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1. 发明申请

WO2019062484A1 一种光学相干断层扫描成像系统审中-公开
公开(公告)号：WO2019062484A1
公开(公告)日：2019-04-04
申请号：PCT/CN2018/103869
申请日：2018-09-04
申请人：视微影像(河南)科技有限公司
发明人：卫星 , 黄炳杰 , 陈军 , 彭先兆
IPC分类号： A61B3/10 , A61B5/00
CPC分类号： A61B3/0016 , A61B3/102 , A61B5/0066 , A61B5/7203
摘要：一种光学相干断层扫描成像系统，包括扫频激光器（1）、马赫-曾德式干涉仪、平衡探测器（2）；干涉仪包括第一光纤耦合器（3）、第二光纤耦合器（4）、样品臂（5）和参考臂；参考臂包括参考臂前段（61）、参考臂后段（62）及延迟臂（63）；参考臂前段（61）的末端通过延迟臂（63）与参考臂后段（62）连接；第一光纤耦合器（3）用于将扫频光源的输出光分为样品光和参考光，并将返回的样品光分配至第二光纤耦合器（4）；延迟臂（63）的寄生反射信号到达第二光纤耦合器（4）的光程与样品光光程的差值大于扫频激光器腔长的8倍，其可以抑制相干重现伪像，可以实现足够的光谱宽度，结构简单，成本较低，不会引起额外的光损耗和偏振色散，可以保证系统的灵敏度。

2. 发明申请

WO2018222282A2 SYSTEMS FOR COHERENT LIGHT DETECTION AND RELATED METHODS 审中-公开
公开(公告)号：WO2018222282A2
公开(公告)日：2018-12-06
申请号：PCT/US2018/027572
申请日：2018-04-13
申请人： NORTHWESTERN UNIVERSITY
发明人： MOHSENI, Hooman , FATHIPOUR, Vala
CPC分类号： G01B9/02004 , A61B3/102 , G01B9/02041 , G01B9/0209
摘要： Systems for coherent light detection are provided, including a system comprising a light source configured to generate light; a first optical assembly configured to split the light into a reference arm and a sample arm; a second optical assembly configured to illuminate a sample with light of the sample arm, thereby generating a sample signal; a third optical assembly configured to combine the sample signal with light of the reference arm, thereby generating an interference signal; and a detector assembly comprising an array of carrier injection photodetectors, the array arranged to collect the interference signal. Methods of using the systems are also provided.

3. 发明申请

WO2018140610A1 OPHTHALMOSCOPY METHOD 审中-公开
公开(公告)号：WO2018140610A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/015256
申请日：2018-01-25
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人： MILLER, Donald Thomas , LIU, Zhuolin , SUZUKI, Kazuhiro
IPC分类号： A61B3/00 , A61B3/10 , A61B3/12 , A61B3/14 , A61B5/00 , G01B9/02 , G06K9/00
CPC分类号： G01B9/02091 , A61B3/0025 , A61B3/102 , G01B9/02034 , G01B9/02041 , G06K9/0014 , G06K9/00147
摘要： A method is provided for observing ganglion cells in a living human eye, comprising: using an adaptive optics optical coherence tomography (AO-OCT) system to image a volume of a retinal patch including a ganglion cell layer (GCL); using 3D subcellular image registration to correct for eye motion, including digitally dissecting the imaged volume; and using organelle motility inside GCL somas to increase cell contrast.

4. 发明申请

WO2018119009A1 AN ULTRA-WIDE FIELD OF VIEW OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM 审中-公开
公开(公告)号：WO2018119009A1
公开(公告)日：2018-06-28
申请号：PCT/US2017/067443
申请日：2017-12-19
申请人： VISUNEX MEDICAL SYSTEMS CO. LTD. , SU, Wei
发明人： SU, Wei
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , A61B3/0091 , A61B3/15 , A61B5/0066 , A61B2562/0233 , G01B9/02015 , G01B9/02041 , G01B9/02091 , G06T2207/30041
摘要： Various embodiments of the present disclosure describe an ultra-wide field of view (FOV) optical coherence tomography (OCT) imaging system. The ultra-wide FOV OCT imaging system can include an imaging probe, a console and a cable. The imaging probe can include an optical widow, a first imaging module and a second imaging module. The first imaging module is configured to form a first image of the eye. The second imaging module is configured to form a second image of the eye. The second imaging module can include a scanning mirror configured to receive a sample arm portion of a second light beam from a second light source and scan the sample arm portion. The console can include the second light source, an interferometer, and a processor. The cable is coupled between the console and the imaging probe and includes a first fiber, a second fiber and a third fiber.

5. 发明申请

WO2017210374A1 APPARATUS FOR CHANGING THE REFRACTIVE POWER OF THE CORNEA 审中-公开
标题翻译：改变角膜折射能力的装置
公开(公告)号：WO2017210374A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035333
申请日：2017-05-31
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： VOGEL, Alfred , LINZ, Norbert , FREIDANK, Sebastian , BIRNGRUBER, Reginald
IPC分类号： A61B3/103 , A61F9/007 , A61F9/008
CPC分类号： A61F9/013 , A61B3/102 , A61B3/107 , A61F2/147 , A61F2/148 , A61F9/0017 , A61F2240/002
摘要： The invention relates to an apparatus for changing the refractive power of the cornea (1), in particular for correcting hyperopia or presbyopia, exhibiting injection means (13, 15) having at least one hollow needle (15) for injecting at least one optically transparent filling material having a predetermined refractive index into an intrastromal corneal pocket (7), characterized by a controllable injection drive (17) that is coupled at least indirectly to the injection means (13, 15) and is designed for changing an amount, to be injected, of the at least one filling material; a device for optical coherence tomography (OCT) (19) that is designed for monitoring the area of the corneal pocket (7) by means of measurement of depth profiles of the cornea (1) on a repeatedly cycled-through scan pattern; and a computing unit (21) that is designed and/or configured to determine from the measurement data of the OCT device (19) at least the radius of curvature of the front (3) of the cornea (1) keeping pace temporally with the repetitions of the scan pattern cycle during the injection, wherein the computing unit (21) is designed and/or configured to control the injection drive (17) for changing the injected amount of the at least one filling material, and namely on the basis of the radius of curvature of the front (3) of the cornea (1) and/or such until a predetermined target criterion is fulfilled.
摘要翻译：本发明涉及用于改变角膜（1）的屈光力的装置，特别是用于矫正远视或老花眼的装置，其具有至少一个空心针（15）的注射装置（13,15）），用于将具有预定折射率的至少一种光学透明填充材料注入角膜内角膜袋（7）中，其特征在于至少间接与注射装置（13,15）耦合的可控注射驱动装置（17），并且设计用于改变所述至少一种填充材料的待注入量; 一种用于光学相干断层扫描（OCT）（19）的设备，其被设计用于通过在重复循环扫描图案上测量角膜（1）的深度轮廓来监测角膜囊（7）的面积; 和计算单元（21），其被设计和/或配置为从OCT设备（19）的测量数据至少确定角膜（1）的前部（3）的曲率半径与其中计算单元（21）被设计和/或构造成控制喷射驱动装置（17）以改变至少一种填充材料的喷射量，即基于角膜（1）的前部（3）的曲率半径和/或直到预定的目标标准被满足为止。

6. 发明申请

WO2017195192A1 LOCALIZED OPTICAL COHERENCE TOMOGRAPHY IMAGES FOR OPHTHALMOLOGICAL SURGICAL PROCEDURES 审中-公开
标题翻译：局部光学相干层析成像用于眼科手术的程序
公开(公告)号：WO2017195192A1
公开(公告)日：2017-11-16
申请号：PCT/IL2017/050504
申请日：2017-05-08
申请人： ELBIT SYSTEMS LTD.
发明人： SCHNEIDER, Ron , ZEITOUNI, Avi
IPC分类号： A61B5/06 , A61B3/14 , A61F9/007 , A61B34/20
CPC分类号： A61B34/20 , A61B3/0025 , A61B3/0058 , A61B3/102 , A61B3/12 , A61B3/1225 , A61B3/14 , A61B3/18 , A61B8/00 , A61B8/10 , A61B2034/2057 , A61B2034/2065 , A61B2090/3735 , A61F9/007 , A61F2009/00851 , A61F2009/00863
摘要： Systems and method are provided which enhance ophthalmological surgical procedures. Systems may include camera(s) configured to capture and magnify eye image(s) (possibly stereoscopic), a tissue position and orientation (P&O) tracker configured to track a P&O of a specified eye tissue, a tool P&O tracker configured to track a P&O of treatment tool(s) and derive a tool tip pointing vector therefrom, a processing unit configured to calculate an intersection between the tool tip pointing vector and the specified eye tissue and to relate spatially optical coherence tomography (OCT) image(s) of the eye tissue to the tool tip location and/or to the intersection, and a display module configured to display the magnified image(s) of the eye tissue with the OCT image(s) associated therewith according to the spatial relation. An OCT imager may be mounted on the tool tip to provide the OCT image(s) in real time.
摘要翻译：提供了增强眼科手术程序的系统和方法。系统可以包括被配置为捕获和放大眼睛图像（可能是立体的）的相机，被配置为跟踪特定眼组织的P＆amp; O的组织位置和定向（P＆amp; O）跟踪器，工具P＆amp; O跟踪器，其被配置为跟踪治疗工具的P＆amp; O并且从其导出工具尖端指向矢量;处理单元，其被配置为计算工具尖端指向矢量与指定的眼睛组织之间的相交并且涉及空间光学相干断层扫描（OCT）图像与工具尖端位置和/或交叉点相关联，以及显示模块，被配置为根据与其相关联的OCT图像显示眼部组织的放大图像（一个或多个）到空间关系。可以在工具尖端安装OCT成像器以实时提供OCT图像。

7. 发明申请

WO2017191128A1 OPHTHALMOLOGISCHE LÄNGENMESSUNG MITTELS DOPPELSTRAHL RAUM-ZEIT-DOMÄNE WAVELENGTH TUNING KURZKOHÄRENZ-INTERFEROMETRIE 审中-公开
标题翻译：眼科长度测量BY双光束时空域波长调谐短相干干涉
公开(公告)号：WO2017191128A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/060410
申请日：2017-05-02
申请人： CARL ZEISS MEDITEC AG
IPC分类号： A61B3/10 , G01B9/02
CPC分类号： A61B3/102 , A61B3/1005
摘要： Diese Anmeldung betrifft die Messung intraokulärer Längen durch Doppelstrahl Fourier-Kurzkohärenz-Interferometrie basierend auf Fresnel-Zonen-artigen Raum-Zeit-Domäne Interferogrammen (RZI) der Purkinje-Sanson Reflexe. Das Messobjekt Auge wird von einem Bündel paralleler,monochromatischer Doppelstrahlen mit in zeitlicher Sequenz unterschiedlichen Wellenlängen beleuchtet. Die Wellenlängen-Spektren der Raum-Zeit-Domäne Interferogramme werden auf ein Photodetektor-Array abgebildet und registriert. Hierbei werden Blickrichtung und Position des Probandenauges mit optischen Hilfsmitteln fixiert und mittels akustischer und optischer Hilfsmittel kontrolliert. Eine Zoom-Optik im Ausgangsstrahl des ophthalmologischen Interferometers erlaubtdurch einfaches Fokussieren die virtuellen Fresnel-Zonen-artigen Raum-Zeit-Domäne Interferogramme des Auges aus Kontrast-optimierten Positionen auf das Photodetektor-Array oder auf einen diesem vorgeschalteten Bildverstärker so abzubilden, dass die positionsabhängige Größenänderung der RZI durch die Maßstabsänderung dieser Abbildung kompensiert wird. Ophthalmologische Teilstrecken-Längenmessung wird in der Augenheilkunde zur Dimensionierung von Abtragparametern für die refraktive Chirurgie,zur Dimensionierung von Linsenimplantaten für die refraktive Chirurgie und für die Katarakt-Chirurgie benutzt.
摘要翻译：
本申请涉及测量intraokul＆AUML; RER L＆AUML;可以通过双喷傅立叶Kurzkoh＆AUML NTS; EnCE的干涉基于菲涅耳状区 - 空间 - 时间的Dom＆AUML; NE干涉浦肯野桑森的（RZI）反射。被测物体的眼睛被时间顺序上不同波长的一束平行单色双光束照亮。空间 - 时间干涉图的波长谱被映射并记录到光电探测器阵列上。在这里，主体眼睛的观察方向和位置由光学辅助装置固定，并通过声学和光学辅助装置进行控制。通过简单地聚焦在虚拟菲涅耳区状空间 - 时间的Dom＆在眼科干涉仪的输出光束AUML变焦光学系统允许的;光检测器阵列，或者连接的上游图像增强BEAR上优化的位置更强，从而成像的眼对比度NE干涉 RZI的取决于位置的量值变化由该图的尺寸变化补偿。眼科部分-L＆AUML;˚F导航用途ř屈光手术和，r是折射的，对于尺寸透镜植入物˚F导航用途手术; ngenmessung是在眼科领域用于标注使用Abtragparametern˚F导航用途ř白内障手术。

8. 发明申请

WO2017134203A1 REPORT DRIVEN WORKFLOW FOR OPHTHALMIC IMAGE DATA ACQUISITION 审中-公开
标题翻译：报告驱动的工作流程用于眼科图像数据采集
公开(公告)号：WO2017134203A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052347
申请日：2017-02-03
申请人： CARL ZEISS MEDITEC, INC. , CARL ZEISS MEDITEC AG
发明人： APPAKAYA, Raghavendra , JINDAL, Gautam , SARKER, Arindam , ZHENG, Ting , CHEN, Xunchang
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B3/0033 , A61B3/102
摘要： An improved workflow for acquiring image data of the eye of a patient is described. The workflow can be used with any ophthalmic diagnostic devices including an Optical Coherence Tomography (OCT) device. This workflow is referred herein as a report driven workflow. Under the report driven workflow, a plurality of report options are presented to the device operator. These report options are selectable to generate a report summarizing analysis relating to a specific pathology or region of the eye. A desired report option is selected by the device operator. Based on the selected report option, one or more scan types are automatically selected by the device software. Image data corresponding to the one or more scan types are captured using the ophthalmic diagnostic device. An analysis for the selected desired report option is generated based on the captured image data and is then presented to the device operator.
摘要翻译：描述了用于获取患者眼睛的图像数据的改进的工作流程。该工作流程可以用于任何眼科诊断设备，包括光学相干断层扫描（OCT）设备。这个工作流程在这里被称为报告驱动的工作流程。在报告驱动的工作流程下，多个报告选项被呈现给设备操作员。这些报告选项是可选择的，以生成汇总与眼睛的特定病理或区域相关的分析的报告。设备操作员选择所需的报告选项。根据选定的报告选项，设备软件会自动选择一种或多种扫描类型。使用眼科诊断设备来捕获对应于一种或多种扫描类型的图像数据。根据捕获的图像数据生成对选择的期望报告选项的分析，然后将其呈现给设备操作员。

9. 发明申请

WO2017106003A1 APPARATUS AND METHOD FOR GENERATING 3-D DATA FOR AN ANATOMICAL TARGET USING OPTICAL FIBER SHAPE SENSING 审中-公开
标题翻译：使用光纤形状生成解剖目标的三维数据的装置和方法
公开(公告)号：WO2017106003A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/065596
申请日：2016-12-08
申请人： INTUITIVE SURGICAL OPERATIONS, INC.
发明人： FROGGATT, Mark , SANBORN, Eric , GIFFORD, Dawn K. , BARBAGLI, Federico
IPC分类号： G01N21/47 , F21V8/00 , G02B21/00
CPC分类号： G01M11/3172 , A61B3/102 , A61B3/107 , A61B5/0066 , A61B5/0261 , A61B5/1459
摘要： A fiber housing includes multiple shape sensing cores and a single optical core. A distal end of the fiber housing is positionable to direct the single optical core to a current point of an anatomical target. Collimated light over a first range of frequencies is projected from the single optical core to the current point. OFDR is used to detect reflected light scattered from the current point and to process the detected light to determine a distance to the current point. Light over a second range of frequencies is projected through the multiple shape sensing optical cores to the distal end of the fiber housing. OFDR is used to measure light reflected from the distal end of the fiber housing back through the multiple shape sensing optical cores and to process the measurement to determine a position in three dimensional space of the distal end of the fiber housing and a pointing direction of the distal end of the fiber housing. A position in three dimensional space of the current point is determined based on the determined position in three dimensional space of the distal end of the fiber housing, the pointing direction of the distal end of the fiber housing, and the determined distance.
摘要翻译：光纤壳体包括多个形状感测芯和单个光芯。光纤壳体的远端可定位成将单个光芯引导至解剖目标的当前点。在第一频率范围内的准直光从单个光芯投射到当前点。 OFDR用于检测当前点散射的反射光，并处理检测到的光以确定到当前点的距离。在第二频率范围内的光通过多个形状感测光纤芯投射到光纤壳体的远端。 OFDR用于测量从光纤壳体的远端反射的光通过多个形状感测光学芯，并且处理该测量以确定光纤壳体的远端的三维空间中的位置以及光纤壳体的指向方向光纤外壳的远端。基于所确定的光纤壳体的远端的三维空间中的位置，光纤壳体的远端的指向方向以及所确定的距离来确定当前点的三维空间中的位置。

10. 发明申请

WO2017087356A1 RESOLUTION ENHANCEMENT OF OCT IMAGES DURING VITREORETINAL SURGERY 审中-公开
标题翻译： OCT图像在手术治疗过程中的分辨率增强
公开(公告)号：WO2017087356A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/061974
申请日：2016-11-15
申请人： NOVARTIS AG
发明人： CHARLES, Steven T.
IPC分类号： A61B3/10 , G06T7/149
CPC分类号： G06T5/50 , A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/13 , A61B3/145 , A61B90/37 , A61B2090/3735 , G06T7/33 , G06T7/38 , G06T2207/10016 , G06T2207/10056 , G06T2207/10101 , G06T2207/20016 , G06T2207/30041 , G06T2207/30101 , G06T2210/41 , G06T2210/44
摘要： Resolution enhancement of OCT images during ophthalmic surgery may be performed with an OCT scanning controller that interfaces to an OCT scanner used with a surgical microscope. Real-time OCT images may be acquired by the OCT scanner, while previously acquired high resolution OCT images are accessed by the OCT scanning controller. The high resolution OCT images may be morphed based on the real-time OCT images to match a deformation of the eye. The morphed high resolution OCT images may be displayed during surgery.
摘要翻译：在眼科手术过程中OCT图像的分辨率增强可以使用与手术显微镜一起使用的OCT扫描仪接口的OCT扫描控制器来执行。实时OCT图像可以由OCT扫描仪采集，而先前采集的高分辨率OCT图像由OCT扫描控制器访问。高分辨率OCT图像可基于实时OCT图像变形以匹配眼睛的变形。变形的高分辨率OCT图像可能会在手术过程中显示。

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