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1. 发明申请

WO2005102222A3 BIORESORBABLE STENT WITH BENEFICIAL AGENT RESERVOIRS 审中-公开
标题翻译：具有有益代理储备的可生物降解固体
公开(公告)号：WO2005102222A3
公开(公告)日：2007-08-23
申请号：PCT/US2005007208
申请日：2005-03-04
申请人： CONOR MEDSYSTEMS INC , SHANLEY JOHN F , LITVACK FRANK , PARKER THEODORE L , DIAZ STEPHEN HUNTER
发明人： SHANLEY JOHN F , LITVACK FRANK , PARKER THEODORE L , DIAZ STEPHEN HUNTER
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61L31/14 , A61L31/16
CPC分类号： A61L31/146 , A61F2/91 , A61F2/915 , A61F2002/821 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2250/0004 , A61F2250/0068 , A61L31/022 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/416
摘要： A bioresorbable drug delivery stent includes a substantially cylindrical expandable stent formed of a bioresorbable material and a plurality of reservoirs or openings formed in the stent containing a beneficial agent matrix comprising a bioresorbable material and drug. The bioresorbable stent material can be a bioresorbable metal alloy, a bioresorbable polymer, or other bioresorbable material which has sufficient structural integrity to support a lumen, such as a blood vessel lumen for a predetermined period of time. The reservoirs containing the beneficial agent matrix allow delivery of the beneficial agent, such as an anti-restenotic drug, for an administration period which is generally equal to or less than a time that the bioresorbable stent is retained in the lumen. The beneficial agent matrix may include one or more bioresorbable polymers in combination with one or more therapeutic agents or drugs and the structure of the beneficial agent matrix can be programmed to achieve a desired release profile for the drug(s) and a desired administration period.
摘要翻译：生物可吸收药物递送支架包括由生物可再吸收材料和形成在支架中的多个储存器或开口形成的基本上圆柱形的可扩张支架，其含有包含生物可再吸收材料和药物的有益剂基质。生物可再吸收的支架材料可以是生物可再吸收的金属合金，生物再吸收的聚合物或其它可生物再吸收的材料，其具有足够的结构完整性以支持诸如血管管腔在内的预定时间段。含有有益剂基质的储存器允许有益剂例如抗再狭窄药物递送给药期，其通常等于或小于生物可再吸收支架保留在管腔中的时间。有益剂基质可以包括一种或多种与一种或多种治疗剂或药物组合的生物可再吸收聚合物，并且可以编程有益药物基质的结构以实现药物所需的释放曲线和期望的给药期。

2. 发明申请

WO2007056648A2 METHODS AND DEVICES FOR REDUCING TISSUE DAMAGE AFTER ISCHEMIC INJURY 审中-公开
标题翻译：用于减少身体损伤后组织损伤的方法和装置
公开(公告)号：WO2007056648A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/060441
申请日：2006-11-01
申请人： CONOR MEDSYSTEMS, INC. , PARKER, Theodore, L. , LITVACK, Frank
发明人： PARKER, Theodore, L. , LITVACK, Frank
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2230/0013 , A61F2250/003 , A61F2250/0068 , A61L2300/416
摘要： Methods and devices are provided for the local delivery of anti-ischemic agents which reduce myocardial tissue damage due to ischemia or reperfusion, in combination with compounds that sensitize the response of the tissue to the anti-ischemic agent. The therapeutic agents are delivered to the myocardial tissue over an administration period sufficient to achieve reduction in ischemic or reperfusion injury of the tissue.
摘要翻译：提供了用于局部递送抗缺血药物的方法和装置，其减少由缺血或再灌注导致的心肌组织损伤，以及使组织对抗缺血剂的反应敏感的化合物。治疗剂在足以实现组织的缺血或再灌注损伤减少的给药期间递送至心肌组织。

3. 发明申请

WO2006105256A3 METHOD FOR LOADING A BENEFICIAL AGENT INTO A MEDICAL DEVICE 审中-公开
公开(公告)号：WO2006105256A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/011576
申请日：2006-03-28
申请人： CONOR MEDSYSTEMS, INC. , DIAZ, Stephen, Hunter , PARKER, Theodore, L. , SHANLEY, John, F.
发明人： DIAZ, Stephen, Hunter , PARKER, Theodore, L. , SHANLEY, John, F.
IPC分类号： A61F2/06
摘要： A system for delivery of a beneficial agent in the form of a viscous liquid or paste allows holes in a medical device to be loaded in a single step process. Another system for loading a beneficial agent into holes in a medical device includes a punch system for punching plugs of beneficial agent from a thin sheet into the holes in the medical device. The loading of a beneficial agent in a paste form or from a thin film also provides the ability to deliver large and potentially sensitive molecules including proteins, enzymes, antibodies, antisense, ribozymes, gene/vector constructs, and cells including endothelial cells.

4. 发明申请

WO2006062639A2 EXPANDABLE MEDICAL DEVICE WITH DIFFERENTIAL HINGE PERFORMANCE 审中-公开
标题翻译：具有差异性铰链性能的可扩展医疗器械
公开(公告)号：WO2006062639A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/039995
申请日：2005-11-02
申请人： CONOR MEDSYSTEMS, INC. , SHANLEY, John, F. , FISHER, Beau, M.
发明人： SHANLEY, John, F. , FISHER, Beau, M.
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： The stent described herein is configured with expandable rings at either end of the stent having increased radial strength compared to the expandable middle rings. This difference between the configuration of the stent at the middle and ends of the stent results in more even expansion properties of the stent, better crimping properties of the stent, and uniform diameter post deployment. The expandable rings are formed by a plurality of struts and a plurality of ductile hinges arranged such that upon expansion, the ductile hinges are deformed while the struts are not deformed.
摘要翻译：本文描述的支架在支架的任一端配置有可膨胀的环，其具有与可膨胀的中间环相比具有增加的径向强度。在支架的中间和末端处的支架的构造之间的这种差异导致支架的更均匀的膨胀性能，支架的更好的卷曲性能和均匀直径的部署后。可膨胀环由多个支柱和多个延性铰链形成，多个延性铰链布置成使得在膨胀时，延性铰链在支柱不变形的同时变形。

5. 发明申请

WO2005115277A3 STENT WITH CONTOURED BRIDGING ELEMENTS 审中-公开
公开(公告)号：WO2005115277A3
公开(公告)日：2005-12-08
申请号：PCT/US2005/017068
申请日：2005-05-16
申请人： CONOR MEDSYSTEMS, INC. , SHANLEY, John, F.
发明人： SHANLEY, John, F.
IPC分类号： A61F2/06
摘要： A stent is formed from a plurality of expandable rings interconnected by a plurality of flexible bridging elements. The stent has a flexible bridging elements which are contoured along their length in such a manner to uniformly distribute energy during deformation.

6. 发明申请

WO2005115277A2 STENT WITH CONTOURED BRIDGING ELEMENTS 审中-公开
标题翻译：具有轮廓桥梁元素的STENT
公开(公告)号：WO2005115277A2
公开(公告)日：2005-12-08
申请号：PCT/US2005017068
申请日：2005-05-16
申请人： CONOR MEDSYSTEMS INC , SHANLEY JOHN F
发明人： SHANLEY JOHN F
IPC分类号： A61F2/00 , A61F2/90 , A61F2/06
CPC分类号： A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： A stent is formed from a plurality of expandable rings interconnected by a plurality of flexible bridging elements. The stent has a flexible bridging elements which are contoured along their length in such a manner to uniformly distribute energy during deformation.
摘要翻译：由多个可挠性桥接元件互连的多个可扩展环形成支架。支架具有柔性桥接元件，其沿着其长度成像，以在变形期间均匀分布能量。

7. 发明申请

WO0232347A3 EXPANDABLE MEDICAL DEVICE FOR DELIVERY OF BENEFICIAL AGENT 审中-公开
标题翻译：用于交付受益人的可扩展医疗设备
公开(公告)号：WO0232347A3
公开(公告)日：2003-02-06
申请号：PCT/US0129646
申请日：2001-09-21
申请人： CONOR MEDSYSTEMS INC , SHANLEY JOHN F
发明人： SHANLEY JOHN F
IPC分类号： A61F2/82 , A61F2/00 , A61L27/04 , A61L27/54 , A61M29/02 , A61F2/06
CPC分类号： A61F2/91 , A61F2/0077 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2250/0068
摘要： An expandable medical device having a plurality of elongated struts (18), the plurality of elongated struts being joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, and the plurality of struts each having a strut width in a circumferential direction. At least one of the plurality of struts includes at least one opening (24) extending at least partially through a thickness of said strut. A beneficial agent may be loaded into the opening within the strut. The expandable medical device may further include a plurality of ductile hinges (20) formed between the elongated struts, the ductile hinges allowing the cylindrical device to be expanded or compressed from the first diameter to the second diameter by deformation of the ductile hinges.
摘要翻译：一种具有多个细长支柱（18）的可扩张医疗装置，所述多个细长支柱被连接在一起以形成一个基本上为圆柱形的装置，该装置可从具有第一直径的圆柱体扩展到具有第二直径的圆筒，每个支柱在圆周方向上具有支撑宽度。所述多个支柱中的至少一个包括至少一个至少部分延伸穿过所述支柱的厚度的开口（24）。有益剂可以装载到支柱内的开口中。可扩展医疗装置还可以包括形成在细长支柱之间的多个延性铰链（20），延性铰链允许圆柱形装置通过延性铰链的变形从第一直径扩展或压缩到第二直径。

8. 发明申请

WO2002062268A2 EXPANDABLE MEDICAL DEVICE WITH LOCKING MECHANISM 审中-公开
标题翻译：具有锁定机构的可扩展医疗装置
公开(公告)号：WO2002062268A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/001234
申请日：2002-02-04
申请人： CONOR MEDSYSTEMS, INC. , SHANLEY, John, F.
发明人： SHANLEY, John, F.
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2250/0004
摘要： According to the present invention there is provided an expandable medical device having, a plurality of elongated beams, the plurality of elongated beams joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of hinges connecting the elongated beams have a hinge width, wherein the hinge width is smaller than the beam width. A pawl is disposed adjacent to and substantially parallel to the hinge prior to expansion of the medical device and a plurality of teeth are adapted to receive the pawl. The present invention additionally provides the benefit of limiting the amount of recoil of an expandable device by engaging a locking mechanism, thereby retaining the expanded diameter of the device.
摘要翻译：根据本发明，提供了一种可扩张医疗装置，其具有多个细长梁，所述多个细长梁连接在一起以形成基本上圆柱形的装置，其可从具有第一直径的圆柱体扩展到具有第二直径的圆柱体。连接细长梁的多个铰链具有铰链宽度，其中铰链宽度小于梁宽度。棘爪在医疗装置膨胀之前邻近并基本平行于铰链设置，并且多个齿适于接纳棘爪。本发明另外提供了通过接合锁定机构来限制可膨胀装置的反冲量的益处，从而保持装置的扩大直径。

9. 发明申请

WO2000071054A1 EXPANDABLE MEDICAL STENT WITH DUCTILE HINGES 审中-公开
标题翻译：可扩展的医疗手套与DUCTILE HINGES
公开(公告)号：WO2000071054A1
公开(公告)日：2000-11-30
申请号：PCT/US2000/013244
申请日：2000-05-12
申请人： CONOR MEDSYSTEMS, INC. , SHANLEY, John, F.
发明人： SHANLEY, John, F.
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558
摘要： An expandable tissue supporting device of the present invention employs ductile hinges at selected points in the expandable device. When expansion forces are applied to the device as a whole, the ductile hinges concentrate expansion stresses and strains in small well defined areas. The expandable tissue supporting device includes a plurality of elongated beams arranged in a cylindrical device and connected together by a plurality of ductile hinges. Although many ductile hinge configurations are possible, the ductile hinges preferably have a substantially constant hinge cross sectional area which is smaller than a beam cross sectional area such that as the device is expanded from a first diameter to a second diameter, the ductile hinges experience plastic deformation while the beams are not plastically deformed. The expandable tissue supporting device can be provided with segments which may be expanded in a specified sequence and/or framed hole features for accommodating bifurcations.
摘要翻译：本发明的可扩张组织支撑装置在可扩张装置中的选定点使用延性铰链。当膨胀力作为整体施加到装置时，延性铰链将膨胀应力和应变集中在小的井定义的区域中。可扩张组织支撑装置包括布置在圆柱形装置中并由多个延性铰链连接在一起的多个细长梁。虽然许多延性铰链结构是可能的，但是延性铰链优选地具有基本上恒定的铰链横截面积，该横截面面积小于横截面积，使得当该装置从第一直径扩展到第二直径时，延性铰链经历塑性梁的变形不会塑性变形。可扩张组织支撑装置可以设置有可以以指定顺序扩展的段和/或用于容纳分叉的框架孔特征。

10. 发明申请

WO2006105126A3 SYSTEM AND METHOD FOR LOADING A BENEFICIAL AGENT INTO A MEDICAL DEVICE 审中-公开
标题翻译：将受益药物装载到医疗装置中的系统和方法
公开(公告)号：WO2006105126A3
公开(公告)日：2008-01-17
申请号：PCT/US2006011346
申请日：2006-03-28
申请人： CONOR MEDSYSTEMS INC , DIAZ STEPHEN HUNTER , PARKER THEODORE L
发明人： DIAZ STEPHEN HUNTER , PARKER THEODORE L
IPC分类号： A61K9/50 , A61F2/06 , B01J13/00 , B05D3/00
CPC分类号： A61L31/146 , A61L31/16 , A61L2300/00
摘要： The beneficial agent is applied into the holes in a medical device in a dry particulate form and is adhered in the hole in a manner that allows release of the drug in a controlled manner. The drug material would be formed into particles and placed in the holes. The solvent would be added to partially liquefy and adhere the drug into the holes. After application of the solvent, the particles are adhered together in a substantially uniform drug containing matrix. The particles may include drhug alone or drug in combination with other materials including a matrix.
摘要翻译：将有益剂以干燥颗粒形式施加到医疗装置的孔中，并以允许以受控方式释放药物的方式粘附在孔中。药物将形成颗粒并放置在孔中。加入溶剂以部分液化并将药物粘附到孔中。在施加溶剂之后，颗粒以基本均匀的含药基质粘合在一起。颗粒可以包括单独的drhug或与包括基质的其它材料组合的药物。

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