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1. 发明申请

WO2016066180A8 TRANSMYOCARDIAL INSERTION UNIT AND ITS USE 审中-公开
标题翻译：心肌梗塞单位及其使用
公开(公告)号：WO2016066180A8
公开(公告)日：2017-07-13
申请号：PCT/EP2014002915
申请日：2014-10-30
申请人： PETER OSYPKA STIFTUNG
IPC分类号： A61B17/34 , A61M1/10 , A61N1/05
CPC分类号： A61B17/3423 , A61B2017/00252 , A61B2017/00867 , A61B2017/3425 , A61B2017/3441 , A61B2017/3488 , A61F2/2427 , A61F2/243 , A61F2/2487 , A61F2/2493 , A61F2/82 , A61M1/1008 , A61M1/101 , A61M1/122 , A61M1/125 , A61N1/056 , A61N1/0587
摘要： The invention relates to an insertion device that for the first time allows gaining access to the left ventricle of the heart, via the tissue forming the wall of the right ventricle and via the ventricular septum. The insertion unit comprises a tubular shaft (5) with a lumen (8) extending there through, said shaft comprising distal, proximal and central sections, whereby the distal and proximal sections are disc-shaped extended thus forming each a double disc (1), (2) resp. (3) (4) and whereby the central section (50) links the distally placed double disc (1), (2) with the proximally placed double disc (3), (4), and whereby pressure valve (6) resp. (7) are fixed inside the shaft preferably on its distal and proximal end. The invention also relates to devices using said insertion unit.
摘要翻译：本发明涉及一种插入装置，其首次允许经由形成右心室壁的组织和经由心室隔膜进入心脏的左心室。插入单元包括具有延伸穿过其中的内腔（8）的管状轴（5），所述轴包括远侧部分，近侧部分和中央部分，由此远侧部分和近侧部分是盘形延伸的，因此形成每个双盘（1），（2）（3），（4）并且由此中央部分（50）将远侧放置的双层盘（1），（2）与近侧放置的双层盘（3），（4）连接，并且由此压力阀（6）（7）优选在其远端和近端固定在轴内。本发明还涉及使用所述插入单元的设备。

2. 发明申请

WO2016066180A1 TRANSMYOCARDIAL INSERTION UNIT AND ITS USE 审中-公开
标题翻译：转移插入单元及其使用
公开(公告)号：WO2016066180A1
公开(公告)日：2016-05-06
申请号：PCT/EP2014/002915
申请日：2014-10-30
申请人： PETER OSYPKA STIFTUNG
发明人： PETER OSYPKA STIFTUNG
IPC分类号： A61B17/34 , A61M1/10 , A61N1/05
CPC分类号： A61B17/3423 , A61B2017/00252 , A61B2017/00867 , A61B2017/3425 , A61B2017/3441 , A61B2017/3488 , A61F2/2427 , A61F2/243 , A61F2/2487 , A61F2/2493 , A61F2/82 , A61M1/1008 , A61M1/101 , A61M1/122 , A61M1/125 , A61N1/056 , A61N1/0587
摘要： The invention relates to an insertion device that for the first time allows gaining access to the left ventricle of the heart, via the tissue forming the wall of the right ventricle and via the ventricular septum. The insertion unit comprises a tubular shaft (5) with a lumen (8) extending there through, said shaft comprising distal, proximal and central sections, whereby the distal and proximal sections are disc-shaped extended thus forming each a double disc (1), (2) resp. (3) (4) and whereby the central section (50) links the distally placed double disc (1), (2) with the proximally placed double disc (3), (4), and whereby pressure valve (6) resp. (7) are fixed inside the shaft preferably on its distal and proximal end. The invention also relates to devices using said insertion unit.
摘要翻译：本发明涉及一种插入装置，其首次允许通过形成右心室的壁并通过心室隔膜的组织进入心脏的左心室。所述插入单元包括管状轴（5），所述管状轴（5）具有在其中延伸的内腔（8），所述轴包括远端，近端和中心区段，由此所述远端和近端区段是圆盘状延伸的，从而形成每个双盘（1），（2）（3）（4），并且由此中心部分（50）将远端放置的双盘（1），（2）与近端放置的双盘（3），（4）连接，并且由此将压力阀（6）（7）优选地在其远端和近端固定在轴内。本发明还涉及使用所述插入单元的装置。

3. 发明申请

WO2013096965A1 METHODS AND DEVICES FOR INTRA-ATRIAL DEVICES HAVING SELECTABLE FLOW RATES 审中-公开
标题翻译：具有可选择流量速率的内部装置的方法和装置
公开(公告)号：WO2013096965A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/071588
申请日：2012-12-24
申请人： DC DEVICES, INC.
发明人： MCNAMARA, Edward , SUTHERLAND, Michael, W. , FINCH, Matthew, J. , FORCUCCI, Stephen, J. , MITZEL, John
IPC分类号： A61F2/06 , A61F2/02 , A61M29/00 , A61L27/58
CPC分类号： A61M27/002 , A61B2017/00247 , A61B2017/00575 , A61B2017/00584 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/2493
摘要： Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. The devices are adapted to permit fluid flow across the membrane in which the device is implanted at first rate, and at a second rate, wherein a difference between the first rate and the second rate is not solely dependent upon variations in blood pressure differential across the membrane due to the heart's pumping cycle. Devices may include an adjustable hydraulic diameter and/or a removable and/or replaceable shunt portion. Devices may include absorbable materials, the absorption of which directly or indirectly causes alterations of the fluid flow capacities the devices.
摘要翻译：公开了通过使哺乳动物的心脏的左心房和右心房升高的血压正常化来治疗心脏病的装置和方法。这些装置适于允许流体以第一速率流过穿过装置的膜的流体，并且以第二速率流动，其中第一速率和第二速率之间的差异不仅仅取决于跨越的血压差的变化由于心脏的泵送周期，膜。设备可以包括可调节的液压直径和/或可拆卸和/或可更换的分路部分。设备可以包括可吸收材料，其吸收直接或间接地导致设备的流体流动能力的改变。

4. 发明申请

WO2012071075A1 DEVICES AND METHODS FOR CORONARY SINUS PRESSURE RELIEF 审中-公开
标题翻译：冠状动脉压力消除的装置和方法
公开(公告)号：WO2012071075A1
公开(公告)日：2012-05-31
申请号：PCT/US2011/041841
申请日：2011-06-24
申请人： DC DEVICES, INC. , MCNAMARA, Edward
发明人： MCNAMARA, Edward
IPC分类号： A61F2/82 , A61L27/04 , A61F2/24 , A61M25/10
CPC分类号： A61F2/82 , A61B17/0057 , A61B17/221 , A61B18/1492 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/22035 , A61B2017/2215 , A61B2018/00023 , A61B2018/00351 , A61B2018/144 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/2493 , A61F2/91 , A61F2002/061 , A61F2002/821 , A61F2220/0008 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/0017 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0098 , A61L31/022 , A61M29/02
摘要： A method and devices for relieving pressure in the left atrium of a patient's heart is disclosed. The method includes using an ablative catheter in a minimally invasive procedure to prepare an opening from the coronary sinus into a left atrium of the patient's heart. Once the opening is prepared, the opening may be enlarged by a technique such as expanding a balloon within the opening. A stent is then placed within the coronary sinus of the patient, with a transverse portion expanding within the opening, allowing blood to flow from the left atrium to the coronary sinus and then to the right atrium. Pressure within the left atrium is thus relieved.
摘要翻译：公开了一种用于缓解患者心脏左心房压力的方法和装置。该方法包括在微创程序中使用消融导管以准备从冠状窦到患者心脏的左心房的开口。一旦准备了开口，可以通过诸如在开口内膨胀气球的技术来扩大开口。然后将支架放置在患者的冠状窦内，横向部分在开口内扩张，允许血液从左心房流动到冠状窦，然后到达右心房。因此左心房内的压力得到缓解。

5. 发明申请

WO2009073521A2 BILIARY SHUNTS, DELIVERY SYSTEMS, METHODS OF USING THE SAME, AND KITS THEREFOR 审中-公开
标题翻译：胆道分娩器，输送系统，使用它们的方法以及为此的试剂盒
公开(公告)号：WO2009073521A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/084888
申请日：2008-11-26
申请人： TREUS MEDICAL, INC. , VAN DAM, Jacques , MILROY, J., Craig , OHLINE, R., Matthew
发明人： VAN DAM, Jacques , MILROY, J., Craig , OHLINE, R., Matthew
IPC分类号： A61M25/088 , A61M25/09 , A61B17/34 , A61B17/94
CPC分类号： A61B17/1114 , A61B17/11 , A61B2017/00278 , A61B2017/1139 , A61F2/04 , A61F2/064 , A61F2/24 , A61F2/2493 , A61F2002/041 , A61F2220/0008 , A61F2250/0039 , A61M25/1002 , A61M27/008 , A61M29/02 , A61M2025/0233 , A61M2025/1072
摘要： The application discloses devices, systems, kits and methods for treating biliary disease. Device comprise, for example, a component configured for deployment between a gallbladder and location within a gastrointestinal tract of a patient which has a proximal end and a distal end with a lumen extending therethrough. A method of deploying the device can be achieved by, for example, creating a duct or fistula between a gallbladder lumen and a portion of a gastrointestinal tract; and providing for drainage from the gallbladder to the gastrointestinal tract.
摘要翻译：本申请公开了用于治疗胆道疾病的装置，系统，试剂盒和方法。装置包括例如构造成用于在胆囊和患者的胃肠道内的位置之间展开的部件，该部件具有近端和远端，腔室延伸贯穿其中。部署该装置的方法可以通过例如在胆囊腔和胃肠道的一部分之间产生导管或瘘来实现，并提供从胆囊到胃肠道的引流。

6. 发明申请

WO2009026530A1 CONDUIT PROTECTOR 审中-公开
标题翻译：电源保护器
公开(公告)号：WO2009026530A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/074044
申请日：2008-08-22
申请人： CARDIOUS, INC. , POKORNEY, James, L. , SCHANKERELI, Kemal
发明人： POKORNEY, James, L. , SCHANKERELI, Kemal
IPC分类号： A61M5/32
CPC分类号： A61B17/3421 , A61B17/3431 , A61B17/3468 , A61F2/2493 , Y10T428/13
摘要： A conduit protector for temporarily minimizing the surface friction on an outside surface of an implant includes a curvilinear sheet formed into a generally cylindrical shape having a first axial edge and a second axial edge, a connecting member coupling the first axial edge of the curvilinear sheet to the second axial edge of the curvilinear sheet, and a release member structured for separating the first axial edge of the curvilinear sheet from the second axial edge of the curvilinear sheet. An inside surface of the curvilinear sheet may have an inner diameter approximately equal to an outer diameter of the outside surface of the implant.
摘要翻译：用于临时最小化植入物外表面上的表面摩擦的导管保护器包括形成为具有第一轴向边缘和第二轴向边缘的大致圆柱形形状的曲线片，将曲线片的第一轴向边缘连接到曲线片的第二轴向边缘以及用于将曲线片的第一轴向边缘与曲线片的第二轴向边缘分离的释放构件。曲线片的内表面可以具有大致等于植入物的外表面的外径的内径。

7. 发明申请

WO2007131553A1 A CONTROLLABLE DEVICE, A KIT AND A METHOD FOR TREATMENT OF DISORDERS IN THE HEART RHYTHM REGULATION SYSTEM 审中-公开
标题翻译：一种可控制的设备，一种治疗心脏调节系统疾病的方法
公开(公告)号：WO2007131553A1
公开(公告)日：2007-11-22
申请号：PCT/EP2006/062403
申请日：2006-05-17
申请人： SYNTACH AG , SOLEM, Jan Otto , NIELSEN, Stevan , JOERGENSEN, Ib , SEIBOLD, Gerd , QUINT, Bodo
发明人： SOLEM, Jan Otto , NIELSEN, Stevan , JOERGENSEN, Ib , SEIBOLD, Gerd , QUINT, Bodo
IPC分类号： A61B17/22 , A61F2/02 , A61B17/00 , A61F2/06 , A61B19/00
CPC分类号： A61B17/320725 , A61B2017/00247 , A61B2017/00256 , A61B2017/2945 , A61B2017/32096 , A61B2018/00392 , A61B2090/037 , A61F2/2493 , A61F2/82
摘要： A tissue cutting device is disclosed, which is structured and arranged to be inserted through the vascular system into a body vessel adjacent to the heart and/or into the heart, and to be subsequently subjected to a change of shape in order to penetrate into the heart tissue. The device comprises at least one connection element that is arranged such that a connection formed from said connection element between a first and second part of said tissue cutting device is configured to break when said connection element is subjected to a specific external influence. The tissue cutting device may thus be used for controllably treating disorders to the heart rhythm regulation system. A kit of devices provides a plurality of devices for creating a lesion pattern for treating such disorders.
摘要翻译：公开了一种组织切割装置，其被构造和布置成通过血管系统插入邻近心脏和/或进入心脏的身体容器中，并且随后经受形状变化以便渗透到心脏组织该装置包括至少一个连接元件，其被布置成使得在所述组织切割装置的第一和第二部分之间从所述连接元件形成的连接被配置为当所述连接元件经受特定的外部影响时断开。因此，组织切割装置可用于可控地治疗心律调节系统的障碍。一套装置提供多个用于创建用于治疗这种疾病的损伤模式的装置。

8. 发明申请

WO2005074367A2 DEVICE AND METHOD FOR CONTROLLING IN-VIVO PRESSURE 审中-公开
标题翻译：用于控制体内压力的装置和方法
公开(公告)号：WO2005074367A2
公开(公告)日：2005-08-18
申请号：PCT/IL2005000131
申请日：2005-02-03
申请人： ATRIA MEDICAL INC , ROTTENBERG DAN , BRAUN ORI , ABA ZAKAY AVRAHAM , SHMULEWITZ ASCHER , ROZY YORAM , KEREN GAD
发明人： ROTTENBERG DAN , BRAUN ORI , ABA ZAKAY AVRAHAM , SHMULEWITZ ASCHER , ROZY YORAM , KEREN GAD
IPC分类号： A61B5/0215 , A61B17/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2442 , A61B5/0215 , A61B17/00234 , A61B2017/00243 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61F2/24 , A61F2/2493 , A61M27/002
摘要： A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
摘要翻译：提供了一种差压调节装置，用于控制身体内的体内压力，特别是在心脏中。该装置可以包括位于身体中的两个或更多流明之间的分流器，以使得流体能够在腔之间流动，并且可调节的流量调节机构被配置为选择性地覆盖分流器的开口，以调节流体的流动分流相对于体腔之间的压力差。在一些实施例中，可以提供联接到可调节流量调节机构的控制机构，以远程激活可调节的流量调节机构。

9. 发明申请

WO0230325A8 FLEXIBLE TRANSMYOCARDIAL IMPLANT 审中-公开
标题翻译：柔性转移植入物
公开(公告)号：WO0230325A8
公开(公告)日：2003-11-13
申请号：PCT/US0131614
申请日：2001-10-10
申请人： HEARTSTENT CORP
发明人： VANNEY GUY P , MOWRY DAVID H
IPC分类号： A61F2/02 , A61F2/82 , A61F2/06
CPC分类号： A61F2/82 , A61F2/2493
摘要： A transmiocardial implant includes a hollow rigid conduit adapted to be inserted into and retained within the heart wall of a heart chamber. The rigid conduit is sufficiently rigid to withstand collapsing in response to contraction forces of the heart wall. A synthetic flexible conduit has a first end secured to the conduit. The flexible conduit is blood compatible. A second end of the flexible conduit is secured to the coronary vessel. The rigid conduit and the flexible conduit define a blood flow path from the heart chamber to the coronary vessel. The flexible conduit is bonded to and wrapped around the rigid conduit for the blood flow path to be defined by a uninterrupted surface of the flexible conduit.
摘要翻译：跨心脏植入物包括适于插入并保持在心室的心壁内的中空刚性导管。刚性导管足够刚性以抵抗心壁收缩力的破坏。合成柔性导管具有固定到导管的第一端。柔性导管与血液兼容。柔性导管的第二端固定到冠状血管。刚性导管和柔性导管限定了从心室到冠状血管的血流路径。柔性导管与柔性导管接合并缠绕在血管路径上，由柔性导管的不间断表面限定。

10. 发明申请

WO0189416A3 DEVICES FOR IN SITU FORMATION OF VASCULAR STRUCTURES 审中-公开
标题翻译：用于形成血管结构的装置
公开(公告)号：WO0189416A3
公开(公告)日：2002-07-04
申请号：PCT/IB0101134
申请日：2001-05-22
申请人： VENTRIGRAFT GMBH
发明人： FOLEY MARK J
IPC分类号： A61F2/02 , A61F2/86 , A61F2/06
CPC分类号： A61F2/86 , A61F2/07 , A61F2/2493 , A61F2220/0008 , A61F2220/0016
摘要： Methods for forming in situ a vascular graft having a lumen adapted to place at least two blood vessels in fluid communication. A mandrel sized and configured to substantially define a lumen of a vascular graft is placed adjacent tissue located in a patient's body, and is substantially maintained in a desired position to form a vascular graft at the desired position. The vascular graft is then used to place at least two blood vessels in fluid communication with each other, for example, it is used as coronary artery bypass graft vessel to deliver blood from the aorta to the distal side of an occluded or partially occluded coronary artery. The invention also provides a system for forming a vascular structure having a lumen. The system includes a mandrel having an exterior surface sized and configured to form a vascular structure as a result of tissue healing around the surface of the mandrel, and a mechanism by which the mandrel is positioned in a desired location relative to tissue so that a vascular structure may form at the position. The mandrel is configured to allow the vascular structure to be used as a graft without harvesting or removing the vascular structure after its formation, for example; the mandrel may be removable or bioabsorbable.
摘要翻译：用于在原位形成具有适于将至少两个血管置于流体连通的腔的血管移植物的方法。将尺寸和构造为基本上限定血管移植物的内腔的心轴放置在位于患者体内的组织附近，并且基本上保持在期望位置以在期望位置形成血管移植物。然后使用血管移植物将至少两个血管相互流体连通，例如，其用作冠状动脉旁路移植血管以将血液从主动脉输送到闭塞或部分闭塞的冠状动脉的远侧。本发明还提供了一种用于形成具有内腔的血管结构的系统。该系统包括具有外表面的心轴，该外表面由于围绕心轴表面的组织愈合而形成血管结构，并且心轴相对于组织位于所需位置的机构，使得血管结构可能在该位置形成。心轴被配置为允许血管结构用作移植物，而不是在其形成之后收获或除去血管结构; 心轴可以是可移除的或生物可吸收的。

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