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1. 发明申请

WO2019121395A1 APPARATUS FOR THE DETECTION OF CARBON DIOXIDE 审中-公开
公开(公告)号：WO2019121395A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/084959
申请日：2018-12-14
申请人： RADIOMETER BASEL AG
发明人： FEHR, Jean-Nöel , ROULET, Jean-Christophe , WEBER, Patrizia , FINCI, Julien , SCHERER, Lukas
IPC分类号： A61B5/145 , A61B5/1455 , A61B5/00 , A61B5/083
CPC分类号： A61B5/14552 , A61B5/0075 , A61B5/0836 , A61B5/14521 , A61B2562/04
摘要： The present invention relates to an apparatus (10) apparatus for the detection of carbon dioxide. It is described to place (210) a part of a housing in contact with a skin area of a patient. the part of the housing and a gas measuring chamber within the housing are configured such that gases diffusing through the skin area of the patient enter the gas measuring chamber. radiation is emitted (220) from a radiation source within the housing, wherein at least some of the radiation emitted by the radiation source enters the gas measuring chamber. The radiation entering the gas measuring chamber has wavelengths that extend over an absorption band of carbon dioxide and has wave- lengths that extend over a region other than the absorption band of carbon dioxide. A radiation filter is positioned (230) relative to the gas measuring chamber such that an interaction radiation path is defined between the radiation source through the gas measuring chamber to the radiation filter. A first radiation detector is positioned (240) relative to the radiation filter such that a first detection radiation path is defined that is in addition to the interaction radiation path, and a second radiation detector is positioned relative to the radiation filter such that a second detection radiation path is defined that is in addition to the interaction radiation path. The radiation filter is con- figured such that radiation in the first detection radiation path has a wavelength that extends over the absorption band of carbon dioxide and with an intensity of radiation that extends over the region other than the absorption band being significantly less than that in the interaction radiation path. The radiation filter is also configured such that radiation in the second detection radiation path has a wavelength that extends over the region other than the absorption band of carbon dioxide and with an intensity of radia- tion that extends over the absorption band being significantly less than that in the inter- action radiation path. a partial pressure of carbon dioxide is determined (250) in the skin of the patient using a signal from the first radiation detector and a signal from the second radiation detector.

2. 发明申请

WO2019115364A1 METHOD AND SYSTEM FOR IMPROVED MEASUREMENT OF LOCALIZED ORAL INFLAMMATION USING CENTROID SAMPLING 审中-公开
公开(公告)号：WO2019115364A1
公开(公告)日：2019-06-20
申请号：PCT/EP2018/083887
申请日：2018-12-06
申请人： KONINKLIJKE PHILIPS N.V.
发明人： DEANE, Steven, Charles , DAVIE, Alan, James
IPC分类号： A61B5/00 , A61B5/06
CPC分类号： A61B5/4552 , A61B5/00 , A61B5/0075 , A61B5/0088 , A61B5/06
摘要： For localizing gingival inflammation within a user's mouth the following steps are carried out using an oral care device (10): (i) sequentially emitting (520) light by a plurality of light sources (48) in a first sequential pattern, wherein at least some of the plurality of light sources are configured to emit light of different wavelengths; (ii) sequentially emitting (530) light in a second sequential pattern which is the reverse of the first sequential pattern; (iii) obtaining (540), by a light detector (40), reflectance measurements to generate first reflectance data from light emitted in the first sequential pattern, and to generate second reflectance data from light emitted in the second sequential pattern; (iv) averaging (550), by a controller (30), first reflectance data and second reflectance data for each wavelength to generate averaged reflectance data; and (v) determining (570), using the averaged reflectance data, whether gingiva at the location is inflamed.

3. 发明申请

WO2019114883A1 VORRICHTUNG ZUR REGISTRIERUNG UND ZUR ZERSTÖRUNG EINZELNER TUMORZELLEN, TUMORZELLENCLUSTER UND MIKROMETASTASEN IM BLUTKREISLAUF 审中-公开
公开(公告)号：WO2019114883A1
公开(公告)日：2019-06-20
申请号：PCT/DE2018/101015
申请日：2018-12-13
申请人： SCHIKORA, Detlef , WEBER, Michael
发明人： SCHIKORA, Detlef , WEBER, Michael
IPC分类号： A61B5/00 , A61N5/06 , A61B5/145 , A61B5/1459
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0086 , A61B5/14503 , A61B5/14546 , A61B5/1459 , A61B5/4836 , A61B5/6852 , A61B5/6876 , A61B2560/0431 , A61B2562/146 , A61N5/062 , A61N2005/0602 , A61N2005/0626 , A61N2005/0652 , A61N2005/0662
摘要： Die vorliegende Erfindung betrifft eine Vorrichtung zur Registrierung von einzelnen Tumorzellen, Tumorzellenclustern und Mikrometastasen im Blutkreislauf, die mit einer photoempfindlichen Substanz angereichert sind. Aufgabe der Erfindung ist es, eine Vorrichtung zur Verfügung zu stellen, die sowohl die sichere diagnostische Erkennung einzelner Tumorzellen im Blutkreislauf von Menschen und Säugetieren als auch deren therapeutische in-situ-Eliminierung ermöglicht. Gelöst wird diese Aufgabe mit einer Vorrichtung die aufweist eine Strahlungsquelle (7, 11) mit intravasaler oder extravasaler Anregung der photoempfindlichen Substanz einen Detektor (1, 12, 13) mit intravasaler oder extravasaler Detektion einer Fluoreszenz- und/oder Phosphorenz- und/oder Lumineszenzstrahlung der angeregten Tumorzellen und/oder Tumorzellencluster und/oder Mikrometastasen ein mit dem Detektor (1, 12, 13) verbundenes Fluoreszenzspektrometer (5) hoher Empfindlichkeit zur Registrierung der emittierten Strahlung einen mit dem Spektrometer (5) verbundenen Computer (6), der die empfangenen Peaks der emittierten Strahlung als Funktion der Zeit aufzeichnet.

4. 发明申请

WO2019055341A1 METHODS AND SYSTEMS FOR USING NEAR INFRARED SPECTROSCOPY TO DETECT COMPARTMENT SYNDROME 审中-公开
公开(公告)号：WO2019055341A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/050196
申请日：2018-09-10
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： TIGHE, Patrick J. , GRAVENSTEIN, Nikolaus , BOEZAART, Andre Pierre , FRITH, Sean A. , GLENN, Alina Zare , KOPPAL, Sanjeev Jagannatha
IPC分类号： A61B5/00 , A61B5/03
CPC分类号： A61B5/03 , A61B5/0073 , A61B5/0075 , A61B5/4519
摘要： According to a method for using near infrared spectroscopy to detect compartment syndrome, an optics array is placed around a body region of a patient that contains a vulnerable compartment of tissue. The optics array includes emitters that generate photons at NIR wavelengths and detectors that detect photons at NIR wavelengths. Photons are emitted from at least one of the emitters, and detected at more than one of the detectors after those photons traveled through the tissues of the body region of the patient. A cross-sectional measure of regional differences in absorption within a cross-section of the body region of the patient is displayed so as to allow detection of compartment syndrome. The method is carried out with a device for using near infrared spectroscopy to detect compartment syndrome.

5. 发明申请

WO2019010348A1 A MINIATURE MICROSCOPE FOR MULTI-CONTRAST OPTICAL IMAGING IN ANIMALS 审中-公开
公开(公告)号：WO2019010348A1
公开(公告)日：2019-01-10
申请号：PCT/US2018/040979
申请日：2018-07-06
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： PATHAK, Arvind , THAKOR, Nitish , SENARATHNA, Janaka , YU, Hang
IPC分类号： G02B21/14 , A61B5/00
CPC分类号： A61B1/00 , A61B5/0042 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0261 , A61B5/1455 , A61B5/489 , G02B21/0008 , G02B21/082 , G02B21/16
摘要： An embodiment in accordance with the present invention provides a miniature microscope capable of performing in vivo, real-time imaging of multiple organ sites in awake and behaving animals (e.g. rodents). A microscope according to the present invention includes multiple optical contrast mechanisms (i.e. contrast arising from neural, hemodynamic and other physiological components). Exemplary contrast mechanisms include, but are not limited to fluorescence, hemoglobin level, deoxyhemoglobin level, and blood flow. The microscope is fully adaptable to in vitro and ex vivo imaging, can be customized to concurrently image at variable magnifications, conduct optogenetic/electrical/chemical stimulations, drug delivery, microdialysis, accompanied by electrical signal recording, wireless image transmission and charging.

6. 发明申请

WO2018172103A1 VERFAHREN UND VORRICHTUNG ZUM ERMITTELN EINES MUNDZUSTANDS 审中-公开
公开(公告)号：WO2018172103A1
公开(公告)日：2018-09-27
申请号：PCT/EP2018/055903
申请日：2018-03-09
申请人： HENKEL AG & CO. KGAA
发明人： BOCK, Andreas , WELSS, Thomas , FRISCHMANN, Matthias
IPC分类号： A61B5/00 , G01J3/00 , G16H10/00 , A61B5/1455
CPC分类号： A61B5/0088 , A61B5/0022 , A61B5/0075 , A61B5/14551 , A61B5/4547 , A61B5/4552 , A61B2505/07 , G16H10/65
摘要： In verschiedenen Ausführungsbeispielen wird ein Verfahren zum Ermitteln eines Mundzustands bereitgestellt. Das Verfahren kann aufweisen: ein Ermitteln mindestens eines Mundzustandsparameters, aufweisend: während eines Belichtens des Mundraums oder einer biologischen Probe eines Nutzers mit sichtbarem Licht und/oder Infrarotlicht, Aufnehmen eines Spektrums und/oder mindestens einer Abbildung von zumindest einem Teil des sichtbaren Lichts und/oder des Infrarotlichts, welches mit der Mund gewechselwirkt hat, wobei das Belichten und das Aufnehmen mittels einer tragbaren Vorrichtung erfolgen kann, Vergleichen zumindest eines Vergleichsbereichs des Spektrums und/oder der mindestens einen Abbildung mit für eine Mehrzahl von Kalibriermundproben gewonnenen Kalibrierspektren und/oder Kalibrierabbildungen, und Ermitteln des mindestens einen Mundzustandsparameters unter Einbeziehung eines Ergebnisses des Vergleichs, und Ermitteln des Mundzustands unter Verwendung des mindestens einen Mundzustandsparameters.

7. 发明申请

WO2018140788A1 APPARATUS, SYSTEM AND METHOD FOR DYNAMIC IN-LINE SPECTRUM COMPENSATION OF AN IMAGE 审中-公开
公开(公告)号：WO2018140788A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/015544
申请日：2018-01-26
申请人： CANON U.S.A. INC.
发明人： GANESAN, Santosh , WANG, Zhuo
IPC分类号： A61B5/00 , G06T7/00 , A61B1/00 , H04N5/235
CPC分类号： G06T5/009 , A61B1/00009 , A61B5/0075 , A61B5/0084 , A61B2576/00 , G06T3/4084 , G06T5/002 , G06T5/20 , G06T5/40 , G06T5/50 , G06T7/0012 , G06T7/10 , G06T2207/10024 , G06T2207/10068 , G06T2207/20032 , H04N5/2351
摘要： An image processing apparatus is provided and includes one or more processors and a memory storing instructions. The one or more processors are controlled to receive image stream data captured by an image capturing apparatus and store, in memory, a current image frame from the received image stream data and store, in memory, a previously received image frame from the received image stream data. The previously received image frame having been received at a time earlier than the current image data frame. Using the previously received image frame data stored in memory, a compensation value representing an illumination spectrum of the previously stored image frame data is calculated and image correction is performed on the current image frame data using the calculated compensation value. The corrected current image frame for display on a display device.

8. 发明申请

WO2018107774A1 应用于内窥镜系统的成像方法审中-公开
公开(公告)号：WO2018107774A1
公开(公告)日：2018-06-21
申请号：PCT/CN2017/096375
申请日：2017-08-08
申请人：深圳开立生物医疗科技股份有限公司
发明人：邱建军 , 冯能云 , 陈云亮
IPC分类号： A61B1/05 , A61B5/00 , G06T7/00
CPC分类号： A61B1/00009 , A61B1/00186 , A61B1/05 , A61B5/0033 , A61B5/0075 , A61B5/0084 , G06T7/0012 , G06T2207/10068
摘要：一种应用于内窥镜系统的成像方法，包括：以预设波段的照射光照射观测部位，采集获得观测部位的反射光图像；将反射光图像的各像素点的色值矩阵分别与图像转换矩阵相乘，获得观测部位的成像结果，图像转换矩阵由权重系数对角矩阵计算获得，权重系数对角矩阵的对角元素为采集的反射光图像在各窄带波段下光强度的权重系数，预设波段被平均分为预设数量的窄带波段。本成像方法，以预设波段光照射观测部位，得到能够区分血管区域和非血管区域的反射光图像，并对图像进行光谱滤波处理，能够增强各区域图像的特征光谱，从而提升了血管区域与非血管区域的差异，使图像对比度提高，提高了成像质量。

9. 发明申请

WO2018064211A1 SYSTEMS AND METHODS FOR BIOLOGICAL METRICS MEASUREMENT 审中-公开
标题翻译：用于生物量度测量的系统和方法
公开(公告)号：WO2018064211A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/053800
申请日：2017-09-27
申请人： SPRY HEALTH, INC.
发明人： FERBER, Elad , DEKELAITA, Andrew , NARAYANAN, Ramkrishnan , COBUT, Pierre-Jean Julien Ghislain
IPC分类号： A61B5/02 , A61B5/024
CPC分类号： A61B5/14552 , A61B5/0075 , A61B5/0205 , A61B5/021 , A61B5/02433 , A61B5/02438 , A61B5/0816 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/7278 , A61B2562/0238 , A61B2562/043
摘要： A wearable member may include a plurality of energy transmitters that are arranged on a surface of the wearable member, each of the energy transmitters being configured to project energy into tissue of a user. A wearable member may include a plurality of energy receivers each of which is configured to generate a signal based on a received portion of the energy that is projected by one or more of the energy transmitters and reflected by the tissue of the user, wherein at least one of the energy transmitters and the energy receivers are multi-dimensionally arranged on the wearable member such that energy reflected by the tissue of the user at locations that are multi-dimensionally different is incident on the plurality of energy receivers. The processor may be configured to calculate a biological metric based on signals generated by at least part of the plurality of energy receivers.
摘要翻译：可佩戴构件可以包括布置在可佩戴构件的表面上的多个能量发射器，每个能量发射器被配置为将能量投射到用户的组织中。可佩带构件可以包括多个能量接收器，每个能量接收器被配置为基于由一个或多个能量发射器投射并由用户的组织反射的能量的接收部分来生成信号，其中至少一个能量发射器和能量接收器中的一个多维地布置在可佩戴构件上，使得用户的组织在多维度不同的位置处反射的能量入射到多个能量接收器上。处理器可以被配置为基于由多个能量接收器的至少一部分生成的信号来计算生物度量。

10. 发明申请

WO2018059659A1 VERFAHREN UND ANORDNUNG ZUR FESTSTELLUNG VON ZUMINDEST EINER INSBESONDERE PATHOLOGISCHEN IMPLIKATION 审中-公开
标题翻译：确定至少一种特定病理学影响的方法和装置
公开(公告)号：WO2018059659A1
公开(公告)日：2018-04-05
申请号：PCT/EP2016/072939
申请日：2016-09-27
申请人： SIEMENS AKTIENGESELLSCHAFT
发明人： ENGEL, Thomas , FLEISCHER, Maximilian , GIGLER, Alexander Michael , PASTUSIAK, Remigiusz , PAUST, Tobias , SIMON, Elfriede , STÜTZ, Evamaria
IPC分类号： A61B5/00 , G01J3/28 , G06K9/00
CPC分类号： A61B5/0075 , A61B5/0086 , A61B5/7267 , A61B5/742 , G01J3/0289 , G01J3/2823 , G01J3/42 , G01J2003/2826
摘要： Zur Feststellung pathologischer Implikationen, z.B. zur Tumordetektion, wird ein hyperspektrales Bild des zu untersuchenden Gewebes in situ aufgenommen und einem Klassifizierungsalgorithmus zugeführt. Das Ergebnis kann auf einem konventionellen Anzeigegerät dargestellt werden oder durch Rückprojektion auf die Oberfläche des untersuchten Gewebes.
摘要翻译：为了确定病理学影响，例如，对于肿瘤检测，待检查的组织的高光谱图像被原位采集并馈送到分类算法。结果可以显示在传统的显示器上，也可以通过逆向投影到被检查的组织表面。

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