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51. 发明申请

WO00069323A3 INTRAVASCULAR DEVICE AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：血管内装置及其制造和使用方法
公开(公告)号：WO00069323A3
公开(公告)日：2001-04-26
申请号：PCT/US2000/013203
申请日：2000-05-11
IPC分类号： A61B17/22 , A61M25/00 , A61M25/01 , A61M25/16 , A61M29/02 , A61B19/00
CPC分类号： A61M25/0029 , A61B17/22 , A61B2017/22077 , A61B2017/22082 , A61M25/007 , A61M25/0108 , A61M2025/0004 , A61M2025/0035 , A61M2025/0037 , A61M2025/0039 , A61M2025/1095 , A61M2202/0208 , A61M2210/0693
摘要： An intravascular device (802) and method of constructing an intravascular device (802). The device (802) has a proximal portion which is stiffer than a distal portion. The device (802) may be advanced through small vessels without the aid of a guidewire although a guidewire may be used when necessary. A preferred method of manufacture uses a liner (804) made of expanded PTFE at the distal portion (828) and etched PTFE at the proximal portion (830). The device (802) has a number of different jacket sections (846, 848, 850, 852, 854, 856), preferably at least four, with increasing durometer extending towards the proximal end of the device (802), and a braided section (808) with varying pic along the length of the device (802).
摘要翻译：血管内装置（802）和构造血管内装置的方法（802）。装置（802）具有比远侧部分更硬的近端部分。尽管可以在必要时使用导丝，设备（802）可以在没有引导线的帮助下通过小容器前进。优选的制造方法使用在远端部分（828）处由膨胀PTFE制成的衬垫（804）并且在近端部分（830）处蚀刻PTFE。装置（802）具有多个不同的护套部分（846,848,850,852,854,856），优选地至少四个，具有朝向装置（802）的近端延伸的增加的硬度，以及编织部分（808），其沿设备（802）的长度变化。

52. 发明申请

WO00067646A1 LATERAL NEEDLE INJECTION APPARATUS AND METHOD 审中-公开
标题翻译：侧针式注射装置和方法
公开(公告)号：WO00067646A1
公开(公告)日：2000-11-16
申请号：PCT/US2000/011134
申请日：2000-04-26
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61M25/00 , A61M31/00
CPC分类号： A61B17/3478 , A61B17/3207 , A61B18/1477 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2018/00214 , A61B2018/00291 , A61B2018/00392 , A61B2018/00589 , A61B2018/1425 , A61B2218/002 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/0089
摘要： A device and method for delivering and injecting fluid into heart tissue utilizing a laterally directed needle to increase injectate (fluid) retention in the heart tissue. The device may comprise a catheter having a shaft wherein the distal end of the shaft includes a primary penetrating member and a secondary penetrating member. The secondary penetrating member includes an injection lumen in fluid communication with a pressurized fluid source. The primary penetrating member penetrates the heart tissue at the injection site in a first direction, and the secondary penetrating member penetrates the heart tissue in a second direction different from the first direction such that fluid leakage from the injection site is reduced and the volume of treated tissue is increased.
摘要翻译：一种用于使用横向定向的针将流体输送和注入心脏组织以增加心脏组织中的注射（流体）保留的装置和方法。该装置可以包括具有轴的导管，其中轴的远端包括主要穿透构件和次要穿透构件。次级穿透构件包括与加压流体源流体连通的注射腔。主要穿透构件在第一方向上在注射部位处穿透心脏组织，并且次级穿透构件沿与第一方向不同的第二方向穿透心脏组织，使得来自注射部位的流体泄漏减少，并且经处理的体积组织增加。

53. 发明申请

WO00066199A1 APPARATUS FOR INJECTING FLUIDS INTO THE WALLS OF BLOOD VESSELS, BODY CAVITIES, AND THE LIKE 审中-公开
标题翻译：将流体注入血液容器，身体穴位和类似物的装置
公开(公告)号：WO00066199A1
公开(公告)日：2000-11-09
申请号：PCT/US2000/011291
申请日：2000-04-25
IPC分类号： A61M31/00 , A61B17/22 , A61B17/34 , A61F2/958 , A61M25/00 , A61M5/00
CPC分类号： A61B17/22 , A61B17/3478 , A61B2017/22077 , A61B2017/22082 , A61M25/0071 , A61M25/1002 , A61M2025/0086 , A61M2025/0087 , A61M2025/0096 , A61M2025/018 , A61M2025/1086
摘要： Apparatus (10) for injecting fluids into the walls of blood vessels, body cavities, and the like, includes a plurality of laterally flexible needles (18) disposed in a catheter for exit either out the distal end of the catheter or the catheter or through corresponding side openings on the catheter. In the latter case, the terminal ends of the needles would be curved laterally, with each terminal end being positioned in a respective side opening so that when the needles were moved forwardly in the catheter, the terminal ends of the needles would move laterally out the respective openings to pierce a vessel or cavity wall (14) adjacent to which the catheter was positioned. Hilts (22) positioned near the terminal ends of the needles serve to control the depth of penetration of the needles.
摘要翻译：用于将流体注射到血管，体腔等的壁中的装置（10）包括设置在导管中的多个横向柔性针（18），用于从导管或导管的远端出来或通过导管上相应的侧面开口。在后一种情况下，针的终端将侧向弯曲，每个终端位于相应的侧开口中，使得当针在导管中向前移动时，针的终端将横向移出相应的开口以刺穿邻近导管定位的容器或空腔壁（14）。位于针的末端附近的小丘（22）用于控制针的穿透深度。

54. 发明申请

WO00009195A1 PERCUTANEOUS IN-SITU CORONARY BYPASS METHOD AND APPARATUS 审中-公开
公开(公告)号：WO00009195A1
公开(公告)日：2000-02-24
申请号：PCT/US1999/017785
申请日：1999-08-04
IPC分类号： A61B1/313 , A61B17/00 , A61B17/064 , A61B17/11 , A61B17/12 , A61B17/22 , A61B17/30 , A61B17/34 , A61B18/00 , A61B18/14 , A61B18/24 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/90 , A61M25/00 , A61M29/00
CPC分类号： A61B17/11 , A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0057 , A61B17/0643 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0004 , A61M2025/0076 , A61M2025/009 , A61M2025/0096 , A61M2025/018 , A61M2025/1052 , A61M2210/125
摘要： Methods, and devices for percutaneous, in situ coronary bypass wherein a tissue puncturing catheter (26) is used to form blood flow paths between an artery, and an adjacent vein such that arterial blood will flow through a segment of the adjacent vein, thereby bypassing a lesion in the artery. The tissue puncturing catheter (26) comprises a flexible catheter having a tissue puncturing apparatus such as a sharp tipped member, an electro-surgical apparatus or a laser beam passable therefrom to create the desired blood flow paths between the artery, and vein. Stent (54) is provided for facilitating blood flow through the blood flow paths, and the segment of the vein used as the bypass conduit. One such stent (54) is specially constructed to carry arterial blood in one direction through the vein segment while allowing venous blood to continue to flow in the opposite direction through that venous segment.
摘要翻译：用于经皮的原位冠状动脉旁路的方法和装置，其中组织穿刺导管（26）用于在动脉和相邻静脉之间形成血流路径，使得动脉血液将流过相邻静脉的一段，从而绕过动脉中的病变。组织穿刺导管（26）包括柔性导管，其具有诸如尖锐部件的组织穿刺装置，电外科手术装置或可从其穿过的激光束，以在动脉和静脉之间产生所需的血流路径。提供支架（54），用于促进血流通过血流路径，静脉段用作旁路导管。一个这样的支架（54）被特别构造成通过静脉段沿一个方向携带动脉血，同时允许静脉血继续沿相反方向流过该静脉段。

55. 发明申请

WO9949910A3 TRANSVASCULAR CATHETERS HAVING IMAGING TRANSDUCERS 审中-公开
标题翻译：具有成像传感器的透射导管
公开(公告)号：WO9949910A3
公开(公告)日：2000-02-17
申请号：PCT/US9907112
申请日：1999-03-31
申请人： TRANSVASCULAR INC
发明人： FLAHERTY J CHRISTOPHER , WHITT JASON B , CHANG JOHN Y , THOLFSEN DAVID R , EVARD PHILLIP C
IPC分类号： A61B8/12 , A61B17/00 , A61B17/11 , A61B17/22 , A61B17/32 , A61B17/34 , A61B19/00 , A61M25/00 , A61M25/01 , A61B8/00 , A61B8/14
CPC分类号： A61M25/0108 , A61B17/22 , A61B17/3207 , A61B2017/00252 , A61B2017/00455 , A61B2017/22077 , A61B2090/3784 , A61B2090/3925
摘要： A catheter device (11) that is useable to penetrate from a blood vessel in which the catheter device (11) is positioned to a target location, comprises a flexible catheter advanced into the blood vessel, a tissue penetrator (85) which is useable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter includes an imaging transducer (81) fixedly mounted on or within the catheter body (13) to provide an imaging signal from which an image of the target location can be obtained. The catheter device (11) may include an imaged marker (101) on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator (85) exits from the catheter (11). Alternatively, or in addition thereto, the imaging transducer (81) may comprise a plurality of imaging elements.
摘要翻译：可用于从其中导管装置（11）定位到目标位置的血管穿透的导管装置（11）包括进入血管的柔性导管，组织穿透器（85），其可用于当正确瞄准时，从血管穿透到目标位置。此外，所述导管包括固定地安装在导管主体（13）上或导管主体（13）内的成像传感器（81），以提供可从其获得目标位置的图像的成像信号。导管装置（11）可以包括在导管上的成像标记（101），以形成可从成像信号获得的图像上的穿透器路径指示，其指示当组织穿透器（85）时组织穿透器将遵循的路径，从导管（11）出来。或者或除此之外，成像换能器（81）可以包括多个成像元件。

56. 发明申请

WO99044524A2 EXPANDABLE PMR DEVICE AND METHOD 审中-公开
标题翻译： DEVICE心肌血运重建经皮DEPLOYABLE和方法
公开(公告)号：WO99044524A2
公开(公告)日：1999-09-10
申请号：PCT/US1999/004987
申请日：1999-03-05
IPC分类号： A61B17/221 , A61B17/00 , A61B17/22 , A61B17/32 , A61B18/14 , A61B17/39
CPC分类号： A61B18/1492 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B18/1477 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft. Another embodiment includes an elongate shaft having a proximal end and a distal end, and a conductor extending therethrough. An insulator disposed around the conductor. At least one conductive loop disposed at the distal end of the shaft. The conductive loop having an electrode disposed at its distal end.
摘要翻译：本发明涉及一种血管内装置和用于同时地形成多个孔在一个心脏腔室的壁经皮心肌血管重建术（PMR）相应的方法。这样的装置包括由沿着其整个长度携带切割探针的柔性臂形成的篮。篮筐的臂在弯曲位置向外保持偏置，以便当它们未被压缩时占据拱形的向外弯曲的形状。该装置包括内轴，该内轴向远端固定到篮的近端部分并可滑动地设置在外轴中。内轴和折叠推车可以缩回到外轴，它们可以被引入血管内进入左心室并使其向远侧前进，迫使篮采取弯曲的形状。通过燃烧空穴在心室的壁并进入心肌应用于实际切割探针的高频电流。在一个实施例中，该装置包括高压流体喷射切割装置。在第二实施例中，该装置使用篮子作为定位可定向切割探针的锚点。在第三个实施方案中，该装置包括向外张开的多个弯曲电极的形成的刷子，其可以接触到心脏腔室的壁接触，一旦它们被引起向远侧移动到从外棒压缩它们。在第四实施例中，该装置包括具有近端和远端的细长轴以及延伸穿过细长轴的导体。驱动器周围放置绝缘体。至少一个导电环被放置在该杆的远端，所述具有在其远端的电极的导电环。

57. 发明申请

WO99025419A1 RECANALIZATION APPARATUS AND DEVICES FOR USE THEREIN AND METHOD 审中-公开
标题翻译：再现装置及其使用的装置和方法
公开(公告)号：WO99025419A1
公开(公告)日：1999-05-27
申请号：PCT/US1998/024199
申请日：1998-11-13
IPC分类号： A61B17/32 , A61B17/00 , A61B17/22 , A61B18/00 , A61F2/82 , A61M25/00 , A61M25/01 , A61M25/08 , A61M29/00
CPC分类号： A61B17/3207 , A61B2017/003 , A61B2017/22077 , A61M25/0084 , A61M29/00 , A61M2025/0089
摘要： The present invention is a recanalization apparatus (11) for crossing a stenosis forming a total occlusion in a lumen in a vessel formed by a vessel wall. The stenosis has a fibrous cap comprising a guiding sheath comprised of a flexible elongate tubular member having proximal and distal extremities. A lumen extends from the proximal extremity to the distal extremity. A hemostasis valve (46) is mounted on the proximal extremity of the flexible elongate tubular member (16). A needle cannula is slidable mounted in the lumen of the guiding sheath, and has proximal distal extremities (58), and has a lumen extending from the proximal extremity to the distal extremity. A sharpened tip (71) is mounted on the distal extremity. The needle cannula has a length so that its proximal extremity extends beyond the proximal extremity of the guiding sheath when the sharpened tip is deployed beyond the distal extremity of the guiding sheath.
摘要翻译：本发明是一种再通设备（11），用于交叉形成由血管壁形成的容器中的内腔中的完全闭塞的狭窄。狭窄具有纤维帽，其包括由具有近端和远端的柔性细长管状构件组成的引导护套。内腔从近端延伸到远端。止血阀（46）安装在柔性细长管状构件（16）的近端上。针插管可滑动地安装在引导护套的内腔中，并且具有近端远端（58），并且具有从近端延伸到远端的内腔。锋利尖端（71）安装在远端上。针插管具有一定的长度，使得当锋利的尖端展开超过引导护套的远端时，其近端延伸超过引导护套的近端。

58. 发明申请

WO98049943A2 BIOPSY DEVICE 审中-公开
标题翻译：活检装置
公开(公告)号：WO98049943A2
公开(公告)日：1998-11-12
申请号：PCT/IB1998/000942
申请日：1998-05-07
IPC分类号： A61B10/02 , A61B1/00 , A61B1/018 , A61B10/00 , A61B10/04 , A61B17/22 , A61B17/34 , A61B90/00
CPC分类号： A61B10/04 , A61B1/018 , A61B10/0045 , A61B17/3403 , A61B2010/0208 , A61B2010/045 , A61B2017/22072 , A61B2017/22077 , A61B2090/062
摘要： The invention relates to a device for endoscopic fine needle biopsy, in which control of the needle (2) is automatized by using a prestressed needle. On release of the spring (8), the needle shoots forward in the direction of the tissue, overcoming frictional force as a result of high acceleration. This reduces the danger of breaking the needle.
摘要翻译：本发明涉及一种用于内窥镜细针穿刺活检的设备，其中，由预加载的针自动所述针（2）的操作，并且在织物的方向的弹簧（8）的释放期间克服了摩擦力向前快速针由于高加速度，从而降低风险针的扭结的降低。

59. 发明申请

WO1997027898A1 METHODS AND APPARATUS FOR CONNECTING OPENINGS FORMED IN ADJACENT BLOOD VESSELS OR OTHER ANATOMICAL STRUCTURES 审中-公开
标题翻译：用于连接相邻血管或其他解剖结构中形成的开口的方法和装置
公开(公告)号：WO1997027898A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001468
申请日：1997-01-31
申请人： TRANSVASCULAR, INC. , EVARD, Philip, C. , FLAHERTY, J., C. , GARIBOTTO, John, T. , MACAULAY, Patrick, E. , MACHOLD, Timothy, R. , MAKOWER, Joshua , WHITT, Jason, B. , ROTH, Alex, T.
发明人： TRANSVASCULAR, INC.
IPC分类号： A61M29/00
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61B2017/1139 , A61B2017/22038 , A61B2017/22077 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2/958 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61F2230/001 , A61M2025/0076 , A61M2025/0096 , A61M2025/1052
摘要： This invention is methods and apparatus for connecting two anatomical passageways, such as blood vessels, in side-to-side fashion. Openings are formed in the sidewalls of the passageways, and a connector apparatus (10) of the present invention is implanted within such openings, and extends between the passageways or blood vessels (BV1, BV2) so as to connect the passageways or blood vessels (BV1, BV2) such that the openings are held in direct alignment with one another, thereby allowing body fluids to pass from one passageway into the other.
摘要翻译：本发明是用于连接诸如血管的两个解剖通道的方法和装置。开口形成在通道的侧壁中，并且本发明的连接器装置（10）植入在这些开口内，并且在通道或血管（BV1，BV2）之间延伸，以便连接通道或血管 BV1，BV2），使得开口保持彼此直接对准，从而允许体液从一个通道进入另一个通道。

60. 发明申请

WO1997027893A1 METHODS AND APPARATUS FOR BLOCKING FLOW THROUGH BLOOD VESSELS 审中-公开
标题翻译：通过血管阻塞流动的方法和装置
公开(公告)号：WO1997027893A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001463
申请日：1997-01-31
申请人： TRANSVASCULAR, INC. , EVARD, Philip, C. , FLAHERTY, J., C. , GARIBOTTO, John, T. , MACAULAY, Patrick, E. , MACHOLD, Timothy, R. , MAKOWER, Joshua , WHITT, Jason, B. , JENSEN, Marc
发明人： TRANSVASCULAR, INC.
IPC分类号： A61M19/00
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0076 , A61M2025/0096 , A61M2025/1052
摘要： This invention is methods and apparatus for occluding blood flow within a blood vessel (22). In a first series of embodiments, the present invention comprises a plurality of embolic devices (16) deployable through the lumen (12) of a conventional catheter (10) such that when deployed, said embolic devices (16) remain resident and occlude blood flow at a specific site within the lumen of the blood vessel (22). Such embolic devices (16) comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso-occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure. In a third series of embodiments, the present invention comprises the combination of an embolization facilitator coupled with the application of an energy force to form an intraluminal closure at a specified site within a vessel.
摘要翻译：本发明是用于阻塞血管内血流的方法和装置（22）。在第一系列实施例中，本发明包括可以通过常规导管（10）的内腔（12）展开的多个栓塞装置（16），使得当展开时，所述栓塞装置（16）保持驻留并阻塞血流在血管（22）的内腔内的特定部位。这种栓塞装置（16）包括机械栓塞装置，其将嵌入或挤压在容器的内腔或封闭给定部位的血流的化学血管闭塞剂。本发明的第二个实施方案包括使用能够吸收容器内腔的设备的真空/烧灼装置，以将容器保持在闭合状态，在那里然后施加足够量的能量以使组织折叠关于器件变性成闭合。在第三系列实施方案中，本发明包括栓塞促进剂与施加能量力的组合，以在血管内的指定部位形成腔内闭合。

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