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1. 发明申请

WO2011028873A2 POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL LEADS CONTAINING THE SAME 审中-公开
标题翻译：聚异丁烯尿素，尿素和尿烷/尿素共聚物和含有相同成分的医用导管
公开(公告)号：WO2011028873A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047633
申请日：2010-09-02
申请人： CARDIAC PACEMAKERS, INC. , DESAI, Shrojalkumar , BODEN, Mark W. , DEROCHE, Steve , FOSTER, Arthur J. , REDDY, Shantanu
发明人： DESAI, Shrojalkumar , BODEN, Mark W. , DEROCHE, Steve , FOSTER, Arthur J. , REDDY, Shantanu
IPC分类号： A61L31/06
CPC分类号： A61N1/056 , A61L31/06 , A61N1/05 , C08G18/4854 , C08G18/698 , Y10T156/10 , Y10T428/31855 , Y10T428/31938 , C08L75/04 , C08L75/02
摘要： The present invention provides medical devices that contain polyisobutylene urethane copolymers, polyisobutylene urea copolymers and polyisobutylene urethane/urea copolymers. More particularly, the present invention provides medical leads that contain such copolymers.
摘要翻译：本发明提供了含有聚异丁烯尿烷共聚物，聚异丁烯脲共聚物和聚异丁烯尿烷/尿素共聚物的医疗器械。更具体地说，本发明提供了含有这种共聚物的医用引线。

2. 发明申请

WO2009076582A3 MELT PROCESSED MATERIALS FOR MEDICAL ARTICLES 审中-公开
标题翻译：医疗用品的熔融加工材料
公开(公告)号：WO2009076582A3
公开(公告)日：2009-12-10
申请号：PCT/US2008086530
申请日：2008-12-12
申请人： BOSTON SCIENT SCIMED INC , STRICKLER FREDERICK H , TENNEY BARRON , BODEN MARK
发明人： STRICKLER FREDERICK H , TENNEY BARRON , BODEN MARK
IPC分类号： C08J9/12
CPC分类号： C08F6/005 , A61L27/34 , A61L29/085 , A61L31/10 , C08F20/10 , C08J9/122 , C08J2201/03 , C08J2353/02 , C08J2367/02 , Y02P20/544 , C08L53/02
摘要： In accordance with an aspect of the invention, methods of forming medical articles are provided, which comprise (a) preparing a melt phase that comprises a molten polymer and a supercritical fluid, (b) forming a polymeric region from the melt phase, and (c) cooling the polymeric region. In certain embodiments, the supercritical fluid is formed from chemical species (e.g., CO2, propane, etc.) that are gases at room temperature (25°C) and atmospheric pressure (1 atm). According to another aspect of the present invention, medical articles are provided which comprise melt-processed polymeric materials. The polymeric materials have a composition that cannot be melt processed without the use of melt-viscosity reducing additives due to thermal degradation, and yet the polymeric material does not contain such additives.
摘要翻译：根据本发明的一个方面，提供了形成医疗制品的方法，其包括（a）制备包含熔融聚合物和超临界流体的熔融相，（b）由熔融相形成聚合物区域，和（ c）冷却聚合物区域。在某些实施方案中，超临界流体由在室温（25℃）和大气压（1atm）下为气体的化学物质（例如CO 2，丙烷等）形成。根据本发明的另一方面，提供了包含熔融加工的聚合物材料的医疗制品。由于热降解，聚合物材料具有不能熔融加工而不使用熔融粘度降低添加剂的组成，而聚合物材料不含有这样的添加剂。

3. 发明申请

WO2008106121A3 MEDICAL DEVICES HAVING POLYMERIC REGIONS BASED ON STYRENE-ISOBUTYLENE COPOLYMERS 审中-公开
标题翻译：基于苯乙烯 - 异丁烯共聚物的聚合物区域的医疗器械
公开(公告)号：WO2008106121A3
公开(公告)日：2009-09-24
申请号：PCT/US2008002504
申请日：2008-02-26
申请人： BOSTON SCIENT SCIMED INC , LINDQUIST JEFFREY S , STRICKLER FREDERICK H , BODEN MARK , SEPPALA JAN , MILLER PAUL J
发明人： LINDQUIST JEFFREY S , STRICKLER FREDERICK H , BODEN MARK , SEPPALA JAN , MILLER PAUL J
IPC分类号： A61L31/04 , A61F2/82 , A61L27/16 , A61L27/34 , A61L29/04 , A61L29/08 , A61L31/10
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包括苯乙烯单体和异丁烯单体的共聚物。此外，共聚物的苯乙烯单体含量通常为25〜50摩尔％。

4. 发明申请

WO2009088912A2 BIODEGRADABLE POLYMERS 审中-公开
标题翻译：生物可降解聚合物
公开(公告)号：WO2009088912A2
公开(公告)日：2009-07-16
申请号：PCT/US2008/088614
申请日：2008-12-31
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BENCO, John , BODEN, Mark
发明人： BENCO, John , BODEN, Mark
IPC分类号： A61L31/06 , A61L31/14
CPC分类号： A61L31/148 , A61L31/04 , A61L31/10
摘要： According to an aspect of the present invention, polymers that have a plurality of well defined polymer segments linked by disulfide linkages are provided. When these disulfide linkages are broken, multiple smaller polymers of lower molecular weight are produced. According to another aspect of the present invention, implantable or insertable medical devices are provided that contain polymers that have a plurality of well defined polymer segments linked by disulfide linkages.
摘要翻译：根据本发明的一个方面，提供了具有通过二硫键连接的多个明确定义的聚合物链段的聚合物。当这些二硫键断裂时，产生较低分子量的多个较小的聚合物。根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包含具有通过二硫键连接的多个明确定义的聚合物链段的聚合物。

5. 发明申请

WO2009039429A2 THERAPEUTIC AGENT-ELUTING MEDICAL DEVICES HAVING TEXTURED POLYMERIC SURFACES 审中-公开
标题翻译：具有纹理聚合物表面的治疗剂治疗医疗器械
公开(公告)号：WO2009039429A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/077101
申请日：2008-09-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Alden , BODEN, Mark , STRICKLER, Frederick, H. , TENNEY, Barron, W.
发明人： FLANAGAN, Alden , BODEN, Mark , STRICKLER, Frederick, H. , TENNEY, Barron, W.
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/414 , A61L2300/416 , C08L71/02
摘要： A medical device comprising: (a) a substrate having first and second surfaces, (b) a therapeutic-agent-eluting polymeric layer disposed over the first substrate surface and (c) a textured polymeric layer that is textured to promote cell attachment, cell growth, or both, disposed over the second surface.
摘要翻译：一种医疗装置，包括：（a）具有第一和第二表面的基底，（b）设置在所述第一基底表面上的治疗剂洗脱聚合物层，和（c）织构化的纹理聚合物层，以促进细胞附着，细胞生长或两者，设置在第二表面上。

6. 发明申请

WO2009006538A2 MODIFIED POLYMERS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：改性聚合物及其制备和使用方法
公开(公告)号：WO2009006538A2
公开(公告)日：2009-01-08
申请号：PCT/US2008/069057
申请日：2008-07-02
申请人： UNIVERSITY OF MASSACHUSETTS LOWELL , SCHWARZ, Marlene , FAUST, Rudolf , OJHA, Umaprasana , BODEN, Mark , STRICKLER, Fred
发明人： SCHWARZ, Marlene , FAUST, Rudolf , OJHA, Umaprasana , BODEN, Mark , STRICKLER, Fred
IPC分类号： C08F8/36 , C08F8/00 , C08J7/12 , C08F295/00 , C08F297/00 , C09D153/00 , A61L31/04 , A61L31/10 , A61L31/16 , A61N1/05
CPC分类号： C08F297/00 , A61L31/048 , A61L31/16 , A61L2300/25 , A61N1/05 , A61N1/375 , C07K17/08 , C08F8/00 , C08F8/30 , C08F8/32 , C08F8/36 , C08F295/00 , C08F297/02 , C08F297/026 , C08L53/00 , C08L53/005 , C08L2666/02 , C09D153/00 , C09D153/005 , C09J153/00 , C09J153/005 , C08L53/02 , C08F8/34
摘要： The present invention provides block copolymers, e.g ., thermoplastic elastomers, having at least one monomer that is covalently bonded to a sulfonate moiety. The present invention also provides block copolymers, e.g ., thermoplastic elastomers, having at least one monomer that is covalently bonded to a peptide. The present invention also provides methods for making and using ( e.g ., in articles of manufacture such as medical devices) the copolymers of the present invention.
摘要翻译：本发明提供了嵌段共聚物，例如热塑性弹性体，其具有至少一种与磺酸盐部分共价键合的单体。本发明还提供了嵌段共聚物，例如热塑性弹性体，其具有至少一种与肽共价结合的单体。本发明还提供制造和使用（例如在制造物品如医疗器械中）本发明共聚物的方法。

7. 发明申请

WO2008030388A2 MEDICAL DEVICES HAVING A COATING FOR PROMOTING ENDOTHELIAL CELL ADHESION 审中-公开
标题翻译：具有促进内皮细胞粘附的涂层的医疗装置
公开(公告)号：WO2008030388A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019109
申请日：2007-08-30
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BENCO, John , BODEN, Mark , BRITO, Shaina , NAIMARK, Wendy , PHAM, Lan
发明人： BENCO, John , BODEN, Mark , BRITO, Shaina , NAIMARK, Wendy , PHAM, Lan
IPC分类号： A61L27/22 , A61L27/50 , A61L27/58 , A61L31/04 , A61L31/14
CPC分类号： A61L31/148 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61L31/047 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/608
摘要： A medical device having a coating of cell adhesion polypeptides to enhance endothelial cell adhesion onto the medical device. The cell adhesion polypeptides may be any of the proteins of the extracellular matrix which are known to play a role in cell adhesion or derivative peptides such as RGD or YlGSR. The polypeptides may be incorporated into the backbone of polymer such as polyurethane, or grafted onto a polymer such polybisphosphonate. The polypeptides may also be carried on antibodies or displayed on bacteriophages. The polypeptides may also be modified to have adhesive amino acid sequences. In certain embodiments, the medical device further comprises a temporary barrier that protects the polypeptides from biofouling. The temporary barrier may be formed of a biodegradable polymer and be constructed as a coating over the polypeptides or as a plurality o micelles encapsulating the polypeptides. In certain embodiments, the polypeptides may be coated onto the medical device in such a manner as to form a monolayer of the polypeptides.
摘要翻译：具有细胞粘附多肽包被以增强内皮细胞粘附到医疗装置上的医疗装置。细胞粘附多肽可以是已知在细胞粘附或衍生肽如RGD或YlGSR中起作用的细胞外基质的任何蛋白质。多肽可以结合到聚合物的主链如聚氨酯中，或者接枝到诸如聚二膦酸盐的聚合物上。多肽也可以携带在抗体上或显示在噬菌体上。多肽也可以被修饰以具有粘性氨基酸序列。在某些实施方案中，医疗装置还包括保护多肽免于生物污损的临时屏障。临时屏障可以由可生物降解的聚合物形成，并且被构建为多肽上的包衣或者作为包封多肽的多个胶束。在某些实施方案中，多肽可以以形成多肽单层的方式被包被到医疗装置上。

8. 发明申请

WO2007112020A3 MEDICAL DEVICES HAVING POLYMER BRUSHES 审中-公开
标题翻译：具有聚合物刷的医疗装置
公开(公告)号：WO2007112020A3
公开(公告)日：2008-02-07
申请号：PCT/US2007007283
申请日：2007-03-22
申请人： BOSTON SCIENT SCIMED INC , BODEN MARK
发明人： BODEN MARK
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L31/16
CPC分类号： A61K47/32 , A61K47/34 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L101/005
摘要： According to an aspect of the present invention, internal medical devices are provided, which contain at least one surface region that comprises a polymer brush. The polymer brush, in turn, contains one or more types of hydrophobic polymer chains and one or more types of hydrophilic polymer chains.
摘要翻译：根据本发明的一个方面，提供内部医疗装置，其包含至少一个包括聚合物刷的表面区域。聚合物刷又依次含有一种或多种类型的疏水性聚合物链和一种或多种类型的亲水性聚合物链。

9. 发明申请

WO2007112020A2 MEDICAL DEVICES HAVING POLYMER BRUSHES 审中-公开
标题翻译：具有聚合物刷的医疗装置
公开(公告)号：WO2007112020A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/007283
申请日：2007-03-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BODEN, Mark
发明人： BODEN, Mark
CPC分类号： A61K47/32 , A61K47/34 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L101/005
摘要： According to an aspect of the present invention, internal medical devices are provided, which contain at least one surface region that comprises a polymer brush. The polymer brush, in turn, contains one or more types of hydrophobic polymer chains and one or more types of hydrophilic polymer chains.
摘要翻译：根据本发明的一个方面，提供内部医疗装置，其包含至少一个包括聚合物刷的表面区域。聚合物刷又依次含有一种或多种疏水聚合物链和一种或多种类型的亲水性聚合物链。

10. 发明申请

WO2006042001A3 STABLE THREE ENZYME CREATININE BIOSENSOR 审中-公开
标题翻译：稳定的三烯酸生物传感器
公开(公告)号：WO2006042001A3
公开(公告)日：2006-07-13
申请号：PCT/US2005035959
申请日：2005-10-05
申请人： BAYER HEALTHCARE LLC , BERBERICH JASON , BODEN MARK W , CHAN ANDY D C , RUSSELL ALAN
发明人： BERBERICH JASON , BODEN MARK W , CHAN ANDY D C , RUSSELL ALAN
IPC分类号： C12Q1/00 , G01N27/26 , G01N33/50
CPC分类号： C12Q1/005
摘要： The invention provides methods for preparing a stable, multiple-use three enzyme biosensor for the amperometric determination of creatinine in biological liquids that has a useful lifetime that extends significantly beyond that of presently available amperometric biosensors. The biosensor prepared by the methods of the invention encompasses a plurality of immobilized enzymes that are applied to the biosensor as an enzyme-polymer composition. The enzymes, which can include creatinine amidohydrolase, creatine amidinohydrolase and sarcosine oxidase, are immobilized into the enzyme-polymer composition simultaneously as well as applied to the biosensor simultaneously. Prior to being immobilized, the enzymes can be chemically modified by attaching one or more polyethylene glycol (PEG) chains per enzyme monomer. The polymer component can be provided by a polyurethane membrane. The invention also provides a method of preparing a biosensor that limits the diffusion of silver ions emanating the reference electrode, thereby preventing, contact between the silver ions and the enzymes. Related methods of preparing an enzyme-polymer composition for incorporation into a multiple use three enzyme biosensor for the amperometric determination of creatinine in biological liquids also are provided. The invention also provides multiple-use biosensors and enzyme-polymer compositions prepared by the methods disclosed.
摘要翻译：本发明提供了制备稳定的多用途三酶生物传感器的方法，所述三维酶生物传感器用于生物液体中肌酸酐的电流分析测定，所述生物液体的使用寿命显着超过目前可用的电流计生物传感器的使用寿命。通过本发明的方法制备的生物传感器包括作为酶 - 聚合物组合物应用于生物传感器的多种固定化酶。可以将肌酸酐酰氨基水解酶，肌酸脒基水解酶和肌氨酸氧化酶的酶同时固定在酶 - 聚合物组合物中，同时应用于生物传感器。在固定化之前，可以通过每个酶单体连接一个或多个聚乙二醇（PEG）链来化学修饰酶。聚合物组分可以由聚氨酯膜提供。本发明还提供一种制备生物传感器的方法，其限制了散发参考电极的银离子的扩散，从而防止银离子与酶之间的接触。还提供了制备用于并入多用途三酶生物传感器中的酶 - 聚合物组合物的相关方法，用于生物液体中肌酸酐的电流分析测定。本发明还提供了通过所公开方法制备的多用途生物传感器和酶 - 聚合物组合物。

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