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1. 发明申请

WO2016118923A1 DRUG-COATED BALLOON 审中-公开
标题翻译：药物包裹的气球
公开(公告)号：WO2016118923A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/014622
申请日：2016-01-22
申请人： INTERSECT ENT, INC.
发明人： KAUFMAN, Richard, E. , STANKUS, John, Joseph , SU, James
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/222 , A61M29/02 , A61M2025/105 , A61M2210/065 , A61M2210/0662 , A61M2210/0668 , A61M2210/0675 , A61M2210/0681 , A61M2210/105
摘要： Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
摘要翻译：这里描述的是用具有药物包衣的可扩张装置来治疗鼻，耳或咽喉病症或疾病的装置，系统和方法。可扩张装置可以以低轮廓构造输送到体腔，并且被扩展以接触周围组织。可扩张装置可以将药物涂层递送或释放到组织。在治疗期间可以使用单个装置的多次膨胀。还可以调节用于可扩张装置的各种涂层赋形剂和制造参数，以增强或缓慢地将药物涂层的转移和/或药物释放到靶组织部位。转移到组织的药物可以作为原位贮库，其能够在移除可扩张装置之后在期望的时间段内维持治疗水平的局部递送的药物。

2. 发明申请

WO2015127900A1 中空微米粒子审中-公开
公开(公告)号：WO2015127900A1
公开(公告)日：2015-09-03
申请号：PCT/CN2015/073382
申请日：2015-02-27
申请人：国玺干细胞应用技术股份有限公司
发明人：赖瑞阳 , 罗丽娟 , 洪子涵 , 张高愿 , 林珀丞 , 庄明熙
IPC分类号： C08G63/91 , C08J3/24 , A61K38/00 , A61K9/50
CPC分类号： C08J9/36 , A61K9/5031 , A61K35/28 , A61K35/35 , A61L27/16 , A61L27/18 , A61L27/22 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2300/222 , A61L2300/236 , A61L2300/25 , A61L2300/252 , A61L2300/64 , A61L2430/28 , C08J2207/10 , C08J2367/04 , C08J2405/08 , C08L67/04 , C08L29/04
摘要：一种中空微米粒子，包括：a) 中空微球；b) 复数个连结分子，连接至该中空微球表面；c) 多肽，连接至少一个连结分子；以及d) 靶标分子，连接至少一个连结分子。中空微球可利用中空结构、多肽及靶标分子来提升负载细胞的量及移植成功的机率。还提供一种中空微球的制造方法及细胞载体。

3. 发明申请

WO2014104898A3 FORMATION OF SEMI-PERMEABLE POROUS ARTIFICIAL SCAB 审中-公开
标题翻译：形成半透明多孔人造皮肤
公开(公告)号：WO2014104898A3
公开(公告)日：2015-01-08
申请号：PCT/PE2013000010
申请日：2013-11-04
申请人： VEGA VILLAVICENCIO PARSIVAL , BATTISTA MIGUEL EDGARDO
发明人： VEGA VILLAVICENCIO PARSIVAL , BATTISTA MIGUEL EDGARDO
IPC分类号： A61K31/702 , A61F13/00 , A61L15/10 , A61L15/14 , A61L26/00 , A61P17/02
CPC分类号： A61L26/0085 , A61K31/136 , A61K31/164 , A61K31/185 , A61K31/573 , A61K31/655 , A61K31/7036 , A61L26/0023 , A61L26/0066 , A61L2300/222 , A61L2300/232 , A61L2300/406 , A61L2300/412 , A61L2300/43 , A61L2300/442 , A61K2300/00
摘要： Self-fixing semi-permeable porous artificial scab designed for protecting eroded or damaged surfaces. The invention applies to any living entity (including plants). The polymerized web of the scab is formed upon application to the damaged surface by a reaction catalysed by the action of enzymes released by the lysed cells. The growth of new, normal cells that can breathe freely without drying out is promoted under this protective surface. The loss of water, proteins and electrolytes is avoided, protection against infections is afforded and the use of gauzes or dressings that damage new skin when removed is replaced. The red aqueous mixture applied by brushing or spraying, which has thixotropic characteristics, was obtained by the physicochemical interaction in the container of the following compounds: azosulfamide of between 1 and 5g% + gentian violet of between 0.004 and 0.007 g% + dexamethasone of between 0.001 and 0.003 g% + panthenol of between 0.5 and 2g% + gentamicin of between 0.03 and 0.06g%.
摘要翻译：自固定的半透水多孔人造痂被设计用于保护受损或损坏的表面。本发明适用于任何生物实体（包括植物）。通过由裂解的细胞释放的酶的作用催化的反应，在施加到损伤的表面上形成疤痕的聚合网。在这种保护性表面下促进了可以自由呼吸而不干燥的新的正常细胞的生长。避免水，蛋白质和电解质的损失，提供免受感染的保护，并且更换使用在去除时损坏新皮肤的纱布或敷料。通过刷涂或喷雾施加的具有触变特性的红色水性混合物通过以下化合物的容器中的物理化学相互作用获得：1至5g％+龙胆紫之间的偶氮磺酰胺为0.004至0.007g％+地塞米松之间的地塞米松 0.001至0.003g％+泛醇0.5至2g％+庆大霉素之间，0.03至0.06g％。

4. 发明申请

WO2011057278A1 DRUG ELUTING COMPOSITE 审中-公开
标题翻译：药物复方
公开(公告)号：WO2011057278A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/056052
申请日：2010-11-09
申请人： GORE ENTERPRISE HOLDINGS, INC. , CLEEK, Robert, L. , CULLY, Edward, H. , HOLLAND, Theresa, A. , MCDANIEL, Thomas, R.
发明人： CLEEK, Robert, L. , CULLY, Edward, H. , HOLLAND, Theresa, A. , MCDANIEL, Thomas, R.
IPC分类号： A61N1/05 , A61L29/00
CPC分类号： A61N1/056 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/608 , A61N1/0568
摘要： The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.
摘要翻译：本发明涉及具有可释放地包含在材料内的治疗组合物的材料。材料被配置为以期望的速率释放治疗组合物。本发明还涉及包含这些材料的器件。

5. 发明申请

WO2010033909A3 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入或不可剥离的医疗器械
公开(公告)号：WO2010033909A3
公开(公告)日：2011-03-10
申请号：PCT/US2009057674
申请日：2009-09-21
申请人： BOSTON SCIENT NEUROMODULATION , OVERSTREET EDWARD HOLMAN , PIANCA ANNE M , KUZMA JANUSZ , PANDIT ADITYA , BRITO SHAINA , RICHARD ROBERT E , DIPIETRO KERRI , STRICKLER FREDERICK H , BODEN MARK , PHAM LAN , ORINSKI WILLIAM
发明人： OVERSTREET EDWARD HOLMAN , PIANCA ANNE M , KUZMA JANUSZ , PANDIT ADITYA , BRITO SHAINA , RICHARD ROBERT E , DIPIETRO KERRI , STRICKLER FREDERICK H , BODEN MARK , PHAM LAN , ORINSKI WILLIAM
IPC分类号： A61L27/16 , C08G77/20
CPC分类号： A61L27/54 , A61L27/18 , A61L27/34 , A61L2300/222 , A61L2300/602 , A61N1/0534 , A61N1/0541 , A61N1/0551 , C08L83/06
摘要： In various aspects, the present invention is directed to implantable neurostimulation leads and methods for their formation. In various additional aspects, the present invention is directed to medical devices having silicone-containing regions with overlying polymeric layers and to methods of forming the same.
摘要翻译：在各个方面，本发明涉及可植入的神经刺激引线及其形成方法。在各种附加方面，本发明涉及具有含有覆盖聚合物层的含硅氧烷的区域的医疗装置及其形成方法。

6. 发明申请

WO2009064372A3 IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING A HIGH DEGREE OF BIOLOGICAL ACTIVITY 审中-公开
标题翻译：具有高度生物活性的固定生物活性物质
公开(公告)号：WO2009064372A3
公开(公告)日：2010-06-24
申请号：PCT/US2008012595
申请日：2008-11-06
申请人： GORE ENTERPRISE HOLDINGS INC , CLEEK ROBERT L , DALY MICHAEL D , PIETRZAK KRZYSZTOF R
发明人： CLEEK ROBERT L , DALY MICHAEL D , PIETRZAK KRZYSZTOF R
IPC分类号： A61L33/00 , A61L2/00 , A61L31/10 , A61L31/12 , A61L33/06 , A61L33/08
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10
摘要： The present invention relates to immobilized biologically active entities having heparin cofactor Il binding activity.
摘要翻译：本发明涉及具有肝素辅因子II结合活性的固定的生物活性实体。

7. 发明申请

WO2010013240A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的组合物和方法
公开(公告)号：WO2010013240A1
公开(公告)日：2010-02-04
申请号：PCT/IL2009/000739
申请日：2009-07-29
申请人： DEKEL PHARMACEUTICALS LTD. , KINDLER, Seth , SHMULEWITZ, Ascher
发明人： KINDLER, Seth , SHMULEWITZ, Ascher
IPC分类号： A01N45/00 , A61K31/56
CPC分类号： A61K31/20 , A61K31/573 , A61K45/06 , A61L27/54 , A61L31/16 , A61L2300/222 , A61L2300/41 , A61K2300/00
摘要： Compositions which include a corticosteroid in combination with an additional compound active in treatment of an inflammatory disorder are provided.
摘要翻译：提供了包含皮质类固醇与治疗炎症性疾病的活性物质的组合物。

8. 发明申请

WO2009029958A3 IMPLANTABLE DELIVERY DEVICE 审中-公开
公开(公告)号：WO2009029958A3
公开(公告)日：2009-06-04
申请号：PCT/US2008075067
申请日：2008-09-02
申请人： SUNSTORM RES CORP , BENSON JAMES R
发明人： BENSON JAMES R
IPC分类号： A61K9/00
CPC分类号： A61K31/565 , A61K9/0024 , A61L27/04 , A61L27/18 , A61L27/54 , A61L2300/222 , A61L2300/43 , A61L2300/602 , C08L67/02 , C08L83/04
摘要： The invention relates to delivery devices and methods for providing more uniform delivery of agents such as drugs. In some embodiments, a delivery device is provided made of one or more implantable materials having predetermined agent-permeable and agent-impermeable regions and a reservoir containing one or more active agents, either alone or in an acceptable composition, as well as methods of administering one or more agents using such a device. Also provided are methods of equilibrating such devices, so that a steady state of agent delivery can be achieved at or soon after introduction of the device to its intended location of use. Methods of use of such devices to deliver an agent are also provided.

9. 发明申请

WO2009029958A2 IMPLANTABLE DELIVERY DEVICE 审中-公开
标题翻译：可植入传送装置
公开(公告)号：WO2009029958A2
公开(公告)日：2009-03-05
申请号：PCT/US2008075067
申请日：2008-09-02
申请人： SUNSTORM RES CORP , BENSON JAMES R
发明人： BENSON JAMES R
IPC分类号： A61K9/00
CPC分类号： A61K31/565 , A61K9/0024 , A61L27/04 , A61L27/18 , A61L27/54 , A61L2300/222 , A61L2300/43 , A61L2300/602 , C08L67/02 , C08L83/04
摘要： The invention relates to delivery devices and methods for providing more uniform delivery of agents such as drugs. In some embodiments, a delivery device is provided made of one or more implantable materials having predetermined agent-permeable and agent-impermeable regions and a reservoir containing one or more active agents, either alone or in an acceptable composition, as well as methods of administering one or more agents using such a device. Also provided are methods of equilibrating such devices, so that a steady state of agent delivery can be achieved at or soon after introduction of the device to its intended location of use. Methods of use of such devices to deliver an agent are also provided.
摘要翻译：本发明涉及用于提供药剂等药剂的更均匀递送的递送装置和方法。在一些实施方案中，递送装置由一种或多种可植入材料制成，所述可植入材料具有预定的药剂可渗透和药剂不可渗透的区域以及含有一种或多种活性剂的储存器，其单独或以可接受的组合物施用，以及施用一个或多个使用这种设备的代理。还提供了平衡这些装置的方法，使得可以在将装置引入其预定使用位置之后或很快之后实现试剂递送的稳定状态。还提供了使用这种装置递送药剂的方法。

10. 发明申请

WO2008019198A1 STEROID-CONTAINING SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND RELATED METHODS 审中-公开
标题翻译： STEROID含有持续释放内分泌植入物及相关方法
公开(公告)号：WO2008019198A1
公开(公告)日：2008-02-14
申请号：PCT/US2007/071737
申请日：2007-06-21
申请人： ALLERGAN, INC. , SUGIMOTO, Hiroshi , BLANDA, Wendy, M. , SPADA, Lon, T. , HUANG, Glenn, T. , CHANG, James, N. , OLEJNIK, Orest , NIVAGGIOLI, Thierry
发明人： SUGIMOTO, Hiroshi , BLANDA, Wendy, M. , SPADA, Lon, T. , HUANG, Glenn, T. , CHANG, James, N. , OLEJNIK, Orest , NIVAGGIOLI, Thierry
IPC分类号： A61K9/00 , A61K45/06 , A61K31/573 , A61K31/58
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译：生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

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