专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996030361A1 PROCESS FOR 2-SUBSTITUTED BENZO[b]THIOPHENE COMPOUNDS AND INTERMEDIATES THEREOF 审中-公开
标题翻译： 2-取代苯并[b]噻吩化合物及其中间体的方法
公开(公告)号：WO1996030361A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004417
申请日：1996-03-28
申请人： ELI LILLY AND COMPANY , HAUSER, Kenneth, L. , PALKOWITZ, Alan, D. , SALL, Daniel, J. , THRASHER, Kenneth, J.
发明人： ELI LILLY AND COMPANY
IPC分类号： C07D333/52
CPC分类号： C07D333/54 , C07D333/56 , C07D333/62 , C07F5/025 , Y02P20/55
摘要： The present invention provides processes for preparing compounds of formula (I), wherein R is -H, -OH, or OR , in which R is a hydroxy protecting group; and R is -H, -OH, or OR , in which R is a hydroxy protecting group, and for preparing compounds of formula (VII), wherein R is -H, -OH, or OR , in which R is a hydroxy protecting group; R is -H, -OH, or OR , in which R is a hydroxy protecting group; R is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; R is bromo, chloro, iodo, or an activating ester group; and n is 2 or 3. Also provided are processes for preparing compounds of formula (VII) in addition to intermediates of formula (IX), wherein R is -OH, or -OR , in which R is a hydroxy protecting group; and Z is bromo, iodo, triflate, or -B(OH)2.
摘要翻译：本发明提供制备式（I）化合物的方法，其中R 1是-H，-OH或OR 3，其中R 3是羟基保护基; 和R 2是-H，-OH或OR 4，其中R 4是羟基保护基，并且用于制备式（VII）的化合物，其中R 1是-H， - OH或OR 3，其中R 3是羟基保护基; R 2是-H，-OH或OR 4，其中R 4是羟基保护基; R 5是1-哌啶基，1-吡咯烷基，甲基-1-吡咯烷基，二甲基-1-吡咯烷基，4-吗啉代，二甲基氨基，二乙基氨基，二异丙基氨基或1-六亚甲基亚氨基; R 6是溴，氯，碘或活化酯基; 还提供了除式（Ⅸ）中间体外还制备式（Ⅶ）化合物的方法，其中R 1'是-OH或-OR 3，其中R 1， 3>是羟基保护基; 和Z是溴，碘，三氟甲磺酸酯或-B（OH）2。

2. 发明申请

WO1997001549A1 BENZOTHIOPHENE COMPOUNDS 审中-公开
标题翻译：苯并噻吩化合物
公开(公告)号：WO1997001549A1
公开(公告)日：1997-01-16
申请号：PCT/US1996010551
申请日：1996-06-25
申请人： ELI LILLY AND COMPANY , JONES, Charles, D. , PALKOWITZ, Alan, D. , THRASHER, Kenneth, J.
发明人： ELI LILLY AND COMPANY
IPC分类号： C07D333/52
CPC分类号： C07D333/60 , C07D333/56
摘要： This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation of the acrylic and propionic acid compounds.
摘要翻译：本发明涉及一类丙烯酸和丙酸化合物及其在治疗绝经后症状和再狭窄中的用途。在其它实施方案中，本发明涉及中间体和用于制备丙烯酸和丙酸化合物的方法。

3. 发明申请

WO1998009625A1 SELECTIVE 'beta'3 ADRENERGIC AGONISTS 审中-公开
标题翻译：选择性beta 3 ADRENERGIC AGONISTS
公开(公告)号：WO1998009625A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015230
申请日：1997-08-28
申请人： ELI LILLY AND COMPANY , CROWELL, Thomas, A. , EVRARD, Deborah, A. , JONES, Charles, D. , MUEHL, Brian, S. , RITO, Christopher, J. , SHUKER, Anthony, J. , THORPE, Andrew, J. , THRASHER, Kenneth, J.
发明人： ELI LILLY AND COMPANY
IPC分类号： A61K31/40
CPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/44 , A61K31/4439 , C07D209/88 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective beta 3 receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and methods of treating Type II diabetes and obesity, comprising administering to a mammal in need thereof compounds of formula (I).
摘要翻译：本发明在医药领域，特别是治疗II型糖尿病和肥胖症。更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3受体激动剂。本发明提供了治疗II型糖尿病和肥胖症的化合物和方法，包括向有需要的哺乳动物施用式（I）化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式