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41. 发明申请

WO2008030963A1 CONTROLLED RELEASE SYSTEMS AND METHODS FOR OSTEAL GROWTH 审中-公开
标题翻译：控制释放系统和方法用于骨质生长
公开(公告)号：WO2008030963A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/077762
申请日：2007-09-06
申请人： WARSAW ORTHOPEDIC, INC. , TRIEU, Hai, H.
发明人： TRIEU, Hai, H.
IPC分类号： A61M31/00
CPC分类号： A61B17/58 , A61B17/7061 , A61B17/7097 , A61B2017/00557 , A61B2017/0256 , A61F2002/2817 , A61F2002/30677 , A61F2002/3068 , A61F2002/444 , A61F2002/4666 , A61F2250/0067 , A61F2250/0068 , A61K9/0024 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/604 , A61M5/14276 , A61M5/16827 , A61M31/002 , A61M2005/14513 , A61M2210/02 , A61M2210/1003 , A61N1/3627 , A61N1/368 , A61N1/3682
摘要： A device includes a first reservoir configured to include a degradation agent, a second reservoir configured to include an osteogenerative agent, and a controller configured to selectively initiate access to the first reservoir or the second reservoir.
摘要翻译：装置包括被配置为包括降解剂的第一储存器，被配置为包括骨代谢剂的第二储存器和被配置为选择性地启动进入第一储存器或第二储存器的控制器。

42. 发明申请

WO2008011612A2 BIOABSORBABLE POLYMERIC MEDICAL DEVICE 审中-公开
标题翻译：生物可吸收聚合物医疗设备
公开(公告)号：WO2008011612A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/074050
申请日：2007-07-20
申请人： ORBUSNEICH MEDICAL, INC. , COTTONE, Robert, J. , YE, Shusheng , PAZIENZA, John
发明人： COTTONE, Robert, J. , YE, Shusheng , PAZIENZA, John
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/9155 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/91591 , A61F2210/0076 , A61F2230/0013 , A61F2230/0054 , A61F2250/001 , A61F2250/0068 , A61F2250/0071 , A61F2250/0098
摘要： In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
摘要翻译：在实施方案中，描述了由可结晶生物可吸收聚合物组合物或共混物制造的具有低免疫原性的心血管管状可锁定和可扩张生物可吸收支架。

43. 发明申请

WO2005086733A3 SURGICAL STENT HAVING MICRO-GEOMETRIC PATTERNED SURFACE 审中-公开
标题翻译：具有微量几何图形表面的外科手术
公开(公告)号：WO2005086733A3
公开(公告)日：2008-01-03
申请号：PCT/US2005007222
申请日：2005-03-03
申请人： BIOLOK INT INC
发明人： ALEXANDER HAROLD , RICCI JOHN L
IPC分类号： A61F2/06 , A61F2/00 , A61F2/90
CPC分类号： A61F2/915 , A61F2/0077 , A61F2/91 , A61F2002/0081 , A61F2002/91533 , A61F2002/9155 , A61F2250/0068
摘要： A surgical stent having thereon micro-geometric patterned surface and the method of use for inhibiting smooth muscle cell growth into stent lumen are disclosed. The surgical stent has a generally cylindrical stent frame configured to be implanted into a body lumen, and the stent frame has thereon a micro-geometric patterned surface with includes a multiplicity of microgrooves distributed in a pre-determined pattern. Each of the microgrooves has a width in a range of from about 4 to about 40 microns and a depth in a range of from about 4 to 40 microns. The surgical stent can further include drug wells, and the surgical stent can have a biocompatible chemical compound, such as thrombosis inhibitor or cell growth inhibitor, embedded in the microgrooves or drug wells.
摘要翻译：公开了一种其上具有微几何图案化表面的手术支架和用于抑制平滑肌细胞生长到支架内腔中的方法。手术支架具有被配置为植入体腔中的大致圆柱形的支架框架，并且支架框架上具有微型几何图案化表面，其包括以预定图案分布的多个微槽。每个微槽的宽度在约4至约40微米的范围内，深度在约4至40微米的范围内。手术支架还可以包括药物孔，并且手术支架可以具有嵌入在微槽或药物孔中的生物相容化学化合物，例如血栓形成抑制剂或细胞生长抑制剂。

44. 发明申请

WO2007118139A2 DRUG ELUTING STRUCTURALLY VARIABLE STENT 审中-公开
标题翻译：药物结构可变的手段
公开(公告)号：WO2007118139A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/066050
申请日：2007-04-05
申请人： VASCULAR CONCEPTS HOLDINGS LIMITED , JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61F2/90
CPC分类号： A61F2/86 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0008 , A61F2230/0017 , A61F2230/0021 , A61F2230/0023 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/45
摘要： The present invention provides a stent including a tubular body having a plurality of reservoirs disposed therein and a therapeutic agent located in the reservoirs or located in the reservoirs and on a surface portion of the tubular body, wherein the stent is free of polymeric material. The invention also provides a drug-eluting stent made from the process of providing a polymer- free stent body having a plurality of reservoirs disposed therein, diluting a therapeutic agent in a polymer- free solvent to form an agent-solvent mixture, coating the stent with the agent-solvent mixture, and allowing the solvent to dissipate from the stent thereby leaving the agent disposed on the stent.
摘要翻译：本发明提供了一种支架，其包括管状主体，其具有设置在其中的多个储存器，以及位于储存器中或位于储存器中以及管状体的表面部分上的治疗剂，其中支架不含聚合材料。本发明还提供了一种药物洗脱支架，其由提供无聚合物支架体的方法制成，该支架主体具有设置在其中的多个储液器，在不含聚合物的溶剂中稀释治疗剂以形成药剂 - 溶剂混合物，与试剂 - 溶剂混合物，并且允许溶剂从支架中消散，从而使放置在支架上的试剂留下。

45. 发明申请

WO2007111801A2 MEDICAL DEVICES HAVING NANOPOROUS COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：具有用于受控治疗药物递送的纳米涂层的医疗装置
公开(公告)号：WO2007111801A2
公开(公告)日：2007-10-04
申请号：PCT/US2007004704
申请日：2007-02-26
申请人： BOSTON SCIENT SCIMED INC , TENNEY BARRON , XU YIXIN , HELMUS MICHAEL N
发明人： TENNEY BARRON , XU YIXIN , HELMUS MICHAEL N
IPC分类号： A61F2/82
CPC分类号： A61F2/02 , A61F2/30767 , A61F2/82 , A61F2/91 , A61F2002/30677 , A61F2002/3068 , A61F2002/3084 , A61F2210/0076 , A61F2250/0068 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/375 , B82Y30/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to perform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含（a）一个或多个含有至少一种治疗剂的凹陷部，和（b）纳米多孔涂层，设置在含治疗剂的凹陷，其调节物质在含治疗剂的凹陷和装置的外部之间的运输。植入式或可插入装置被配置为执行超出仅药物输送的作用，例如在身体内提供机械和/或电功能以及其它功能。本发明的优点在于，可以提供医疗装置，其释放的量远远超过纳米多孔涂层内的空隙体积，同时提供延伸超过药物递送的功能。这种释放可以进一步接近或实现零级动力学药物释放曲线。

46. 发明申请

WO2007033152A3 COMPOSITION, SYSTEM AND METHOD FOR MODULATING RELEASE KINETICS IN IMPLANTABLE DRUG DELIVERY DEVICES BY MODIFYING DRUG SOLUBILITY 审中-公开
标题翻译：通过改变药物溶解度来调节可植入药物递送装置中的释放动力学的组合物，系统和方法
公开(公告)号：WO2007033152A3
公开(公告)日：2007-10-04
申请号：PCT/US2006035453
申请日：2006-09-12
申请人： CONOR MEDSYSTEMS INC , PARKER THEODORE L , DIAZ STEPHEN HUNTER , SHANLEY JOHN F , DANG DIANE MAI HUONG , NGUYEN THAI MINH
发明人： PARKER THEODORE L , DIAZ STEPHEN HUNTER , SHANLEY JOHN F , DANG DIANE MAI HUONG , NGUYEN THAI MINH
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0068 , A61K9/0024 , A61L31/022 , A61L2300/416 , A61L2300/63
摘要： An implantable drug delivery device loaded with a beneficial agent is provided, wherein the beneficial agent is in two different forms, a first form having a higher solubility and a second form having a lower solubility, and wherein the two different forms are present in a proportion which is selected to achieve a desired release rate.
摘要翻译：提供了一种装载有益剂的可植入药物递送装置，其中有益剂是两种不同形式，具有较高溶解度的第一形式和具有较低溶解度的第二种形式，并且其中两种不同形式以一定比例存在其被选择以实现期望的释放速率。

47. 发明申请

WO2007094934A1 RADIO FREQUENCY INDUCED DRUG ELUTION 审中-公开
标题翻译：无线电频率诱导药物
公开(公告)号：WO2007094934A1
公开(公告)日：2007-08-23
申请号：PCT/US2007/001903
申请日：2007-01-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BEHAN, Niall , MALONE, Anthony , FLANAGAN, Alden , O'BRIEN, Barry , MOTHERWELL, John , MCMORROW, David
发明人： BEHAN, Niall , MALONE, Anthony , FLANAGAN, Alden , O'BRIEN, Barry , MOTHERWELL, John , MCMORROW, David
IPC分类号： A61F2/88 , A61K9/00
CPC分类号： A61F2/88 , A61F2210/009 , A61F2250/0001 , A61F2250/0035 , A61F2250/0068 , A61L31/14 , A61L31/16 , A61L2300/608 , A61M31/002 , A61N2/002
摘要： A medical device including at least one reservoir, adapted to contain a material, such as a therapeutic agent, and sealed by a cover. The reservoir is openable, so as to release the material, for example, by (i) disintegration of the cover, (ii) movement of the cover to an open position, and/or (iii) a change of composition or properties of the cover allowing the material to pass therethrough. The power required to open the reservoir is provided by a current induced in a coil associated with the medical device by a change in magnetic flux in the area of the medical device.
摘要翻译：一种包括至少一个储存器的医疗装置，其适于容纳诸如治疗剂的材料，并被盖子密封。储存器是可打开的，以便释放材料，例如通过（i）盖子的分解，（ii）盖子移动到打开位置，和/或（iii）改变构件的组成或特性盖子允许材料通过。通过在医疗装置的区域中的磁通量的变化，通过在与医疗装置相关联的线圈中感应的电流来提供打开储存器所需的功率。

48. 发明申请

WO2007092833A2 DRUG DELIVERY STENT WITH EXTENDED IN VIVO DRUG RELEASE 审中-公开
标题翻译：药物递送手提袋在VIVO药物释放
公开(公告)号：WO2007092833A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/061666
申请日：2007-02-06
申请人： CONOR MEDSYSTEMS, INC. , PARKER, Theodore, L. , SHANLEY, John, F. , LITVACK, Frank
发明人： PARKER, Theodore, L. , SHANLEY, John, F. , LITVACK, Frank
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0068 , A61L2300/416 , A61L2300/602
摘要： A method for reducing the level of restenosis following a stent placement medical Intervention involves the continuous administration of a dose of an anti- restenotic agent , such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled and extended drug release profile for a period of at least 60 days in vivo. The in vivo release profile is determined by in vivo animai experiments involving implanting a series of stents in animals, explanting the stents from the animals at selected time points, and extracting remaining drug from the cxplanted stents.
摘要翻译：用于降低支架置入后再狭窄水平的方法医疗干预包括从支架到需要在受控和延长的药物释放曲线中治疗的血管组织连续施用一定剂量的抗再狭窄剂如紫杉醇在体内至少60天的时间。通过体内动物实验来确定体内释放曲线，包括在动物中植入一系列支架，在选定的时间点从动物中移除支架，以及从植入的支架中提取剩余的药物。

49. 发明申请

WO2007041593A3 ANTI-SCARRING DRUG COMBINATIONS AND USE THEREOF 审中-公开
标题翻译：抗惊厥药物组合及其使用
公开(公告)号：WO2007041593A3
公开(公告)日：2007-07-26
申请号：PCT/US2006038675
申请日：2006-10-03
申请人： COMBINATORX INC , ANGIOTECH INT AG , HUNTER WILLIAM L , TOLEIKIS PHILIP M , GRAVETT DAVID M , GRAU DANIEL S , BORISY ALEXIS , KEITH CURTIS T , AUSPITZ BENJAMIN A , NICHOLS M JAMES , JOST-PRICE EDWARD ROYDON , SERBEDZIJA GEORGE N
发明人： HUNTER WILLIAM L , TOLEIKIS PHILIP M , GRAVETT DAVID M , GRAU DANIEL S , BORISY ALEXIS , KEITH CURTIS T , AUSPITZ BENJAMIN A , NICHOLS M JAMES , JOST-PRICE EDWARD ROYDON , SERBEDZIJA GEORGE N
IPC分类号： A61F2/02 , A61F2/06
CPC分类号： A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K47/6957
摘要： The present invention provides devices or implants that comprise anti- scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fÊbrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
摘要翻译：本发明提供了包含抗瘢痕形成药物组合，方法或制造这样的装置或植入物的装置或植入物，以及在装置或植入物和围绕装置或植入物的组织之间抑制纤维化的方法。本发明还提供了包含抗结合药物组合的组合物及其在各种医学应用中的用途，包括预防手术粘连，治疗炎性关节炎，治疗瘢痕和瘢痕疙瘩，治疗血管疾病和预防软骨失利。

50. 发明申请

WO2007041593A2 ANTI-SCARRING DRUG COMBINATIONS AND USE THEREOF 审中-公开
标题翻译：抗瘢痕药物组合及其用途
公开(公告)号：WO2007041593A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/038675
申请日：2006-10-03
申请人： COMBINATORX, INCORPORATED , ANGIOTECH INTERNATIONAL AG , HUNTER, William, L. , TOLEIKIS, Philip, M. , GRAVETT, David, M. , GRAU, Daniel, S. , BORISY, Alexis , KEITH, Curtis, T. , AUSPITZ, Benjamin, A. , NICHOLS, M., James , JOST-PRICE, Edward, Roydon , SERBEDZIJA, George, N.
发明人： HUNTER, William, L. , TOLEIKIS, Philip, M. , GRAVETT, David, M. , GRAU, Daniel, S. , BORISY, Alexis , KEITH, Curtis, T. , AUSPITZ, Benjamin, A. , NICHOLS, M., James , JOST-PRICE, Edward, Roydon , SERBEDZIJA, George, N.
IPC分类号： A61F2/02
CPC分类号： A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K47/6957
摘要： The present invention provides devices or implants that comprise anti- scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fÊbrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
摘要翻译：本发明提供包含抗瘢痕形成药物组合的装置或植入物，方法或制造此类装置或植入物，以及抑制装置或植入物与装置或植入物周围的组织之间的纤维化的方法。本发明还提供了包含抗f＆Ecirc;糖尿病药物组合的组合物，以及它们在各种医学应用中的用途，包括防止手术粘连，治疗炎性关节炎，治疗瘢痕和瘢痕疙瘩，治疗血管疾病和预防软骨损失。

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