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1. 发明申请

WO2010009382A2 ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：分析测量和管理设备及相关方法
公开(公告)号：WO2010009382A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050971
申请日：2009-07-17
申请人： LIFESCAN, INC. , SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARTLE, Robert
发明人： SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARTLE, Robert
IPC分类号： A61B5/00 , G06F3/048 , H04L9/32 , G08B1/08 , G06F15/16 , G06N5/02
CPC分类号： A61B5/4839 , A61B5/14532 , G06F19/00 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： Various embodiments of a diabetes management system are provided. One exemplary system may include an analyte measurement device and a therapeutic agent delivery device. The measurement device includes a measurement unit, display, and first wireless module. The therapeutic agent delivery device has a delivery device housing, delivery mechanism disposed in the housing that delivers a dosage of the agent to the user upon actuation by the user or health care provider, and a second wireless module. The second module, automatically, without prompting from a user or any active input or action by the user, transmits a signal to the first wireless module indicative of: (a) type of therapeutic agent delivered; and (b) amount of therapeutic agent delivered to the user; or (c) type of therapeutic agent device from which the therapeutic agent was administered. Also described are diabetes management devices and methods.
摘要翻译：提供了糖尿病管理系统的各种实施例。一个示例性系统可以包括分析物测量装置和治疗剂递送装置。测量装置包括测量单元，显示器和第一无线模块。治疗剂递送装置具有输送装置壳体，设置在壳体中的输送机构，其在用户或医疗保健提供者致动时将剂量的剂量递送给使用者，以及第二无线模块。自动地，第二模块在不提示用户或用户的任何有效输入或动作的情况下，向第一无线模块发送指示：（a）递送的治疗剂的类型; 和（b）递送给使用者的治疗剂量; 或（c）施用治疗剂的治疗剂装置的类型。还描述了糖尿病管理装置和方法。

2. 发明申请

WO2007035666A3 ELECTROKINETIC INFUSION PUMP SYSTEM 审中-公开
标题翻译：电动输液泵系统
公开(公告)号：WO2007035666A3
公开(公告)日：2007-10-04
申请号：PCT/US2006036340
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BENETT WILLIAM , ROBERTS NEIL E , BOHM SEBASTIAN , SIEH ZARA
发明人： KRULEVITCH PETER , BENETT WILLIAM , ROBERTS NEIL E , BOHM SEBASTIAN , SIEH ZARA
IPC分类号： A61M31/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Various methods and devices are provided for delivering an infusion liquid using an electrokinetic infusion pump. The electrokinetic infusion pump can generally include an infusion housing having an infusion reservoir. The infusion reservoir has an infusion outlet and is capable of containing an infusion liquid. A plunger is movably coupled to the infusion housing and is adapted to be manually displaced relative to the infusion housing to load the infusion reservoir with infusion liquid. A movable partition can be disposed within the infusion housing and has a first surface in communication with an electrokinetic solution and a second surface, isolated from the first surface, in communication with the infusion reservoir. The electrokinetic infusion pump can further include an electrokinetic engine integrated within the plunger and adapted to selectively deliver electric potential across an electrokinetic porous media to cause the electrokinetic solution within the electrokinetic engine to displace the movable partition to effect delivery of at least a portion of the infusion liquid through the infusion outlet.
摘要翻译：提供用于使用电动输液泵输送输液的各种方法和装置。电动输液泵通常可以包括具有输注储器的输液罩。输注槽具有输液口，并且能够容纳输液。柱塞可移动地联接到输注壳体，并且适于相对于输注壳体手动移位以用输注液体加载输注储存器。可移动隔板可以设置在输注外壳内，并且具有与电动溶液连通的第一表面和与第一表面隔离的与输注储存器连通的第二表面。电动输液泵还可以包括集成在柱塞内的电动发动机，并适于选择性地跨电动多孔介质输送电势，以使电动发动机内的电动溶液移动可动隔板，从而实现至少一部分输液通过输液口。

3. 发明申请

WO2007035563A2 MALFUNCTION DETECTION VIA PRESSURE PULSATION 审中-公开
标题翻译：通过压力脉冲进行故障检测
公开(公告)号：WO2007035563A2
公开(公告)日：2007-03-29
申请号：PCT/US2006036164
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
发明人： KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和液体流失状况（例如，断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中形成阻塞，这可能破坏从泵分散的流体的控制。同样，输液器断开连接也会导致液体损失，这可能是破坏性的。对于控制输液泵的系统而言，这种中断可能会很麻烦，例如闭环控制器。相应地，本文描述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，可以使用位置传感器来监测来自输液泵的流体流量，将测量值与期望值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其他算法。

4. 发明申请

WO2007035658A3 INFUSION PUMPS WITH A POSITION DETECTOR 审中-公开
标题翻译：带位置检测器的输液泵
公开(公告)号：WO2007035658A3
公开(公告)日：2007-11-01
申请号：PCT/US2006036330
申请日：2006-09-18
申请人： LIFESCAN INC , ZHAO MINGQI , KRULEVITCH PETER
发明人： ZHAO MINGQI , KRULEVITCH PETER
IPC分类号： G01F25/00 , A61M1/00
CPC分类号： A61M5/14244 , A61M5/1452 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/702
摘要： An infusion pump (e.g., an electrokinetic infusion pump) includes an infusion pump module and an engine that can drive a moveable piston non-mechanically. In addition, the infusion pump module includes a position detector configured for sensing a dispensing state of the infusion pump module. Such information can be utilized in a control scheme to control fluid displacement within and out of the pump. Descriptions of different types of position detectors, such as magnetic sensors (e.g., an anisotropic magnetic resistive sensor), and their implementation in detecting infusion pump fluid displacement are described.
摘要翻译：输液泵（例如电动输液泵）包括输液泵模块和可以非机械地驱动可移动活塞的发动机。另外，输液泵模块包括配置用于感测输液泵模块的分配状态的位置检测器。这样的信息可以用于控制方案中以控制泵内部和外部的流体排量。描述了不同类型的位置检测器（诸如磁性传感器（例如，各向异性磁阻传感器））的描述以及它们在检测输注泵流体位移中的实施方式。

5. 发明申请

WO2007035658A2 INFUSION PUMPS WITH A POSITION DETECTOR 审中-公开
标题翻译：具有位置检测器的输液泵
公开(公告)号：WO2007035658A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036330
申请日：2006-09-18
申请人： LIFESCAN, INC. , ZHAO, Mingqi , KRULEVITCH, Peter
发明人： ZHAO, Mingqi , KRULEVITCH, Peter
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/1452 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/702
摘要： An infusion pump (e.g., an electrokinetic infusion pump) includes an infusion pump module and an engine that can drive a moveable piston non-mechanically. In addition, the infusion pump module includes a position detector configured for sensing a dispensing state of the infusion pump module. Such information can be utilized in a control scheme to control fluid displacement within and out of the pump. Descriptions of different types of position detectors, such as magnetic sensors (e.g., an anisotropic magnetic resistive sensor), and their implementation in detecting infusion pump fluid displacement are described.
摘要翻译：输液泵（例如，电动输液泵）包括可以非机械地驱动可移动活塞的输液泵模块和发动机。此外，输液泵模块包括位置检测器，其被配置为感测输注泵模块的分配状态。这样的信息可以用于控制方案中以控制泵内和泵外的流体位移。描述不同类型的位置检测器，例如磁传感器（例如，各向异性磁阻传感器）及其在检测输液泵流体位移中的实现。

6. 发明申请

WO2004107973A1 SERPENTINE AND CORDUROY CIRCUITS TO ENHANCE THE STRETCHABLITY OF A STRETCHABLE ELECTRONIC DEVICE 审中-公开
标题翻译： SERPENTINE和CORDUROY电路，以提高可扩展电子设备的可伸缩性
公开(公告)号：WO2004107973A1
公开(公告)日：2004-12-16
申请号：PCT/US2004/016819
申请日：2004-05-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MAGHRIBI, Mariam, N. , KRULEVITCH, Peter, A. , WILSON, Thomas, S. , HAMILTON, Julie, K. , PARK, Christina
发明人： MAGHRIBI, Mariam, N. , KRULEVITCH, Peter, A. , WILSON, Thomas, S. , HAMILTON, Julie, K. , PARK, Christina
IPC分类号： A61B5/00
CPC分类号： C08J5/18 , A61B5/04001 , A61B2562/02 , A61B2562/164 , A61N1/0452 , A61N1/0476 , A61N1/0492 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/0553 , C08J2383/04 , H05K1/0283 , H05K1/118 , H05K2201/0133 , H05K2201/09263 , H05K2203/0271 , Y10T428/24917 , Y10T428/31663 , Y10T428/31707
摘要： A stretchable electronic apparatus and method of producing the apparatus. The apparatus has a central longitudinal axis and the apparatus is stretchable in a longitudinal direction generally aligned with the central longitudinal axis. The apparatus comprises a stretchable polymer body, and at least one circuit line operatively connected to the stretchable polymer body, the at least one circuit line extending in the longitudinal direction and having a longitudinal component that extends in the longitudinal direction and having an offset component that is at an angle to the longitudinal direction, the longitudinal component and the offset component allowing the apparatus to stretch in the longitudinal direction while maintaining the integrity of the at least one circuit line.
摘要翻译：一种可拉伸电子设备及其制造方法。该装置具有中心纵向轴线，并且该装置在大致与中心纵向轴线对准的纵向方向上是可拉伸的。该装置包括可拉伸的聚合物主体，以及至少一个可操作地连接到可拉伸聚合物主体的电路线，所述至少一个电路线在纵向上延伸并且具有沿纵向方向延伸的纵向部件，并且具有偏移部件，与纵向方向成一角度，纵向分量和偏移分量允许装置在纵向方向上拉伸，同时保持至少一条电路线的完整性。

7. 发明申请

WO2011047298A2 PALM ACTIVATED DRUG DELIVERY DEVICE 审中-公开
标题翻译： PALM活性药物递送装置
公开(公告)号：WO2011047298A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052894
申请日：2010-10-15
申请人： CENTOCOR ORTHO BIOTECH INC. , OLSON, Lorin, P. , KRULEVITCH, Peter , GLENCROSS, James , WANG, Jingli , FOLEY, Nicholas , ZHAO, Mingqi
发明人： OLSON, Lorin, P. , KRULEVITCH, Peter , GLENCROSS, James , WANG, Jingli , FOLEY, Nicholas , ZHAO, Mingqi
IPC分类号： A61M5/32 , A61M5/20
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译：公开了一种用于肠胃外递送药物如药物的装置。该装置包括上部壳体和下部壳体，其中上部壳体被构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下部壳体移动。 p>

8. 发明申请

WO2010098929A1 DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：药物递送管理系统和方法
公开(公告)号：WO2010098929A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022242
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara , PRICE, David, M., D.
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara , PRICE, David, M., D.
IPC分类号： A61B5/00 , A61K38/28
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a "smart" drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen in conjunction with a data management unit(s) DMU. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module. Methods of using the drug delivery system are also described.
摘要翻译：提供了“智能”药物递送系统的各种实施例，其包括与数据管理单元DMU结合的附加模块和可重复使用或一次性药物笔。附加模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，笔是否被引发或摇动以充分混合胰岛素混合物，传输与胰岛素相关的信息剂量和注射到数据管理单元，提供提醒，错误警告或关于不正确使用或重复使用针头的信息，轨道上留下的药物量或笔的使用持续时间，以及在药物到期时的使用时间，或提供用于定位放错的笔和模块的声音报警器。还描述了使用药物递送系统的方法。

9. 发明申请

WO2010098927A1 MEDICAL MODULE FOR DRUG DELIVERY PEN 审中-公开
标题翻译：药物输送笔的医疗模块
公开(公告)号：WO2010098927A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022236
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
IPC分类号： A61M5/315
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a medical module are provided which includes a primary module housing, a secondary module housing, a dosage sensor, a power source, and a microcontroller. The module is configured to be attached to a disposable drug delivery pen or a reusable drug delivery pen so that the module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module.
摘要翻译：提供了包括主模块外壳，次模块外壳，剂量传感器，电源和微控制器的医疗模块的各种实施例。模块被配置为附接到一次性药物输送笔或可重复使用的药物递送笔，使得模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，是否已经被注射或摇动彻底混合胰岛素混合物，将与胰岛素剂量和注射相关的信息传输到数据管理单元，提供提醒，错误警告或关于不当使用或重复使用针头的消息，跟踪笔上留下的药物的量或使用持续时间关于药物到期的笔，或提供用于定位放错的笔和模块的声音报警器。

10. 发明申请

WO2009137661A1 ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：分析测量和管理设备及相关方法
公开(公告)号：WO2009137661A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/043125
申请日：2009-05-07
申请人： LIFESCAN, INC. , SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARLTE, Robert
发明人： SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARLTE, Robert
IPC分类号： A61B5/00 , A61M5/172
CPC分类号： A61B5/4839 , A61B5/14532 , A61M5/14244 , A61M5/1723 , A61M2005/14208 , G06F19/00
摘要： A method for measuring and managing an analyte (e.g., blood glucose) in a bodily fluid includes storing a therapeutic administration protocol in a memory module of an analyte measurement and management device and measuring the analyte in the bodily fluid sample using an analyte measurement module of the device. The method also includes calculating, with a processor module of the device, a recommended therapeutic agent dosage (for example, an insulin dosage) and a recommended administration time for user-activated delivery of the dosage by employing the therapeutic administration protocol. The method further includes displaying the recommended therapeutic agent dosage and administration time to a user on a visual display of the device, delivering a therapeutic agent dosage to the user via a user-activated therapeutic agent delivery device, and detecting the user-activated administration of the therapeutic agent using a delivery device communication module of the device. In addition, the method includes communicating the aforementioned detection to the processor module and/or memory module using the delivery device communication module. The method employs analyte measurement, memory, processor, and delivery device modules, as well as a visual display, and user interface that are integrated as a single hand-held unit.
摘要翻译：用于测量和管理体液中的分析物（例如，血糖）的方法包括将分析物测量和管理装置的存储器模块中的治疗性给药方案存储在体液样品中，并使用分析物测量模块装置。该方法还包括利用该设备的处理器模块，通过使用治疗性给药方案来计算推荐的治疗剂剂量（例如，胰岛素剂量）和用户激活的剂量递送的推荐给药时间。该方法还包括在设备的视觉显示上向用户显示推荐的治疗剂剂量和给药时间，经由用户激活的治疗剂递送装置向用户递送治疗剂剂量，以及检测用户激活的给药时间所述治疗剂使用所述装置的递送装置通信模块。此外，该方法包括使用传送设备通信模块将上述检测传送到处理器模块和/或存储器模块。该方法采用分析物测量，存储器，处理器和传送设备模块，以及作为单个手持单元集成的可视显示器和用户界面。

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