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1. 发明申请

WO2006069033A9 AUTOMATIC LV / RV CAPTURE VERIFICATION AND DIAGNOSTICS 审中-公开
标题翻译：自动LV / RV捕获验证和诊断
公开(公告)号：WO2006069033A9
公开(公告)日：2006-10-12
申请号：PCT/US2005046055
申请日：2005-12-20
申请人： MEDTRONIC INC , SHETH NIRAV VIJAY , RUETER JOHN C , BURNES JOHN E , MONGEON LUC R , KLECKNER KAREN J , YERICH CHARLES G
发明人： SHETH NIRAV VIJAY , RUETER JOHN C , BURNES JOHN E , MONGEON LUC R , KLECKNER KAREN J , YERICH CHARLES G
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3712
摘要： The present invention provides a technique for verifying pacing capture of a ventricular chamber, particularly to ensure desired delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT"). The invention also provides for ventricular capture management by delivering a single ventricular pacing stimulus and checking inter-ventricular conduction during a temporal window to determine if the ventricular pacing stimulus captured the chamber. If a loss-of-capture (LOC) signal results from the capture management testing, then the characteristics of the applied pacing pulses are modified and the conduction test repeated. In the event that the LOC signal persists, a pacing mode-switch to an atrial-based pacing therapy and/or non-bi-ventricular pacing regimen can be implemented.
摘要翻译：本发明提供了一种用于验证心室的起搏捕获的技术，特别是确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的期望递送。本发明还通过递送单个心室起搏刺激和在时间窗口期间检查心室间传导来确定心室起搏刺激是否捕获腔室来提供心室捕获管理。如果捕获管理测试产生捕获损失（LOC）信号，则应用起搏脉冲的特性被修改，并重复传导测试。在LOC信号持续存在的情况下，可以实现起搏模式切换到基于心房的起搏治疗和/或非双心室起搏方案。

2. 发明申请

WO2006105458A2 METHOD OF OPTIMIZING MECHANICAL HEART RATE DURING DELIVERY OF COUPLED OR PAIRED PACING 审中-公开
标题翻译：联动或配对交付期间优化机械心率的方法
公开(公告)号：WO2006105458A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/012129
申请日：2006-03-30
申请人： MEDTRONIC, INC. , HAVEL, William, J. , KRAUSE, Paul, G. , KLECKNER, Karen, J. , DENO, D., Curtis
发明人： HAVEL, William, J. , KRAUSE, Paul, G. , KLECKNER, Karen, J. , DENO, D., Curtis
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/37
摘要： A method of operating a cardiac pacing device that optimizes the mechanical heart rate using coordinated potentiation therapy while maximizing the opportunity for intrinsic AV conduction to occur. The method may include adjusting the timing of extra stimulus intervals during coupled or paired pacing to promote AV conduction and to effect changes in rate according to certain embodiments of the invention. Other embodiments may include adjusting the atrial pacing rate to achieve a desired target rate consistent with AV conduction. A mode switch to a dual-chamber pacing mode may be provided according to certain embodiments of the invention to ensure a ventricular rate that meets or exceeds a minimum mechanical rate.
摘要翻译：一种操作心脏起搏装置的方法，其使用协同增强疗法优化机械心率，同时最大限度地发挥固有AV传导的机会。该方法可以包括根据本发明的某些实施例在耦合或配对起搏期间调整额外刺激间隔的时间以促进AV传导并且实现速率变化。其他实施例可以包括调整心房起搏速率以实现与AV传导一致的期望目标速率。根据本发明的某些实施例，可以提供到双室起搏模式的模式切换，以确保满足或超过最小机械速率的心室率。

3. 发明申请

WO2012106067A1 DETECTION OF WAVEFORM ARTIFACT 审中-公开
标题翻译：检测波浪文艺
公开(公告)号：WO2012106067A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/020616
申请日：2012-01-09
申请人： MEDTRONIC, INC. , KARAMANOGLU, Mustafa , KLECKNER, Karen J. , BENNETT, Tommy D.
发明人： KARAMANOGLU, Mustafa , KLECKNER, Karen J. , BENNETT, Tommy D.
IPC分类号： A61B5/021
CPC分类号： G06F19/3406 , A61B5/02116 , A61B5/02125 , A61B5/7217 , A61B5/7239 , G06K9/0053 , G16H40/63
摘要： A medical device system including a physiological sensor is configured to perform a method for detecting signal artifact in a signal waveform acquired by the sensor. A signal waveform is sensed in a patient using the physiological sensor and a fiducial point associated with the sensed waveform is identified. A point value is established using the fiducial point. Signal artifact is detected in response to the established point value and an established threshold, and at least a portion of the signal waveform is rejected in response to detecting signal artifact.
摘要翻译：包括生理传感器的医疗装置系统被配置为执行用于检测由传感器获取的信号波形中的信号伪影的方法。使用生理传感器在患者中感测到信号波形，并且识别与感测到的波形相关联的基准点。使用基准点建立点值。响应于建立的点值和建立的阈值检测信号伪影，并且响应于检测到信号伪影而拒绝信号波形的至少一部分。

4. 发明申请

WO2005035056A1 SECURE AND EFFICACIOUS THERAPY DELIVERY FOR AN EXTRA-SYSTOLIC STIMULATION PACING ENGINE 审中-公开
标题翻译：安全和有效的治疗用于超声波刺激发动机的治疗
公开(公告)号：WO2005035056A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/033276
申请日：2004-10-07
申请人： MEDTRONIC, INC. , KLECKNER, Karen, J. , PRIEVE, Kathleen, A. , GILLBERG, Jeffrey, M. , ZHOU, Rebn , ANDERSON, Kenneth, M. , DENO, D. Curtis , ZILLMER, Glenn, C. , KLEPFER, Ruth, N. , SPLETT, Vincent, E.
发明人： KLECKNER, Karen, J. , PRIEVE, Kathleen, A. , GILLBERG, Jeffrey, M. , ZHOU, Rebn , ANDERSON, Kenneth, M. , DENO, D. Curtis , ZILLMER, Glenn, C. , KLEPFER, Ruth, N. , SPLETT, Vincent, E.
IPC分类号： A61N1/39
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： An extra-systolic stimulation (ESS) therapy addresses cardiac dysfunction including heart failure. ESS therapy employs atrial and/or ventricular extra-systoles via pacing-level stimulation to a heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). The present invention relates to therapy delivery guidance and options for improved ESS therapy delivery. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：收缩期刺激（ESS）治疗涉及心脏功能障碍，包括心力衰竭。 ESS治疗通过对心脏的起搏水平刺激使用心房和/或心室超心动过速。这些额外的收缩期必须正确定时，以达到对心肌力学（功效）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。本发明涉及治疗递送指导和改善ESS治疗递送的选择。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

5. 发明申请

WO2008151231A1 METHOD AND APPARATUS FOR DETECTING NOISE IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于检测可植入医疗装置中的噪声的方法和装置
公开(公告)号：WO2008151231A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065767
申请日：2008-06-04
申请人： MEDTRONIC, INC. , RITSCHER, David E. , KRAUSE, Paul, G. , KLECKNER, Karen J. , LU, Steven Ning , KASZAS, Cameron J. , HEMMING, Michael T.
发明人： KRAUSE, Paul, G. , KLECKNER, Karen J. , LU, Steven Ning , KASZAS, Cameron J. , HEMMING, Michael T.
IPC分类号： A61B5/0456 , A61B5/0464 , A61B5/0468 , A61N1/362 , A61N1/37 , A61B5/046 , A61N1/39
CPC分类号： A61N1/3704 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/7203 , A61N1/3925 , A61N1/3956
摘要： ABSTRACT An implantable medical device and associated method monitor a physiological signal for sensing physiological events and detecting a physiological condition in response to the sensed physiological events. The device senses a first event from the physiological signal, senses a noise signal in the physiological signal and senses a next event from the physiological signal wherein the first event and the next event define a signal interval. The signal interval is declared as a noisy interval in response to the sensed noise signal.
摘要翻译：摘要一种植入式医疗装置和相关联的方法监测用于感测生理事件的生理信号并且响应于感测到的生理事件来检测生理状况。该装置从生理信号感测第一事件，感测生理信号中的噪声信号，并感测来自生理信号的下一个事件，其中第一事件和下一个事件定义信号间隔。响应于感测的噪声信号，信号间隔被声明为噪声间隔。

6. 发明申请

WO2007115104A9 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 审中-公开
公开(公告)号：WO2007115104A9
公开(公告)日：2007-12-21
申请号：PCT/US2007065520
申请日：2007-03-29
申请人： MEDTRONIC INC , ZHANG XUSHENG , STADLER ROBERT W , GHANEM RAJA N , KLECKNER KAREN J , KRAUSE PAUL G , MAHAJAN VEERDHAVAL
发明人： ZHANG XUSHENG , STADLER ROBERT W , GHANEM RAJA N , KLECKNER KAREN J , KRAUSE PAUL G , MAHAJAN VEERDHAVAL
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/39 , H04B15/00
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, determining whether the sensed cardiac signals are corrupted by noise in response to the determined inflections and the generated pulse amplitude threshold, and determining, in response to the sensed cardiac signals being corrupted by noise, whether the sensed cardiac signals are both corrupted by noise and shockable.

7. 发明申请

WO2006069032A1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 审中-公开
标题翻译： LV阈值测量和捕获管理
公开(公告)号：WO2006069032A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/046054
申请日：2005-12-20
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , STROEBEL, John, C. , PARIKH, Purvee, Praduman , KLECKNER, Karen, J.
发明人： SHELDON, Todd, J. , STROEBEL, John, C. , PARIKH, Purvee, Praduman , KLECKNER, Karen, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate o ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT").
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近的心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在的速率o确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

8. 发明申请

WO2013016374A1 PROMOTING INTRINSIC ACTIVATION IN SINGLE CHAMBER IMPLANTABLE CARDIAC PACING SYSTEM 审中-公开
标题翻译：促进单室可植入护理系统的内在活动
公开(公告)号：WO2013016374A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048041
申请日：2012-07-25
申请人： MEDTRONIC, INC. , DEMMER, Wade M , KLECKNER, Karen J. , BELK, Paul A.
发明人： DEMMER, Wade M , KLECKNER, Karen J. , BELK, Paul A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/36507 , A61N1/36592
摘要： Cardiac pacing methods for an implantable single chamber pacing system, establish an offset rate for pacing at a predetermined decrement from either a baseline rate (i.e. dictated by a rate response sensor), or an intrinsic rate. Pacing maintains the offset rate until x of y successive events are paced events, at which time the offset rate is switched to the baseline rate for pacing over a predetermined period of time. Following the period, if an intrinsic event is not immediately detected, within the interval of the offset rate, the rate is switched back to baseline for pacing over an increased period of time. Some methods establish a preference rate, between the offset and baseline rates, wherein an additional criterion, for switching from the offset rate to the baseline rate, is established with respect to the preference rate.
摘要翻译：用于可植入单室起搏系统的心脏起搏方法，以基线速率（即由速率响应传感器指定）或内在速率以预定减量建立起搏偏移率。起搏维持偏移率，直到y个连续事件的x为起搏事件，此时偏移速率被切换到预定时间段内的起搏基准速率。在该期间之后，如果不立即检测到固有事件，则在偏移率的间隔内，速率将在增加的时间段内切换回基线。一些方法在偏移和基线速率之间建立偏好率，其中针对偏好率建立用于从偏移率转换到基线速率的附加标准。

9. 发明申请

WO2009148429A1 ELECTROGRAM STORAGE FOR SUSPECTED NON-PHYSIOLOGICAL EPISODES 审中-公开
标题翻译：电生物存储用于悬浮的非生理性EPISODES
公开(公告)号：WO2009148429A1
公开(公告)日：2009-12-10
申请号：PCT/US2008/009199
申请日：2008-07-30
申请人： MEDTRONIC, INC. , OUSDIGIAN, Kevin, T. , CONDIE, Catherine, R. , KLECKNER, Karen, J. , GUNDERSON, Bruce, D.
发明人： OUSDIGIAN, Kevin, T. , CONDIE, Catherine, R. , KLECKNER, Karen, J. , GUNDERSON, Bruce, D.
IPC分类号： A61N1/37 , A61B5/0245 , A61N1/08
CPC分类号： A61N1/3702 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/0538 , A61B5/7264 , A61B2560/0276 , A61N1/3704 , A61N2001/083
摘要： Techniques for storing electrograms (EGMs) that are associated with sensed episodes or events that may be non-physiological and, instead, associated with a sensing integrity condition are described. In some examples, a device or system identifies suspected non-physiological NSTs, and stores an EGM for the suspected non-physiological NSTs within an episode log. In some examples, a device or system determines whether to store an EGM for a suspected non- physiological episode or event based on whether an impedance integrity criterion has been satisfied. For example, a device or system may store an EGM for a detected short interval if the impedance integrity criterion has been met. In some examples, a device or system determines whether to buffer EGM data based on whether an impedance integrity criterion or other sensing integrity criterion has been met.
摘要翻译：描述了用于存储与可能是非生理感知的事件相关联的电描记图（EGM）的技术，并且相反地与感测完整性条件相关联。在一些示例中，设备或系统识别疑似非生理NST，并且在发作日志中存储用于可疑非生理NST的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准来确定是否存储用于怀疑非生理事件或事件的EGM。例如，如果已经满足了阻抗完整性标准，则设备或系统可以存储用于检测到的短间隔的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准或其他感测完整性标准来确定是否缓冲EGM数据。

10. 发明申请

WO2006105458A8 METHOD OF OPTIMIZING MECHANICAL HEART RATE DURING DELIVERY OF COUPLED OR PAIRED PACING 审中-公开
标题翻译：联动或配对交付期间优化机械心率的方法
公开(公告)号：WO2006105458A8
公开(公告)日：2007-02-08
申请号：PCT/US2006012129
申请日：2006-03-30
申请人： MEDTRONIC INC , HAVEL WILLIAM J , KRAUSE PAUL G , KLECKNER KAREN J , DENO D CURTIS
发明人： HAVEL WILLIAM J , KRAUSE PAUL G , KLECKNER KAREN J , DENO D CURTIS
IPC分类号： A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/37

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