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1. 发明申请

WO2008036801A3 METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION 审中-公开
标题翻译：通过吸入传递药物的方法和系统
公开(公告)号：WO2008036801A3
公开(公告)日：2008-07-31
申请号：PCT/US2007078999
申请日：2007-09-20
申请人： NEXT SAFETY INC , LEMAHIEU EDWARD , JONES CHARLES , STERN TOM , HEBRANK JACK , HUNTER CHARLES ERIC , DUVALL LYNDELL , HARTLEY CHRIS , BALLOU BERNARD L , HUNTER JOCELYN , MCNEIL LAURIE , WETZEL PAUL , CRISS RON
发明人： LEMAHIEU EDWARD , JONES CHARLES , STERN TOM , HEBRANK JACK , HUNTER CHARLES ERIC , DUVALL LYNDELL , HARTLEY CHRIS , BALLOU BERNARD L , HUNTER JOCELYN , MCNEIL LAURIE , WETZEL PAUL , CRISS RON
IPC分类号： A61K9/12
CPC分类号： A61M16/06 , A61M11/005 , A61M11/008 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M15/001 , A61M15/0085 , A61M15/009 , A61M15/025 , A61M16/0051 , A61M16/0057 , A61M16/0066 , A61M16/0069 , A61M16/024 , A61M16/109 , A61M16/161 , A61M2016/0027 , A61M2016/0039 , A61M2205/3569 , A61M2205/3592 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2206/14 , A61M2230/06 , A61M2230/201 , A61M2230/205 , A61M2230/30
摘要： Systems and methods for delivery of a drug to the respiratory system of a patient where the drug is supplied at a positive pressure relative to atmospheric pressure are provided. In particular, the drugs are delivered to the respiratory system of a patient who is capable of unassisted breathing. With the systems and methods of the present disclosure, medication available in a variety of forms is introduced in a controlled fashion into the air stream in aerosol, nebulized, or vaporized form.
摘要翻译：提供了用于将药物输送到患者的呼吸系统中的系统和方法，其中药物以相对于大气压力的正压供应。特别是，药物被输送到能够无辅助呼吸的患者的呼吸系统。利用本公开的系统和方法，以各种形式可获得的药物以受控的方式以气溶胶，雾化或蒸发形式引入气流中。

2. 发明申请

WO2008036801A2 METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION 审中-公开
标题翻译：通过吸入传递药物的方法和系统
公开(公告)号：WO2008036801A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/078999
申请日：2007-09-20
申请人： NEXT SAFETY, INC. , LEMAHIEU, Edward , JONES, Charles , STERN, Tom , HEBRANK, Jack , HUNTER, Charles, Eric , DUVALL, Lyndell , HARTLEY, Chris , BALLOU, Bernard, L. , HUNTER, Jocelyn , MCNEIL, Laurie , WETZEL, Paul , CRISS, Ron
发明人： LEMAHIEU, Edward , JONES, Charles , STERN, Tom , HEBRANK, Jack , HUNTER, Charles, Eric , DUVALL, Lyndell , HARTLEY, Chris , BALLOU, Bernard, L. , HUNTER, Jocelyn , MCNEIL, Laurie , WETZEL, Paul , CRISS, Ron
IPC分类号： A62B7/00 , A62B9/00
CPC分类号： A61M16/06 , A61M11/005 , A61M11/008 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M15/001 , A61M15/0085 , A61M15/009 , A61M15/025 , A61M16/0051 , A61M16/0057 , A61M16/0066 , A61M16/0069 , A61M16/024 , A61M16/109 , A61M16/161 , A61M2016/0027 , A61M2016/0039 , A61M2205/3569 , A61M2205/3592 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2206/14 , A61M2230/06 , A61M2230/201 , A61M2230/205 , A61M2230/30
摘要： Systems and methods for delivery of a drug to the respiratory system of a patient where the drug is supplied at a positive pressure relative to atmospheric pressure are provided. In particular, the drugs are delivered to the respiratory system of a patient who is capable of unassisted breathing. With the systems and methods of the present disclosure, medication available in a variety of forms is introduced in a controlled fashion into the air stream in aerosol, nebulized, or vaporized form.
摘要翻译：提供了用于将药物递送到患者的呼吸系统的系统和方法，其中药物以相对于大气压的正压被供应。特别地，药物被输送到能够无助呼吸的患者的呼吸系统。利用本公开的系统和方法，以各种形式可用的药物以受控的方式引入气溶胶，雾化或蒸发形式的空气流中。

3. 发明申请

WO2005051936A1 PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS 审中-公开
标题翻译：苯维生素化合物作为维生素D受体调节剂
公开(公告)号：WO2005051936A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/035527
申请日：2004-11-16
申请人： ELI LILLY AND COMPANY , GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , YEE, Ying, Kwong
发明人： GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , YEE, Ying, Kwong
IPC分类号： C07D307/68
CPC分类号： C07D307/68
摘要： The present invention relates to novel, non-secosteroidal, phenyl-furan compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译：本发明涉及具有维生素D受体（VDR）调节活性的新型非甾体甾体苯基呋喃化合物，其比1α，25二羟基维生素D3低钙高。这些化合物可用于治疗骨病和牛皮癣。

4. 发明申请

WO2004048309A1 VITAMIN D RECEPTOR MODULATORS 审中-公开
标题翻译：维生素D受体调节剂
公开(公告)号：WO2004048309A1
公开(公告)日：2004-06-10
申请号：PCT/US2003/035055
申请日：2003-11-20
申请人： ELI LILLY AND COMPANY , BUNEL, Emilio, Enrique , GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , YEE, Ying, Kwong
发明人： BUNEL, Emilio, Enrique , GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , YEE, Ying, Kwong
IPC分类号： C07C59/90
CPC分类号： C07D207/27 , C07C59/48 , C07C59/64 , C07C59/66 , C07C59/90 , C07C65/24 , C07C65/34 , C07C65/40 , C07C69/732 , C07C69/734 , C07C69/738 , C07C69/76 , C07C69/94 , C07C235/34 , C07C235/42 , C07C311/51 , C07C317/28 , C07D207/26 , C07D233/78 , C07D257/04 , C07D257/06 , C07D261/12 , C07D271/113 , C07D277/34 , C07D295/185
摘要： The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译：本发明涉及具有维生素D受体（VDR）调节活性的新型非非甾体二芳基化合物，其比1a，25二羟基维生素D3低钙血红素。这些化合物可用于治疗骨病和牛皮癣。

5. 发明申请

WO2004017960A1 TREATMENT OF LOWER URINARY TRACT SYMPTOMS ASSOCIATED WITH OVERACTIVE BLADDER IN MEN AND WOMEN 审中-公开
标题翻译：治疗男性和女性与乳腺癌相关的下尿路症状
公开(公告)号：WO2004017960A1
公开(公告)日：2004-03-04
申请号：PCT/EP2003/008696
申请日：2003-08-05
申请人： JANSSEN PHARMACEUTICA N.V. , JONES, Charles, Richard , LEAKER, Brian , WYLLIE, Michael, Grant
发明人： JONES, Charles, Richard , LEAKER, Brian , WYLLIE, Michael, Grant
IPC分类号： A61K31/404
CPC分类号： A61K45/06 , A61K31/085 , A61K31/216 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/4174 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/453 , A61K31/454 , A61K31/4706 , A61K31/517 , A61K2300/00
摘要： This invention relates to pharmaceutical combinations suitable for treating the lower urinary tract symptoms associated with either overactive bladder or mild to moderate benign prostatic hyperplasia, which combinations contain an alpha-adrenoceptor antagonist and a 5-HT 4 antagonist. The combinations of the invention are particularly suitable for treating moderate or severe symptomatology.
摘要翻译：本发明涉及适用于治疗膀胱过度活动症或轻度至中度良性前列腺增生症的下尿路症状的药物组合，该组合含有α肾上腺素受体拮抗剂和5-HT4拮抗剂。本发明的组合特别适用于治疗中度或严重症状。

6. 发明申请

WO2003014599A1 HYDRAULISCHE STEUERSYSTEME 审中-公开
标题翻译：液压控制系统
公开(公告)号：WO2003014599A1
公开(公告)日：2003-02-20
申请号：PCT/DE2002/002747
申请日：2002-07-26
申请人： LUK LAMELLEN UND KUPPLUNGSBAU BETEILIGUNGS KG , JONES, Charles, John , O'SULLIVAN, Eugene, M.
发明人： JONES, Charles, John , O'SULLIVAN, Eugene, M.
IPC分类号： F16H61/30
CPC分类号： F16H61/30 , B60W10/02 , B60W10/10 , B60W30/1819 , F16H61/2807 , F16H63/46 , F16H2061/0253
摘要： Ein Verfahren zum Betreiben eines hydraulischen Steuersystems für den Gangwählmechanismus eines Motorfahrzeuges mit ersten und zweiten doppeltwirkenden Hydraulikstellgliedern (114,115), einem Hauptsteuerventil (150), das zum ausgewählten Verbinden einer Seite der Hydraulikstellglieder mit einer Versorgungsquelle (275) mit unter Druck stehender Hydraulikflüssigkeit oder mit einem Volumsausgleichsgefäss (278) geeignet ist.
摘要翻译：操作液压控制系统，用于具有第一和第二双作用液压致动器的机动车辆（114115），主控制阀（150），所述一个用于与加压的液压流体的液压致动器的一侧有选择地连接到一个供应源（275），或与所述齿轮选择机构的方法 Volumsausgleichsgefäss（278）是合适的。

7. 发明申请

WO9922328A8 SYSTEM AND METHOD OF TARGETED MARKETING 审中-公开
标题翻译：目标市场的系统与方法
公开(公告)号：WO9922328A8
公开(公告)日：1999-06-24
申请号：PCT/US9822613
申请日：1998-10-26
申请人： MARKETSWITCH CORP , JONES CHARLES L III , EGINTON WILLIAM A
发明人： JONES CHARLES L III , EGINTON WILLIAM A
IPC分类号： G06Q10/06 , G06Q30/02 , G06F17/60
CPC分类号： G06Q30/02 , G06Q10/06375 , G06Q30/0204 , G06Q30/0207 , G06Q30/0251
摘要： A system and method of targeted marketing to consumers, including businesses and associates, based upon the financial characteristics of the consumer, type offer being made and the channel of communication for delivery of the offer. The consumer is characterized based upon financial, behavioral, and socioeconomic factors. The offer is characterized based upon the consumer and the potential for the consumer accepting the offer. The channel of communication for delivery of the offer is also characterized and combined with the consumer and consumer-offer characteristics to arrive at a net present value of the offer to be made. If the net present value is sufficient the offer is processed and presented to the consumer. If the net present value is not sufficient, the offer is revised to present a better value to the consumer (or discarded if the required offer value can not be created) thereby enhancing the chances that the consumer will accept the offer in question. In this way the system and method of the target marketing creates value in both releasing, and not releasing specific offers.
摘要翻译：基于消费者的财务特征，正在进行的类型报价以及用于交付报价的通信渠道，向消费者（包括企业和联营公司）进行有针对性的营销的系统和方法。消费者的特征是基于财务，行为和社会经济因素。该报价的特点是消费者和消费者接受报价的潜力。用于交付报价的通信渠道也被特征化并结合消费者和消费者提供特征，以获得要提供的净现值。如果净现值足够，报价将被处理并提交给消费者。如果净现值不足，则对报价进行修改，以向消费者呈现更好的价值（如果不能创建所需的报价值，则丢弃），从而增加消费者接受有关报价的机会。以这种方式，目标营销的系统和方法在释放和不发布特定优惠方面创造价值。

8. 发明申请

WO1998028162A1 CLUTCH CONTROL SYSTEM 审中-公开
标题翻译：离合器控制系统
公开(公告)号：WO1998028162A1
公开(公告)日：1998-07-02
申请号：PCT/GB1997003497
申请日：1997-12-19
申请人： AP KONGSBERG LIMITED , JONES, Charles, John , MARTIN, Paul, Grahame
发明人： AP KONGSBERG LIMITED
IPC分类号： B60K41/02
CPC分类号： B60W30/18 , B60W10/02 , B60W10/10 , B60W10/11 , B60W30/1819 , B60W2510/0225 , B60W2510/0291 , B60W2510/0604 , B60W2510/0638 , B60W2710/0644 , F16D48/066 , F16D2500/10412 , F16D2500/3026 , F16D2500/30404 , F16D2500/30426 , F16D2500/3067 , F16D2500/50236 , F16D2500/50245 , F16D2500/50251 , F16D2500/7041 , F16D2500/70605 , F16H63/46 , Y10T477/6392 , Y10T477/6425 , Y10T477/78
摘要： A method of determining, during a clutch re-engagement process, the kiss-point of a vehicle clutch (14) having a driven plate (40) which drives a vehicle from an engine (10) via a multi-ratio transmission (12). The clutch is operated via a clutch actuating mechanism (20, 22) under the control of an electronic control means (36) using a method comprising the steps of: checking that the throttle (18) of the engine is closed and that the vehicle is in an engine overrun condition; partially re-engaging the clutch (14) up to a point (Y) where the clutch increases the engine speed to a substantially constant level below the speed of the driven plate (40) of the clutch; measuring (34) the position of the clutch actuating mechanism (20, 22) when in said partially engaged condition; computing from said position measurement(s) and the known engagement/torque characteristics (T1, T2, T3) of the clutch the current kiss-point position (T); saving said current kiss-point position (T), and completing the engagement of the clutch.
摘要翻译：一种在离合器重新接合过程中确定具有经由多比率变速器（12）从发动机（10）驱动车辆的从动板（40）的车辆离合器（14）的接点，。在电子控制装置（36）的控制下，通过离合器致动机构（20,22）操作离合器，该方法包括以下步骤：检查发动机的节气门（18）是否关闭，并且车辆是发动机超限状态; 将所述离合器（14）部分地再次接合到所述离合器（Y）的点（Y），其中所述离合器将所述发动机转速提高到低于所述离合器的从动板（40）的速度的基本上恒定的水平; 当处于所述部分接合状态时，测量（34）离合器致动机构（20,22）的位置; 从所述位置测量和所述离合器的已知接合/扭矩特性（T1，T2，T3）计算当前吻点位置（T）; 节省当前的吻点位置（T），并完成离合器的接合。

9. 发明申请

WO1997001549A1 BENZOTHIOPHENE COMPOUNDS 审中-公开
标题翻译：苯并噻吩化合物
公开(公告)号：WO1997001549A1
公开(公告)日：1997-01-16
申请号：PCT/US1996010551
申请日：1996-06-25
申请人： ELI LILLY AND COMPANY , JONES, Charles, D. , PALKOWITZ, Alan, D. , THRASHER, Kenneth, J.
发明人： ELI LILLY AND COMPANY
IPC分类号： C07D333/52
CPC分类号： C07D333/60 , C07D333/56
摘要： This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation of the acrylic and propionic acid compounds.
摘要翻译：本发明涉及一类丙烯酸和丙酸化合物及其在治疗绝经后症状和再狭窄中的用途。在其它实施方案中，本发明涉及中间体和用于制备丙烯酸和丙酸化合物的方法。

10. 发明申请

WO1996009041A1 BENZOTHIOPHENE COMPOUNDS, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：苯并噻吩化合物，组合物和方法
公开(公告)号：WO1996009041A1
公开(公告)日：1996-03-28
申请号：PCT/US1995012350
申请日：1995-09-18
申请人： ELI LILLY AND COMPANY , BRYANT, Henry, Uhlman , CULLINAN, George, Joseph , DODGE, Jeffrey, Alan , FAHEY, Kennan, Joseph , JONES, Charles, David
发明人： ELI LILLY AND COMPANY
IPC分类号： A61K31/34
CPC分类号： C07D333/56 , A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5377 , A61K31/55 , Y02P20/55
摘要： The present invention provides novel benzothiophene compounds, pharmaceutical formulations, and processes for preparation thereof, and methods of using such compounds for alleviating the symptoms of post-menopausal syndrome and inhibiting endometriosis, uterine fibrosis, and smooth muscle cell proliferation.
摘要翻译：本发明提供新的苯并噻吩化合物，药物制剂及其制备方法，以及使用这些化合物减轻绝经后综合征症状和抑制子宫内膜异位，子宫纤维化和平滑肌细胞增殖的方法。

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