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1. 发明申请

WO2010033909A2 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入或不可剥离的医疗器械
公开(公告)号：WO2010033909A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057674
申请日：2009-09-21
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , OVERSTREET, Edward, Holman , PIANCA, Anne, M. , KUZMA, Janusz , PANDIT, Aditya , BRITO, Shaina , RICHARD, Robert, E. , DIPIETRO, Kerri , STRICKLER, Frederick, H. , BODEN, Mark , PHAM, Lan , ORINSKI, William
发明人： OVERSTREET, Edward, Holman , PIANCA, Anne, M. , KUZMA, Janusz , PANDIT, Aditya , BRITO, Shaina , RICHARD, Robert, E. , DIPIETRO, Kerri , STRICKLER, Frederick, H. , BODEN, Mark , PHAM, Lan , ORINSKI, William
IPC分类号： A61L27/16
CPC分类号： A61L27/54 , A61L27/18 , A61L27/34 , A61L2300/222 , A61L2300/602 , A61N1/0534 , A61N1/0541 , A61N1/0551 , C08L83/06
摘要： In various aspects, the present invention is directed to implantable neurostimulation leads and methods for their formation. In various additional aspects, the present invention is directed to medical devices having silicone-containing regions with overlying polymeric layers and to methods of forming the same.
摘要翻译：在各个方面，本发明涉及可植入的神经刺激引线及其形成方法。在各种附加方面，本发明涉及具有含有覆盖聚合物层的含硅氧烷的区域的医疗装置及其形成方法。

2. 发明申请

WO2010033483A1 METHODS AND SYSTEMS OF CONVEYING FINE STRUCTURE INFORMATION TO A COCHLEAR IMPLANT PATIENT 审中-公开
标题翻译：将精细结构信息传送给海绵体植入物的方法和系统
公开(公告)号：WO2010033483A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/056926
申请日：2009-09-15
申请人： ADVANCED BIONICS, LLC , LITVAK, Leonid, M. , SAOJI, Aniket, S. , SPAHR, Anthony, J. , OVERSTREET, Edward, H.
发明人： LITVAK, Leonid, M. , SAOJI, Aniket, S. , SPAHR, Anthony, J. , OVERSTREET, Edward, H.
IPC分类号： A61N1/36 , A61N1/32 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36032 , A61N1/0541 , A61N1/323 , A61N1/36036 , A61N1/36185
摘要： An exemplary method of conveying fine structure information to a cochlear implant patient includes dividing an audio signal into a plurality of analysis channels, generating electrical stimulation in accordance with the information contained within each of the analysis channels, applying the electrical stimulation to at least one stimulation site within a patient via a plurality of stimulation channels, and at least partially isolating one of the stimulation channels from a rest of the stimulation channels, wherein fine structure information is conveyed to the patient via the isolated stimulation channel. Corresponding methods and systems are also disclosed.
摘要翻译：将精细结构信息传送到耳蜗植入患者的示例性方法包括将音频信号划分成多个分析通道，根据包含在每个分析通道内的信息产生电刺激，将电刺激应用于至少一个刺激通过多个刺激通道在患者体内的位置，并且至少部分地将刺激通道中的一个与其余刺激通道隔离，其中精细结构信息经由隔离的刺激通道传送给患者。还公开了相应的方法和系统。

3. 发明申请

WO2010033909A3 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入或不可剥离的医疗器械
公开(公告)号：WO2010033909A3
公开(公告)日：2011-03-10
申请号：PCT/US2009057674
申请日：2009-09-21
申请人： BOSTON SCIENT NEUROMODULATION , OVERSTREET EDWARD HOLMAN , PIANCA ANNE M , KUZMA JANUSZ , PANDIT ADITYA , BRITO SHAINA , RICHARD ROBERT E , DIPIETRO KERRI , STRICKLER FREDERICK H , BODEN MARK , PHAM LAN , ORINSKI WILLIAM
发明人： OVERSTREET EDWARD HOLMAN , PIANCA ANNE M , KUZMA JANUSZ , PANDIT ADITYA , BRITO SHAINA , RICHARD ROBERT E , DIPIETRO KERRI , STRICKLER FREDERICK H , BODEN MARK , PHAM LAN , ORINSKI WILLIAM
IPC分类号： A61L27/16 , C08G77/20
CPC分类号： A61L27/54 , A61L27/18 , A61L27/34 , A61L2300/222 , A61L2300/602 , A61N1/0534 , A61N1/0541 , A61N1/0551 , C08L83/06
摘要： In various aspects, the present invention is directed to implantable neurostimulation leads and methods for their formation. In various additional aspects, the present invention is directed to medical devices having silicone-containing regions with overlying polymeric layers and to methods of forming the same.
摘要翻译：在各个方面，本发明涉及可植入的神经刺激引线及其形成方法。在各种附加方面，本发明涉及具有含有覆盖聚合物层的含硅氧烷的区域的医疗装置及其形成方法。

4. 发明申请

WO2009029866A2 MINIMIZING TRAUMA DURING AND AFTER INSERTION OF A COCHLEAR LEAD 审中-公开
标题翻译：最小化颅脑插入过程中和插入后的创伤
公开(公告)号：WO2009029866A2
公开(公告)日：2009-03-05
申请号：PCT/US2008/074890
申请日：2008-08-29
申请人： ADVANCED BIONICS, LLC , OVERSTREET, Edward, H. , FALTYS, Michael, A. , XIE, Jian , COLVIN, Michael, S.
发明人： OVERSTREET, Edward, H. , FALTYS, Michael, A. , XIE, Jian , COLVIN, Michael, S.
IPC分类号： A61N1/05 , A61K9/00 , A61F11/00
CPC分类号： A61N1/0541 , A61K9/0024 , A61K9/0046 , A61K31/495
摘要： A method for delivering dexamethasone base (DXMb) via an implantable electrode (195, 1200, 1400, 1500, 1600) includes coupling DXMb to the implantable electrode (195, 1200, 1400, 1500, 1600) and inserting the implantable electrode (195, 1200, 1400, 1500, 1600) into animal tissue (150), the DXMb eluting into the animal tissue (150). An implantable nerve stimulating device (100, 1200, 1400, 1500, 1600) includes an elongated member (195) having a distal end bearing at least one electrode; and DXMb coupled to the elongated member (195), the DXMb being eluted into tissue (150) surrounding the elongated member (195).
摘要翻译：通过植入式电极（195,1200,1400,1500,1600）递送地塞米松基质（DXMb）的方法包括将DXMb偶联至植入式电极（195,1200,1400,1500,1600）和将植入式电极（195,1200,1400,1500,1600）插入动物组织（150）中，DXMb洗脱到动物组织（150）中。一种植入式神经刺激装置（100,1200,1400,1500,1600）包括：细长构件（195），其具有承载至少一个电极的远端; 和DXMb联接到细长构件（195），DXMb被洗提到围绕细长构件（195）的组织（150）中。

5. 发明申请

WO2006053020A2 SLURRY DEWATERING AND CONVERSION OF BIOSOLIDS TO A RENEWABLE FUEL 审中-公开
标题翻译：生物柴油降解和转化为可再生燃料
公开(公告)号：WO2006053020A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040544
申请日：2005-11-08
申请人： ENERTECH ENVIRONMENTAL, INC. , DICKINSON, Norman, L. , BOLIN, Kevin, M. , OVERSTREET, Edward , DOOLEY, Brian
发明人： DICKINSON, Norman, L. , BOLIN, Kevin, M. , OVERSTREET, Edward , DOOLEY, Brian
IPC分类号： C10L5/42
CPC分类号： C10G1/02 , C02F11/10 , C02F2103/001 , C10G1/00 , C10G2300/1003 , C10G2300/1011 , C10G2300/4043 , C10G2300/4081 , C10G2300/805 , C10G2300/807 , C10L5/46 , C10L9/086 , F23G7/001 , Y02E20/16 , Y02E50/10 , Y02E50/30 , Y02E50/343 , Y02P30/20 , Y02P30/446 , Y02W10/37 , Y02W30/47
摘要： In the processes for treating municipal sewage and storm water containing biosolids to discharge standards, biosolids, even after dewatering, contain typically about 80% water bound in the dead cells of the biosolids, which gives biosolids a negative heating value. It can be incinerated only at the expense of purchased fuel. Biosolids are heated to a temperature at which their cell structure is destroyed and, preferably, at which carbon dioxide is split off to lower the oxygen content of the biosolids. The resulting char is not hydrophilic, and it can be efficiently dewatered and/or dried and is a viable renewable fuel. This renewable fuel can be supplemented by also charging conventional biomass (yard and crop waste, etc.) in the same or in parallel facilities. Similarly, non-renewable hydrophilic fuels can be so processed in conjunction with the processing of biosolids to further augment the energy supply.
摘要翻译：在处理含有生物固体排放标准的城市污水和雨水的过程中，即使在脱水后，生物固体通常在生物固体的死细胞中含有大约80％的水结合，这给生物固体带来负热值。它只能以所购燃料为代价来焚烧。将生物固体加热到它们的细胞结构被破坏的温度，并且优选地分解二氧化碳以降低生物固体的氧含量。所得到的炭不是亲水的，并且可以有效地脱水和/或干燥并且是可行的可再生燃料。这种可再生燃料可以通过在相同或并行设施中装载常规生物质（院子和作物废物等）来补充。类似地，不可再生的亲水燃料可以与生物固体的加工一起被加工以进一步增加能量供应。

6. 发明申请

WO2009029866A3 MINIMIZING TRAUMA DURING AND AFTER INSERTION OF A COCHLEAR LEAD 审中-公开
标题翻译：在引进领导之前和之后最小化TRAUMA
公开(公告)号：WO2009029866A3
公开(公告)日：2009-05-07
申请号：PCT/US2008074890
申请日：2008-08-29
申请人： ADVANCED BIONICS LLC , OVERSTREET EDWARD H , FALTYS MICHAEL A , XIE JIAN , COLVIN MICHAEL S
发明人： OVERSTREET EDWARD H , FALTYS MICHAEL A , XIE JIAN , COLVIN MICHAEL S
IPC分类号： A61N1/05 , A61F11/00 , A61K9/00
CPC分类号： A61N1/0541 , A61K9/0024 , A61K9/0046 , A61K31/495
摘要： A method for delivering dexamethasone base (DXMb) via an implantable electrode (195, 1200, 1400, 1500, 1600) includes coupling DXMb to the implantable electrode (195, 1200, 1400, 1500, 1600) and inserting the implantable electrode (195, 1200, 1400, 1500, 1600) into animal tissue (150), the DXMb eluting into the animal tissue (150). An implantable nerve stimulating device (100, 1200, 1400, 1500, 1600) includes an elongated member (195) having a distal end bearing at least one electrode; and DXMb coupled to the elongated member (195), the DXMb being eluted into tissue (150) surrounding the elongated member (195).
摘要翻译：通过可植入电极（195,12400,1400,1600）递送地塞米松碱（DXMb）的方法包括将DXMb连接到可植入电极（195,1200,1400,1500,1600）并将可植入电极（195， 1200,1400,1600）转移到动物组织（150）中，DXMb洗脱到动物组织（150）中。植入式神经刺激装置（100,1200,1400,1500,1600）包括细长构件（195），其具有至少一个电极的远端; 和耦合到细长构件（195）的DXMb，DXMb被洗脱到围绕细长构件（195）的组织（150）中。

7. 发明申请

WO2006053020A3 SLURRY DEWATERING AND CONVERSION OF BIOSOLIDS TO A RENEWABLE FUEL 审中-公开
标题翻译：生物柴油降解和转化为可再生燃料
公开(公告)号：WO2006053020A3
公开(公告)日：2007-02-15
申请号：PCT/US2005040544
申请日：2005-11-08
申请人： ENERTECH ENVIRONMENTAL INC , DICKINSON NORMAN L , BOLIN KEVIN M , OVERSTREET EDWARD , DOOLEY BRIAN
发明人： DICKINSON NORMAN L , BOLIN KEVIN M , OVERSTREET EDWARD , DOOLEY BRIAN
IPC分类号： C10L7/00
CPC分类号： C10G1/02 , C02F11/10 , C02F2103/001 , C10G1/00 , C10G2300/1003 , C10G2300/1011 , C10G2300/4043 , C10G2300/4081 , C10G2300/805 , C10G2300/807 , C10L5/46 , C10L9/086 , F23G7/001 , Y02E20/16 , Y02E50/10 , Y02E50/30 , Y02E50/343 , Y02P30/20 , Y02P30/446 , Y02W10/37 , Y02W30/47
摘要： In the processes for treating municipal sewage and storm water containing biosolids to discharge standards, biosolids, even after dewatering, contain typically about 80% water bound in the dead cells of the biosolids, which gives biosolids a negative heating value. It can be incinerated only at the expense of purchased fuel. Biosolids are heated to a temperature at which their cell structure is destroyed and, preferably, at which carbon dioxide is split off to lower the oxygen content of the biosolids. The resulting char is not hydrophilic, and it can be efficiently dewatered and/or dried and is a viable renewable fuel. This renewable fuel can be supplemented by also charging conventional biomass (yard and crop waste, etc.) in the same or in parallel facilities. Similarly, non-renewable hydrophilic fuels can be so processed in conjunction with the processing of biosolids to further augment the energy supply.
摘要翻译：在处理含有生物固体排放标准的城市污水和雨水的过程中，即使在脱水后，生物固体通常在生物固体的死细胞中含有约80％的水结合，这给生物固体带来负热值。它只能以所购燃料为代价来焚烧。将生物固体加热到它们的细胞结构被破坏的温度，并且优选地分解二氧化碳以降低生物固体的氧含量。所得到的炭不是亲水的，并且可以有效地脱水和/或干燥，并且是可行的可再生燃料。这种可再生燃料可以补充在同一或同时设施中的常规生物质（院子和作物废弃物等）。类似地，不可再生的亲水燃料可以与生物固体的加工一起被加工，以进一步增加能量供应。

8. 发明申请

WO03015863A3 GRADUAL RECRUITMENT OF MUSCLE/NEURAL EXCITABLE TISSUE USING HIGH-RATE ELECTRICAL STIMULATION PARAMETERS 审中-公开
标题翻译：使用高频率电刺激参数的肌肉/神经兴奋组织的渐进性补充
公开(公告)号：WO03015863A3
公开(公告)日：2003-04-03
申请号：PCT/US0225861
申请日：2002-08-13
申请人： ADVANCED BIONICS CORP , OVERSTREET EDWARD H
发明人： OVERSTREET EDWARD H
IPC分类号： A61N1/36 , A61N1/32
CPC分类号： A61N1/36071 , A61N1/32
摘要： A neurostimulator system (170) stimulates excitable muscle or neural tissue through multiple electrodes (E1, E2, ... En) fast enough to induce stochastic neural firing, thereby acting to restore "spontaneous" neural activity. The type of stimulation provided by the neurostimulator involves the use of a high rate, e.g., greater than about 2000 Hz, pulsitile stimulation signal generated by a high rate pulse generator (172). The stream of pulses generated by the high rate pulse generator is amplitude modulated in an output driver circuit (176) with control information, provided by a modulation control element (178). Such amplitude-modulated pulsitile stimulation exploits the subtle electro physiological differences between cells comprising excitable tissue in order to desynchronize action potentials within the population of excitable tissue. Such desynchronization induces a wider distribution of population thresholds, as well as a wider electrical dynamic range, thereby better mimicking biological recruitment characteristics.
摘要翻译：神经刺激器系统（170）通过多个电极（E1，E2，... En）以足够快的速度刺激可兴奋的肌肉或神经组织，以诱导随机神经激发，从而起到恢复“自发”神经活动的作用。由神经刺激器提供的刺激类型涉及使用高速率，例如大于约2000Hz的由高速率脉冲发生器（172）产生的脉动刺激信号。由高速脉冲发生器产生的脉冲流在具有由调制控制元件（178）提供的控制信息的输出驱动器电路（176）中被幅度调制。这种调幅脉动刺激利用包含可兴奋组织的细胞之间的细微电生理差异，以便使可兴奋组织群体内的动作电位失去同步。这种失步导致人口阈值的更广泛分布，以及更宽的电动态范围，从而更好地模拟生物招募特征。

9. 发明申请

WO2003015863A2 GRADUAL RECRUITMENT OF MUSCLE/NEURAL EXCITABLE TISSUE USING HIGH-RATE ELECTRICAL STIMULATION PARAMETERS 审中-公开
标题翻译：使用高速电刺激参数的肌肉/神经激素组织的渐进性
公开(公告)号：WO2003015863A2
公开(公告)日：2003-02-27
申请号：PCT/US2002/025861
申请日：2002-08-13
申请人： ADVANCED BIONICS CORPORATION , OVERSTREET, Edward, H.
发明人： OVERSTREET, Edward, H.
IPC分类号： A61N
CPC分类号： A61N1/36071 , A61N1/32
摘要： A neurostimulator system (170) stimulates excitable muscle or neural tissue through multiple electrodes (E1, E2, ... En) fast enough to induce stochastic neural firing, thereby acting to restore "spontaneous" neural activity. The type of stimulation provided by the neurostimulator involves the use of a high rate, e.g., greater than about 2000 Hz, pulsitile stimulation signal generated by a high rate pulse generator (172). The stream of pulses generated by the high rate pulse generator is amplitude modulated in an output driver circuit (176) with control information, provided by a modulation control element (178). Such amplitude-modulated pulsitile stimulation exploits the subtle electro physiological differences between cells comprising excitable tissue in order to desynchronize action potentials within the population of excitable tissue. Such desynchronization induces a wider distribution of population thresholds, as well as a wider electrical dynamic range, thereby better mimicking biological recruitment characteristics.
摘要翻译：神经刺激器系统（170）通过多个电极（E1，E2，... En）刺激可激发的肌肉或神经组织，足以诱发随机神经发作，从而起到恢复“自发”神经活动的作用。由神经刺激器提供的刺激类型涉及使用由高速率脉冲发生器（172）产生的高速率，例如大于约2000Hz的脉动刺激信号。由高速率脉冲发生器产生的脉冲流在具有由调制控制元件（178）提供的控制信息的输出驱动器电路（176）中进行幅度调制。这种幅度调制的脉动刺激利用包含可兴奋组织的细胞之间的微妙电生理差异，以便使可兴奋组织群体内的动作电位失去同步。这种去同步引起更广泛的人口阈值分布，以及更广泛的电动态范围，从而更好地模仿生物招募特征。

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