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1. 发明申请

WO2019089741A1 ESOPHAGEAL STENT INCLUDING A VALVE MEMBER 审中-公开
公开(公告)号：WO2019089741A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058431
申请日：2018-10-31
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： COYNE, Martin , FEENEY, Niall , BYRNE, James , HOLEHONNUR, Harshad , DOLAN, Jonathan
IPC分类号： A61F2/04 , A61F2/24
CPC分类号： A61F2/90 , A61F2/04 , A61F2/2412 , A61F2/2418 , A61F2002/044 , A61F2210/0076 , A61F2230/0008 , A61F2240/001 , A61F2250/0039 , A61F2250/0069 , B29D23/00
摘要： An example medical device is disclosed. An example medical device includes an expandable stent. The stent includes a tubular scaffold formed of one or more interwoven filament. The tubular scaffold includes an inner surface and a flexible valve extending radially inward from the inner surface of the scaffold. Further, the valve is configured to shift between a closed configuration and an open configuration and the one or more filaments of the scaffold bias the valve to the closed configuration while in a nominally deployed state.

2. 发明申请

WO2016109738A3 IMPLANTABLE ENDOPROSTHESIS FOR AORTIC ANEURYSM 审中-公开
标题翻译：可行的内源性恶性肿瘤
公开(公告)号：WO2016109738A3
公开(公告)日：2017-01-05
申请号：PCT/US2015068172
申请日：2015-12-30
申请人： CORDIS CORP
发明人： CHOUBEY ANIMESH , MAJERCAK DAVID
IPC分类号： A61F2/07 , A61F2/954
CPC分类号： A61F2/07 , A61F2/954 , A61F2002/061 , A61F2002/067 , A61F2230/0008
摘要： Described are various embodiments of an improved endoprosthesis that includes at least one tubular graft section coupled to additional tubular graft sections which are then coupled to a tubular bifurcated main section. Various embodiments described and shown herein allow for a health care provider to design and select an appropriate AAA implant for AAA presentations other than an infrarenal AAA.
摘要翻译：描述了改进的内假体的各种实施例，其包括联接到另外的管状移植部分的至少一个管状移植部分，然后将其连接到管状分叉的主部分。本文描述和示出的各种实施例允许医疗保健提供者设计和选择用于除了肾下AAA之外的AAA呈现的适当的AAA植入物。

3. 发明申请

WO2016203040A1 ENDOLUMINAL VASCULAR PROSTHESES AND METHOD OF DEPLOYING SUCH PROSTHESES 审中-公开
标题翻译：支气管扩张和分娩方法
公开(公告)号：WO2016203040A1
公开(公告)日：2016-12-22
申请号：PCT/EP2016/064166
申请日：2016-06-20
申请人： BERG, Patrick , BERG, Victor Charles , BENTA PHARMA INDUSTRIES
发明人： BERG, Patrick , BERG, Victor Charles
IPC分类号： A61F2/07 , A61F2/90 , A61F2/954 , A61F2/962 , A61F2/06 , A61F2/82
CPC分类号： A61F2/07 , A61F2/90 , A61F2/954 , A61F2/962 , A61F2002/061 , A61F2002/077 , A61F2002/823 , A61F2230/0008 , A61F2230/0026 , A61F2230/0076 , A61F2250/0037 , A61F2250/0098
摘要： The present invention relates to endoluminal vascular prostheses and methods of deploying such prostheses. More particularly this invention relates to systems, apparatuses and methods for deploying stents and/or stentgrafts and creating fenestrations in such devices while they are deployed in situ within body lumens, such as blood vessels, to provide additional flow pathways and/or join with other flow‐directing or structural devices. It is the object of the invention to provide a flexible endovascular device implanted in the aorta with a self‐expandable stent allowing blood flow through the struts during implantation and during cannulation and connection of target vessels with the aortic lumen by the use of stentgrafts. After connection of all the target vessels, the residual lumen between aortic wall and aortic stent is sealed with polymer‐filled endobags.
摘要翻译：本发明涉及腔内血管假体和部署这种假体的方法。更具体地说，本发明涉及用于展开支架和/或支架移植物并且在这些装置内部部署在体腔（例如血管）内原位部署以便提供额外的流动途径和/或与其他部件连接的部件的系统，装置和方法导流或结构装置。本发明的目的是提供一种在主动脉中植入具有自扩张支架的柔性血管内装置，其允许在植入期间血液流过支柱，以及通过使用支架移植物将靶血管与主动脉腔插管和连接。所有目标血管连接后，主动脉壁和主动脉支架之间的残留管腔用聚合物填充的内包装密封。

4. 发明申请

WO2016116816A3 INTRAVASCULAR DEVICES AND DELIVERY SYSTEMS AND USES THEREOF 审中-公开
标题翻译：血管内装置和输送系统及其用途
公开(公告)号：WO2016116816A3
公开(公告)日：2016-10-13
申请号：PCT/IB2016000192
申请日：2016-01-20
申请人： KEYSTONE HEART LTD
发明人： SHEMESH TZEELA MIKOVSKY , GERA MORAN , ASHKENAZI AMIT
IPC分类号： A61F2/06 , A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/0095
摘要： In general, the invention features an intravascular device, a delivery system, and methods for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels The intravascular device of the invention may prevent passage of a particle in a blood vessel from passing through a filter supported by a frame, upper and lower stabilizers, and a wire. The wire may be used to stabilize the device upon its deployment and installation within a blood vessel. Further, in some embodiments, the invention features a delivery system and methods for introduction of the device into a blood vessel.
摘要翻译：一般而言，本发明的特征在于血管内装置，输送系统以及用于过滤或偏转栓子或其他大型物体以进入受保护的一次或多次容器的方法。本发明的血管内装置可防止血管中的粒子从穿过由框架支撑的过滤器，上部稳定器和下部稳定器以及电线。导线可用于在装置展开和安装在血管内时稳定装置。此外，在一些实施例中，本发明的特征在于用于将装置引入血管中的输送系统和方法。

5. 发明申请

WO2016110848A9 SYSTEM AND METHOD FOR EMBOLIC PROTECTION 审中-公开
标题翻译：用于栓塞保护的系统和方法
公开(公告)号：WO2016110848A9
公开(公告)日：2016-10-13
申请号：PCT/IL2016050016
申请日：2016-01-06
申请人： JAVELIN MEDICAL LTD , SHINAR GUY , NETA AVRAHAM , DAN YAIR , KAUFMAN EYAL , YODFAT OFER , BRODER SAGIT
发明人： SHINAR GUY , NETA AVRAHAM , DAN YAIR , KAUFMAN EYAL , YODFAT OFER , BRODER SAGIT
IPC分类号： A61F2/01 , A61B17/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2220/0008 , A61F2230/0008 , A61F2230/0071 , A61F2230/0091
摘要： Embodiments of the present disclosure provide a removable embolic protection device for deployment at a body vessel, as well as systems and methods for implanting the device within a vessel of a patient.
摘要翻译：本公开的实施例提供用于在身体血管处展开的可移除的栓塞防护装置，以及用于将装置植入患者的脉管内的系统和方法。

6. 发明申请

WO2016154478A1 GENDER-SPECIFIC MESH IMPLANT WITH BARRIER FOR INGUINAL HERNIA REPAIR 审中-公开
标题翻译：性别特殊的MESH植入与障碍用于INNUILA HERNIA修复
公开(公告)号：WO2016154478A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/024090
申请日：2016-03-24
申请人： HEXAGON HEALTH, INC.
发明人： TOWFIGH, Shirin
IPC分类号： A61F2/02 , A61F2/08
CPC分类号： A61F2/0063 , A61B17/0057 , A61F2002/0068 , A61F2230/0006 , A61F2230/0008 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0078 , A61F2230/008 , A61F2250/0078
摘要： Disclosed herein are gender-specific implantable mesh for inguinal hernia repair in a patient, comprising: a fabric layer comprising a side defining a surface area wherein the fabric layer is configured to enable tissue adhesion to said mesh; an anti-adhesive barrier comprising a shape configured to prevent direct contact between the fabric layer and both a spermatic cord and a genital nerve upon implantation, wherein the shape covers a part of the surface area on the side of the fabric layer, the part being less than 25%, and wherein the shape is oblique to a horizontally-oriented centerline and a vertically-oriented centerline; and a keyhole configured to fit the genital nerve and the spermatic cord of the patient therethrough without constriction, wherein the keyhole is oblique and inferior to a horizontally-oriented centerline and medial to a vertically-oriented centerline.
摘要翻译：本文公开了用于患者腹股沟疝修补的性别特异性可植入网，其包括：织物层，其包含限定表面区域的侧面，其中所述织物层被配置为使得能够组织粘附到所述网状物; 一种抗粘合屏障，其包括被配置为防止织物层与植入后的精索和生殖器神经两者之间的直接接触的形状，其中该形状覆盖织物层侧面上的一部分表面区域，该部分是小于25％，并且其形状与水平取向的中心线和垂直取向的中心线倾斜; 以及构造成将患者的生殖器神经和精索固定在其中而不收缩的锁眼，其中，所述锁孔是倾斜的，并且低于水平定向的中心线并且向内垂直定向的中心线。

7. 发明申请

WO2016114928A1 MITRAL BILEAFLET VALVE 审中-公开
标题翻译：麻药双流阀
公开(公告)号：WO2016114928A1
公开(公告)日：2016-07-21
申请号：PCT/US2015/068020
申请日：2015-12-30
申请人： HORIZON SCIENTIFIC CORP. , ZENG, Min, Frank , LO, Pham
发明人： ZENG, Min, Frank , LO, Pham
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61F2230/0034
摘要： A heart valve assembly has a leaflet support structure and a leaflet assembly. The leaflet support structure has a wire frame that supports the leaflet assembly. The leaflet assembly has first and second separate leaflets, each of which is comprised of a skirt section and a sinus leaflet section. Each skirt section has a flange portion and a body portion that has a smaller diameter than the flange portion, with the body portion having opposing side edges, and a curved opening defined by a first stitching edge at about the central portion of the body portion. Each sinus leaflet section has an outflow edge, and a curved second stitching edge, with the sinus leaflet section stitched to the skirt section along the first and second stitching edges. The opposing side edges of the body portion of the first leaflet are stitched to the corresponding side edges of the body portion of the second leaflet.
摘要翻译：心脏瓣膜组件具有小叶支撑结构和小叶组件。小叶支撑结构具有支撑传单组件的线框架。小叶组件具有第一和第二分开的单张，每个小叶由裙部和窦叶片部分组成。每个裙部具有凸缘部分和主体部分，其具有比凸缘部分更小的直径，主体部分具有相对的侧边缘，以及由主体部分的中心部分周围的第一缝合边限定的弯曲开口。每个窦叶片部分具有流出边缘和弯曲的第二缝合边缘，其中窦瓣片部分沿着第一和第二缝合边缘缝合到裙部。第一传单的主体部分的相对的侧边缘被缝合到第二传单的主体部分的对应的侧边缘。

8. 发明申请

WO2015188273A1 METHOD OF DETECTING CANCER BASED ON SPERMINE/SPERMIDINE N'-ACETYLTRANSFERASE GENE EXPRESSION 审中-公开
标题翻译：基于SPERMINE / SPERMIDINE N-乙酰基转移酶基因表达检测癌症的方法
公开(公告)号：WO2015188273A1
公开(公告)日：2015-12-17
申请号：PCT/CA2015/050534
申请日：2015-06-09
申请人： BIOMARK TECHNOLOGIES INC.
发明人： BUX, Rashid , CHENG, Brian , TAPPIA, Paramjit S. , RAMJIAWAN, Bram
IPC分类号： C12Q1/68 , C12Q1/48 , G01N33/573 , G01N33/574
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2210/0076 , A61F2220/0008 , A61F2230/0006 , A61F2230/0008 , C12Q1/6886 , C12Q2600/158 , G01N33/57484 , G01N2333/91057
摘要： Elevated levels of spermidine/spermine N 1 -acetyltransferase (SSAT) gene expression expression were observed in breast, prostate and lung cancer cell lines. Elevated levels of SSAT gene expression were verified in tissues from patients with breast, prostate and lung cancer. Elevated SSAT gene expression is elevated in different human cancers and elevated SSAT gene expression may accordingly serve as a companion diagnostic biomarker for detection and monitoring of cancer progression.
摘要翻译：在乳腺癌，前列腺癌和肺癌细胞系中观察到亚精胺/精胺N1-acetyltransferase（SSAT）基因表达水平升高。在乳腺癌，前列腺癌和肺癌患者组织中检测到SSAT基因表达水平升高。升高的SSAT基因表达在不同的人类癌症中升高，并且升高的SSAT基因表达可以相应地作为癌症进展的检测和监测的伴随诊断生物标志物。

9. 发明申请

WO2014179568A3 TWO-LAYER OCULAR IMPLANT 审中-公开
标题翻译：双层OCULAR IMPLANT
公开(公告)号：WO2014179568A3
公开(公告)日：2015-11-12
申请号：PCT/US2014036370
申请日：2014-05-01
申请人： ODIN BIOTECH
发明人： CSAKY KARL
IPC分类号： A61F9/007 , A61M35/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F2/14 , A61F9/0017 , A61F2210/0004 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2240/00 , A61F2240/004 , A61F2250/0067 , A61K31/26 , A61L27/18 , A61L2430/16 , B29D11/023 , B29K2083/00 , C08L83/04
摘要： The present invention generally relates to local therapies for the eye and, more particularly, to shaped controlled-release ocular implant devices, including methods for making and using such devices, for delivery of therapeutic agents to the eye. A molded two-layer ocular implant comprises a therapeutic agent for treatment or prevention of a disorder of the eye. The implant comprises a polymer layer and a silicone adhesive layer with a therapeutic agent interspersed therein and joined to the polymer layer. This implant is for placement in the sub-Tenons space of the eye and provides sustained release of the therapeutic agent during the treatment or prevention of the disorder of the eye.
摘要翻译：本发明一般涉及用于眼睛的局部治疗，更具体地说，涉及成形的控制释放眼部植入装置，包括制造和使用这些装置的方法，用于将治疗剂递送至眼睛。模制的双层眼部植入物包括用于治疗或预防眼睛疾病的治疗剂。植入物包括聚合物层和具有散布在其中并与聚合物层连接的治疗剂的硅氧烷粘合剂层。该植入物用于放置在眼睛的子Tenon空间中并且在治疗或预防眼睛疾病期间提供治疗剂的持续释放。

10. 发明申请

WO2015109375A1 ENDOPRÓTESE PARA TRATAMENTO ENDOVASCULAR DE ANEURISMAS OU DISSECÇÕES TORACOABDOMINAIS DA AORTA E ENDOPRÓTESE PARA TRATAMENTO ENDOVASCULAR DE ANEURISMAS OU DISSECÇÕES DA AORTA ABDOMINAL QUE COMPROMETAM AS ARTÉRIAS ILÍACAS 审中-公开
标题翻译：内镜下治疗胸腔积液性动脉炎或内分泌腺内切除术治疗腹主动脉炎的内窥镜治疗或治疗ILIAC ARTERIES的病例
公开(公告)号：WO2015109375A1
公开(公告)日：2015-07-30
申请号：PCT/BR2014/000043
申请日：2014-01-23
申请人： BIOKYRA PESQUISA E DESENVOLVIMENTO LTDA.
发明人： LOURENÇO, Marco Antonio , DE SOUZA, Charles Cristian Facchini , MASIERO FILHO, Isaias
IPC分类号： A61F2/07
CPC分类号： A61F2/07 , A61F2/856 , A61F2/89 , A61F2002/061 , A61F2002/072 , A61F2230/0008 , A61F2250/0039
摘要： A presente invenção se refere a uma endoprótese (1) para o tratamento endovascular de aneurismas ou dissecções toracoabdominais da aorta, em que dita endoprótese (1) é dotada de região proximal (2), região intermediária (3) e região distal (4), possuindo cinco cilindros internos (5), (7), (9), (11) e (13), paralelos ao eixo longitudinal da endoprótese (1), ditos cilindros internos (5), (7), (9), (11) e (13) sendo dotados de aberturas (6), (8), (10), (12) e (14) elípticas dispostas na região intermediária (3). A presente invenção refere-se também a uma endoprótese (50) para tratamento endovascular de aneurismas ou dissecções da aorta abdominal que comprometam as artérias ilíacas, em que dita endoprótese (50) é dotada de região proximal (51), região intermediária (52) e região distal (53), possuindo um cilindro interno (54), paralelo ao eixo longitudinal da endoprótese (50), dito cilindro interno (54) sendo dotado de abertura (55) elíptica disposta na região intermediária (52).
摘要翻译：本发明涉及用于胸腹主动脉瘤或解剖的血管内治疗的内用假体（1），其中内假体（1）具有近端区域（2），中间区域（3）和远侧区域（4），包括平行于内用假体（1）的纵向轴线的五个内筒（5），（7），（9），（11）和（13），所述内筒（5），（7），（9）（11）和（13）在中间区域（3）中具有椭圆形孔（6），（8），（10），（12）和（14）。本发明还涉及一种用于血管内治疗腹主动脉瘤或内窥镜的内用假体（50），所述腹内主动脉瘤或憩室损伤髂动脉，其中内假体（50）具有近端区域（51），中间区域（52）和远端区域（53），包括平行于内用假体（50）的纵向轴线的内筒（54），所述内筒（54）在中间区域（52）中具有椭圆形孔（55）。

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