘要翻译：提供起搏参数以解决心房事件发生后的预定义消隐期间发生的串扰和内在心室事件。这些参数与协议一起使用以最小化或减少心室起搏，其中在消隐期间忽略内部心室事件可能会影响该方案的性能。

6. 发明申请

WO03030988B1 LEAD SYSTEM FOR PROVIDING ELECTRICAL STIMULATION TO THE BUNDLE OF HIS 审中-公开
标题翻译：提供电刺激的引导系统
公开(公告)号：WO03030988B1
公开(公告)日：2003-08-07
申请号：PCT/US0233662
申请日：2002-10-07
申请人： MEDTRONIC INC
发明人： ALINDER JASON , CASAVANT DAVID A , HESS DOUGLAS N , GRENZ DAVID A , FREIBORG MIKE , CLEMENS WILLIAM J , RUFF MICHAEL A
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： Methods and endocardial screw-in leads for enabling provision of electrical stimulation to the heart, particularly the His Bundle in the intraventricular septal wall. An endocardial screw-in lead having a distal end coupled to a retractable fixation helix wherein a distal portion of the fixation helix extends beyond the lead distal end when the fixation helix is fully retracted or partially extended is positioned in proximity to the His Bundle in the septal wall. The lead body is rotated to attach the distal portion of the fixation helix into the septal wall. The fixation helix is rotated with respect to the lead body to fully extend the fixation helix so that a portion of the fixation helix is in proximity to the His Bundle, enabling provision of electrical stimulation to the His Bundle and/or to sense electrical signals of the heart traversing the His Bundle through the fixation helix.
摘要翻译：方法和心内螺旋引线，用于对心脏，特别是心室间隔壁中的His束提供电刺激。一种心内膜螺钉，其具有联接到可缩回的固定螺旋的远端，其中当所述固定螺旋完全缩回或部分延伸时，所述固定螺旋的远端部分延伸超过所述引导远端，所述远端部位于所述固定螺旋隔壁。引导体旋转以将固定螺旋的远端部分附接到隔壁中。固定螺旋线相对于引线体旋转以完全延伸固定螺旋，使得固定螺旋的一部分靠近His束，使得能够向His束提供电刺激和/或感测电信号心脏通过固定螺旋穿过他的束。

7. 发明申请

WO2006057754A9 SELF LIMITED RATE RESPONSE 审中-公开
公开(公告)号：WO2006057754A9
公开(公告)日：2006-08-17
申请号：PCT/US2005038419
申请日：2005-10-25
申请人： MEDTRONIC INC , BELK PAUL A , CASAVANT DAVID A
发明人： BELK PAUL A , CASAVANT DAVID A
IPC分类号： A61N1/37
CPC分类号： A61N1/37 , A61N1/368
摘要： Rate responsive pacing is limited in an atrial based pacing mode by the AV interval in order to avoid or minimize ventricular encroachment of atrial pacing. The AV or VA interval is used to permit rate responsiveness; modulate rate responsiveness or to determine a dynamic upper sensor rate.

8. 发明申请

WO2004041354A8 RESPIRATORY NERVE STIMULATION 审中-公开
标题翻译：呼吸神经刺激
公开(公告)号：WO2004041354A8
公开(公告)日：2005-04-07
申请号：PCT/US0333901
申请日：2003-10-27
申请人： MEDTRONIC INC
发明人： CASAVANT DAVID A , HAVEL WILLIAM J
IPC分类号： A61N1/05 , A61N1/36 , A61N1/365
CPC分类号： A61N1/3601 , A61N1/365 , A61N2001/0585
摘要： The invention is directed to an implantable medical device that stimulates a nerve associated with respiration. The nerve may, for example be a phrenic nerve, and the stimulation may cause a diaphragm of the patient to contract. The implantable medical device receives a signal that indicates a need for increased cardiac output and stimulates the nerve in response to the signal. The implantable medical device may receive such a signal by, for example, detecting a ventricular tachyarrhythmia, sensing a pressure that indicates a need for increased cardiac output, or receiving a signal from a patient via a patient activator. Stimulation of the nerve may increase cardiac output of a beating or defibrillating heart
摘要翻译：本发明涉及刺激与呼吸相关的神经的可植入医疗装置。神经可能例如是膈神经，并且刺激可能导致患者的隔膜收缩。该可植入医疗装置接收一信号，该信号指示需要增加心输出量并响应信号刺激神经。可植入医疗装置可以通过例如检测心室快速性心律失常，感测指示增加心输出量的需要的压力或者经由患者激活器从患者接收信号来接收这种信号。刺激神经可能会增加心脏输出的跳动或除颤心脏

9. 发明申请

WO03063961A8 METHOD AND ARRANGEMENT FOR USING ATRIAL PACING TO PREVENT EARLY RECURRENCE OF ATRIAL FIBRILLATION 审中-公开
标题翻译：使用ATRIAL PACING预防ATRIAL FIBRILLATION早期复发的方法和布置
公开(公告)号：WO03063961A8
公开(公告)日：2004-02-19
申请号：PCT/US0302426
申请日：2003-01-27
申请人： MEDTRONIC INC
发明人： UJHELYI MICHAEL R , EULER DAVID R , CASAVANT DAVID A , SHETH NIRAV VIJAY
IPC分类号： A61B5/0402 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： A method for preventing early recurrence of atrial fibrillation by pacing a heart in AAI mode at a rate faster than the intrinsic rate for a selected period of time immediately after delivering therapy to terminate the fibrillation. Ventricular backup pacing in VVI mode may also be provided during the atrial pacing.
摘要翻译：一种通过在递送治疗之后立即在选择的时间段内的速率快于AAI模式的心脏起搏以预防心房颤动的早期复发的方法来终止原纤维颤动。在心房起搏期间也可以提供VVI模式的心室起搏。

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