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1. 发明申请

WO2004067191A3 ALTERATION OF SURFACE AFFINITIES 审中-公开
标题翻译：表面活性物质的改变
公开(公告)号：WO2004067191A3
公开(公告)日：2004-12-23
申请号：PCT/US2004002498
申请日：2004-01-29
申请人： HARVARD COLLEGE , JIANG XINGYU , FERRIGNO ROSARIA , WHITESIDES GEORGE M
发明人： JIANG XINGYU , FERRIGNO ROSARIA , WHITESIDES GEORGE M
IPC分类号： B01J20/32 , B05D3/14
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/3227 , B01J20/3248 , B01J20/3251 , B01J20/3274 , B01J20/3285 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B05D3/14 , B05D3/207 , G01N33/54353 , G01N2610/00 , Y10S436/823 , Y10T436/118339
摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
摘要翻译：本发明提供了一系列用于改变表面性质（例如，细胞毒性和/或亲水性）的方法，组合物和制品，通过将至少一部分表面暴露于非化学，产生场和/或力，例如电场。场/力可以通过任何合适的技术来产生。例如，可以通过在表面上施加电压，通过电感应等来产生该场。在某些实施例中，表面包括附着于其上的分子，当暴露于非化学，力产生场和/或从而改变表面的至少一部分的化学成分。在一组实施方案中，连接到表面的分子可以包括在表面上形成自组装单层的分子。在一些实施方案中，附着于表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），通过该分子可以使分子附着于表面。在某些情况下，分子可以在一个或多个亲水基团例如未改性的乙二醇部分的非附着端封端。在一些情况下，附着于表面的分子可以包括可结合各种实体的一个或多个部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，该技术用于使用于确定有效增加或减少细胞形状变化和/或表面活力的药物和/或治疗的细胞运动性和/或扩散和筛选试验。

2. 发明申请

WO2009121037A3 THREE-DIMENSIONAL MICROFLUIDIC DEVICES 审中-公开
标题翻译：三维微流体器件
公开(公告)号：WO2009121037A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038693
申请日：2009-03-27
申请人： HARVARD COLLEGE , CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
发明人： CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
IPC分类号： G01N35/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括由多个图案化的多孔亲水层和设置在每两个相邻的图案化多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有流体不可渗透的屏障，其基本上渗透多孔亲水层的厚度并限定图案化多孔亲水层内的一个或多个亲水区域的边界。不透流体层具有与至少一个相邻图案化多孔亲水层内的亲水区域的至少一部分对齐的开口。还描述了微流体测定装置，微流体混合器，微流体控制装置。

3. 发明申请

WO2008127649A3 SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION 审中-公开
标题翻译：通过接触电气组装的系统和方法
公开(公告)号：WO2008127649A3
公开(公告)日：2009-06-04
申请号：PCT/US2008004704
申请日：2008-04-11
申请人： HARVARD COLLEGE , WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
发明人： WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
IPC分类号： C08J5/12 , B05D1/04 , C08J7/00
CPC分类号： C08J5/12 , B05D3/14 , B05D7/02 , B05D2401/32 , C08J7/047 , C08J2327/18 , C08J2433/12
摘要： The present invention generally relates to the charging of materials via contact electrification, including systems and methods of assembly using contact electrification. One aspect of the present invention is directed to systems and methods of identifying and synthesizing nonionic polymeric materials that can be charged using contact electrification. Another aspect of the present invention is directed to methods of localizing charged particles or other materials on such surfaces, for example, in the presence of a controlled humidity environment. Yet another aspect of the present invention is directed to a surface comprising positively and negatively charged regions. Oppositely charged materials may be attracted to those regions. Other aspects of the invention are directed to methods of making, using, and promoting such materials, or kits containing such materials.
摘要翻译：本发明一般涉及通过接触带电充电材料，包括使用接触带电装配的系统和组装方法。本发明的一个方面涉及鉴定和合成可以使用接触带电充电的非离子聚合物材料的系统和方法。本发明的另一方面涉及将带电粒子或其它材料定位在这些表面上的方法，例如在受控湿度环境的存在下。本发明的另一方面涉及包括正带电和带负电荷的区域的表面。对这些区域可能会吸引相反电荷的材料。本发明的其它方面涉及制造，使用和促进这些材料或包含这种材料的试剂盒的方法。

4. 发明申请

WO2008051432A3 PATTERNING OF IONIC POLYMERS 审中-公开
标题翻译：离子聚合物的构图
公开(公告)号：WO2008051432A3
公开(公告)日：2009-04-09
申请号：PCT/US2007022219
申请日：2007-10-18
申请人： HARVARD COLLEGE , LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
发明人： LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与解决方案。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

5. 发明申请

WO2007061448A3 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：微流控网络中导电路径，微型计算机和微结构的制造
公开(公告)号：WO2007061448A3
公开(公告)日：2008-08-28
申请号：PCT/US2006019787
申请日：2006-05-18
申请人： HARVARD COLLEGE , BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
发明人： BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
IPC分类号： H05K3/10 , B01F13/00 , B01L3/00 , B29C39/12
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

6. 发明申请

WO2008060449A2 MICROFLUIDIC DETECTOR 审中-公开
标题翻译：微流体检测器
公开(公告)号：WO2008060449A2
公开(公告)日：2008-05-22
申请号：PCT/US2007023595
申请日：2007-11-09
申请人： HARVARD COLLEGE , BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
发明人： BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/54373 , G01N2333/16 , G01N2333/70503 , G01N2800/24
摘要： Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.
摘要翻译：提供了用于确定指示疾病状况的分析物的文章和方法。在一些实施方案中，本文描述的制品和方法可以用于确定流体样品中组分（例如特定类型的细胞）的定性或定量存在。在一个特定实施例中，提供了用于快速检测T细胞的低成本微流体系统。微流体系统可以在通道中使用固定的抗体和粘附分子以从流体样本（例如小体积血液）捕获T细胞。捕获的T细胞可以使用对T细胞受体（TCR）特异性的抗体用金属胶体（例如金纳米颗粒）标记，并且可以将金属银催化沉淀到细胞上。捕获的T细胞的数量可以被计数，并且可以指示患者的疾病状况，例如严重的联合免疫缺陷或人类免疫缺陷病毒。

7. 发明申请

WO2004002627A2 METHOD AND APPARATUS FOR FLUID DISPERSION 审中-公开
标题翻译：流体分散方法及装置
公开(公告)号：WO2004002627A2
公开(公告)日：2004-01-08
申请号：PCT/US0320542
申请日：2003-06-30
申请人： HARVARD COLLEGE , STONE HOWARD A , ANNA SHELLY L , BONTOUX NATHALIE , LINK DARREN ROY , WEITZ DAVID A , GITLIN IRINA , GARSTECKI PIOTR , DILUZIO WILLOW , WHITESIDES GEORGE M , KUMACHEVA EUGENIA
发明人： STONE HOWARD A , ANNA SHELLY L , BONTOUX NATHALIE , LINK DARREN ROY , WEITZ DAVID A , GITLIN IRINA , GARSTECKI PIOTR , DILUZIO WILLOW , WHITESIDES GEORGE M , KUMACHEVA EUGENIA
IPC分类号： B01F3/08 , B01F5/06 , B01F13/00 , B01L3/00 , B05B7/04
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

8. 发明申请

WO0203142A2 ELECTRIC MICROCONTACT PRINTING METHOD AND APPARATUS 审中-公开
标题翻译：电动微型打印方法和装置
公开(公告)号：WO0203142A2
公开(公告)日：2002-01-10
申请号：PCT/US0121151
申请日：2001-07-02
申请人： HARVARD COLLEGE , JACOBS HEIKO O , WHITESIDES GEORGE M
发明人： JACOBS HEIKO O , WHITESIDES GEORGE M
IPC分类号： G03F7/00 , G03G5/02
CPC分类号： G03G5/02 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F7/0002
摘要： A method and apparatus for providing electric microcontact printing is provided. A stamp is brought into contact with the surface of a substrate to provide high resolution features. Aspects of the invention may be used for data storage, microcontact printing, and for other applications requiring high resolution pattern transfer.
摘要翻译：提供了一种用于提供电微接触印刷的方法和装置。使印模与基板的表面接触以提供高分辨率特征。本发明的各方面可用于数据存储，微接触印刷以及需要高分辨率图案转印的其它应用。

9. 发明申请

WO2012148472A3 SOFT ROBOTIC ACTUATORS 审中-公开
标题翻译：软手动执行器
公开(公告)号：WO2012148472A3
公开(公告)日：2013-07-25
申请号：PCT/US2011061720
申请日：2011-11-21
申请人： HARVARD COLLEGE , ILIEVSKI FILIP , CHEN XIN , MAZZEO AARON D , WHITESIDES GEORGE M , SHEPHERD ROBERT , MARTINEZ RAMSES , CHOI WON JAE , KWOK SEN W , MORIN STEPHEN , STOKES ADAM , NIE ZHIHONG
发明人： ILIEVSKI FILIP , CHEN XIN , MAZZEO AARON D , WHITESIDES GEORGE M , SHEPHERD ROBERT , MARTINEZ RAMSES , CHOI WON JAE , KWOK SEN W , MORIN STEPHEN , STOKES ADAM , NIE ZHIHONG
IPC分类号： B25J9/00
CPC分类号： F15B15/10 , B25J9/1075 , B25J9/142 , B25J11/00 , F15B7/06
摘要： A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.
摘要翻译：软机器人装置包括具有宽度，长度和厚度的柔性体，其中所述厚度为至少1mm，所述柔性体具有设置在所述柔性体内的至少一个通道，所述通道由上，下和侧限定壁，其中至少一个壁是应变限制; 以及与所述至少一个通道流体连通的加压入口，所述至少一个通道定位和布置成使得当所述软自动装置通过所述入口被加压时，与所述应变限制壁相对的壁优先地膨胀。

10. 发明申请

WO2013052171A3 MANIPULATION OF FLAMES AND RELATED METHODS AND APPARATUS 审中-公开
标题翻译：火焰的操作及相关方法和装置
公开(公告)号：WO2013052171A3
公开(公告)日：2013-06-20
申请号：PCT/US2012040171
申请日：2012-05-31
申请人： HARVARD COLLEGE , CADEMARTIRI LUDOVICO , MACE CHARLES R , SHEPHERD ROBERT FOSTER , MAZZEO AARON D , BISHOP KYLE J M , CHIECHI RYAN C , WHITESIDES GEORGE M
发明人： CADEMARTIRI LUDOVICO , MACE CHARLES R , SHEPHERD ROBERT FOSTER , MAZZEO AARON D , BISHOP KYLE J M , CHIECHI RYAN C , WHITESIDES GEORGE M
IPC分类号： F23D14/00 , F23D14/84 , F23D99/00 , F23N5/00
CPC分类号： F23N5/00 , F23C99/001
摘要： Manipulation of flames is described using electric fields. In those instances in which electric fields are used, the electric fields may be time-varying gradient electric fields, and in some instances may be oscillating electiic fields. The manipulation may include extinction, suppression, control of mixing of the flame, concentration, and/or bending, among other types.
摘要翻译：使用电场描述火焰的操纵。在使用电场的情况下，电场可以是时变梯度电场，并且在一些情况下可以是振荡电场。操作可以包括灭火，抑制，火焰混合的控制，浓缩和/或弯曲等。

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