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1. 发明申请

WO2005024411A2 ANALYTE INJECTION SYSTEM 审中-公开
标题翻译：分析注射系统
公开(公告)号：WO2005024411A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/029227
申请日：2004-09-07
申请人： CALIPER LIFE SCIENCES, INC. , PARK, Charles , KECHAGIA, Persefoni , SPAID, Michael , JENSEN, Morten , KAZAKOVA, Irina, G. , MOLHO, Josh
发明人： PARK, Charles , KECHAGIA, Persefoni , SPAID, Michael , JENSEN, Morten , KAZAKOVA, Irina, G. , MOLHO, Josh
IPC分类号： G01N27/447
CPC分类号： B01L3/502753 , B01L3/502715 , B01L3/502746 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0415 , B01L2400/084 , G01N27/44743 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separation of analytes from other sample constituents can be enhanced using skewing channel ITP.
摘要翻译：本发明提供了用于将分析物注入分离通道以进行分离和检测的方法和系统。在通过检测到的电压事件触发注射之前，可以对样品进行预处理并通过等速电泳（ITP）进行浓缩。使用偏斜通道ITP可以增强分析物与其他样品成分的分离。

2. 发明申请

WO2001073417A1 ULTRA HIGH THROUGHPUT MICROFLUIDIC ANALYTICAL SYSTEMS AND METHODS 审中-公开
标题翻译：超高速微流控分析系统及方法
公开(公告)号：WO2001073417A1
公开(公告)日：2001-10-04
申请号：PCT/US2001/009074
申请日：2001-03-22
申请人： CALIPER TECHNOLOGIES CORP. , KOPF-SILL, Anne, R. , CHOW, Andrea, W. , JANN, Peter, C. , JENSEN, Morten, J. , SPAID, Michael , KENNEDY, Colin, B. , KENNEDY, Michael
发明人： KOPF-SILL, Anne, R. , CHOW, Andrea, W. , JANN, Peter, C. , JENSEN, Morten, J. , SPAID, Michael , KENNEDY, Colin, B. , KENNEDY, Michael
IPC分类号： G01N27/26
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/54 , B01L9/527 , B01L2200/023 , B01L2200/027 , B01L2200/028 , B01L2200/147 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44782 , G01N35/0099 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421
摘要： Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.
摘要翻译：分析系统和方法，其使用模块化接口结构（600）来提供样本基板（630）和分析单元（610）之间的界面，其中分析单元（610）具有用于实现各种分析和控制功能的特定接口布置。使用模块化接口结构（600）的每个模块的多个变体有利地提供了使用具有特定分析和控制系统接口布置的特定基板或类别的基板执行大量测试的成本有效和有效的方式。还提供了用于同时分析多个并行微通道（622）中的反应或条件的改进的光学照明和检测系统。

3. 发明申请

WO2005068993A1 ANALYTE INJECTION SYSTEM 审中-公开
标题翻译：分析系统
公开(公告)号：WO2005068993A1
公开(公告)日：2005-07-28
申请号：PCT/US2004/018551
申请日：2004-06-12
申请人： CALIPER LIFE SCIENCES, INC. , WAKO PURE CHEMICAL INDUSTRIES, LTD.
发明人： PARK, Charles , KECHAGIA, Persefoni , SPAID, Michael , JENSEN, Morten , KAZAKOVA, Irina, G. , MOLHO, Josh , KAWABATA, Tomohisa , WATANABE, Mitsuo
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0673 , B01L2400/0415 , C12Q1/6804 , C12Q1/6883 , G01N27/44773 , C12Q2565/629 , C12Q2565/125 , C12Q2563/179
摘要： This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.
摘要翻译：本发明提供了用于空间分离样品中的至少第一和第二组分的方法和装置，其在一个示例性实施方案中包括将第一和第二组分引入载体流体中的微流体装置的第一微流体通道，所述载体流体包括间隔电解质溶液和层叠所述第一和第二组分通过在前导电解质溶液和尾部电解质溶液之间的等速电泳，其中所述间隔电解质溶液包含在电场中具有中间迁移率的离子，所述离子存在于所述前导和后续电解质溶液中的离子的迁移率之间，间隔电解质溶液包含以下间隔离子MOPS，MES，壬酸，D-葡糖醛酸，乙酰水杨酸，4-乙氧基苯甲酸，戊二酸，3-苯基丙酸，苯氧基乙酸，半胱氨酸，马尿酸，p 羟基苯乙酸，异丙基丙二酸，衣康酸a cid，柠康酸，3,5-二甲基苯甲酸，2,3-二甲基苯甲酸，对羟基肉桂酸和5-溴-2,4-二羟基苯甲酸，其中第一组分包含DNA-抗体缀合物，第二组分包含第二组分包含DNA抗体缀合物和分析物的复合物。

4. 发明申请

WO2020139905A1 SILVER NANOWIRE TRANSPARENT CONDUCTIVE FILMS 审中-公开
公开(公告)号：WO2020139905A1
公开(公告)日：2020-07-02
申请号：PCT/US2019/068515
申请日：2019-12-26
申请人： CAMBRIOS FILM SOLUTIONS CORPORATION , SPAID, Michael
发明人： SPAID, Michael , TUTTLE, Derek , CHEN, Pin-chu , WOLK, Jeff , DAI, Haixia
IPC分类号： H01B1/22
摘要： An electrically-conductive film that includes a substrate and a plurality of metal nanostmctures supported on the substrate, with the nanostmctures connecting to provide a network having electrical conductivity along the network. The film includes a first overcoat matrix on the nanostmctures and the substrate, and can includes a second overcoat matrix on the nanostmctures and the first overcoat matrix. The second overcoat matrix can have a thickness sufficient to cover the nanostmctures and the first overcoat matrix. The film allows an electrical contact material that extends through the second overcoat matrix to electrically connect to the nanostmctures at a contact area. The first overcoat matrix can have a thickness within a range of 1 to 3 average diameter of the nanostmctures. The combination of the first overcoat matrix and second overcoat matrix can fully cover the nanostmctures.

5. 发明申请

WO2013142461A1 DRY GAS THRUST BEARING FOR USE IN ROTATING EQUIPMENT 审中-公开
标题翻译：干燥轴承用于旋转设备
公开(公告)号：WO2013142461A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/032901
申请日：2013-03-19
申请人： FLOWSERVE MANAGEMENT COMPANY , STEINMANN, Detlev , THOM, Jack , CARPENTER, Timothy, D. , BUITER, Chris , BRADSHAW, Bryan , SPAID, Michael
发明人： STEINMANN, Detlev , THOM, Jack , CARPENTER, Timothy, D. , BUITER, Chris , BRADSHAW, Bryan , SPAID, Michael
IPC分类号： F16C17/04 , F16C27/08
CPC分类号： F16C32/0603 , F01D25/168 , F01D25/22 , F16C17/04 , F16C27/08 , F16C2360/42
摘要： and more particularly, this thrust bearing is designed to support compressor/turbine thrust loads in an improved arrangement which does not require oil lubrication and which is designed to support necessary shaft thrust loading by the utilization of a dry gas film. The bearing includes a shaft rotor 23 between two axially movable stators 39 and relies on a dry gas film to separate the rotor 23 and stators 39. The stators 39 are axially loaded by a double spring package 64 arranged in series wherein a lightly loaded spring engages the stator 39 during zero thrust applications, and as the shaft 14 begins to rotate and encounter axial thrust, a heavier stiffer spring, greater than the thrust load, quickly engages.
摘要翻译：并且更具体地，该推力轴承被设计成以改进的布置来支撑压缩机/涡轮机推力载荷，其不需要油润滑并且被设计成通过利用干燥气体膜来支撑必要的轴推力负载。该轴承包括位于两个可轴向移动的定子39之间的轴转子23，并且依靠干燥气体薄膜来分离转子23和定子39.定子39由串联布置的双弹簧组件64轴向加载，其中轻载弹簧与定子39在零推力应用期间，并且当轴14开始旋转并遇到轴向推力时，大于推力载荷的较重的较硬的弹簧快速接合。

6. 发明申请

WO2004083443A1 SINGLE MOLECULE AMPLIFICATION AND DETECTION OF DNA 审中-公开
标题翻译：单分子放大和DNA的检测
公开(公告)号：WO2004083443A1
公开(公告)日：2004-09-30
申请号：PCT/US2003/040599
申请日：2003-12-19
申请人： CALIPER TECHNOLOGIES CORP. , KNAPP, Michael, R. , BAKER, Jill, M. , CHOW, Andrea , KOPF-SILL, Anne , SPAID, Michael
发明人： KNAPP, Michael, R. , BAKER, Jill, M. , CHOW, Andrea , KOPF-SILL, Anne , SPAID, Michael
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2200/16 , B01L2300/1827 , B01L2400/0406 , C12Q1/6837 , C12Q1/6851 , C12Q2531/113 , C12Q2565/629 , C12Q2527/143 , C12Q2547/107 , C12Q2537/157
摘要： Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of rare nucleic acids are provided.
摘要翻译：提供了用于进行单分子扩增用于稀有核酸的检测，定量和统计分析的方法和系统。

7. 发明申请

WO2003076052A1 MIXED MODE MICROFLUIDIC SYSTEMS ABSTRACT OF THE DISCLOSURE 审中-公开
标题翻译：混合模式微流系统摘要摘要
公开(公告)号：WO2003076052A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/006688
申请日：2003-03-04
申请人： CALIPER TECHNOLOGIES CORP. , CHIEN, Ring-Ling , PARCE, J. Wallace , SPAID, Michael
发明人： CHIEN, Ring-Ling , PARCE, J. Wallace , SPAID, Michael
IPC分类号： B01D57/00
CPC分类号： B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , F04B19/006 , G01N27/44791 , H02N11/006
摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.
摘要翻译：采用混合流体流动分布的方法和系统，通过通道网络优化材料的运动。这些系统采用基于混合压力和电动的流动系统，用于通过互连的通道网络移动材料，同时保持各个通道段之间的互连。特别地，本发明通常涉及通道网络，其中第一通道段中的流动由具有随后的抛物线流动分布的压力流驱动，而在互连通道段中的流动由其动力流以及随之而来的塞流动分布主导。本发明还提供了通道网络，其中通道段中的流体流动由压力和电场驱动，并且通过改变通道网络的各个通道段中施加的压力和电场来分离流体塞中包含的多个物质。

8. 发明申请

WO2004015419A1 METHODS AND SYSTEMS FOR MONITORING MOLECULAR INTERACTIONS 审中-公开
标题翻译：监测分子相互作用的方法和系统
公开(公告)号：WO2004015419A1
公开(公告)日：2004-02-19
申请号：PCT/US2003/024626
申请日：2003-08-06
申请人： CALIPER TECHNOLOGIES CORP. , SPAID, Michael , WOLK, Jeffrey, A.
发明人： SPAID, Michael , WOLK, Jeffrey, A.
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： The present invention relates to novel methods and systems for determining the interaction of molecules using the phenomena of Taylor-Aris dispersion present in fluid flow in conduits. The method involves relating a change in dispersion of molecules to their level of interaction. The present invention also relates to an assay method using Taylor-Aris dispersion in a microfluidic system in order to examine molecular interactions in a variety of chemical and biochemical systems.
摘要翻译：本发明涉及使用存在于管道中的流体流中的泰勒 - 阿里斯分散现象确定分子相互作用的新方法和系统。该方法涉及将分子的分散变化与其相互作用的水平相关联。本发明还涉及在微流体系统中使用泰勒 - 阿里斯分散体以测试各种化学和生化系统中的分子相互作用的测定方法。

9. 发明申请

WO2011025782A1 CONTACT RESISTANCE MEASUREMENT FOR RESISTANCE LINEARITY IN NANOSTRUCTURE THIN FILMS 审中-公开
标题翻译：接触电阻测量在纳米薄膜中的电阻线性
公开(公告)号：WO2011025782A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046493
申请日：2010-08-24
申请人： CAMBRIOS TECHNOLOGIES CORPORATION , SPAID, Michael , PSCHENITZKA, Florian
发明人： SPAID, Michael , PSCHENITZKA, Florian
IPC分类号： G06F3/045
CPC分类号： G06F3/045
摘要： The present disclosure is directed to a transparent conductor for use in touch panel devices having a plurality of nanostructures therein that provides reliable output based on user touch or pen input. To determine if a touch panel is reliable, there is disclosed a method of measuring voltages across the transparent conductor when it is touched. These measured voltages are converted into contact resistances, which are statistically analyzed. A median contact resistance is determined based on the converted contact resistances. The remaining set of converted contact resistances are analyzed to determine if they are within acceptable limits. Acceptable limits may include most of the contact resistances falling within a range, none of the contact resistances exceeding an upper limit, and a difference in contact resistances converted for different users or pens does not exceed a maximum variability.
摘要翻译：本公开涉及一种用于其中具有多个纳米结构的触摸面板装置的透明导体，其基于用户触摸或笔输入提供可靠的输出。为了确定触摸面板是否可靠，公开了一种当触摸时测量透明导体上的电压的方法。这些测量的电压被转换为接触电阻，进行统计分析。基于转换的接触电阻确定中值接触电阻。分析剩余的一组转换的接触电阻以确定它们是否在可接受的限度内。可接受的限制可以包括大部分接触电阻落在一个范围内，接触电阻不超过上限，并且不同用户或笔转换的接触电阻差不超过最大变化。

10. 发明申请

WO2008013516A2 SEED LAYERS, CAP LAYERS, AND THIN FILMS AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：种子层，盖层和薄膜及其制造方法
公开(公告)号：WO2008013516A2
公开(公告)日：2008-01-31
申请号：PCT/US2006/018805
申请日：2006-05-15
申请人： CAMBRIOS TECHNOLOGIES CORP. , DAI, Haixia , PAKBAZ, Hash , SPAID, Michael , NIKIFOROV, Theo
发明人： DAI, Haixia , PAKBAZ, Hash , SPAID, Michael , NIKIFOROV, Theo
CPC分类号： C23C18/1608 , B82Y30/00 , C23C18/1844 , C23C18/50 , H01L21/288 , H01L21/76814 , H01L21/76843 , H01L21/76849 , H01L21/7685 , H01L21/76861 , H01L21/76864 , H01L21/76867 , H01L21/76868 , H01L21/76871 , H01L21/76874 , H01L21/76879
摘要： A seed layer is formed on a substrate using a first biological agent. The seed layer may comprise densified nanoparticles which are bound to the biological agent. The seed layer is then used for a deposition of a metal layer, such as a barrier layer, an interconnect layer, a cap layer and/or a bus line for a solid state device.
摘要翻译：使用第一生物因子在基底上形成种子层。种子层可以包含与生物因子结合的致密化的纳米粒子。然后，种子层用于固态器件的金属层（例如阻挡层，互连层，帽层和/或总线）的沉积。

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