专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2014085802A1 HIGH-THROUGHPUT DYNAMIC REAGENT DELIVERY SYSTEM 审中-公开
标题翻译：高通量动态试剂递送系统
公开(公告)号：WO2014085802A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072575
申请日：2013-12-02
申请人： THE BROAD INSTITUTE, INC. , ESPCI INNOV SAS , GRIFFITHS, Andrew, D. , LEMAN, Marie , NICOL, Robert , STEELMAN, Scott
发明人： GRIFFITHS, Andrew, D. , LEMAN, Marie , NICOL, Robert , STEELMAN, Scott
IPC分类号： B01L3/02 , B01F5/04 , B01L3/00
CPC分类号： B01J19/0046 , B01F3/0807 , B01F5/0473 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F15/0246 , B01J2219/00378 , B01J2219/00698 , B01J2219/00722 , B01J2219/00727 , B01L3/0268 , B01L3/502715 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0867 , B01L2400/0403 , B01L2400/0415
摘要： The present invention relates to systems and methods for manipulating droplets within a high through put microfluidic system.
摘要翻译：本发明涉及用于操纵高通量微流体系统内的液滴的系统和方法。

2. 发明申请

WO2013130827A1 THREE-DIMENSIONAL DIGITAL MICROFLUIDIC SYSTEM 审中-公开
标题翻译：三维数字微流体系统
公开(公告)号：WO2013130827A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028351
申请日：2013-02-28
申请人： SPARKLE POWER INC.
发明人： WANG, Gary Chorng-Jyh
IPC分类号： G01N31/00
CPC分类号： G01N27/44791 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L3/563 , B01L2300/0816 , B01L2300/0874 , B01L2400/0427 , B81B1/00 , B81B2201/0214 , B81B2201/058
摘要： A three-dimensional digital microfluidic system comprises a first plate with a first electrode, a second plate with a second electrode, and a microfluidic drop in between the first and the second electrode. The electrodes are able to be actuated in sequence such that the microfluidic drop is able to be transported. A bridge plate is able to be included.
摘要翻译：三维数字微流体系统包括具有第一电极的第一板，具有第二电极的第二板和在第一和第二电极之间的微流体液滴。电极能够依次致动，使得微流体液滴能够被输送。可以包括桥板。

3. 发明申请

WO2012151192A2 MOLECULAR DIAGNOSTICS PLATFORM 审中-公开
标题翻译：分子诊断平台
公开(公告)号：WO2012151192A2
公开(公告)日：2012-11-08
申请号：PCT/US2012/035963
申请日：2012-05-01
申请人： ADVANCED LIQUID LOGIC, INC. , BORT, Donovan , GRAHAM, Carrie , PAMULA, Vamsee , POLLACK, Michael , SISTA, Ramakrishna , SRINIVASAN, Vijay
发明人： BORT, Donovan , GRAHAM, Carrie , PAMULA, Vamsee , POLLACK, Michael , SISTA, Ramakrishna , SRINIVASAN, Vijay
CPC分类号： G01N27/44791 , B01F1/0027 , B01F13/0071 , B01F13/0076 , B01F2001/0055 , B01F2215/0037 , B01L3/502761 , B01L3/502792 , B01L2200/0605 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/089 , B01L2400/0406 , B01L2400/0418 , B01L2400/0427 , B01L2400/043 , B01L2400/0487 , B81B1/004
摘要： A method of mixing a droplet, the method comprising providing a droplet on a surface, forming the droplet into a first "U" shape having a bottom region and two terminal ends, and simultaneously merging the terminal ends and splitting the droplet at the bottom region to form a second "U" shape which is substantially opposite the first "U" shape.
摘要翻译：一种混合液滴的方法，所述方法包括在表面上提供液滴，将所述液滴形成为具有底部区域和两个末端的第一“U”形状，并同时合并末端并在底部区域分离液滴以形成与第一“U”形大致相反的第二“U”形。

4. 发明申请

WO2012135259A1 INJECTION OF MULTIPLE VOLUMES INTO OR OUT OF DROPLETS 审中-公开
标题翻译：将多个体积注入或倒入滴管中
公开(公告)号：WO2012135259A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/030811
申请日：2012-03-28
申请人： GNUBIO, INC. , ABATE, Adam , KIANI, Sepehr , HUNG, Tony , MARY, Pascaline , ESMAIL, Adnan, Moez
发明人： ABATE, Adam , KIANI, Sepehr , HUNG, Tony , MARY, Pascaline , ESMAIL, Adnan, Moez
IPC分类号： F16K31/48
CPC分类号： B01L3/5027 , B01F13/0071 , B01F13/0076 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2300/1861 , B01L2400/0424 , B01L2400/0436 , B01L2400/0442 , F04B19/006 , F16K99/0019
摘要： The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.
摘要翻译：本发明通常涉及用于将多个基本上受控制的体积注入或流出液滴的系统，以及包含该液滴的方法和试剂盒。本发明的系统包括至少一个微流体通道，一个或多个注射通道，与一个或多个注射通道中的每一个相关联的注射入口，以及用于破坏液滴和流体和/或乳液之间的界面的机构，其中所述至少一个微流体通道包括一个或多个液滴在其中流动，并且其中所述一个或多个注射通道中的每一个在其中包括至少一种流体和/或乳液。

5. 发明申请

WO2011126892A2 DROPLET OPERATIONS PLATFORM 审中-公开
标题翻译： DROPLET操作平台
公开(公告)号：WO2011126892A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/030543
申请日：2011-03-30
申请人： ADVANCED LIQUID LOGIC, INC. , SRINIVASAN, Vijay , SUDARSAN, Arjun , BAUER, William Craig , SMITH, Gregory F. , POORE, Matthew , WANG, Tih-Hong
发明人： BAUER, William Craig , POORE, Matthew , WANG, Tih-Hong
CPC分类号： G01N27/44734 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L7/525 , B01L7/54 , B01L2200/027 , B01L2200/06 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , B01L2400/0427 , B01L2400/043 , B01L2400/0677 , B01L2400/0683 , G01N27/44791
摘要： The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations. The droplet actuator device may include a bottom substrate and a top substrate separated from each other to form a gap therebetween; an arrangement of droplet operations electrodes arranged on one or both of the bottom and/or top substrates for conducting droplet operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and one or more openings arranged to provide a fluidic path from the one or more compartments into the gap, upon breach of a breachable seal separating the one or more compartments and openings.
摘要翻译：本发明涉及一种液滴致动器装置和用于生物样品的综合样品制备和分析的方法。提供液滴致动器装置用于进行液滴操作。液滴致动器装置可以包括彼此分离的底部基板和顶部基板，以在它们之间形成间隙; 布置在底部和/或顶部衬底中的一个或两个上的液滴操作电极的布置，用于在其上进行液滴操作; 试剂储存层，包含一个或多个结合到顶部基底的隔室; 以及一个或多个开口，其布置成在违反分离所述一个或多个隔室和开口的可破裂密封件时提供从所述一个或多个隔室进入所述间隙的流体路径。

6. 发明申请

WO2011023405A1 METHOD AND ELECTRO-FLUIDIC DEVICE TO PRODUCE EMULSIONS AND PARTICLE SUSPENSIONS 审中-公开
标题翻译：用于生产乳液和颗粒悬浮液的方法和电流装置
公开(公告)号：WO2011023405A1
公开(公告)日：2011-03-03
申请号：PCT/EP2010/005307
申请日：2010-08-30
申请人： GEORGIA TECH RESEARCH CORPORATION , UNIVERSIDAD DE SEVILLA , UNIVERSIDAD DE MÁLAGA , BARRERO RIPOLL, Antonio , GONZÁLEZ-LOSCERTALES, Ignacio , GUNDABALA, Venkata, Ramana , FERNÁNDEZ-NIEVES, Alberto
发明人： BARRERO RIPOLL, Antonio , GONZÁLEZ-LOSCERTALES, Ignacio , GUNDABALA, Venkata, Ramana , FERNÁNDEZ-NIEVES, Alberto
IPC分类号： B01F3/08 , B01F13/00
CPC分类号： B01F3/0815 , B01F3/0807 , B01F13/0062 , B01F13/0076 , B01F2005/0034 , B01F2215/0445
摘要： The invention refers to a method, and to a device to produce emulsions and particle suspensions by using electro-hydrodinamic forces and microfluidics This combined use allow the production of droplets with mean diameters which may be either smaller than those obtained in conventional microfluidic devices or larger than those obtained by electrospray, bridging the gap between the two methods acting independently.
摘要翻译：本发明涉及一种方法，以及通过使用电加氢力和微流体产生乳剂和颗粒悬浮液的装置。该组合使用允许产生平均直径的液滴，其平均直径可以小于在常规微流体装置或更大尺寸中获得的平均直径比通过电喷雾获得的那些，桥接两种独立方法之间的间隙。

7. 发明申请

WO2010110843A1 DROPLET GENERATOR 审中-公开
标题翻译： DROPLET发电机
公开(公告)号：WO2010110843A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/000703
申请日：2010-03-09
申请人： EASTMAN KODAK COMPANY , CLARKE, Andrew , DARTNELL, Nicholas, J. , RIDER, Christopher, Barrie
发明人： CLARKE, Andrew , DARTNELL, Nicholas, J. , RIDER, Christopher, Barrie
IPC分类号： B01F3/08 , B01F13/00 , B05B1/34 , B05B7/04
CPC分类号： B01L3/502715 , B01F13/0062 , B01F13/0076 , B01F13/0079 , B01L2300/0861 , B05B7/0408 , B41J2/02 , Y10S435/808 , Y10S436/805 , Y10S436/809 , Y10T436/117497 , Y10T436/118339 , Y10T436/25
摘要： A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.
摘要翻译：一种用于周期性地扰动微流体装置内的流场以提供高速度的规则液滴形成的方法和装置。

8. 发明申请

WO2010110842A1 DROPLET GENERATOR 审中-公开
标题翻译： DROPLET发电机
公开(公告)号：WO2010110842A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/000700
申请日：2010-03-09
申请人： EASTMAN KODAK COMPANY , CLARKE, Andrew , DARTNELL, Nicholas, J. , RIDER, Christopher, Barrie
发明人： CLARKE, Andrew , DARTNELL, Nicholas, J. , RIDER, Christopher, Barrie
IPC分类号： B01F13/00 , B05B1/34 , B05B7/04 , B01J2/04 , B41J2/03 , A61M11/06 , A01C23/04
CPC分类号： B01L3/502715 , B01F13/0062 , B01F13/0076 , B01F13/0079 , B01L2300/0861 , B05B7/0408 , B41J2/02 , Y10S435/808 , Y10S436/805 , Y10S436/809 , Y10T436/117497 , Y10T436/118339 , Y10T436/25
摘要： A method and device for passively periodically perturbing the flow field within a microfluidic device to cause regular droplet formation at high speed.
摘要翻译：用于被动地周期性地扰乱微流体装置内的流场以使高速下形成规则的液滴的方法和装置。

9. 发明申请

WO2010045357A3 ENHANCED ON-CHIP SERS BASED BIOMOLECULAR DETECTION USING ELECTROKINETICALLY ACTIVE MICROWELLS 审中-公开
标题翻译：利用电动激活微孔增强基于片上SERS的生物分子检测
公开(公告)号：WO2010045357A3
公开(公告)日：2010-07-01
申请号：PCT/US2009060675
申请日：2009-10-14
申请人： UNIV CORNELL , ERICKSON DAVID , HUH YUN SUK , BATT CARL A , LOWE ADAM JOSEPH
发明人： ERICKSON DAVID , HUH YUN SUK , BATT CARL A , LOWE ADAM JOSEPH
IPC分类号： G01N33/483
CPC分类号： C12Q1/6827 , B01F13/0076 , B01L3/50273 , B01L3/502761 , B01L2300/0636 , B01L2300/0654 , B01L2300/0809 , B01L2300/0829 , B01L2300/0887 , B01L2400/0415 , B01L2400/0424 , C12Q1/6862 , C12Q2565/632 , G01N21/658 , C12Q2563/137 , C12Q2531/137
摘要： A method for detecting target nucleic acids such as SNPs is provided. The method comprises performing a ligase detection reaction (LDR), performing surface enhanced Raman scattering (SERS) on the LDR, and analyzing the outcome of the LDR using analysis and/or quantification of the SERS by detecting an emitted Raman signature. The LDR-SERS method can be used for sensitive and specific detection of any nucleic acid sequence of interest. A microfluidic SERS detection device is also provided. The device comprises electrokinetically active microwells for mixing and concentrating analytes and in which analytes can be quantified. The device can be used for performing the LDR-SERS method in optofluidic chip format.
摘要翻译：提供了检测靶核酸如SNP的方法。该方法包括执行连接酶检测反应（LDR），对LDR执行表面增强拉曼散射（SERS），并且通过检测发射的拉曼签名使用SERS的分析和/或定量分析LDR的结果。 LDR-SERS方法可用于敏感和特异性检测任何感兴趣的核酸序列。还提供了微流体SERS检测装置。该装置包含用于混合和浓缩分析物的电动活性微孔，并且可以量化分析物。该器件可用于执行光流控芯片格式的LDR-SERS方法。

10. 发明申请

WO2010019782A2 METHODS, SYSTEMS, AND PRODUCTS FOR CONDUCTING DROPLET OPERATIONS 审中-公开
标题翻译：方法，系统和产品用于进行滴灌操作
公开(公告)号：WO2010019782A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/053725
申请日：2009-08-13
申请人： STURMER, Ryan, A. , SMITH, Gregory, F. , FOGLEMAN, Michael , BRAFFORD, Keith, R. , RONGALI, Sai, Ram , ADVANCED LIQUID LOGIC, INC.
发明人： STURMER, Ryan, A. , SMITH, Gregory, F. , FOGLEMAN, Michael , BRAFFORD, Keith, R. , RONGALI, Sai, Ram
IPC分类号： B01J19/08 , G06F9/455 , G06F19/00
CPC分类号： G06F19/00 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , F04B17/00 , F04B19/006 , F04B49/065
摘要： The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes. Another aspect of the software components of the invention is a droplet actuator description file that contains the physical and electrical description of the droplet actuator. Another aspect of the software components of the invention is a router component for determining routes of droplet operations in a droplet actuator. Another aspect of the software components of the invention is the use of tri-state vectors for programming sequences in a droplet actuator. Still other aspects are provided.
摘要翻译：本发明提供了用于在液滴致动器操作中使用的修改的液滴致动器系统，软件和软件执行方法以及配置和编程为执行这样的软件的液滴致动器系统。本发明的软件组件的一个方面是用于微流体系统的每个硬件组件的接口描述文件，其允许在不修改用于执行液滴操作协议的程序的情况下改变硬件组件。本发明的软件组件的另一方面是建立电极对电极关系和液滴致动器配置的其他方面，其可以在编程液滴操作协议时使用。本发明的软件组件的另一方面是预定电极元件的物理设计库，其可以在构建电极的布局时由液滴致动器设计者使用。本发明的软件组件的另一方面是液滴致动器描述文件，其包含液滴致动器的物理和电气描述。本发明的软件组件的另一方面是用于确定液滴致动器中的液滴操作路线的路由器组件。本发明的软件组件的另一方面是使用三态向量来在液滴致动器中编程序列。还提供了其他方面。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式