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    • 4. 发明申请
    • TRANSCUTANEOUS ANALYTE SENSOR
    • TRANSCUTANEOUS分析仪传感器
    • WO2011041463A3
    • 2011-07-14
    • PCT/US2010050788
    • 2010-09-29
    • DEXCOM INCNEALE PAUL VBOOCK ROBERTBOHM SEBASTIANSIMPSON PETER CBRAUKER JAMES
    • NEALE PAUL VBOOCK ROBERTBOHM SEBASTIANSIMPSON PETER CBRAUKER JAMES
    • A61B5/151A61B5/157
    • A61B5/14865A61B5/14503A61B5/14532A61B5/14546A61B5/1468A61B5/1473A61B5/1486A61B5/6843A61B5/6848A61B5/6849A61B2560/0443A61B2562/0209A61B2562/04
    • A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
    • 提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。 在一些实施例中,经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160,以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。 体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120,传感器主体120包括材料或支撑构件130,材料或支撑构件130提供足够的柱强度,以允许传感器主体可在主机组织中推出而不用 实质屈曲。 离体部分170可以被配置为包括(或可操作地连接)传感器电子单元,并且可以包括安装单元150.此处还描述了传感器主体和组织刺穿元件的各种配置,其可以用于保护 传感器体的膜。
    • 9. 发明申请
    • MALFUNCTION DETECTION WITH DERIVATIVE CALCULATION
    • 导数计算的失效检测
    • WO2007035564A3
    • 2007-07-12
    • PCT/US2006036165
    • 2006-09-18
    • LIFESCAN INCKRULEVITCH PETERBOHM SEBASTIANZHAO MINGGIANEX DEON
    • KRULEVITCH PETERBOHM SEBASTIANZHAO MINGGIANEX DEON
    • B01D57/02
    • A61M5/14244A61M5/14248A61M5/1452A61M5/16831A61M5/172A61M2005/14513A61M2205/3317A61M2205/3389
    • Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
    • 讨论了检测输液泵中的闭塞和液体流失状况(例如,断开和/或泄漏)的系统和方法。 例如,电动输液泵可能在流体流动路径中形成阻塞,这可能破坏从泵分散的流体的控制。 同样,输液器断开连接也会导致液体损失,这可能是破坏性的。 对于控制输液泵的系统而言,这种中断可能会很麻烦,例如闭环控制器。 相应地,本文描述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。 例如,可以使用位置传感器来监测来自输液泵的流体流量,将测量值与期望值进行比较以检测堵塞或流体损失状况。 还描述了用于利用位置传感器的其他算法。
    • 10. 发明申请
    • ELECTROKINETIC INFUSION PUMP SYSTEM
    • 电动注入泵系统
    • WO2007035666A2
    • 2007-03-29
    • PCT/US2006/036340
    • 2006-09-18
    • LIFESCAN, INC.KRULEVITCH, PeterBENETT, WilliamROBERTS, Neil, E.BOHM, SebastianSIEH, Zara
    • KRULEVITCH, PeterBENETT, WilliamROBERTS, Neil, E.BOHM, SebastianSIEH, Zara
    • A61M1/00
    • A61M5/14244A61M5/14248A61M5/1452A61M5/16831A61M5/172A61M2005/14513A61M2205/3317A61M2205/3389
    • Various methods and devices are provided for delivering an infusion liquid using an electrokinetic infusion pump. The electrokinetic infusion pump can generally include an infusion housing having an infusion reservoir. The infusion reservoir has an infusion outlet and is capable of containing an infusion liquid. A plunger is movably coupled to the infusion housing and is adapted to be manually displaced relative to the infusion housing to load the infusion reservoir with infusion liquid. A movable partition can be disposed within the infusion housing and has a first surface in communication with an electrokinetic solution and a second surface, isolated from the first surface, in communication with the infusion reservoir. The electrokinetic infusion pump can further include an electrokinetic engine integrated within the plunger and adapted to selectively deliver electric potential across an electrokinetic porous media to cause the electrokinetic solution within the electrokinetic engine to displace the movable partition to effect delivery of at least a portion of the infusion liquid through the infusion outlet.
    • 提供了使用电动输液泵输送输液的各种方法和装置。 电动输液泵通常可以包括具有输液容器的输液壳体。 输液容器具有输液出口并且能够容纳输注液体。 柱塞可移动地联接到输液壳体并适于相对于输液壳体手动移位以将输液储液器装载输液。 可移动分隔件可以设置在输液壳体内并且具有与电动溶液连通的第一表面和与输液储存器连通的与第一表面隔开的第二表面。 电动输液泵可以进一步包括集成在柱塞内的电动发动机,并且适于在电动多孔介质上选择性地递送电势,以使电动力发动机内的电动力溶液移位可动分隔物以实现至少一部分 输液通过输液出口。