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1. 发明申请

WO2010033909A2 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入或不可剥离的医疗器械
公开(公告)号：WO2010033909A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057674
申请日：2009-09-21
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , OVERSTREET, Edward, Holman , PIANCA, Anne, M. , KUZMA, Janusz , PANDIT, Aditya , BRITO, Shaina , RICHARD, Robert, E. , DIPIETRO, Kerri , STRICKLER, Frederick, H. , BODEN, Mark , PHAM, Lan , ORINSKI, William
发明人： OVERSTREET, Edward, Holman , PIANCA, Anne, M. , KUZMA, Janusz , PANDIT, Aditya , BRITO, Shaina , RICHARD, Robert, E. , DIPIETRO, Kerri , STRICKLER, Frederick, H. , BODEN, Mark , PHAM, Lan , ORINSKI, William
IPC分类号： A61L27/16
CPC分类号： A61L27/54 , A61L27/18 , A61L27/34 , A61L2300/222 , A61L2300/602 , A61N1/0534 , A61N1/0541 , A61N1/0551 , C08L83/06
摘要： In various aspects, the present invention is directed to implantable neurostimulation leads and methods for their formation. In various additional aspects, the present invention is directed to medical devices having silicone-containing regions with overlying polymeric layers and to methods of forming the same.
摘要翻译：在各个方面，本发明涉及可植入的神经刺激引线及其形成方法。在各种附加方面，本发明涉及具有含有覆盖聚合物层的含硅氧烷的区域的医疗装置及其形成方法。

2. 发明申请

WO2007136574A3 MEDICAL DEVICES HAVING POLYMERIC REGIONS BASED ON VINYL ETHER BLOCK COPOLYMERS 审中-公开
标题翻译：基于乙烯基嵌段共聚物的聚合物区域医疗器械
公开(公告)号：WO2007136574A3
公开(公告)日：2008-11-27
申请号：PCT/US2007011376
申请日：2007-05-11
申请人： BOSTON SCIENT SCIMED INC , RICHARD ROBERT E , SCHWARZ MARLENE C , BODEN MARK
发明人： RICHARD ROBERT E , SCHWARZ MARLENE C , BODEN MARK
IPC分类号： A61L31/10 , A61L27/14 , A61L27/34 , A61L31/04
CPC分类号： A61L27/34 , A61L27/16 , A61L31/10 , C08L53/00 , C08L35/08
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。嵌段共聚物包括（a）含有至少一种高Tg乙烯基醚单体的至少一种高Tg（玻璃化转变温度）聚合物嵌段和（b）含有至少一种低Tg乙烯基醚单体的至少一种低Tg聚合物嵌段。

3. 发明申请

WO2008082445A1 MEDICAL DEVICES BASED ON MODIFIED POLYOLS 审中-公开
标题翻译：基于改性聚合物的医疗器械
公开(公告)号：WO2008082445A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/021384
申请日：2007-10-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RICHARD, Robert, E.
发明人： RICHARD, Robert, E.
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： A61L31/04 , A61L31/048 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L29/04
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain at least one region of polymeric material. The at least one region of polymeric material contains at least one polymer selected from the following (a) at least one polymer that contains a polyol chain having charged groups along its length, (b) at least one polymer that contains a polyol chain having biodegradable polymer side chains along its length and (c) a combination thereof.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个聚合物材料区域。聚合材料的至少一个区域包含至少一种选自以下的聚合物（a）至少一种聚合物，其包含沿其长度具有带电荷基团的多元醇链，（b）至少一种含有可生物降解的多元醇链的聚合物聚合物侧链沿其长度和（c）它们的组合。

4. 发明申请

WO2008076618A2 FREEZE THAW METHODS FOR MAKING POLYMER PARTICLES 审中-公开
标题翻译：用于制备聚合物颗粒的冻结法
公开(公告)号：WO2008076618A2
公开(公告)日：2008-06-26
申请号：PCT/US2007086231
申请日：2007-12-03
申请人： BOSTON SCIENT SCIMED INC , RICHARD ROBERT E , TAN SHARON MI LIN
发明人： RICHARD ROBERT E , TAN SHARON MI LIN
IPC分类号： C08J3/00
CPC分类号： A61K9/0019 , A61K9/1635 , C08J3/12 , C08J2329/04 , Y10T428/2982
摘要： Freeze thaw methods for making polymer particles, as well as related particles, compositions and methods are disclosed.
摘要翻译：公开了用于制备聚合物颗粒的冻融方法以及相关的颗粒，组合物和方法。

5. 发明申请

WO2007136504A2 MEDICAL DEVICES HAVING BIOACTIVE SURFACES 审中-公开
标题翻译：具有生物表面的医疗器械
公开(公告)号：WO2007136504A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/010026
申请日：2007-04-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RICHARD, Robert, E. , HELMUS, Michael, N.
发明人： RICHARD, Robert, E. , HELMUS, Michael, N.
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L53/00
摘要： According to an aspect of the present invention, medical devices are provided, which contain (a) a substrate and (b) a polymeric region disposed over the substrate which contains at least one block copolymer. The block copolymer, in turn, contains at least two polymer blocks which phase separate into two or more immiscible phase domains within the polymeric region. Moreover, a bioactive species is covalently attached to at least one of the polymer blocks. By attaching the bioactive species selectively to at least one polymer block, self-assembled clusters of the bioactive species are created as the blocks phase separate into immiscible phase domains.
摘要翻译：根据本发明的一个方面，提供了包含（a）基底和（b）设置在基底上的含有至少一种嵌段共聚物的聚合物区域的医疗装置。嵌段共聚物又包含至少两个聚合物嵌段，其相分离成聚合物区域内的两个或多个不混溶的相域。此外，生物活性物质共价连接至至少一个聚合物嵌段。通过将生物活性物质选择性地附着到至少一个聚合物嵌段上，随着块相分离成不混溶相域，产生生物活性物质的自组装簇。

6. 发明申请

WO2006083904A3 MEDICAL DEVICES HAVING POROUS POLYMERIC REGIONS FOR CONTROLLED DRUG DELIVERY AND REGULATED BIOCOMPATIBILITY 审中-公开
标题翻译：具有多个聚合物区域用于控制药物递送和调节生物活性的医疗装置
公开(公告)号：WO2006083904A3
公开(公告)日：2007-04-05
申请号：PCT/US2006003455
申请日：2006-02-01
申请人： BOSTON SCIENT SCIMED INC , RICHARD ROBERT E , STRICKLER FREDERICK H , SCHWARZ MARLENE C , FAUST RODOLF , SHRIRANG RANADE V , HELMUS MICHAEL N
发明人： RICHARD ROBERT E , STRICKLER FREDERICK H , SCHWARZ MARLENE C , FAUST RODOLF , SHRIRANG RANADE V , HELMUS MICHAEL N
IPC分类号： A61L27/40 , A61L31/12
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrate polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物可分解的聚合物相，并且经历相分离的聚合物区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米级尺寸的崩解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

7. 发明申请

WO2006062975A3 ORIENTING POLYMER DOMAINS FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：定向聚合物领域用于控制药物递送
公开(公告)号：WO2006062975A3
公开(公告)日：2007-01-11
申请号：PCT/US2005044128
申请日：2005-12-07
申请人： BOSTON SCIENT SCIMED INC , RANADE SHRIRANG V , RICHARD ROBERT E , DAO KINH-LUAN LENNY , GIDO SAMUEL P , ISAACS-SODEYE AKINBODE IDOWU
发明人： RANADE SHRIRANG V , RICHARD ROBERT E , DAO KINH-LUAN LENNY , GIDO SAMUEL P , ISAACS-SODEYE AKINBODE IDOWU
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphage separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices fromed from the above techniques.
摘要翻译：本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。该方法包括提供包含聚合物组合物的前体区域，该聚合物组合物包含彼此不混溶的两个或更多个微小间隔分离的聚合物区域，以及通过包括施加包括电场，磁场的取向场的方法形成所述释放区域，机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。因此，本发明进一步涉及从医疗装置调节治疗剂释放速率的方法。本发明的其它方面涉及来自上述技术的医疗装置。

8. 发明申请

WO2006062975A2 ORIENTING POLYMER DOMAINS FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：定向聚合物领域用于控制药物递送
公开(公告)号：WO2006062975A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044128
申请日：2005-12-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RANADE, Shrirang, V. , RICHARD, Robert, E. , DAO, Kinh-Luan (Lenny) , GIDO, Samuel, P. , ISAACS-SODEYE, Akinbode, Idowu
发明人： RANADE, Shrirang, V. , RICHARD, Robert, E. , DAO, Kinh-Luan (Lenny) , GIDO, Samuel, P. , ISAACS-SODEYE, Akinbode, Idowu
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphage separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices fromed from the above techniques.
摘要翻译：本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。该方法包括提供包含聚合物组合物的前体区域，该聚合物组合物包含彼此不混溶的两个或更多个微小间隔分离的聚合物区域，以及通过包括施加包括电场，磁场的取向场的方法形成所述释放区域，机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。因此，本发明进一步涉及从医疗装置调节治疗剂的释放速率的方法。本发明的其它方面涉及来自上述技术的医疗装置。

9. 发明申请

WO2005011769A3 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES CONTAINING ACRYLIC COPOLYMER FOR CONTROLLED DELIVERY OF THERAPEUTIC AGENT 审中-公开
公开(公告)号：WO2005011769A3
公开(公告)日：2005-02-10
申请号：PCT/US2004/024925
申请日：2004-07-30
申请人： SCIMED LIFE SYSTEMS, INC. , RICHARD, Robert, E. , SCHWARZ, Marlene, C.
发明人： RICHARD, Robert, E. , SCHWARZ, Marlene, C.
IPC分类号： A61L27/34
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises an acrylic copolymer, which comprises (i) a plurality of rubbery acrylic units and (ii) a plurality of hard units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.

10. 发明申请

WO2005011767A1 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES CONTAINING SILICONE COPOLYMER FOR CONTROLLED DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：含有硅酮共聚物的可植入或不可剥离的医疗器械用于治疗药物的控制输送
公开(公告)号：WO2005011767A1
公开(公告)日：2005-02-10
申请号：PCT/US2004/024586
申请日：2004-07-29
申请人： SCIMED LIFE SYSTEMS, INC. , RICHARD, Robert, E. , SCHWARZ, Marlene, C. , STRICKLER, Frederick, H.
发明人： RICHARD, Robert, E. , SCHWARZ, Marlene, C. , STRICKLER, Frederick, H.
IPC分类号： A61L27/34
CPC分类号： A61K9/0024 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/602 , C08L83/04
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises a silicone copolymer that contains a plurality of siloxane units and a plurality of non-siloxane units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区域还包含含有多个硅氧烷单元和多个非硅氧烷单元的硅氧烷共聚物。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

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