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1. 发明申请

WO2011072055A3 METHODS AND ARRANGEMENTS FOR ANALYSIS, DIAGNOSIS, AND TREATMENT MONITORING OF VOCAL FOLDS BY OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：通过光学相干平面图分析，诊断和治疗眼睛的方法和安排
公开(公告)号：WO2011072055A3
公开(公告)日：2011-09-29
申请号：PCT/US2010059534
申请日：2010-12-08
申请人： GEN HOSPITAL CORP , YUN SEOK-HYUN , KOBLER JAMES B
发明人： YUN SEOK-HYUN , KOBLER JAMES B
IPC分类号： A61B1/24 , A61B1/247
CPC分类号： A61B1/00172 , A61B1/2673 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B5/7285
摘要： Exemplary embodiments of an apparatus and a method can be provided. For example, a first information can be obtained for at least one signal that is (i) at least partially periodic and (ii) associated with at least one structure. In addition, a second information associated with the structure can be generated at multiple time points within a single cycle of the at least one signal. The second information can include information for the structure below a surface thereof. Further, it is possible to generate a third information based on the first information and the second information, where the third information is associated with at least one characteristic of the structure.
摘要翻译：可以提供装置和方法的示例性实施例。例如，可以获得至少一个信号的第一信息，该至少一个信号是（i）至少部分周期性的和（ii）与至少一个结构相关联的信号。此外，与该结构相关联的第二信息可以在至少一个信号的单个周期内的多个时间点产生。第二信息可以包括其表面下方的结构的信息。此外，可以基于第一信息和第二信息生成第三信息，其中第三信息与结构的至少一个特征相关联。

2. 发明申请

WO2005001401A3 PROCESS AND APPARATUS FOR A WAVELENGTH TUNING SOURCE 审中-公开
标题翻译：波长调谐源的过程和装置
公开(公告)号：WO2005001401A3
公开(公告)日：2005-04-28
申请号：PCT/US2004018045
申请日：2004-06-04
申请人： GEN HOSPITAL CORP , BOUMA BRETT E , YUN SEOK-HYUN , OH WILLIAM , DEBOER JOHANNES , TEARNEY GUILLERMO
发明人： BOUMA BRETT E , YUN SEOK-HYUN , OH WILLIAM , DEBOER JOHANNES , TEARNEY GUILLERMO
IPC分类号： A61B5/00 , G01J3/12 , G01J9/02 , G01N21/47 , G02B27/48 , G01J3/18 , H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括至少一个光谱分离装置，其被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件。装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

3. 发明申请

WO2006039091A3 SYSTEM AND METHOD FOR OPTICAL COHERENCE IMAGING 审中-公开
标题翻译：用于光学相干成像的系统和方法
公开(公告)号：WO2006039091A3
公开(公告)日：2006-07-27
申请号：PCT/US2005032422
申请日：2005-09-12
申请人： GEN HOSPITAL CORP , YUN SEOK-HYUN , BOUMA BRETT EUGENE , TEARNEY GUILLERMO J , DEBOER JOHANNES F
发明人： YUN SEOK-HYUN , BOUMA BRETT EUGENE , TEARNEY GUILLERMO J , DEBOER JOHANNES F
IPC分类号： G01N21/47
CPC分类号： G01B9/02014 , G01B9/02004 , G01B9/02044 , G01B9/02069 , G01B9/02077 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795
摘要： A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second electro-magnetic radiation received from the reference. At least one particular detector may have a particular electrical integration time, and can receive at least a portion of the signal for a time duration which has a first portion with a first power level greater than a predetermined threshold and a second portion immediately preceding or following the first portion. The second portion may have a second power level that is less than the predetermined threshold, and extends for a time period which may be, e.g., approximately more than 10% of the particular electrical integration time.
摘要翻译：提供了用于成像样品例如生物样品的系统和方法。特别地，可以产生转发到样品的至少一个源电磁辐射和参考。可以使用多个检测器，所述检测器中的至少一个检测器能够检测与从样本接收的至少一个第一电磁辐射的组合相关联的信号和从参考接收的至少一个第二电磁辐射。至少一个特定检测器可以具有特定的电积分时间，并且可以接收信号的至少一部分持续一段持续时间，该持续时间具有第一部分具有大于预定阈值的第一功率电平，以及紧接在之前或之后的第二部分第一部分。第二部分可以具有小于预定阈值的第二功率电平，并且延伸可以是例如大约超过特定电积分时间的10％的时间段。

4. 发明申请

WO2007133961A3 PROCESSES, ARRANGEMENTS AND SYSTEMS FOR PROVIDING FREQUENCY DOMAIN IMAGING OF A SAMPLE 审中-公开
标题翻译：用于提供样品的频域成像的过程，安排和系统
公开(公告)号：WO2007133961A3
公开(公告)日：2008-01-31
申请号：PCT/US2007068214
申请日：2007-05-04
申请人： GEN HOSPITAL CORP , YUN SEOK-HYUN , DE BOER JOHANNES F
发明人： YUN SEOK-HYUN , DE BOER JOHANNES F
IPC分类号： A61B3/12 , A61B5/00 , G01B9/02 , G01N21/45 , G01N21/47
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/1233 , A61B3/14 , A61B5/0059 , A61B5/0066 , A61B5/418 , G01N21/45 , G01N21/4795
摘要： Apparatus, arrangement and method are provided for obtaining information associated with an anatomical structure or a sample using optical microscopy. For example, a radiation can be provided which includes at least one first electro-magnetic radiation directed to be provided to an anatomical sample and at least one second electro-magnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength is shorter than approximately 1150 nm. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. At least one image corresponding to at least one portion of the sample can be generated using data associated with the interference. In addition, at least one source arrangement can be provided which is configured to provide an electro-magnetic radiation which has a wavelength that varies over time. A period of a variation of the wavelength of the first electro-magnetic radiation can be shorter than 1 millisecond, and the wavelength is shorter than approximately 1150 nm.
摘要翻译：提供了用于使用光学显微镜获得与解剖结构或样品相关联的信息的装置，布置和方法。例如，可以提供辐射，其包括至少一个被引导到解剖样品的第一电磁辐射和指向参考的至少一个第二电磁辐射。辐射的波长可随时间变化，波长比约1150nm短。可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。可以使用与干扰相关联的数据来生成对应于样本的至少一部分的至少一个图像。此外，可以提供至少一个源装置，其被配置为提供具有随时间变化的波长的电磁辐射。第一电磁辐射的波长变化的周期可以短于1毫秒，并且波长比约1150nm短。

5. 发明申请

WO2007092911A3 METHODS, ARRANGEMENTS AND SYSTEMS FOR OBTAINING INFORMATION ASSOCIATED WITH AN ANATOMICAL SAMPLE USING OPTICAL MICROSCOPY 审中-公开
标题翻译：使用光学显微镜获取与解剖样品相关的信息的方法，安排和系统
公开(公告)号：WO2007092911A3
公开(公告)日：2007-10-04
申请号：PCT/US2007061815
申请日：2007-02-08
申请人： GEN HOSPITAL CORP , YUN SEOK-HYUN
发明人： YUN SEOK-HYUN
IPC分类号： A61B5/00 , G01J3/44 , G01N21/17 , G01N21/63
CPC分类号： G01N21/4795 , A61B3/102 , A61B3/117 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/0097 , A61B5/4088 , A61B5/412 , A61B5/413 , C07K14/70503 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01B9/02091 , G01J3/4412 , G01N21/1717 , G01N21/636 , G01N2021/1725 , G01N2021/638 , G01N2201/06 , G01N2201/0612 , G01N2800/042 , G01N2800/387 , G01N2800/7023 , G01N2800/7028 , G02B21/0052
摘要： Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.
摘要翻译：提供了用于获得与解剖样品相关联的信息的安排和方法。例如，可以向解剖样品提供至少一个第一电磁辐射，以便在解剖样品中产生至少一个声波。可以基于声波产生至少一个第二电磁辐射。可以提供至少一个第二电磁辐射的至少一部分，以便确定与解剖样品的至少一部分相关联的信息。此外，可以分析基于与第二电磁辐射相关联的数据的信息。第一电磁辐射可以包括至少一个第一幅度和至少一个第一频率。第二电磁辐射可以包括至少一个第二幅度和至少一个第二频率。数据可以涉及第一和第二幅度之间的第一差异和/或第一和第二频率之间的第二差异。第二个差异可能在-100 GHz到100 GHz之间，不包括零。

6. 发明申请

WO2009134719A3 APPARATUS AND METHOD FOR CROSS AXIS PARALLEL SPECTROSCOPY 审中-公开
标题翻译：跨轴平行光谱仪的装置和方法
公开(公告)号：WO2009134719A3
公开(公告)日：2010-02-18
申请号：PCT/US2009041827
申请日：2009-04-27
申请人： GEN HOSPITAL CORP , YUN SEOK-HYUN , SCARCELLI GIULIANO
发明人： YUN SEOK-HYUN , SCARCELLI GIULIANO
IPC分类号： G01J1/42 , G01J3/02 , G01J3/12
CPC分类号： G01J3/26 , G01J3/02 , G01J3/0208 , G01J3/0229 , G01J3/14 , G01J3/18
摘要： An exemplary embodiment of apparatus and method to measure and filter the spectrum of electro-magnetic radiation using multiple dispersive elements, such as diffraction gratings or VIPA etalons, concatenated in a cross-axis orthogonal arrangement can be provided. For example, it is possible to receive at least one first electro-magnetic radiation and generate at least one second electro-magnetic radiation using at least one first spectral separating arrangement. A first spectrum of the second electro-magnetic radiation can be dispersed along at least one first dispersive axis with respect to a propagation direction of the second electro-magnetic radiation. In addition, it is possible to, using at least one second arrangement, receive the second electro-magnetic radiation and produce at least one third electromagnetic radiation having a second spectrum dispersed along at least one second dispersive axis with respect to a propagation direction of the third electromagnetic radiation. The orientations of the respective first and second dispersive axes can be different from one another. The first and/or second dispersive arrangements can be VIPA etalon arrangements
摘要翻译：可以提供使用跨越轴正交排列连接的多个色散元件（例如衍射光栅或VIPA标准具）测量和过滤电磁辐射光谱的装置和方法的示例性实施例。例如，可以使用至少一个第一光谱分离装置接收至少一个第一电磁辐射并产生至少一个第二电磁辐射。第二电磁辐射的第一光谱可以相对于第二电磁辐射的传播方向沿着至少一个第一色散轴分散。此外，可以使用至少一个第二布置来接收第二电磁辐射并产生至少一个第三电磁辐射，其具有沿着至少一个第二色散轴分散的第二光谱，该第二光谱相对于第三电磁辐射。相应的第一和第二分散轴的取向可以彼此不同。第一和/或第二分散装置可以是VIPA标准具配置

7. 发明申请

WO2008137637A3 METHODS, ARRANGEMENTS AND SYSTEMS FOR OBTAINING INFORMATION ASSOCIATED WITH A SAMPLE USING BRILLOUIN MICROSCOPY 审中-公开
标题翻译：方法，安装和系统用于获取与使用BRILLOUIN MICROSCOPY的样品相关的信息
公开(公告)号：WO2008137637A3
公开(公告)日：2009-01-08
申请号：PCT/US2008062354
申请日：2008-05-02
申请人： GEN HOSPITAL CORP , YUN SEOK-HYUN , SCARCELLI GIULIANO
发明人： YUN SEOK-HYUN , SCARCELLI GIULIANO
IPC分类号： G01J3/26 , G01J3/44 , G01N21/63
CPC分类号： G01J3/4412 , G01J3/26
摘要： Exemplary embodiments of methods, arrangements and systems for obtaining information about a sample can be provided. For example, in one exemplary embodiment, it is possible to receive a first electro-magnetic radiation from a sample which is based on a second electro-magnetic radiation forwarded to the sample. The first electro-magnetic radiation may have a first frequency and the second electro-magnetic radiation may have a second frequency which is different from the first frequency. The difference between the first and second frequencies can be based on an acoustic wave inside the sample related to at least one characteristic of the sample. Further, it is possible to receive at least a portion of the first electromagnetic radiation and separate it into a particular finite number (N) of frequency component radiations. In addition, it is possible to receive a particular energy of more than 1/N of energy of the third electro-magnetic radiation, and generate information associated with the sample. Certain exemplary embodiments of the present invention are capable of obtaining information associated with a sample, particularly its mechanical properties, non- contact using electromagnetic radiation.
摘要翻译：可以提供用于获得关于样本的信息的方法，布置和系统的示例性实施例。例如，在一个示例性实施例中，可以从基于转发到样本的第二电磁辐射的样本接收第一电磁辐射。第一电磁辐射可以具有第一频率，并且第二电磁辐射可以具有不同于第一频率的第二频率。第一和第二频率之间的差异可以基于与样品的至少一个特征相关的样品内的声波。此外，可以接收第一电磁辐射的至少一部分并将其分离成特定有限数量（N）的频率分量辐射。此外，可以接收第三电磁辐射能量大于1 / N的特定能量，并产生与样品相关的信息。本发明的某些示例性实施例能够获得与样品相关的信息，特别是其机械特性，使用电磁辐射的非接触。

8. 发明申请

WO2007019574A3 APPARATUS, METHODS AND STORAGE MEDIUM FOR PERFORMING POLARIZATION-BASED QUADRATURE DEMODULATION IN OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：用于在光学相干平台中进行基于偏振度的平移解调的装置，方法和存储介质
公开(公告)号：WO2007019574A3
公开(公告)日：2007-05-10
申请号：PCT/US2006031275
申请日：2006-08-09
申请人： GEN HOSPITAL CORP , VAKOC BENJAMIN J , YUN SEOK-HYUN , TEARNEY GUILLERMO J , BOUMA BRETT EUGENE
发明人： VAKOC BENJAMIN J , YUN SEOK-HYUN , TEARNEY GUILLERMO J , BOUMA BRETT EUGENE
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01B9/02044 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02072 , G01B9/02081 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/45 , G01J2009/0265 , G01N21/21 , G01N21/274 , G01N21/4795
摘要： Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample 130 and at least one second electro-magnetic radiation to a reference, such that the first and/or second electro-magnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation 405 associated with the first radiation can be combined with a second polarization component of at least one fourth radiation 400 associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another. Apparatus and method are used for quadrature detection of swept source Fourier domain optical coherence tomography.
摘要翻译：可以向样品130提供至少一个第一电磁辐射和至少一个第二电磁辐射至参考的装置，方法和存储介质，使得第一和/或第二电磁辐射具有随着时间的推移发生变化此外，与第一辐射相关联的至少一个第三辐射405的第一偏振分量可以与与第二辐射相关联的至少一个第四辐射400的第二偏振分量彼此组合。可以将第一和第二偏振特别地控制为至少大致彼此正交。扫描源傅立叶域光学相干断层扫描的正交检测使用的装置和方法。

9. 发明申请

WO2006130802A2 APPARATUS, METHOD AND SYSTEM FOR PERFORMING PHASE-RESOLVED OPTICAL FREQUENCY DOMAIN IMAGING 审中-公开
标题翻译：用于执行相位决定的光学频域成像的装置，方法和系统
公开(公告)号：WO2006130802A2
公开(公告)日：2006-12-07
申请号：PCT/US2006021375
申请日：2006-06-01
申请人： GEN HOSPITAL CORP , VAKOC BENJAMIN J , YUN SEOK-HYUN , TEARNEY GUILLERMO J , BOUMA BRETT EUGENE , DE BOER JOHANNES F
发明人： VAKOC BENJAMIN J , YUN SEOK-HYUN , TEARNEY GUILLERMO J , BOUMA BRETT EUGENE , DE BOER JOHANNES F
CPC分类号： A61B5/0073 , A61B5/0066 , A61B2560/0223 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/49
摘要： Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.
摘要翻译：提供了使用从参考和样本接收的信号的装置，系统和方法。特别地，提供了一种辐射，其包括指向样品的至少一个第一电磁辐射和指向该参考的至少一个第二电磁辐射。辐射的频率随时间而变化。可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。可以获得与干扰的至少一个频率分量的至少一个相位相关联的特定信号，并将特定信号与至少一个特定信息进行比较。此外，可以接收辐射的至少一部分并提供另外的辐射，使得可以基于另外的信号来校准特定信号。

10. 发明申请

WO2011139972A3 APPARATUS, METHOD AND SYSTEM FOR GENERATING OPTICAL RADIATION FROM BIOLOGICAL GAIN MEDIA 审中-公开
标题翻译：用于从生物增益介质产生光学辐射的装置，方法和系统
公开(公告)号：WO2011139972A3
公开(公告)日：2012-03-29
申请号：PCT/US2011034810
申请日：2011-05-02
申请人： GEN HOSPITAL CORP , YUN SEOK-HYUN , GATHER MALTE C
发明人： YUN SEOK-HYUN , GATHER MALTE C
IPC分类号： G01N33/48 , C12M1/34 , G01N21/00 , G01N33/52
CPC分类号： C09K11/06 , C09K2211/10 , C09K2211/14 , G01N21/645 , G01N21/7746 , G02B6/138 , G02B6/29341 , H01S3/08022 , H01S3/08059 , H01S3/083 , H01S3/094034 , H01S3/094076 , H01S3/168 , H01S3/20 , H01S3/213
摘要： In one exemplary embodiment, an apparatus can be provided which includes at least one biological medium that causes gain. According to another exemplary embodiment, an arrangement can be provided which is configured to be provided in an anatomical structure. This exemplary arrangement can include at least one emitter having a cross-sectional area of at most 10 microns within the anatomical structure, and which is configured to generate at least one laser radiation. In a further exemplary embodiment, an apparatus can be provided which can include at least one medium which is configured to cause gain; and at least one optical biological resonator which is configured to provide an optical feedback to the medium. In still another exemplary embodiment, a process can be whereas, a solution of an optical medium can be applied to a substrate. Further, it is possible to generate a wave guide having a shape that is defined by (i) at least one property of the solution of the optical medium, or (ii) drying properties thereof.
摘要翻译：在一个示例性实施例中，可以提供包括引起增益的至少一个生物介质的装置。根据另一示例性实施例，可以提供被配置为设置在解剖结构中的布置。该示例性布置可以包括在解剖结构内具有至多10微米的横截面积的至少一个发射器，并且被配置为产生至少一个激光辐射。在另一示例性实施例中，可以提供可以包括被配置为引起增益的至少一个介质的装置; 以及被配置为向介质提供光学反馈的至少一个光学生物谐振器。在另一示例性实施例中，可以将光学介质的溶液施加到基板上。此外，可以生成具有由（i）光学介质的溶液的至少一种性质或（ii）其干燥性质）定义的形状的波导。

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