专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2019070871A1 THERAPEUTIC BIOELECTROMAGNETIC FIELDS, PAIN RELIEF DEVICES AND RELATED METHODS 审中-公开
公开(公告)号：WO2019070871A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/054190
申请日：2018-10-03
申请人： PREZACOR, INC.
发明人： KARPF, Gary
IPC分类号： A61B5/04 , A61B5/00 , A61N1/04 , A61N1/36 , A61N1/372 , A01N25/26 , A61K9/00 , A61K9/16 , A61K9/70 , A61L15/18 , A61K33/24
CPC分类号： A61N1/0452 , A61B5/04001 , A61B5/04002 , A61B5/4839 , A61B5/4848 , A61N1/0456 , A61N1/0484 , A61N1/0496 , A61N1/36021 , A61N1/36132 , A61N1/37241 , A61N1/37247
摘要： A pain relief device is provided. The pain relief device includes: (i) a body portion including a contact region configured for contacting a subject; and (ii) a monopolar transmitter including a single electrical pole for providing an electrical signal to the body portion for treatment of the subject.

2. 发明申请

WO2018237384A1 DETERMINING A STATE OF A SOLID TUMOR BASED ON NEURAL ACTIVITY WITHIN THE SOLID TUMOR 审中-公开
公开(公告)号：WO2018237384A1
公开(公告)日：2018-12-27
申请号：PCT/US2018/039293
申请日：2018-06-25
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： DURAND, Dominique M. , MCCALLUM, Grant A.
IPC分类号： A61B5/00 , A61B5/04 , A61N1/05
CPC分类号： A61B5/4836 , A61B5/04001 , A61B5/4029 , A61B5/4839 , A61B5/4842 , A61B5/6847 , A61B5/686 , A61N1/0551 , A61N1/36002 , A61N1/36139
摘要： One aspect of the present disclosure relates a method of diagnosis and/or treatment of a solid tumor. The method includes directly measuring neural activity within a solid tumor for a time and determining a state of the solid tumor based on the neural activity. The diagnosis and/or treatment can be determined based on the state of the solid tumor. In some instances, the neural activity can be used in a closed loop to detect the neural activity, determine the state, determine the risk, apply treatment, check again for neural activity, and cease treatment when the neural activity is gone.

3. 发明申请

WO2018227002A1 SYSTEMS AND METHODS FOR RUGGEDIZED PENETRATING MEDICAL ELECTRODE ARRAYS 审中-公开
公开(公告)号：WO2018227002A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036529
申请日：2018-06-07
申请人： NEURONEXUS TECHNOLOGIES, INC.
发明人： HETKE, Jamille Farraye , VETTER, Rio J. , RACKHAM, Carlos , KIPKE, Daryl R.
IPC分类号： A61N1/05 , A61B5/04
CPC分类号： A61N1/0502 , A61B5/04 , A61B5/04001 , A61B5/0422 , A61B5/686 , A61B5/6869 , A61B18/1477 , A61B2018/0016 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0587
摘要： Systems and methods for ruggedized neural probes are provided. Such probes may be adapted for penetrating tissue. An exemplary ruggedized penetrating electrode array system includes an elongate shank having one or more electrodes disposed on at least one exterior surface thereof and a backend structure. A proximal end of the elongate shank is secured to the backend structure. The exemplary array system further includes an elongate carrier secured to the backend structure and extending away from the backend structure toward the distal end of the elongate shank, the elongate carrier being more rigid than the elongate shank. Methods for fabricating such an array system are also provided.

4. 发明申请

WO2018169955A1 SYSTEMS AND METHODS FOR NEURAL DRUG DELIVERY AND MODULATION OF BRAIN ACTIVITY 审中-公开
公开(公告)号：WO2018169955A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022183
申请日：2018-03-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： DAGDEVIREN, Canan , LANGER, Robert , CIMA, Michael J.
IPC分类号： A61M5/32 , A61B5/04 , A61B5/00 , A61N1/05 , A61N1/04 , A61M5/158
CPC分类号： A61M5/158 , A61B5/0084 , A61B5/04001 , A61B5/4064 , A61B5/6868 , A61M5/1723 , A61M5/329 , A61M5/3294 , A61M25/0084 , A61M2005/1588 , A61M2202/04 , A61M2205/02 , A61M2205/051 , A61M2205/054 , A61M2205/3303 , A61M2207/00 , A61M2210/0693 , A61M2230/08 , A61N1/0488 , A61N1/0529
摘要： A neural drug delivery system is disclosed. In an embodiment, the system includes two or more microtubes, each having a distal end, a proximal end, and elongate channel body extending therebetween; an electrode having a distal end, a proximal end, and elongate body extending therebetween; an elongate carrying template supporting the microtubes and the electrode in an aligned stack; and an annular needle having a distal end and a proximal end, and housing the carrying template, the microtubes, and the electrode. The system may include at least one pump fluidically connected to the proximal end(s) of one or more of the microtubes. The pump may be configured to deliver a fluid drug on demand through the elongate channel body and out of the distal end of the microtubes.

5. 发明申请

WO2018068013A1 AN IMPLANTABLE ELECTROCORTICOGRAM BRAIN-COMPUTER INTERFACE SYSTEM FOR RESTORING EXTREMITY MOVEMENT 审中-公开
标题翻译：用于恢复极端运动的可植入式电子记忆脑计算机接口系统
公开(公告)号：WO2018068013A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055652
申请日：2017-10-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： HEYDARI, Payam , NENADIC, Zoran , DO, An , LIU, Charles
IPC分类号： A61B5/00 , A61B5/04 , G06F3/00 , G06F3/01
CPC分类号： A61B5/04001 , A61B5/04004 , A61B5/0476 , A61B5/4851 , A61B5/6868 , A61B5/7225 , A61F2/72 , A61H2201/165 , A61N1/0534 , G06F3/00 , G06F3/01 , G06F3/015
摘要： A fully-implantable brain-computer interface cyber-physical system capable of acquiring and analyzing electrocorticogram ("ECoG") signals, recorded directly from the subdural space of the brain, to enable direct brain control of a prosthetic (e.g., a robotic gait exoskeleton or a functional electrical stimulation ("FES") system) is disclosed. The present system comprises a plurality of electrodes, for acquiring the ECoG signals, and a digital signal processor ("DSP") for deriving a plurality of real-time commands from the ECoG signals. These real-time commands may then be wireless!y transmitted to the prosthetic for execution. Further, to avoid wireless data transmission of the ECoG signals from the plurality of electrodes to the DSP, which would expose the brain, skull, and scalp tissue to potentially harmful radio frequencies, a subcutaneous tunneling cable operatively couples the plurality of electrodes and the DSP.
摘要翻译：能够获取和分析直接从大脑硬膜下腔空间记录的脑电图（“ECoG”）信号的完全可植入的脑 - 计算机接口网络 - 物理系统，以能够直接控制脑公开了假体（例如，机器人步态外骨骼或功能性电刺激（“FES”）系统）。本系统包括用于获取ECoG信号的多个电极以及用于从ECoG信号导出多个实时命令的数字信号处理器（“DSP”）。这些实时命令然后可以无线传输到义肢进行执行。此外，为了避免ECoG信号从多个电极到DSP的无线数据传输，其将使脑，颅骨和头皮组织暴露于可能有害的射频，皮下隧道电缆可操作地耦合多个电极和DSP

6. 发明申请

WO2017217158A1 BIOPOTENTIAL MEASURING APPARATUS 审中-公开
标题翻译：生物测量仪器
公开(公告)号：WO2017217158A1
公开(公告)日：2017-12-21
申请号：PCT/JP2017/018075
申请日：2017-05-12
申请人： NIHON KOHDEN CORPORATION
发明人： SATO Makoto , MAEDA Toshiki
IPC分类号： A61B5/00 , A61B5/0484 , A61N1/37 , A61B5/04 , A61B5/0428
CPC分类号： A61B5/053 , A61B5/04001 , A61B5/04004 , A61B5/04288 , A61B5/0484 , A61B5/7203 , A61B5/7217 , A61B5/7225 , A61B5/725 , A61B2560/0468 , A61B2562/0214 , A61N1/371
摘要： A stimulating section (2) applies stimulation to a living body (100). A first lead electrode (3) and a second lead electrode (4) are attached on the living body (100). A first amplifier circuit (5) amplifies potential difference that is evoked between the first lead electrode (3) and the second lead electrode (4) due to the stimulation. A first switch (6) cancels electrical connection between the first amplifier circuit (5) and each of the first lead electrode (3) and the second lead electrode (4) at least while the stimulation is applied. A high-pass filter (7) includes a capacitor (C) and filters a frequency component of an output from the first amplifier circuit (5) that is no less than a predetermined value. A second amplifier circuit (8) amplifies the output from the first amplifier circuit (5). A second switch (10) stops charging/discharging of the capacitor (C) and decreases a gain of the second amplifier circuit (8) at least while the first switch (6) cancels the electrical connection.
摘要翻译：刺激部（2）对生物体（100）施加刺激。第一引线电极（3）和第二引线电极（4）附着在生物体（100）上。第一放大器电路（5）放大由于刺激而在第一引线电极（3）和第二引线电极（4）之间引起的电位差。至少在施加刺激时，第一开关（6）抵消第一放大器电路（5）与第一引线电极（3）和第二引线电极（4）中的每一个之间的电连接。高通滤波器（7）包括电容器（C）并且对第一放大器电路（5）的输出的频率分量进行滤波，该频率分量不小于预定值。第二放大器电路（8）放大来自第一放大器电路（5）的输出。至少在第一开关（6）取消电连接的同时，第二开关（10）停止电容器（C）的充电/放电并且减小第二放大器电路（8）的增益。

7. 发明申请

WO2017143191A1 NERVE STIMULATION SYSTEMS AND METHODS USING AN EXTERNAL WIRELESS POWER SOURCE 审中-公开
标题翻译：神经刺激系统和使用外部无线电源的方法
公开(公告)号：WO2017143191A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018371
申请日：2017-02-17
申请人： VERILY LIFE SCIENCES LLC
发明人： PEPIN, Brian Marc , OTIS, Brian
IPC分类号： A61N1/372 , A61N1/378 , A61N1/05 , A61N1/36 , A61B5/04 , A61N1/375 , A61B5/00
CPC分类号： A61N1/0556 , A61B5/04001 , A61B5/4041 , A61B5/686 , A61B5/6877 , A61B2560/0219 , A61B2562/0209 , A61B2562/164 , A61N1/36128 , A61N1/36139 , A61N1/37223 , A61N1/37229 , A61N1/3758 , A61N1/3787 , H02J7/025 , H02J7/345 , H02J50/10
摘要： Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.
摘要翻译：提供系统和方法用于利用可植入装置刺激一个或多个神经。可植入装置可以包括包括环形天线的天线电路和包括整流二极管的控制电路，该整流二极管用于对由外部电磁场在天线电路中感应的交流电压进行整流。可植入装置还可以包括用于存储来自整流电压的能量而不使用电池的可充电存储元件。该装置还可以包括电极阵列，该电极阵列包含一组电极，用于响应于从控制电路接收的控制信号使用所存储的能量来发射电场。装置的组件可以被固定到柔性聚合物基底上，所述柔性聚合物基底包括在基底的基本上矩形主体部分的至少两个边缘上的可连接的外围突片，用于在待刺激的一个或多个神经周围形成箍带。

8. 发明申请

WO2017127551A1 ADDRESSABLE VERTICAL NANOWIRE PROBE ARRAYS AND FABRICATION METHODS 审中-公开
标题翻译：可寻址的垂直纳米探针阵列和制造方法
公开(公告)号：WO2017127551A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014143
申请日：2017-01-19
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： DAYEH, Shadi A. , CHEN, Renjie , LEE, Sang Heon , LIU, Ren , RO, Yun Goo , TANAKA, Atsunori , HWANG, Yoontae
IPC分类号： B82B3/00 , B82B1/00 , B82Y5/00 , B82Y15/00 , A61B5/042 , A61B5/04
CPC分类号： A61B5/04001 , A61B2562/0285 , A61B2562/046 , A61B2562/125 , B81B2201/055 , B81C1/00111 , B82Y15/00
摘要： A nanowire probe sensor array including a substrate with a metal pattern thereon. An array of semiconductor vertical nanowire probes extends away from the substrate, and at least some of probes, and preferably all, are individually electrically addressed through the metal pattern. The metal pattern is insulated with dielectric, and base and stem portions of the nanowires are also preferably insulated. A fabrication process patterns metal connections on a substrate. A semiconductor substrate is bonded to the metal pattern. The semiconductor substrate is etched to form the neural nanowire probes that are bonded to the metal pattern. Dielectric is then deposited to insulate the metal pattern.
摘要翻译：纳米线探针传感器阵列，包括其上具有金属图案的衬底。半导体垂直纳米线探针的阵列从衬底延伸出来，并且探针中的至少一些，并且优选地全部通过金属图案单独电寻址。金属图案用电介质绝缘，并且纳米线的基部和杆部也优选地绝缘。制造工艺在衬底上图案化金属连接。半导体衬底结合到金属图案。蚀刻半导体衬底以形成结合到金属图案的神经纳米线探针。然后沉积电介质以绝缘金属图案。

9. 发明申请

WO2017106490A1 SYSTEMS AND METHODS FOR LINEAR-TIME CLUSTERING FOR BOUNDED, REPEATABLE, RARE EVENTS IN PHYSIOLOGICAL SIGNALS 审中-公开
标题翻译：用于生理信号中有界，可重复，稀有事件的线性时间聚类的系统和方法
公开(公告)号：WO2017106490A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066914
申请日：2016-12-15
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： BOWER, Mark, R. , BOWER, Regina, S. , KUCEWICZ, Michael, T. , WORRELL, Gregory, A.
IPC分类号： A61B5/00 , A61B5/024 , A61B5/04 , A61B5/0408 , A61B5/08 , A61B5/1455 , A61B6/00
CPC分类号： A61B5/7203 , A61B5/04001 , A61B5/4806
摘要： Described herein are methods and systems for clustering events in temporal signals, such as physiological signals. In some embodiments, a method for identifying events of interest from noisy physiological signal data is provided, the method comprising: receiving physiological signal data; generating filtered signal using a filter defined by a spectral band; generating signal peak data by identifying, for each of a plurality of time windows, a signal peak in the filtered data; grouping waveforms corresponding to the time windows based on the signal peak data to generate clustered event data; determining parameters for a noise beta distribution; identifying a cluster of waveforms that does not fall within the noise beta distribution; generating a graphical representation based on the waveforms in the cluster; and displaying the graphical representation.
摘要翻译：这里描述的是用于对诸如生理信号之类的时间信号中的事件进行聚类的方法和系统。在一些实施例中，提供了一种用于从嘈杂的生理信号数据中识别感兴趣事件的方法，所述方法包括：接收生理信号数据; 使用由频谱带限定的滤波器来生成经滤波的信号; 通过为多个时间窗口中的每一个识别滤波数据中的信号峰值来产生信号峰值数据; 基于信号峰值数据对与时间窗相对应的波形进行分组以生成聚集事件数据; 确定噪声β分布的参数; 识别不属于噪声β分布的一组波形; 基于集群中的波形生成图形表示; 并显示图形表示。

10. 发明申请

WO2017100140A2 APPARATUS FOR EFFECTIVE ABLATION AND NERVE SENSING ASSOCIATED WITH DENERVATION 审中-公开
标题翻译：用于有效消融和与神经损伤相关的神经感测的装置
公开(公告)号：WO2017100140A2
公开(公告)日：2017-06-15
申请号：PCT/US2016/065017
申请日：2016-12-05
申请人： ABLATIVE SOLUTIONS, INC.
发明人： FISCHELL, David, R. , FISCHELL, Tim, A. , GHAZAROSSIAN, Vartan , ALMANY, Steven , JOHN, Michael, Sasha
IPC分类号： A61M25/00
CPC分类号： A61B5/6848 , A61B5/04001 , A61B18/06 , A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/143 , A61B2018/1475 , A61M2025/0087 , A61N7/022
摘要： An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. Tire catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.
摘要翻译：用于神经活动消融和/或感测的血管内导管包括一个或多个通过支撑导管（导针元件）前进的针，所述导管延伸以接触肾动脉壁的内表面或其他导管允许针穿过血管壁进入包括介质，外膜和周围空间的外腔组织的人体血管。轮胎导管还包括对引导管提供径向和侧向支撑的结构，使得引导管均匀地打开并且当尖锐的针前进穿透血管壁时保持它们抵靠血管壁的内表面的位置。针末端附近的电极允许在尝试肾去神经支配之前和之后感测神经活动。在组合的实施方式中，消融能量或流体从外膜中或外膜附近的针递送以消融介质外的神经，同时在神经介质内节约神经。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式