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1. 发明申请

WO2015006489A8 BLOOD-BASED SCREEN FOR DETECTING NEUROLOGICAL DISEASES IN PRIMARY CARE SETTINGS 审中-公开
标题翻译：用于检测主要护理环境中的神经病变的基于血液的筛选
公开(公告)号：WO2015006489A8
公开(公告)日：2015-02-19
申请号：PCT/US2014046015
申请日：2014-07-09
申请人： UNIV NORTH TEXAS , UNIV TEXAS
发明人： O'BRYANT SID E , BARBER ROBERT C , XIAO GUANGHUA , GERMAN DWIGHT
IPC分类号： G01N33/53 , G01N33/573 , G01N33/68
CPC分类号： G01N33/6896 , A61B5/4088 , G01N2570/00 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835 , G01N2800/387 , G06F19/18 , G06F19/20
摘要： The present invention includes methods and kits for the diagnosing a neurological disease within primary care settings comprising: obtaining a blood test sample from a subject, measuring IL-7 and TNFα biomarkers in the blood sample, comparing the level of the one or a combination of biomarkers and neurocognitive screening tests with the level of a corresponding one or combination of biomarkers in a normal blood sample and neurocognitive screening tests, and predicting that an increase in the level of the blood test sample in relation to that of the normal blood sample indicates that the subject is likely to have a neurological disease.
摘要翻译：本发明包括用于诊断初级保健设置中的神经疾病的方法和试剂盒，包括：从受试者获得血液测试样品，测量血液样品中的IL-7和TNFα生物标志物，比较血液样品中的一种或其组合的水平生物标志物和神经认知筛选试验，其中正常血液样品中的相应一种或组合的生物标志物水平和神经认知筛选试验，并且预测血液测试样品相对于正常血液样品的水平的增加表明该科目可能有神经系统疾病。

2. 发明申请

WO2013050383A3 IN VITRO METHOD TO DETERMINE THE RISK OF A PREGNANT WOMAN OF CARRYING A FETUS WITH FETAL ANEUPLOIDY 审中-公开
标题翻译：以体外方法确定携带肛门异位症的妊娠妇女的风险
公开(公告)号：WO2013050383A3
公开(公告)日：2013-06-06
申请号：PCT/EP2012069489
申请日：2012-10-02
申请人： CEZANNE S A S , DEMIRDJIAN GAIANE , DARBOURET BRUNO
发明人： DEMIRDJIAN GAIANE , DARBOURET BRUNO
IPC分类号： G01N33/68 , C07K16/00
CPC分类号： G01N33/689 , G01N2800/387
摘要： The present invention relates to the risk assessment of fetal aneuploidy in a fetus determination of paraoxonase 1 (PON-1) in a sample obtained from a pregnant woman.
摘要翻译：本发明涉及胎儿非整倍体胎儿在从孕妇取得的样品中测定对氧磷酶1（PON-1）的风险评估。

3. 发明申请

WO2013053359A1 DIAGNOSTIC AND PROGNOSTIC USE OF PROMBP-COMPLEXES 审中-公开
标题翻译： PROMBP复合物的诊断和预防性使用
公开(公告)号：WO2013053359A1
公开(公告)日：2013-04-18
申请号：PCT/DK2012/000112
申请日：2012-10-12
申请人： AARHUS UNIVERSITET
发明人： OXVIG, Claus , KLØVERPRIS, Søren
IPC分类号： G01N33/50 , G01N33/68 , C07K7/14
CPC分类号： G01N33/689 , G01N2333/47 , G01N2333/471 , G01N2333/4716 , G01N2333/8121 , G01N2800/368 , G01N2800/387
摘要： The present Invention relates to a diagnostic and/or prognostic method comprising measurements of proMBP-complexes (major basic protein, PRG2). In particular the Invention relates to a diagnostic and/or prognostic method comprising measurements of the concentration of two or more proMBP-complexes. Further, the Invention relates to a method for determining the redox state In a pregnant female. Additionally, the Invention relates to a reaction kit comprising detection means for detecting two or more proMBP complexes, as well as to various uses of the reaction kit. Further, the invention relates to a method of diagnosis of preeclampsia by determining the ratio between proMBP protein in complex with PAPP-A and proMBP protein in complex with angiotensinogen (ATG).
摘要翻译：本发明涉及包括proMBP-复合物（主要的基本蛋白质，PRG2）的测量的诊断和/或预后方法。具体地，本发明涉及包括两个或更多个proMBP-复合物的浓度测量的诊断和/或预后方法。此外，本发明涉及一种在孕妇中测定氧化还原状态的方法。此外，本发明涉及包含检测两种或更多种proMBP复合物的检测装置以及反应试剂盒的各种用途的反应试剂盒。此外，本发明涉及通过确定与PAPP-A复合的proMBP蛋白与与血管紧张素原（ATG）复合的proMBP蛋白之间的比例来诊断先兆子痫的方法。

4. 发明申请

WO2012101268A1 IN VITRO METHOD TO DETERMINE THE RISK OF A PREGNANT WOMAN OF CARRYING A FETUS WITH FETAL ANEUPLOIDY 审中-公开
标题翻译：以体外方法确定携带肛门异位症的妊娠妇女的风险
公开(公告)号：WO2012101268A1
公开(公告)日：2012-08-02
申请号：PCT/EP2012/051375
申请日：2012-01-27
申请人： CEZANNE S.A.S. , DARBOURET, Bruno , DEMIRDJIAN, Gaiané
发明人： DARBOURET, Bruno , DEMIRDJIAN, Gaiané
IPC分类号： G01N33/68
CPC分类号： G01N33/573 , G01N33/689 , G01N2333/9125 , G01N2800/387
摘要： The present invention relates to the risk assessment of chromosomal aneupolidy in a fetus by the determination of purine nucleoside phophorylase (PNP) in a sample obtained from pregnant women.
摘要翻译：本发明涉及通过在从孕妇中获得的样品中嘌呤核苷磷酸化酶（PNP）的测定来评估胎儿中染色体无规性的风险。

5. 发明申请

WO2011014741A1 METHODS AND COMPOSITIONS FOR CELL STABILIZATION 审中-公开
标题翻译：用于细胞稳定的方法和组合物
公开(公告)号：WO2011014741A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/043854
申请日：2010-07-30
申请人： ARTEMIS HEALTH, INC. , DENG, David
发明人： DENG, David
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12Q1/6806 , G01N33/80 , G01N2800/387 , Y10T436/143333
摘要： Fragile cells have value for use in diagnosing many types of conditions. There is a need for compositions that stabilize fragile cells. The stabilization compositions of the provided invention allow for the stabilization, enrichment, and analysis of fragile cells, including fetal cells, circulating tumor cells, and stem cells.
摘要翻译：脆性细胞具有用于诊断许多类型病症的价值。需要稳定易碎细胞的组合物。所提供的发明的稳定化组合物允许稳定，富集和分析脆性细胞，包括胎儿细胞，循环肿瘤细胞和干细胞。

6. 发明申请

WO2007109293A3 EARLY DIAGNOSIS OF CONGENITAL ABNORMALITIES IN THE OFFSPRING OF DIABETIC MOTHERS 审中-公开
标题翻译：早期诊断糖尿病患者心理不适
公开(公告)号：WO2007109293A3
公开(公告)日：2008-08-14
申请号：PCT/US2007006966
申请日：2007-03-21
申请人： UNIV YALE , MADRI JOSEPH , NATH ANJALI , KRAUTHAMMER MICHAEL , SNYDER MICHAEL , DAVIDOV EUGENE
发明人： MADRI JOSEPH , NATH ANJALI , KRAUTHAMMER MICHAEL , SNYDER MICHAEL , DAVIDOV EUGENE
IPC分类号： C12Q1/70 , A01N37/18 , A61K38/00 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/689 , G01N2800/368 , G01N2800/385 , G01N2800/387
摘要： The present invention relates to the identification of a series of biomarkers, the detection of which is prognostic for women at risk of becoming hyperglycemic during pregnancy and/or fetuses at risk of developing congenital anomalies as a result of maternal hyperglycemia.
摘要翻译：本发明涉及一系列生物标志物的鉴定，其检测对于怀孕期间成为高血糖危险的妇女和/或由于母亲高血糖而发展为先天性异常的胎儿的胎儿是预后的。

7. 发明申请

WO2007035585A2 SYSTEMS AND METHODS FOR ENRICHMENT OF ANALYTES 审中-公开
标题翻译：用于富集分析物的系统和方法
公开(公告)号：WO2007035585A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036202
申请日：2006-09-15
申请人： LIVING MICROSYSTEMS, INC. , THE GENERAL HOSPITAL CORPORATION , KAPUR, Ravi , TONER, Mehmet , HUANG, Lotien, Richard , BARBER, Tom , CARVALHO, Bruce , GRAY, Darren , BALIS, Ulysses , WALSH, John , GRISHAM, Michael , TOMPKINS, Ron , SCHMIDT, Martin
发明人： KAPUR, Ravi , TONER, Mehmet , HUANG, Lotien, Richard , BARBER, Tom , CARVALHO, Bruce , GRAY, Darren , BALIS, Ulysses , WALSH, John , GRISHAM, Michael , TOMPKINS, Ron , SCHMIDT, Martin
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/80 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , B03C2201/18 , B03C2201/26 , B82Y15/00 , B82Y30/00 , G01N1/4077 , G01N33/54366 , G01N33/569 , G01N33/574 , G01N2001/4088 , G01N2333/805 , G01N2800/387 , G06F19/18
摘要： The invention relates to one or more size-based separation modules adapted to increase a concentration of a first analyte in a sample by at least 10,000 fold, wherein said first analyte has an initial concentration in said sample of less than 1 x 10 -3 analytes/µL, and an analyzer for analyzing said first analytes in an enriched medium. Methods of using the separation modules for identifying a characteristic associated with a condition in a patient e.g. a fetal abnormality are also provided.
摘要翻译：本发明涉及一种或多种基于尺寸的分离模块，其适于将样品中第一分析物的浓度提高至少10,000倍，其中所述第一分析物在所述样品中具有初始浓度小于1×10 -3个分析物/μL，以及用于分析富集培养基中的所述第一分析物的分析仪。使用分离模块来识别与患者中的病症相关的特征的方法，例如，还提供胎儿异常。

8. 发明申请

WO2006034427A2 DIAGNOSIS OF FETAL ANEUPLOIDY 审中-公开
标题翻译：诊断子宫内膜异位症
公开(公告)号：WO2006034427A2
公开(公告)日：2006-03-30
申请号：PCT/US2005034083
申请日：2005-09-20
申请人： PROTEOGENIX INC , ROSENFELD RON , NAGALLA SRINIVASA R
发明人： ROSENFELD RON , NAGALLA SRINIVASA R
IPC分类号： C12Q1/68 , G01N33/00
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/689 , G01N2500/00 , G01N2800/368 , G01N2800/385 , G01N2800/387
摘要： The invention relates to a method for the early non-invasive diagnosis of fetal aneuploidy. In particular, the invention concerns the diagnosis of fetal aneuploidy by identifying protein expression patterns characteristics of fetal aneuploidy in a maternal biological fluid, such as maternal serum or amniotic fluid.
摘要翻译：本发明涉及早期非侵入性诊断胎儿非整倍体的方法。特别地，本发明涉及通过鉴定母体生物液体如母体血清或羊水中胎儿非整倍体的蛋白质表达模式特征来诊断胎儿非整倍体。

9. 发明申请

WO2004100773A3 DIAGNOSTIC AND THERAPEUTIC TREATMENTS RELATED TO MITOCHONDRIAL DISORDERS 审中-公开
标题翻译：诊断和治疗与麻醉病毒相关的治疗
公开(公告)号：WO2004100773A3
公开(公告)日：2005-02-03
申请号：PCT/US2004014996
申请日：2004-05-12
申请人： UNIV COLORADO , NEWELL ROGERS MARTHA KAREN , VILLALOBOS-MENUEY ELIZABETH , MELAMEDE ROBERT , CAMLEY ROBERT
发明人： NEWELL ROGERS MARTHA KAREN , VILLALOBOS-MENUEY ELIZABETH , MELAMEDE ROBERT , CAMLEY ROBERT
IPC分类号： A01K67/00 , A01K67/027 , A01K67/033 , A01N63/00 , A01N65/00 , A61B20060101 , A61K35/12 , C07H21/02 , C07H21/04 , C12N5/00 , C12N5/02 , C12N5/0797 , G01N33/50
CPC分类号： A01K67/0275 , A01K2227/105 , A01K2267/0306 , A61K35/12 , C12N5/0623 , C12N2510/00 , G01N33/5079 , G01N2800/387
摘要： The invention is based in part on the discovery that chromosomal disorders such as Down Syndrome can be diagnosed by assessing maternal mitochondrial status. Thus the invention relates to diagnostic and therapeutic methods and related products for chromosomal disorders such as Downs Syndrome, for example, for identifying a risk of fetal Downs syndrome and methods of mitigating that risk. The methods also re useful for other therapies where it is desirable to manipulate mitochondria such as tissue generation.
摘要翻译：本发明部分基于通过评估母体线粒体状态来诊断染色体疾病如唐氏综合征的发现。因此，本发明涉及用于染色体病症例如唐氏综合征的诊断和治疗方法及相关产品，例如用于鉴定胎儿唐氏综合征的风险和减轻该风险的方法。该方法对于其中需要操纵线粒体如组织生成的其它疗法也是有用的。

10. 发明申请

WO2004087863A2 NON-INVASIVE PRENATAL GENETIC DIAGNOSIS USING TRANSCERVICAL CELLS 审中-公开
标题翻译：使用TRANSCERVICAL细胞的非侵入性预防性遗传诊断
公开(公告)号：WO2004087863A2
公开(公告)日：2004-10-14
申请号：PCT/IL2004/000304
申请日：2004-04-01
申请人： MONALIZA MEDICAL, LTD. , AMIEL, Aliza , FEJGIN, Moshe, D.
发明人： AMIEL, Aliza , FEJGIN, Moshe, D.
IPC分类号： C12N
CPC分类号： C12Q1/6879 , C12Q1/6841 , C12Q1/6883 , C12Q2600/156 , G01N33/689 , G01N2800/36 , G01N2800/368 , G01N2800/387
摘要： A non-invasive, risk-free method of prenatal diagnosis is provided. According to the method of the present invention transcervical specimens are subjected to trophoblast-specific immunostaining followed by FISH and/or PRINS analyses in order to determine fetal gender and/or identify chromosomal abnormalities in a fetus.
摘要翻译：提供了一种非侵入性，无风险的产前诊断方法。根据本发明的方法，将子宫颈标本进行滋养细胞特异性免疫染色，然后进行FISH和/或PRINS分析，以确定胎儿性别和/或鉴定胎儿中的染色体异常。

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